Search Results (3 kinases found)
Gene name
Organism
Protein name
FYN
Human
Tyrosine-protein kinase Fyn
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
FYN_HUMAN
- Accession #
-
P06241
- Protein names
-
- Tyrosine-protein kinase Fyn
- EC 2.7.10.2
- Proto-oncogene Syn
- Proto-oncogene c-Fyn
- Src-like kinase
- SLK
- p59-Fyn
- Gene names
-
- FYN
- Description
-
Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). {ECO:0000250|UniProtKB:P39688, ECO:0000269|PubMed:11005864, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117, ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091, ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597, ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:7822789}.
- Links
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Search Substrates of FYN (Human)
- Adherens junction
- Axon guidance
- Cholinergic synapse
- Fc epsilon RI signaling pathway
- Focal adhesion
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- Pathogenic Escherichia coli infection
- Phospholipase D signaling pathway
- Platelet activation
- Prion disease
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- Viral myocarditis
- ATP binding
- CD4 receptor binding
- CD8 receptor binding
- Fc-gamma receptor signaling pathway involved in phagocytosis
- MAPK cascade
- Schaffer collateral - CA1 synapse
- T cell costimulation
- T cell receptor binding
- T cell receptor signaling pathway
- actin filament
- activated T cell proliferation
- adaptive immune response
- alpha-tubulin binding
- axon guidance
- blood coagulation
- calcium ion transport
- cell body
- cell differentiation
- cellular response to L-glutamate
- cellular response to amyloid-beta
- cellular response to glycine
- cellular response to peptide hormone stimulus
- cellular response to platelet-derived growth factor stimulus
- cellular response to transforming growth factor beta stimulus
- cytokine-mediated signaling pathway
- cytosol
- dendrite
- dendrite morphogenesis
- dendritic spine maintenance
- detection of mechanical stimulus involved in sensory perception of pain
- disordered domain specific binding
- endosome
- enzyme binding
- ephrin receptor binding
- ephrin receptor signaling pathway
- extrinsic component of cytoplasmic side of plasma membrane
- feeding behavior
- forebrain development
- glial cell projection
- glutamatergic synapse
- growth factor receptor binding
- heart process
- identical protein binding
- innate immune response
- intracellular signal transduction
- learning
- leukocyte migration
- membrane raft
- metal ion binding
- mitochondrion
- modulation of chemical synaptic transmission
- negative regulation of dendritic spine maintenance
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- negative regulation of gene expression
- negative regulation of hydrogen peroxide biosynthetic process
- negative regulation of inflammatory response to antigenic stimulus
- negative regulation of neuron apoptotic process
- negative regulation of oxidative stress-induced cell death
- negative regulation of protein catabolic process
- negative regulation of protein ubiquitination
- neuron migration
- non-membrane spanning protein tyrosine kinase activity
- nucleus
- peptide hormone receptor binding
- peptidyl-tyrosine phosphorylation
- perinuclear endoplasmic reticulum
- perinuclear region of cytoplasm
- phosphatidylinositol 3-kinase binding
- phospholipase activator activity
- phospholipase binding
- plasma membrane
- platelet activation
- positive regulation of I-kappaB kinase/NF-kappaB signaling
- positive regulation of cysteine-type endopeptidase activity
- positive regulation of neuron death
- positive regulation of neuron projection development
- positive regulation of non-membrane spanning protein tyrosine kinase activity
- positive regulation of phosphatidylinositol 3-kinase signaling
- positive regulation of protein kinase B signaling
- positive regulation of protein localization to membrane
- positive regulation of protein localization to nucleus
- positive regulation of protein targeting to membrane
- positive regulation of tyrosine phosphorylation of STAT protein
- postsynaptic density
- postsynaptic density, intracellular component
- protein autophosphorylation
- protein phosphorylation
- protein tyrosine kinase activity
- regulation of calcium ion import across plasma membrane
- regulation of cell shape
- regulation of defense response to virus by virus
- regulation of glutamate receptor signaling pathway
- regulation of peptidyl-tyrosine phosphorylation
- response to amyloid-beta
- response to ethanol
- response to hydrogen peroxide
- response to singlet oxygen
- signaling receptor binding
- stimulatory C-type lectin receptor signaling pathway
- tau protein binding
- tau-protein kinase activity
- transmembrane receptor protein tyrosine kinase activity
- transmembrane receptor protein tyrosine kinase signaling pathway
- transmembrane transporter binding
- type 5 metabotropic glutamate receptor binding
- vascular endothelial growth factor receptor signaling pathway

LYN
Human
Tyrosine-protein kinase Lyn
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
LYN_HUMAN
- Accession #
-
P07948
- Protein names
-
- Tyrosine-protein kinase Lyn
- EC 2.7.10.2
- Lck/Yes-related novel protein tyrosine kinase
- V-yes-1 Yamaguchi sarcoma viral related oncogene homolog
- p53Lyn
- p56Lyn
- Gene names
-
- LYN
- JTK8
- Description
-
Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity). {ECO:0000250|UniProtKB:P25911, ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:10748115, ECO:0000269|PubMed:10891478, ECO:0000269|PubMed:11435302, ECO:0000269|PubMed:11517336, ECO:0000269|PubMed:11825908, ECO:0000269|PubMed:14726379, ECO:0000269|PubMed:15795233, ECO:0000269|PubMed:16467205, ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:17977829, ECO:0000269|PubMed:18056483, ECO:0000269|PubMed:18070987, ECO:0000269|PubMed:18235045, ECO:0000269|PubMed:18577747, ECO:0000269|PubMed:18802065, ECO:0000269|PubMed:19290919, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:7687428}.
- Links
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Search Substrates of LYN (Human)
- ATP binding
- B cell homeostasis
- B cell receptor signaling pathway
- Fc receptor mediated inhibitory signaling pathway
- Fc receptor mediated stimulatory signaling pathway
- Fc-epsilon receptor signaling pathway
- Fc-gamma receptor signaling pathway involved in phagocytosis
- Golgi apparatus
- SH3 domain binding
- T cell costimulation
- adaptive immune response
- adherens junction
- blood coagulation
- cell differentiation
- cellular response to DNA damage stimulus
- cellular response to extracellular stimulus
- cellular response to heat
- cellular response to retinoic acid
- cytoplasm
- cytosol
- dendritic cell differentiation
- enzyme binding
- ephrin receptor binding
- ephrin receptor signaling pathway
- erythrocyte differentiation
- extracellular exosome
- extrinsic component of cytoplasmic side of plasma membrane
- gamma-tubulin binding
- glutamatergic synapse
- glycosphingolipid binding
- growth hormone receptor signaling pathway via JAK-STAT
- histamine secretion by mast cell
- immune response-regulating cell surface receptor signaling pathway
- innate immune response
- integrin alpha2-beta1 complex
- integrin binding
- intracellular membrane-bounded organelle
- intracellular signal transduction
- kinase activity
- leukocyte migration
- lipopolysaccharide-mediated signaling pathway
- membrane raft
- mitochondrial crista
- mitochondrial intermembrane space
- negative regulation of B cell proliferation
- negative regulation of ERK1 and ERK2 cascade
- negative regulation of MAP kinase activity
- negative regulation of cell population proliferation
- negative regulation of immune response
- negative regulation of inflammatory response to antigenic stimulus
- negative regulation of intracellular signal transduction
- negative regulation of mast cell proliferation
- negative regulation of myeloid leukocyte differentiation
- negative regulation of protein phosphorylation
- negative regulation of toll-like receptor 2 signaling pathway
- negative regulation of toll-like receptor 4 signaling pathway
- neuron projection development
- non-membrane spanning protein tyrosine kinase activity
- nucleus
- oligodendrocyte development
- peptidyl-tyrosine phosphorylation
- perinuclear region of cytoplasm
- phosphoprotein binding
- phosphorylation-dependent protein binding
- plasma membrane
- platelet activation
- platelet degranulation
- platelet-derived growth factor receptor binding
- positive regulation of Fc receptor mediated stimulatory signaling pathway
- positive regulation of Ras protein signal transduction
- positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
- positive regulation of cell migration
- positive regulation of cell population proliferation
- positive regulation of cellular component movement
- positive regulation of dendritic cell apoptotic process
- positive regulation of glial cell proliferation
- positive regulation of mast cell proliferation
- positive regulation of neuron projection development
- positive regulation of oligodendrocyte progenitor proliferation
- positive regulation of phosphatidylinositol 3-kinase activity
- positive regulation of phosphatidylinositol 3-kinase signaling
- positive regulation of protein phosphorylation
- positive regulation of stress-activated protein kinase signaling cascade
- positive regulation of tyrosine phosphorylation of STAT protein
- postsynaptic density
- postsynaptic specialization, intracellular component
- protein autophosphorylation
- protein phosphorylation
- protein tyrosine kinase activity
- regulation of B cell apoptotic process
- regulation of B cell receptor signaling pathway
- regulation of ERK1 and ERK2 cascade
- regulation of cell adhesion mediated by integrin
- regulation of cytokine production
- regulation of erythrocyte differentiation
- regulation of mast cell activation
- regulation of mast cell degranulation
- regulation of monocyte chemotaxis
- regulation of platelet aggregation
- regulation of protein phosphorylation
- regulation of release of sequestered calcium ion into cytosol
- response to amino acid
- response to axon injury
- response to carbohydrate
- response to hormone
- response to insulin
- response to organic cyclic compound
- response to sterol depletion
- response to toxic substance
- signal transduction
- signaling receptor binding
- stimulatory C-type lectin receptor signaling pathway
- tolerance induction to self antigen
- toll-like receptor 4 signaling pathway
- transmembrane receptor protein tyrosine kinase activity
- transmembrane receptor protein tyrosine kinase signaling pathway
- transmembrane transporter binding
- ubiquitin protein ligase binding
- viral process

PRKACA
Human
cAMP-dependent protein kinase catalytic subunit alpha
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
KAPCA_HUMAN
- Accession #
-
P17612
- Protein names
-
- cAMP-dependent protein kinase catalytic subunit alpha
- PKA C-alpha
- EC 2.7.11.11
- Gene names
-
- PRKACA
- PKACA
- Description
-
Phosphorylates a large number of substrates in the cytoplasm and the nucleus (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984). Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, SOX9 and VASP (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:21423175). RORA is activated by phosphorylation (PubMed:21514275). Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (PubMed:19949837). Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP (PubMed:15642694, PubMed:20356841). Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated (PubMed:17333334). RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+) (PubMed:17693412). PSMC5/RPT6 activation by phosphorylation stimulates proteasome (PubMed:17565987). Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation (PubMed:15905176). NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding (PubMed:15642694). Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By similarity). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA (PubMed:16387847, PubMed:18836454). Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (PubMed:21085490). {ECO:0000250|UniProtKB:P05132, ECO:0000250|UniProtKB:P27791, ECO:0000269|PubMed:15642694, ECO:0000269|PubMed:15905176, ECO:0000269|PubMed:16387847, ECO:0000269|PubMed:17333334, ECO:0000269|PubMed:17565987, ECO:0000269|PubMed:17693412, ECO:0000269|PubMed:18836454, ECO:0000269|PubMed:19949837, ECO:0000269|PubMed:20356841, ECO:0000269|PubMed:21085490, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21514275, ECO:0000269|PubMed:21812984}.; [Isoform 2]: Phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. {ECO:0000250|UniProtKB:P05132}.
- Links
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Search Substrates of PRKACA (Human)
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Aldosterone synthesis and secretion
- Amoebiasis
- Amphetamine addiction
- Apelin signaling pathway
- Autophagy
- Bile secretion
- Calcium signaling pathway
- Chemical carcinogenesis
- Chemokine signaling pathway
- Cholinergic synapse
- Circadian entrainment
- Cocaine addiction
- Cortisol synthesis and secretion
- Cushing syndrome
- Dilated cardiomyopathy
- Dopaminergic synapse
- Endocrine and other factor
- Endocrine resistance
- Estrogen signaling pathway
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glucagon signaling pathway
- Glutamatergic synapse
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hedgehog signaling pathway
- Human T
- Human cytomegalovirus infection
- Human papillomavirus infection
- Inflammatory mediator regulation of TRP channels
- Insulin secretion
- Insulin signaling pathway
- Long
- Longevity regulating pathway
- MAPK signaling pathway
- Melanogenesis
- Morphine addiction
- Olfactory transduction
- Oocyte meiosis
- Ovarian steroidogenesis
- Oxytocin signaling pathway
- Parathyroid hormone synthesis, secretion and action
- Parkinson disease
- Pathways in cancer
- Platelet activation
- Prion disease
- Progesterone
- Proteoglycans in cancer
- Ras signaling pathway
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renin secretion
- Retrograde endocannabinoid signaling
- Salivary secretion
- Serotonergic synapse
- Taste transduction
- Thermogenesis
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- Tight junction
- Vascular smooth muscle contraction
- Vasopressin
- Vibrio cholerae infection
- Viral carcinogenesis
- Wnt signaling pathway
- cAMP signaling pathway
- AMP-activated protein kinase activity
- ATP binding
- G2/M transition of mitotic cell cycle
- acrosomal vesicle
- activation of protein kinase A activity
- adaptive immune response
- blood coagulation
- cAMP-dependent protein kinase activity
- cAMP-dependent protein kinase complex
- calcium channel complex
- calcium-mediated signaling using intracellular calcium source
- cell communication by electrical coupling involved in cardiac conduction
- cellular response to epinephrine stimulus
- cellular response to glucagon stimulus
- cellular response to glucose stimulus
- cellular response to heat
- cellular response to parathyroid hormone stimulus
- centrosome
- chemical synaptic transmission
- ciliary basal body-plasma membrane docking
- ciliary base
- cytokine-mediated signaling pathway
- cytoplasm
- cytosol
- dendritic spine
- extracellular exosome
- high-density lipoprotein particle assembly
- mRNA processing
- magnesium ion binding
- manganese ion binding
- membrane
- mesoderm formation
- mitochondrion
- modulation of chemical synaptic transmission
- negative regulation of inflammatory response to antigenic stimulus
- negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
- neural tube closure
- neuromuscular junction
- nuclear speck
- nucleoplasm
- nucleotide-activated protein kinase complex
- nucleus
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- perinuclear region of cytoplasm
- plasma membrane raft
- positive regulation of protein export from nucleus
- protein autophosphorylation
- protein domain specific binding
- protein kinase A regulatory subunit binding
- protein kinase A signaling
- protein kinase activity
- protein kinase binding
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- protein serine/threonine/tyrosine kinase activity
- regulation of G2/M transition of mitotic cell cycle
- regulation of bicellular tight junction assembly
- regulation of cardiac conduction
- regulation of cardiac muscle contraction
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
- regulation of cytosolic calcium ion concentration
- regulation of heart rate
- regulation of macroautophagy
- regulation of osteoblast differentiation
- regulation of proteasomal protein catabolic process
- regulation of protein binding
- regulation of protein processing
- regulation of ryanodine-sensitive calcium-release channel activity
- renal water homeostasis
- sperm capacitation
- sperm flagellum
- sperm midpiece
- stimulatory C-type lectin receptor signaling pathway
- ubiquitin protein ligase binding
