KANPHOS_Str

Search Results (160 substrates found)

Displaying 1 - 20 of 160 Items
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Gene name
Organism
Protein name
Abi1
Mouse
Abl interactor 1
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
ABI1_MOUSE
Accession #
Q8CBW3
Protein names
  • Abl interactor 1
  • Abelson interactor 1
  • Abi-1
  • Ablphilin-1
  • Eps8 SH3 domain-binding protein
  • Eps8-binding protein
  • Spectrin SH3 domain-binding protein 1
  • e3B1
Gene names
  • Abi1
  • Ssh3bp1
Description
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus (v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:10499589, ECO:0000269|PubMed:11526477, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15143189, ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:7590237}.
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Search Kinases of Abi1 (Mouse)
KEGG Pathways (1)
Phosphorylation Site Information
Adcy3
Mouse
Adenylate cyclase type 3
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
ADCY3_MOUSE
Accession #
Q8VHH7
Protein names
  • Adenylate cyclase type 3
  • EC 4.6.1.1
  • ATP pyrophosphate-lyase 3
  • Adenylate cyclase type III
  • AC-III
  • Adenylate cyclase, olfactive type
  • Adenylyl cyclase 3
  • AC3
Gene names
  • Adcy3
Description
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:9768837, PubMed:11055432, PubMed:25329148). Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis (PubMed:9768837, PubMed:11055432). Required for the perception of odorants (PubMed:11055432). Required for normal sperm motility and normal male fertility (PubMed:15705663). Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet (PubMed:25329148). {ECO:0000269|PubMed:11055432, ECO:0000269|PubMed:15705663, ECO:0000269|PubMed:9768837}.
Links

Search Kinases of Adcy3 (Mouse)
Phosphorylation Site Information
AKAP13
Human
A-kinase anchor protein 13
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
AKP13_HUMAN
Accession #
Q12802
Protein names
  • A-kinase anchor protein 13
  • AKAP-13
  • AKAP-Lbc
  • Breast cancer nuclear receptor-binding auxiliary protein
  • Guanine nucleotide exchange factor Lbc
  • Human thyroid-anchoring protein 31
  • Lymphoid blast crisis oncogene
  • LBC oncogene
  • Non-oncogenic Rho GTPase-specific GTP exchange factor
  • Protein kinase A-anchoring protein 13
  • PRKA13
  • p47
Gene names
  • AKAP13
  • BRX
  • HT31
  • LBC
Description
Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:25186459, PubMed:24993829). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:23716597, PubMed:21224381). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:9627117, PubMed:11579095). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}.
Links

Search Kinases of AKAP13 (Human)
Phosphorylation Site Information
ALOX5
Human
Polyunsaturated fatty acid 5-lipoxygenase
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
LOX5_HUMAN
Accession #
P09917
Protein names
  • Polyunsaturated fatty acid 5-lipoxygenase
  • EC 1.13.11.-
  • Arachidonate 5-lipoxygenase
  • 5-LO
  • 5-lipoxygenase
  • EC 1.13.11.34
Gene names
  • ALOX5
  • LOG5
Description
Catalyzes the oxygenation of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to 5-hydroperoxyeicosatetraenoate (5-HPETE) followed by the dehydration to 5,6- epoxyeicosatetraenoate (Leukotriene A4/LTA4), the first two steps in the biosynthesis of leukotrienes, which are potent mediators of inflammation (PubMed:8631361, PubMed:21233389, PubMed:22516296, PubMed:24282679, PubMed:19022417, PubMed:23246375, PubMed:8615788, PubMed:24893149, PubMed:31664810). Also catalyzes the oxygenation of arachidonate into 8-hydroperoxyicosatetraenoate (8-HPETE) and 12-hydroperoxyicosatetraenoate (12-HPETE) (PubMed:23246375). Displays lipoxin synthase activity being able to convert (15S)-HETE into a conjugate tetraene (PubMed:31664810). Although arachidonate is the preferred substrate, this enzyme can also metabolize oxidized fatty acids derived from arachidonate such as (15S)-HETE, eicosapentaenoate (EPA) such as (18R)- and (18S)-HEPE or docosahexaenoate (DHA) which lead to the formation of specialized pro-resolving mediators (SPM) lipoxin and resolvins E and D respectively, therefore it participates in anti-inflammatory responses (PubMed:21206090, PubMed:31664810, PubMed:8615788, PubMed:17114001, PubMed:32404334). Oxidation of DHA directly inhibits endothelial cell proliferation and sprouting angiogenesis via peroxisome proliferator-activated receptor gamma (PPARgamma) (By similarity). It does not catalyze the oxygenation of linoleic acid and does not convert (5S)-HETE to lipoxin isomers (PubMed:31664810). In addition to inflammatory processes, it participates in dendritic cell migration, wound healing through an antioxidant mechanism based on heme oxygenase-1 (HO-1) regulation expression, monocyte adhesion to the endothelium via ITGAM expression on monocytes (By similarity). Moreover, it helps establish an adaptive humoral immunity by regulating primary resting B cells and follicular helper T cells and participates in the CD40-induced production of reactive oxygen species (ROS) after CD40 ligation in B cells through interaction with PIK3R1 that bridges ALOX5 with CD40 (PubMed:21200133). Also may play a role in glucose homeostasis, regulation of insulin secretion and palmitic acid-induced insulin resistance via AMPK (By similarity). Can regulate bone mineralization and fat cell differentiation increases in induced pluripotent stem cells (By similarity). {ECO:0000250|UniProtKB:P48999, ECO:0000269|PubMed:17114001, ECO:0000269|PubMed:19022417, ECO:0000269|PubMed:21200133, ECO:0000269|PubMed:21206090, ECO:0000269|PubMed:21233389, ECO:0000269|PubMed:22516296, ECO:0000269|PubMed:23246375, ECO:0000269|PubMed:24282679, ECO:0000269|PubMed:24893149, ECO:0000269|PubMed:31664810, ECO:0000269|PubMed:32404334, ECO:0000269|PubMed:8615788, ECO:0000269|PubMed:8631361}.
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Search Kinases of ALOX5 (Human)
Gene Ontology Terms (52)
Phosphorylation Site Information
APEX2
Human
DNA-
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
APEX2_HUMAN
Accession #
Q9UBZ4
Protein names
  • DNA-
  • apurinic or apyrimidinic site
  • EC 3.1.-.-
  • AP endonuclease XTH2
  • APEX nuclease 2
  • APEX nuclease-like 2
  • Apurinic-apyrimidinic endonuclease 2
  • AP endonuclease 2
Gene names
  • APEX2
  • APE2
  • APEXL2
  • XTH2
Description
Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes. {ECO:0000269|PubMed:11376153, ECO:0000269|PubMed:16687656, ECO:0000269|PubMed:19443450}.
Links

Search Kinases of APEX2 (Human)
KEGG Pathways (1)
Phosphorylation Site Information
APOBEC3G
Human
DNA dC->dU-editing enzyme APOBEC-3G
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ABC3G_HUMAN
Accession #
Q9HC16
Protein names
  • DNA dC->dU-editing enzyme APOBEC-3G
  • EC 3.5.4.-
  • APOBEC-related cytidine deaminase
  • APOBEC-related protein
  • ARCD
  • APOBEC-related protein 9
  • ARP-9
  • CEM-15
  • CEM15
  • Deoxycytidine deaminase
  • A3G
Gene names
  • APOBEC3G
  • MDS019
Description
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against Vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons. {ECO:0000269|PubMed:12167863, ECO:0000269|PubMed:12808465, ECO:0000269|PubMed:12808466, ECO:0000269|PubMed:12809610, ECO:0000269|PubMed:12859895, ECO:0000269|PubMed:12970355, ECO:0000269|PubMed:14528300, ECO:0000269|PubMed:14557625, ECO:0000269|PubMed:15031497, ECO:0000269|PubMed:16378963, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:18288108, ECO:0000269|PubMed:19458006, ECO:0000269|PubMed:20219927, ECO:0000269|PubMed:20335265, ECO:0000269|PubMed:21123384, ECO:0000269|PubMed:21835787, ECO:0000269|PubMed:22791714, ECO:0000269|PubMed:22807680, ECO:0000269|PubMed:22915799, ECO:0000269|PubMed:23097438, ECO:0000269|PubMed:23152537}.
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Search Kinases of APOBEC3G (Human)
Phosphorylation Site Information
App
Rat
Amyloid-beta A4 protein
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
A4_RAT
Accession #
P08592
Protein names
  • Amyloid-beta A4 protein
  • ABPP
  • APP
  • Alzheimer disease amyloid A4 protein homolog
  • Amyloid precursor protein
  • Amyloid-beta precursor protein
  • Amyloidogenic glycoprotein
  • AG
  • S-APP-alpha
  • S-APP-beta
  • Beta-secretase C-terminal fragment
  • Beta-CTF
  • Abeta42
  • Beta-APP42
  • Abeta40
  • Beta-APP40
  • Alpha-secretase C-terminal fragment
  • Alpha-CTF
  • 42
  • 40
  • Gamma-CTF(59
  • Gamma-CTF(57
  • Gamma-CTF(50
Gene names
  • App
Description
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapes in axons (By similarity). May be involved in copper homeostasis/oxidative stress through copper ion reduction. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV (By similarity). The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1 (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P05067}.; Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Binds transient metals such as copper, zinc and iron. Rat and mouse amyloid-beta peptides bind only weakly transient metals and have little reducing activity due to substitutions of transient metal chelating residues. Amyloid-beta protein 42 may activate mononuclear phagocytes in the brain and elicits inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Also binds GPC1 in lipid rafts (By similarity). {ECO:0000250}.; Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain.; The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis. {ECO:0000250}.; N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). {ECO:0000250}.
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Search Kinases of App (Rat)
Gene Ontology Terms (148)
Phosphorylation Site Information
Asic1
Rat
Acid-sensing ion channel 1
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ASIC1_RAT
Accession #
P55926
Protein names
  • Acid-sensing ion channel 1
  • ASIC1
  • Amiloride-sensitive cation channel 2, neuronal
  • Brain sodium channel 2
  • BNaC2
Gene names
  • Asic1
  • Accn2
  • Bnac2
Description
Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 discrimates stronger than isoform 1 between monovalent cations. Isoform 3 can flux Ca(2+) while isoform 1 cannot. Heteromeric channels composed of isoform 2 and isoform 3 are active but have a lower pH-sensitivity. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. {ECO:0000269|PubMed:11448963, ECO:0000269|PubMed:11588592, ECO:0000269|PubMed:12198124, ECO:0000269|PubMed:15369669, ECO:0000269|PubMed:9062189, ECO:0000269|PubMed:9360943, ECO:0000269|PubMed:9707631}.
Links

Search Kinases of Asic1 (Rat)
Phosphorylation Site Information
Atp2a2
Rat
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
AT2A2_RAT
Accession #
P11507
Protein names
  • Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
  • SERCA2
  • SR Ca(2+
  • EC 7.2.2.10
  • Calcium pump 2
  • Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform
  • Endoplasmic reticulum class 1/2 Ca(2+
Gene names
  • Atp2a2
Description
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation. Also modulates ER contacts with lipid droplets, mitochondria and endosomes. {ECO:0000250|UniProtKB:P16615}.; [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}.
Links

Search Kinases of Atp2a2 (Rat)
Gene Ontology Terms (55)
Phosphorylation Site Information
C11orf52
Human
Uncharacterized protein C11orf52
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CK052_HUMAN
Accession #
Q96A22
Protein names
  • Uncharacterized protein C11orf52
Gene names
  • C11orf52
Description
N/A
Links

Search Kinases of C11orf52 (Human)
KEGG Pathways (0)
N/A
Gene Ontology Terms (1)
Phosphorylation Site Information
C1orf87
Human
Uncharacterized protein C1orf87
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CA087_HUMAN
Accession #
Q8N0U7
Protein names
  • Uncharacterized protein C1orf87
Gene names
  • C1orf87
Description
N/A
Links

Search Kinases of C1orf87 (Human)
KEGG Pathways (0)
N/A
Gene Ontology Terms (0)
N/A
Phosphorylation Site Information
Cacna1b
Rat
Voltage-dependent N-type calcium channel subunit alpha-1B
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
CAC1B_RAT
Accession #
Q02294
Protein names
  • Voltage-dependent N-type calcium channel subunit alpha-1B
  • Brain calcium channel III
  • BIII
  • Calcium channel, L type, alpha-1 polypeptide isoform 5
  • Voltage-gated calcium channel subunit alpha Cav2.2
Gene names
  • Cacna1b
  • Cach5
  • Cacnl1a5
Description
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (PubMed:1317580). They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. {ECO:0000269|PubMed:1317580}.
Links

Search Kinases of Cacna1b (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Cacna1c
Mouse
Voltage-dependent L-type calcium channel subunit alpha-1C
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
CAC1C_MOUSE
Accession #
Q01815
Protein names
  • Voltage-dependent L-type calcium channel subunit alpha-1C
  • Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle
  • MELC-CC
  • Mouse brain class C
  • MBC
  • Voltage-gated calcium channel subunit alpha Cav1.2
Gene names
  • Cacna1c
  • Cach2
  • Cacn2
  • Cacnl1a1
  • Cchl1a1
Description
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:14609949, PubMed:18586882, PubMed:21216955, PubMed:25368181, PubMed:28119464). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:21216955). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:14609949, PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). {ECO:0000250|UniProtKB:P15381, ECO:0000269|PubMed:14609949, ECO:0000269|PubMed:18586882, ECO:0000269|PubMed:21216955, ECO:0000269|PubMed:25368181, ECO:0000269|PubMed:28119464, ECO:0000305}.
Links

Search Kinases of Cacna1c (Mouse)
Gene Ontology Terms (72)
Phosphorylation Site Information
CACNB1
Human
Voltage-dependent L-type calcium channel subunit beta-1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CACB1_HUMAN
Accession #
Q02641
Protein names
  • Voltage-dependent L-type calcium channel subunit beta-1
  • CAB1
  • Calcium channel voltage-dependent subunit beta 1
Gene names
  • CACNB1
  • CACNLB1
Description
Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:8107964, PubMed:15615847). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964). {ECO:0000250|UniProtKB:P19517, ECO:0000269|PubMed:1309651, ECO:0000269|PubMed:15615847, ECO:0000269|PubMed:8107964}.
Links

Search Kinases of CACNB1 (Human)
Phosphorylation Site Information
Cacnb2
Rat
Voltage-dependent L-type calcium channel subunit beta-2
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
CACB2_RAT
Accession #
Q8VGC3
Protein names
  • Voltage-dependent L-type calcium channel subunit beta-2
  • CAB2
  • Calcium channel voltage-dependent subunit beta 2
Gene names
  • Cacnb2
  • Cacnlb2
Description
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. {ECO:0000250, ECO:0000269|PubMed:11604404, ECO:0000269|PubMed:12042350, ECO:0000269|PubMed:1370480}.
Links

Search Kinases of Cacnb2 (Rat)
Phosphorylation Site Information
Camk2a
Rat
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
KCC2A_RAT
Accession #
P11275
Protein names
  • Calcium/calmodulin-dependent protein kinase type II subunit alpha
  • CaM kinase II subunit alpha
  • CaMK-II subunit alpha
  • EC 2.7.11.17
Gene names
  • Camk2a
Description
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (PubMed:15312654). Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (By similarity). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11798, ECO:0000250|UniProtKB:Q9UQM7, ECO:0000269|PubMed:15312654}.
Links

Search Kinases of Camk2a (Rat)
Gene Ontology Terms (57)
Phosphorylation Site Information
CAMK2A
Human
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
KCC2A_HUMAN
Accession #
Q9UQM7
Protein names
  • Calcium/calmodulin-dependent protein kinase type II subunit alpha
  • CaM kinase II subunit alpha
  • CaMK-II subunit alpha
  • EC 2.7.11.17
Gene names
  • CAMK2A
  • CAMKA
  • KIAA0968
Description
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}.
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Search Kinases of CAMK2A (Human)
Phosphorylation Site Information
Camk2a
Mouse
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
KCC2A_MOUSE
Accession #
P11798
Protein names
  • Calcium/calmodulin-dependent protein kinase type II subunit alpha
  • CaM kinase II subunit alpha
  • CaMK-II subunit alpha
  • EC 2.7.11.17
Gene names
  • Camk2a
Description
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development. Also regulates the migration of developing neurons (By similarity). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (PubMed:23502535). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:Q9UQM7, ECO:0000269|PubMed:23502535, ECO:0000269|PubMed:23805378}.; [Isoform Alpha KAP]: Has no kinase activity. {ECO:0000269|PubMed:8524307}.
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Search Kinases of Camk2a (Mouse)
Gene Ontology Terms (57)
Phosphorylation Site Information
Camk2b
Rat
Calcium/calmodulin-dependent protein kinase type II subunit beta
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
KCC2B_RAT
Accession #
P08413
Protein names
  • Calcium/calmodulin-dependent protein kinase type II subunit beta
  • CaM kinase II subunit beta
  • CaMK-II subunit beta
  • EC 2.7.11.17
Gene names
  • Camk2b
Description
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. {ECO:0000250|UniProtKB:Q13554, ECO:0000269|PubMed:12873385, ECO:0000269|PubMed:15312654, ECO:0000269|PubMed:17272343}.
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Search Kinases of Camk2b (Rat)
Phosphorylation Site Information
CAMK2D
Human
Calcium/calmodulin-dependent protein kinase type II subunit delta
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
KCC2D_HUMAN
Accession #
Q13557
Protein names
  • Calcium/calmodulin-dependent protein kinase type II subunit delta
  • CaM kinase II subunit delta
  • CaMK-II subunit delta
  • EC 2.7.11.17
Gene names
  • CAMK2D
  • CAMKD
Description
Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. {ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}.
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Search Kinases of CAMK2D (Human)
Gene Ontology Terms (51)
Phosphorylation Site Information
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