Search Results (160 substrates found)
Gene name
Organism
Protein name
Abi1
Mouse
Abl interactor 1
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
ABI1_MOUSE
- Accession #
-
Q8CBW3
- Protein names
-
- Abl interactor 1
- Abelson interactor 1
- Abi-1
- Ablphilin-1
- Eps8 SH3 domain-binding protein
- Eps8-binding protein
- Spectrin SH3 domain-binding protein 1
- e3B1
- Gene names
-
- Abi1
- Ssh3bp1
- Description
-
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus (v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:10499589, ECO:0000269|PubMed:11526477, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15143189, ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:7590237}.
- Links
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Search Kinases of Abi1 (Mouse)
- SCAR complex
- SH3 domain binding
- actin polymerization or depolymerization
- cell leading edge
- cytoskeleton
- dendrite morphogenesis
- filopodium tip
- glutamatergic synapse
- growth cone
- lamellipodium
- lamellipodium morphogenesis
- megakaryocyte development
- neuron projection
- nucleus
- peptidyl-tyrosine phosphorylation
- postsynapse to nucleus signaling pathway
- postsynaptic density
- protein tyrosine kinase activator activity
- signaling adaptor activity
- somitogenesis
- transcription factor binding

Adcy3
Mouse
Adenylate cyclase type 3
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
ADCY3_MOUSE
- Accession #
-
Q8VHH7
- Protein names
-
- Adenylate cyclase type 3
- EC 4.6.1.1
- ATP pyrophosphate-lyase 3
- Adenylate cyclase type III
- AC-III
- Adenylate cyclase, olfactive type
- Adenylyl cyclase 3
- AC3
- Gene names
-
- Adcy3
- Description
-
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:9768837, PubMed:11055432, PubMed:25329148). Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis (PubMed:9768837, PubMed:11055432). Required for the perception of odorants (PubMed:11055432). Required for normal sperm motility and normal male fertility (PubMed:15705663). Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet (PubMed:25329148). {ECO:0000269|PubMed:11055432, ECO:0000269|PubMed:15705663, ECO:0000269|PubMed:9768837}.
- Links
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Search Kinases of Adcy3 (Mouse)
- Adrenergic signaling in cardiomyocytes
- Aldosterone synthesis and secretion
- Apelin signaling pathway
- Bile secretion
- Calcium signaling pathway
- Chemical carcinogenesis
- Chemokine signaling pathway
- Cholinergic synapse
- Circadian entrainment
- Cortisol synthesis and secretion
- Cushing syndrome
- Dilated cardiomyopathy
- Endocrine resistance
- Estrogen signaling pathway
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glutamatergic synapse
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Human T
- Human cytomegalovirus infection
- Inflammatory mediator regulation of TRP channels
- Insulin secretion
- Longevity regulating pathway
- Melanogenesis
- Metabolic pathways
- Morphine addiction
- Olfactory transduction
- Oocyte meiosis
- Ovarian steroidogenesis
- Oxytocin signaling pathway
- Pancreatic secretion
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Phospholipase D signaling pathway
- Platelet activation
- Progesterone
- Purine metabolism
- Rap1 signaling pathway
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salivary secretion
- Thermogenesis
- Thyroid hormone synthesis
- Vascular smooth muscle contraction
- Vasopressin
- cAMP signaling pathway
- cGMP
- ATP binding
- Golgi apparatus
- acrosome reaction
- activation of adenylate cyclase activity
- adenylate cyclase activity
- adenylate cyclase-activating G protein-coupled receptor signaling pathway
- cAMP biosynthetic process
- calcium- and calmodulin-responsive adenylate cyclase activity
- calmodulin binding
- cellular response to forskolin
- cilium
- cytoplasm
- flagellated sperm motility
- integral component of membrane
- integral component of plasma membrane
- intracellular signal transduction
- membrane
- membrane raft
- metal ion binding
- nucleus
- olfactory learning
- plasma membrane
- sensory perception of smell
- single fertilization

AKAP13
Human
A-kinase anchor protein 13
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
AKP13_HUMAN
- Accession #
-
Q12802
- Protein names
-
- A-kinase anchor protein 13
- AKAP-13
- AKAP-Lbc
- Breast cancer nuclear receptor-binding auxiliary protein
- Guanine nucleotide exchange factor Lbc
- Human thyroid-anchoring protein 31
- Lymphoid blast crisis oncogene
- LBC oncogene
- Non-oncogenic Rho GTPase-specific GTP exchange factor
- Protein kinase A-anchoring protein 13
- PRKA13
- p47
- Gene names
-
- AKAP13
- BRX
- HT31
- LBC
- Description
-
Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:25186459, PubMed:24993829). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:23716597, PubMed:21224381). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:9627117, PubMed:11579095). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}.
- Links
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Search Kinases of AKAP13 (Human)
- G protein-coupled receptor signaling pathway
- MAP-kinase scaffold activity
- adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
- adrenergic receptor signaling pathway
- bone development
- cAMP-dependent protein kinase activity
- cardiac muscle cell differentiation
- cell cortex
- cell growth involved in cardiac muscle cell development
- cytosol
- guanyl-nucleotide exchange factor activity
- heart development
- intracellular signal transduction
- membrane
- metal ion binding
- molecular adaptor activity
- nuclear export
- nucleus
- perinuclear region of cytoplasm
- positive regulation of I-kappaB kinase/NF-kappaB signaling
- positive regulation of MAP kinase activity
- positive regulation of Rho protein signal transduction
- positive regulation of apoptotic process
- protein kinase A binding
- regulation of Rho protein signal transduction
- regulation of sarcomere organization
- regulation of small GTPase mediated signal transduction
- small GTPase binding

ALOX5
Human
Polyunsaturated fatty acid 5-lipoxygenase
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
LOX5_HUMAN
- Accession #
-
P09917
- Protein names
-
- Polyunsaturated fatty acid 5-lipoxygenase
- EC 1.13.11.-
- Arachidonate 5-lipoxygenase
- 5-LO
- 5-lipoxygenase
- EC 1.13.11.34
- Gene names
-
- ALOX5
- LOG5
- Description
-
Catalyzes the oxygenation of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to 5-hydroperoxyeicosatetraenoate (5-HPETE) followed by the dehydration to 5,6- epoxyeicosatetraenoate (Leukotriene A4/LTA4), the first two steps in the biosynthesis of leukotrienes, which are potent mediators of inflammation (PubMed:8631361, PubMed:21233389, PubMed:22516296, PubMed:24282679, PubMed:19022417, PubMed:23246375, PubMed:8615788, PubMed:24893149, PubMed:31664810). Also catalyzes the oxygenation of arachidonate into 8-hydroperoxyicosatetraenoate (8-HPETE) and 12-hydroperoxyicosatetraenoate (12-HPETE) (PubMed:23246375). Displays lipoxin synthase activity being able to convert (15S)-HETE into a conjugate tetraene (PubMed:31664810). Although arachidonate is the preferred substrate, this enzyme can also metabolize oxidized fatty acids derived from arachidonate such as (15S)-HETE, eicosapentaenoate (EPA) such as (18R)- and (18S)-HEPE or docosahexaenoate (DHA) which lead to the formation of specialized pro-resolving mediators (SPM) lipoxin and resolvins E and D respectively, therefore it participates in anti-inflammatory responses (PubMed:21206090, PubMed:31664810, PubMed:8615788, PubMed:17114001, PubMed:32404334). Oxidation of DHA directly inhibits endothelial cell proliferation and sprouting angiogenesis via peroxisome proliferator-activated receptor gamma (PPARgamma) (By similarity). It does not catalyze the oxygenation of linoleic acid and does not convert (5S)-HETE to lipoxin isomers (PubMed:31664810). In addition to inflammatory processes, it participates in dendritic cell migration, wound healing through an antioxidant mechanism based on heme oxygenase-1 (HO-1) regulation expression, monocyte adhesion to the endothelium via ITGAM expression on monocytes (By similarity). Moreover, it helps establish an adaptive humoral immunity by regulating primary resting B cells and follicular helper T cells and participates in the CD40-induced production of reactive oxygen species (ROS) after CD40 ligation in B cells through interaction with PIK3R1 that bridges ALOX5 with CD40 (PubMed:21200133). Also may play a role in glucose homeostasis, regulation of insulin secretion and palmitic acid-induced insulin resistance via AMPK (By similarity). Can regulate bone mineralization and fat cell differentiation increases in induced pluripotent stem cells (By similarity). {ECO:0000250|UniProtKB:P48999, ECO:0000269|PubMed:17114001, ECO:0000269|PubMed:19022417, ECO:0000269|PubMed:21200133, ECO:0000269|PubMed:21206090, ECO:0000269|PubMed:21233389, ECO:0000269|PubMed:22516296, ECO:0000269|PubMed:23246375, ECO:0000269|PubMed:24282679, ECO:0000269|PubMed:24893149, ECO:0000269|PubMed:31664810, ECO:0000269|PubMed:32404334, ECO:0000269|PubMed:8615788, ECO:0000269|PubMed:8631361}.
- Links
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Search Kinases of ALOX5 (Human)
- arachidonate 12(S)-lipoxygenase activity
- arachidonate 5-lipoxygenase activity
- arachidonate 8(S)-lipoxygenase activity
- arachidonic acid metabolic process
- cytokine-mediated signaling pathway
- cytosol
- dendritic cell migration
- extracellular region
- extracellular space
- ficolin-1-rich granule lumen
- glucose homeostasis
- hepoxilin biosynthetic process
- humoral immune response
- hydrolase activity
- interleukin-18-mediated signaling pathway
- iron ion binding
- leukocyte chemotaxis involved in inflammatory response
- leukocyte migration involved in inflammatory response
- leukotriene A4 biosynthetic process
- leukotriene biosynthetic process
- leukotriene metabolic process
- leukotriene production involved in inflammatory response
- linoleic acid metabolic process
- lipid oxidation
- lipoxin biosynthetic process
- lipoxygenase pathway
- long-chain fatty acid biosynthetic process
- negative regulation of angiogenesis
- negative regulation of endothelial cell proliferation
- negative regulation of inflammatory response
- negative regulation of response to endoplasmic reticulum stress
- negative regulation of sprouting angiogenesis
- negative regulation of vascular wound healing
- negative regulation of wound healing
- neutrophil degranulation
- nuclear envelope
- nuclear envelope lumen
- nuclear matrix
- nuclear membrane
- nucleoplasm
- oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
- perinuclear region of cytoplasm
- positive regulation of bone mineralization
- positive regulation of leukocyte adhesion to arterial endothelial cell
- regulation of cellular response to oxidative stress
- regulation of cytokine production involved in inflammatory response
- regulation of fat cell differentiation
- regulation of inflammatory response
- regulation of inflammatory response to wounding
- regulation of insulin secretion
- regulation of reactive oxygen species biosynthetic process
- secretory granule lumen

APEX2
Human
DNA-
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
APEX2_HUMAN
- Accession #
-
Q9UBZ4
- Protein names
-
- DNA-
- apurinic or apyrimidinic site
- EC 3.1.-.-
- AP endonuclease XTH2
- APEX nuclease 2
- APEX nuclease-like 2
- Apurinic-apyrimidinic endonuclease 2
- AP endonuclease 2
- Gene names
-
- APEX2
- APE2
- APEXL2
- XTH2
- Description
-
Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes. {ECO:0000269|PubMed:11376153, ECO:0000269|PubMed:16687656, ECO:0000269|PubMed:19443450}.
- Links
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Search Kinases of APEX2 (Human)
- DNA binding
- DNA recombination
- DNA-(apurinic or apyrimidinic site) endonuclease activity
- base-excision repair
- cell cycle
- double-stranded DNA 3'-5' exodeoxyribonuclease activity
- endonuclease activity
- fibrillar center
- intracellular membrane-bounded organelle
- mitochondrion
- nucleoplasm
- nucleus
- phosphodiesterase I activity
- zinc ion binding

APOBEC3G
Human
DNA dC->dU-editing enzyme APOBEC-3G
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ABC3G_HUMAN
- Accession #
-
Q9HC16
- Protein names
-
- DNA dC->dU-editing enzyme APOBEC-3G
- EC 3.5.4.-
- APOBEC-related cytidine deaminase
- APOBEC-related protein
- ARCD
- APOBEC-related protein 9
- ARP-9
- CEM-15
- CEM15
- Deoxycytidine deaminase
- A3G
- Gene names
-
- APOBEC3G
- MDS019
- Description
-
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against Vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons. {ECO:0000269|PubMed:12167863, ECO:0000269|PubMed:12808465, ECO:0000269|PubMed:12808466, ECO:0000269|PubMed:12809610, ECO:0000269|PubMed:12859895, ECO:0000269|PubMed:12970355, ECO:0000269|PubMed:14528300, ECO:0000269|PubMed:14557625, ECO:0000269|PubMed:15031497, ECO:0000269|PubMed:16378963, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:18288108, ECO:0000269|PubMed:19458006, ECO:0000269|PubMed:20219927, ECO:0000269|PubMed:20335265, ECO:0000269|PubMed:21123384, ECO:0000269|PubMed:21835787, ECO:0000269|PubMed:22791714, ECO:0000269|PubMed:22807680, ECO:0000269|PubMed:22915799, ECO:0000269|PubMed:23097438, ECO:0000269|PubMed:23152537}.
- Links
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Search Kinases of APOBEC3G (Human)
- DNA cytosine deamination
- DNA demethylation
- P-body
- RNA binding
- apolipoprotein B mRNA editing enzyme complex
- base conversion or substitution editing
- cytidine deaminase activity
- cytidine deamination
- cytidine to uridine editing
- cytoplasm
- cytosol
- defense response to virus
- deoxycytidine deaminase activity
- identical protein binding
- innate immune response
- negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
- negative regulation of transposition
- negative regulation of viral genome replication
- negative regulation of viral process
- nucleus
- positive regulation of defense response to virus by host
- ribonucleoprotein complex
- viral process
- zinc ion binding

App
Rat
Amyloid-beta A4 protein
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
A4_RAT
- Accession #
-
P08592
- Protein names
-
- Amyloid-beta A4 protein
- ABPP
- APP
- Alzheimer disease amyloid A4 protein homolog
- Amyloid precursor protein
- Amyloid-beta precursor protein
- Amyloidogenic glycoprotein
- AG
- S-APP-alpha
- S-APP-beta
- Beta-secretase C-terminal fragment
- Beta-CTF
- Abeta42
- Beta-APP42
- Abeta40
- Beta-APP40
- Alpha-secretase C-terminal fragment
- Alpha-CTF
- 42
- 40
- Gamma-CTF(59
- Gamma-CTF(57
- Gamma-CTF(50
- Gene names
-
- App
- Description
-
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapes in axons (By similarity). May be involved in copper homeostasis/oxidative stress through copper ion reduction. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV (By similarity). The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1 (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P05067}.; Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Binds transient metals such as copper, zinc and iron. Rat and mouse amyloid-beta peptides bind only weakly transient metals and have little reducing activity due to substitutions of transient metal chelating residues. Amyloid-beta protein 42 may activate mononuclear phagocytes in the brain and elicits inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Also binds GPC1 in lipid rafts (By similarity). {ECO:0000250}.; Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain.; The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis. {ECO:0000250}.; N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). {ECO:0000250}.
- Links
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Search Kinases of App (Rat)
- COPII-coated ER to Golgi transport vesicle
- DNA binding
- Golgi apparatus
- Golgi-associated vesicle
- Notch signaling pathway
- PTB domain binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- adult locomotory behavior
- amyloid fibril formation
- antibacterial humoral response
- antifungal humoral response
- antimicrobial humoral immune response mediated by antimicrobial peptide
- apical part of cell
- astrocyte activation
- astrocyte activation involved in immune response
- astrocyte projection
- axo-dendritic transport
- axon
- axon midline choice point recognition
- axonogenesis
- cell adhesion
- cell surface
- cell-cell junction
- cellular copper ion homeostasis
- cellular process
- cellular response to amyloid-beta
- cellular response to cAMP
- cellular response to copper ion
- cellular response to manganese ion
- cellular response to nerve growth factor stimulus
- cellular response to norepinephrine stimulus
- cholesterol metabolic process
- ciliary rootlet
- clathrin-coated pit
- cognition
- collateral sprouting in absence of injury
- cytoplasm
- cytoplasmic vesicle
- defense response to Gram-negative bacterium
- defense response to Gram-positive bacterium
- dendrite development
- dendritic shaft
- dendritic spine
- early endosome
- endocytosis
- endosome
- enzyme binding
- extracellular matrix organization
- extracellular space
- forebrain development
- growth cone
- growth cone filopodium
- growth cone lamellipodium
- growth factor receptor binding
- heparin binding
- identical protein binding
- innate immune response
- integral component of membrane
- ionotropic glutamate receptor signaling pathway
- learning
- learning or memory
- locomotory behavior
- low-density lipoprotein particle receptor binding
- mRNA polyadenylation
- main axon
- mating behavior
- membrane
- membrane raft
- microglia development
- microglial cell activation
- modulation of age-related behavioral decline
- modulation of excitatory postsynaptic potential
- negative regulation of cell population proliferation
- negative regulation of gene expression
- negative regulation of long-term synaptic potentiation
- negative regulation of neuron differentiation
- neuromuscular junction
- neuromuscular process controlling balance
- neuron apoptotic process
- neuron projection
- neuron projection development
- neuron projection maintenance
- neuron remodeling
- nuclear envelope lumen
- obsolete activation of MAPK activity
- peptidase activator activity
- perikaryon
- perinuclear region of cytoplasm
- plasma membrane
- positive regulation of DNA-binding transcription factor activity
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of G2/M transition of mitotic cell cycle
- positive regulation of JNK cascade
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of NIK/NF-kappaB signaling
- positive regulation of T cell migration
- positive regulation of amyloid fibril formation
- positive regulation of chemokine production
- positive regulation of endothelin production
- positive regulation of gene expression
- positive regulation of glycolytic process
- positive regulation of inflammatory response
- positive regulation of interleukin-1 beta production
- positive regulation of interleukin-6 production
- positive regulation of long-term synaptic potentiation
- positive regulation of mitotic cell cycle
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of peptidyl-threonine phosphorylation
- positive regulation of phosphorylation
- positive regulation of protein binding
- positive regulation of protein metabolic process
- positive regulation of protein phosphorylation
- positive regulation of transcription by RNA polymerase II
- positive regulation of tumor necrosis factor production
- presynaptic active zone
- protein phosphorylation
- receptor complex
- recycling endosome
- regulation of epidermal growth factor-activated receptor activity
- regulation of gene expression
- regulation of long-term neuronal synaptic plasticity
- regulation of multicellular organism growth
- regulation of peptidyl-tyrosine phosphorylation
- regulation of presynapse assembly
- regulation of protein binding
- regulation of response to calcium ion
- regulation of spontaneous synaptic transmission
- regulation of synapse structure or activity
- regulation of translation
- response to interleukin-1
- response to lead ion
- response to oxidative stress
- response to radiation
- response to yeast
- rough endoplasmic reticulum
- serine-type endopeptidase inhibitor activity
- signaling receptor activator activity
- smooth endoplasmic reticulum
- smooth endoplasmic reticulum calcium ion homeostasis
- spindle midzone
- suckling behavior
- synapse
- synapse organization
- synaptic assembly at neuromuscular junction
- synaptic vesicle
- terminal bouton
- transition metal ion binding
- visual learning

Asic1
Rat
Acid-sensing ion channel 1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ASIC1_RAT
- Accession #
-
P55926
- Protein names
-
- Acid-sensing ion channel 1
- ASIC1
- Amiloride-sensitive cation channel 2, neuronal
- Brain sodium channel 2
- BNaC2
- Gene names
-
- Asic1
- Accn2
- Bnac2
- Description
-
Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 discrimates stronger than isoform 1 between monovalent cations. Isoform 3 can flux Ca(2+) while isoform 1 cannot. Heteromeric channels composed of isoform 2 and isoform 3 are active but have a lower pH-sensitivity. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. {ECO:0000269|PubMed:11448963, ECO:0000269|PubMed:11588592, ECO:0000269|PubMed:12198124, ECO:0000269|PubMed:15369669, ECO:0000269|PubMed:9062189, ECO:0000269|PubMed:9360943, ECO:0000269|PubMed:9707631}.
- Links
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Search Kinases of Asic1 (Rat)
- Golgi apparatus
- acid-sensing ion channel activity
- associative learning
- behavioral fear response
- calcium ion transmembrane transport
- cation channel activity
- cation transport
- cell surface
- cellular response to pH
- inorganic cation transmembrane transport
- inorganic cation transmembrane transporter activity
- integral component of membrane
- integral component of plasma membrane
- ion channel activity
- ion gated channel activity
- ion transmembrane transport
- ligand-gated sodium channel activity
- memory
- negative regulation of neurotransmitter secretion
- protein homotrimerization
- regulation of membrane potential
- response to acidic pH
- response to amphetamine
- sensory perception of pain
- sensory perception of sour taste
- sodium ion transmembrane transport
- synapse

Atp2a2
Rat
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
AT2A2_RAT
- Accession #
-
P11507
- Protein names
-
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
- SERCA2
- SR Ca(2+
- EC 7.2.2.10
- Calcium pump 2
- Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform
- Endoplasmic reticulum class 1/2 Ca(2+
- Gene names
-
- Atp2a2
- Description
-
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation. Also modulates ER contacts with lipid droplets, mitochondria and endosomes. {ECO:0000250|UniProtKB:P16615}.; [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}.
- Links
-
Search Kinases of Atp2a2 (Rat)
- Adrenergic signaling in cardiomyocytes
- Alzheimer disease
- Arrhythmogenic right ventricular cardiomyopathy
- Calcium signaling pathway
- Cardiac muscle contraction
- Diabetic cardiomyopathy
- Dilated cardiomyopathy
- Hypertrophic cardiomyopathy
- Pancreatic secretion
- Pathways of neurodegeneration
- Spinocerebellar ataxia
- Thyroid hormone signaling pathway
- cAMP signaling pathway
- cGMP
- ATP binding
- ATP hydrolysis activity
- ER-nucleus signaling pathway
- P-type calcium transporter activity
- P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential
- P-type proton-exporting transporter activity
- S100 protein binding
- T-tubule organization
- apical ectoplasmic specialization
- autophagosome assembly
- autophagosome membrane docking
- calcium ion binding
- calcium ion import into sarcoplasmic reticulum
- calcium ion transmembrane transport
- calcium ion transport
- calcium ion transport from cytosol to endoplasmic reticulum
- cardiac muscle hypertrophy in response to stress
- cellular calcium ion homeostasis
- cellular response to heat
- cellular response to oxidative stress
- endoplasmic reticulum
- endoplasmic reticulum membrane
- enzyme binding
- extrinsic component of cytoplasmic side of plasma membrane
- integral component of membrane
- lutropin-choriogonadotropic hormone receptor binding
- membrane
- mitochondrion-endoplasmic reticulum membrane tethering
- negative regulation of heart contraction
- negative regulation of receptor binding
- organelle localization by membrane tethering
- organelle organization
- perinuclear region of cytoplasm
- plasma membrane bounded cell projection
- positive regulation of endoplasmic reticulum calcium ion concentration
- protein C-terminus binding
- protein-containing complex
- regulation of calcium ion-dependent exocytosis of neurotransmitter
- regulation of cardiac muscle cell action potential involved in regulation of contraction
- regulation of cardiac muscle cell membrane potential
- regulation of cardiac muscle contraction by calcium ion signaling
- regulation of muscle contraction
- regulation of the force of heart contraction
- relaxation of cardiac muscle
- response to endoplasmic reticulum stress
- response to lipopolysaccharide
- response to peptide hormone
- ribbon synapse
- sarcoplasmic reticulum
- sarcoplasmic reticulum calcium ion transport
- sarcoplasmic reticulum membrane
- skeletal muscle contraction
- transition between fast and slow fiber
- transmembrane transporter binding
- vesicle membrane

C11orf52
Human
Uncharacterized protein C11orf52
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CK052_HUMAN
- Accession #
-
Q96A22
- Protein names
-
- Uncharacterized protein C11orf52
- Gene names
-
- C11orf52
- Description
-
N/A
- Links
-
Search Kinases of C11orf52 (Human)
N/A

C1orf87
Human
Uncharacterized protein C1orf87
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CA087_HUMAN
- Accession #
-
Q8N0U7
- Protein names
-
- Uncharacterized protein C1orf87
- Gene names
-
- C1orf87
- Description
-
N/A
- Links
-
Search Kinases of C1orf87 (Human)
N/A
N/A

Cacna1b
Rat
Voltage-dependent N-type calcium channel subunit alpha-1B
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
CAC1B_RAT
- Accession #
-
Q02294
- Protein names
-
- Voltage-dependent N-type calcium channel subunit alpha-1B
- Brain calcium channel III
- BIII
- Calcium channel, L type, alpha-1 polypeptide isoform 5
- Voltage-gated calcium channel subunit alpha Cav2.2
- Gene names
-
- Cacna1b
- Cach5
- Cacnl1a5
- Description
-
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (PubMed:1317580). They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. {ECO:0000269|PubMed:1317580}.
- Links
-
Search Kinases of Cacna1b (Rat)
N/A
- ATP binding
- Schaffer collateral - CA1 synapse
- axon terminus
- calcium ion binding
- calcium ion import
- calcium ion transmembrane transport
- calcium ion transport
- chemical synaptic transmission
- dendrite
- dendritic shaft
- glutamatergic synapse
- high voltage-gated calcium channel activity
- locomotory behavior
- membrane
- modulation of chemical synaptic transmission
- neuron projection
- neuronal cell body
- neurotransmitter secretion
- plasma membrane
- positive regulation of neurotransmitter secretion
- protein C-terminus binding
- protein phosphatase 2A binding
- protein-containing complex
- regulation of blood pressure
- regulation of calcium ion transport
- regulation of heart contraction
- regulation of ion transmembrane transport
- response to amyloid-beta
- response to ethanol
- response to organic cyclic compound
- response to pain
- response to testosterone
- sensory perception of pain
- voltage-gated calcium channel activity
- voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
- voltage-gated calcium channel complex

Cacna1c
Mouse
Voltage-dependent L-type calcium channel subunit alpha-1C
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
CAC1C_MOUSE
- Accession #
-
Q01815
- Protein names
-
- Voltage-dependent L-type calcium channel subunit alpha-1C
- Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle
- MELC-CC
- Mouse brain class C
- MBC
- Voltage-gated calcium channel subunit alpha Cav1.2
- Gene names
-
- Cacna1c
- Cach2
- Cacn2
- Cacnl1a1
- Cchl1a1
- Description
-
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:14609949, PubMed:18586882, PubMed:21216955, PubMed:25368181, PubMed:28119464). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:21216955). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:14609949, PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). {ECO:0000250|UniProtKB:P15381, ECO:0000269|PubMed:14609949, ECO:0000269|PubMed:18586882, ECO:0000269|PubMed:21216955, ECO:0000269|PubMed:25368181, ECO:0000269|PubMed:28119464, ECO:0000305}.
- Links
-
Search Kinases of Cacna1c (Mouse)
- Adrenergic signaling in cardiomyocytes
- Aldosterone synthesis and secretion
- Alzheimer disease
- Amphetamine addiction
- Arrhythmogenic right ventricular cardiomyopathy
- Calcium signaling pathway
- Cardiac muscle contraction
- Chemical carcinogenesis
- Cholinergic synapse
- Circadian entrainment
- Cortisol synthesis and secretion
- Cushing syndrome
- Dilated cardiomyopathy
- Dopaminergic synapse
- GABAergic synapse
- Glutamatergic synapse
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hypertrophic cardiomyopathy
- Insulin secretion
- Long
- MAPK signaling pathway
- Oxytocin signaling pathway
- Pathways of neurodegeneration
- Prion disease
- Renin secretion
- Retrograde endocannabinoid signaling
- Serotonergic synapse
- Taste transduction
- Type II diabetes mellitus
- Vascular smooth muscle contraction
- cAMP signaling pathway
- cGMP
- L-type voltage-gated calcium channel complex
- T-tubule
- Z disc
- adult walking behavior
- alpha-actinin binding
- calcium ion import
- calcium ion import across plasma membrane
- calcium ion transmembrane transport
- calcium ion transmembrane transport via high voltage-gated calcium channel
- calcium ion transport
- calcium ion transport into cytosol
- calcium-ion regulated exocytosis
- calmodulin binding
- camera-type eye development
- cardiac conduction
- cardiac muscle cell action potential involved in contraction
- caveolar macromolecular signaling complex
- cell communication involved in cardiac conduction
- cell surface
- cellular calcium ion homeostasis
- chemical synaptic transmission
- cytoplasm
- dendrite
- dendritic shaft
- embryonic forelimb morphogenesis
- enzyme binding
- glucose homeostasis
- glutamatergic synapse
- growth hormone secretion
- heart development
- high voltage-gated calcium channel activity
- immune system development
- insulin secretion
- integral component of membrane
- integral component of plasma membrane
- integral component of postsynaptic membrane
- integral component of presynaptic membrane
- membrane
- membrane depolarization during AV node cell action potential
- membrane depolarization during atrial cardiac muscle cell action potential
- membrane depolarization during cardiac muscle cell action potential
- metal ion binding
- neuronal cell body
- perikaryon
- plasma membrane
- positive regulation of adenylate cyclase activity
- positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
- positive regulation of cytosolic calcium ion concentration
- postsynaptic density
- postsynaptic density membrane
- postsynaptic membrane
- presynaptic membrane
- protein domain specific binding
- protein phosphatase 2A binding
- protein-containing complex
- regulation of blood pressure
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
- regulation of heart rate by cardiac conduction
- regulation of organ growth
- regulation of vasoconstriction
- regulation of ventricular cardiac muscle cell action potential
- sarcolemma
- smooth muscle contraction
- smooth muscle contraction involved in micturition
- translation initiation factor binding
- transmembrane transporter binding
- visual learning
- voltage-gated calcium channel activity
- voltage-gated calcium channel activity involved in AV node cell action potential
- voltage-gated calcium channel activity involved in cardiac muscle cell action potential
- voltage-gated calcium channel complex
- voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential

CACNB1
Human
Voltage-dependent L-type calcium channel subunit beta-1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CACB1_HUMAN
- Accession #
-
Q02641
- Protein names
-
- Voltage-dependent L-type calcium channel subunit beta-1
- CAB1
- Calcium channel voltage-dependent subunit beta 1
- Gene names
-
- CACNB1
- CACNLB1
- Description
-
Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:8107964, PubMed:15615847). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964). {ECO:0000250|UniProtKB:P19517, ECO:0000269|PubMed:1309651, ECO:0000269|PubMed:15615847, ECO:0000269|PubMed:8107964}.
- Links
-
Search Kinases of CACNB1 (Human)
- cardiac conduction
- cellular response to amyloid-beta
- chemical synaptic transmission
- high voltage-gated calcium channel activity
- neuromuscular junction development
- plasma membrane
- regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
- regulation of voltage-gated calcium channel activity
- sarcolemma
- synapse
- voltage-gated calcium channel activity
- voltage-gated calcium channel complex

Cacnb2
Rat
Voltage-dependent L-type calcium channel subunit beta-2
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
CACB2_RAT
- Accession #
-
Q8VGC3
- Protein names
-
- Voltage-dependent L-type calcium channel subunit beta-2
- CAB2
- Calcium channel voltage-dependent subunit beta 2
- Gene names
-
- Cacnb2
- Cacnlb2
- Description
-
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. {ECO:0000250, ECO:0000269|PubMed:11604404, ECO:0000269|PubMed:12042350, ECO:0000269|PubMed:1370480}.
- Links
-
Search Kinases of Cacnb2 (Rat)
- L-type voltage-gated calcium channel complex
- actin filament binding
- calcium channel regulator activity
- calcium ion import
- calcium ion transport
- chemical synaptic transmission
- high voltage-gated calcium channel activity
- identical protein binding
- membrane depolarization during AV node cell action potential
- membrane depolarization during atrial cardiac muscle cell action potential
- neuromuscular junction development
- phosphoprotein binding
- photoreceptor ribbon synapse
- positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
- positive regulation of calcium ion transport
- positive regulation of high voltage-gated calcium channel activity
- presynapse
- protein domain specific binding
- protein kinase binding
- protein localization to plasma membrane
- regulation of heart rate by cardiac conduction
- regulation of voltage-gated calcium channel activity
- visual perception
- voltage-gated calcium channel activity
- voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
- voltage-gated calcium channel complex

Camk2a
Rat
Calcium/calmodulin-dependent protein kinase type II subunit alpha
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
KCC2A_RAT
- Accession #
-
P11275
- Protein names
-
- Calcium/calmodulin-dependent protein kinase type II subunit alpha
- CaM kinase II subunit alpha
- CaMK-II subunit alpha
- EC 2.7.11.17
- Gene names
-
- Camk2a
- Description
-
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (PubMed:15312654). Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (By similarity). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11798, ECO:0000250|UniProtKB:Q9UQM7, ECO:0000269|PubMed:15312654}.
- Links
-
Search Kinases of Camk2a (Rat)
- Adrenergic signaling in cardiomyocytes
- Aldosterone synthesis and secretion
- Amphetamine addiction
- Axon guidance
- Calcium signaling pathway
- Cholinergic synapse
- Circadian entrainment
- Cushing syndrome
- Diabetic cardiomyopathy
- Dopaminergic synapse
- ErbB signaling pathway
- Gastric acid secretion
- Glioma
- Glucagon signaling pathway
- GnRH signaling pathway
- HIF
- Inflammatory mediator regulation of TRP channels
- Insulin secretion
- Lipid and atherosclerosis
- Long
- Melanogenesis
- Necroptosis
- Neurotrophin signaling pathway
- Olfactory transduction
- Oocyte meiosis
- Oxytocin signaling pathway
- Parkinson disease
- Pathways in cancer
- Pathways of neurodegeneration
- Proteoglycans in cancer
- Tuberculosis
- Wnt signaling pathway
- cAMP signaling pathway
- ATP binding
- G1/S transition of mitotic cell cycle
- GTPase activating protein binding
- NMDA selective glutamate receptor signaling pathway
- Schaffer collateral - CA1 synapse
- angiotensin-activated signaling pathway
- axon
- calcium ion transport
- calcium- and calmodulin-dependent protein kinase complex
- calcium-dependent protein serine/threonine kinase activity
- calmodulin binding
- calmodulin dependent kinase signaling pathway
- calmodulin-dependent protein kinase activity
- cytoplasm
- cytosol
- dendrite
- dendrite cytoplasm
- dendrite morphogenesis
- dendritic spine
- dendritic spine development
- glutamate receptor binding
- glutamatergic postsynaptic density
- glutamatergic synapse
- identical protein binding
- ionotropic glutamate receptor signaling pathway
- kinase activity
- membrane
- metal ion binding
- mitochondrion
- negative regulation of hydrolase activity
- neuron projection
- neuronal cell body
- nucleus
- peptidyl-serine phosphorylation
- peptidyl-threonine autophosphorylation
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of calcium ion transport
- positive regulation of cardiac muscle cell apoptotic process
- postsynaptic cytosol
- postsynaptic density
- postsynaptic neurotransmitter receptor diffusion trapping
- postsynaptic specialization membrane
- presynaptic cytosol
- protein autophosphorylation
- protein homodimerization activity
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- regulation of endocannabinoid signaling pathway
- regulation of mitochondrial membrane permeability involved in apoptotic process
- regulation of neuron migration
- regulation of neuronal synaptic plasticity
- regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
- regulation of neurotransmitter secretion
- regulation of protein localization to plasma membrane
- regulation of synaptic vesicle docking
- response to ischemia

CAMK2A
Human
Calcium/calmodulin-dependent protein kinase type II subunit alpha
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
KCC2A_HUMAN
- Accession #
-
Q9UQM7
- Protein names
-
- Calcium/calmodulin-dependent protein kinase type II subunit alpha
- CaM kinase II subunit alpha
- CaMK-II subunit alpha
- EC 2.7.11.17
- Gene names
-
- CAMK2A
- CAMKA
- KIAA0968
- Description
-
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}.
- Links
-
Search Kinases of CAMK2A (Human)
- Adrenergic signaling in cardiomyocytes
- Aldosterone synthesis and secretion
- Amphetamine addiction
- Axon guidance
- Calcium signaling pathway
- Cholinergic synapse
- Circadian entrainment
- Cushing syndrome
- Diabetic cardiomyopathy
- Dopaminergic synapse
- ErbB signaling pathway
- Gastric acid secretion
- Glioma
- Glucagon signaling pathway
- GnRH signaling pathway
- HIF
- Inflammatory mediator regulation of TRP channels
- Insulin secretion
- Lipid and atherosclerosis
- Long
- Melanogenesis
- Necroptosis
- Neurotrophin signaling pathway
- Olfactory transduction
- Oocyte meiosis
- Oxytocin signaling pathway
- Parkinson disease
- Pathways in cancer
- Pathways of neurodegeneration
- Proteoglycans in cancer
- Tuberculosis
- Wnt signaling pathway
- cAMP signaling pathway
- ATP binding
- G1/S transition of mitotic cell cycle
- MAPK cascade
- Wnt signaling pathway, calcium modulating pathway
- angiotensin-activated signaling pathway
- calcium ion transport
- calcium- and calmodulin-dependent protein kinase complex
- calcium-dependent protein serine/threonine kinase activity
- calmodulin binding
- calmodulin-dependent protein kinase activity
- cytoplasm
- cytosol
- dendritic spine
- dendritic spine development
- endocytic vesicle membrane
- glutamate receptor binding
- identical protein binding
- interferon-gamma-mediated signaling pathway
- kinase activity
- metal ion binding
- mitochondrion
- negative regulation of hydrolase activity
- neuron projection
- nucleoplasm
- nucleus
- peptidyl-serine phosphorylation
- peptidyl-threonine autophosphorylation
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of calcium ion transport
- positive regulation of cardiac muscle cell apoptotic process
- postsynaptic density
- protein autophosphorylation
- protein homodimerization activity
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- regulation of NMDA receptor activity
- regulation of cellular response to heat
- regulation of endocannabinoid signaling pathway
- regulation of mitochondrial membrane permeability involved in apoptotic process
- regulation of neuron migration
- regulation of neuronal synaptic plasticity
- regulation of neurotransmitter secretion
- response to ischemia

Camk2a
Mouse
Calcium/calmodulin-dependent protein kinase type II subunit alpha
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
KCC2A_MOUSE
- Accession #
-
P11798
- Protein names
-
- Calcium/calmodulin-dependent protein kinase type II subunit alpha
- CaM kinase II subunit alpha
- CaMK-II subunit alpha
- EC 2.7.11.17
- Gene names
-
- Camk2a
- Description
-
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development. Also regulates the migration of developing neurons (By similarity). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (PubMed:23502535). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:Q9UQM7, ECO:0000269|PubMed:23502535, ECO:0000269|PubMed:23805378}.; [Isoform Alpha KAP]: Has no kinase activity. {ECO:0000269|PubMed:8524307}.
- Links
-
Search Kinases of Camk2a (Mouse)
- Adrenergic signaling in cardiomyocytes
- Aldosterone synthesis and secretion
- Amphetamine addiction
- Axon guidance
- Calcium signaling pathway
- Cholinergic synapse
- Circadian entrainment
- Cushing syndrome
- Diabetic cardiomyopathy
- Dopaminergic synapse
- ErbB signaling pathway
- Gastric acid secretion
- Glioma
- Glucagon signaling pathway
- GnRH signaling pathway
- HIF
- Inflammatory mediator regulation of TRP channels
- Insulin secretion
- Lipid and atherosclerosis
- Long
- Melanogenesis
- Necroptosis
- Neurotrophin signaling pathway
- Olfactory transduction
- Oocyte meiosis
- Oxytocin signaling pathway
- Parkinson disease
- Pathways in cancer
- Pathways of neurodegeneration
- Proteoglycans in cancer
- Tuberculosis
- Wnt signaling pathway
- cAMP signaling pathway
- ATP binding
- G1/S transition of mitotic cell cycle
- GTPase activating protein binding
- NMDA selective glutamate receptor signaling pathway
- Schaffer collateral - CA1 synapse
- angiotensin-activated signaling pathway
- axon
- calcium ion transport
- calcium- and calmodulin-dependent protein kinase complex
- calcium-dependent protein serine/threonine kinase activity
- calmodulin binding
- calmodulin dependent kinase signaling pathway
- calmodulin-dependent protein kinase activity
- cytoplasm
- cytosol
- dendrite
- dendrite cytoplasm
- dendrite morphogenesis
- dendritic spine
- dendritic spine development
- glutamate receptor binding
- glutamatergic postsynaptic density
- glutamatergic synapse
- identical protein binding
- ionotropic glutamate receptor signaling pathway
- kinase activity
- membrane
- metal ion binding
- mitochondrion
- negative regulation of hydrolase activity
- neuron projection
- neuronal cell body
- nucleus
- peptidyl-serine phosphorylation
- peptidyl-threonine autophosphorylation
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of calcium ion transport
- positive regulation of cardiac muscle cell apoptotic process
- postsynaptic cytosol
- postsynaptic density
- postsynaptic neurotransmitter receptor diffusion trapping
- postsynaptic specialization membrane
- presynaptic cytosol
- protein autophosphorylation
- protein homodimerization activity
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- regulation of endocannabinoid signaling pathway
- regulation of mitochondrial membrane permeability involved in apoptotic process
- regulation of neuron migration
- regulation of neuronal synaptic plasticity
- regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
- regulation of neurotransmitter secretion
- regulation of protein localization to plasma membrane
- regulation of synaptic vesicle docking
- response to ischemia

Camk2b
Rat
Calcium/calmodulin-dependent protein kinase type II subunit beta
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
KCC2B_RAT
- Accession #
-
P08413
- Protein names
-
- Calcium/calmodulin-dependent protein kinase type II subunit beta
- CaM kinase II subunit beta
- CaMK-II subunit beta
- EC 2.7.11.17
- Gene names
-
- Camk2b
- Description
-
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. {ECO:0000250|UniProtKB:Q13554, ECO:0000269|PubMed:12873385, ECO:0000269|PubMed:15312654, ECO:0000269|PubMed:17272343}.
- Links
-
Search Kinases of Camk2b (Rat)
- Adrenergic signaling in cardiomyocytes
- Aldosterone synthesis and secretion
- Amphetamine addiction
- Axon guidance
- Calcium signaling pathway
- Cholinergic synapse
- Circadian entrainment
- Cushing syndrome
- Diabetic cardiomyopathy
- Dopaminergic synapse
- ErbB signaling pathway
- Gastric acid secretion
- Glioma
- Glucagon signaling pathway
- GnRH signaling pathway
- HIF
- Inflammatory mediator regulation of TRP channels
- Insulin secretion
- Lipid and atherosclerosis
- Long
- Melanogenesis
- Necroptosis
- Neurotrophin signaling pathway
- Olfactory transduction
- Oocyte meiosis
- Oxytocin signaling pathway
- Parkinson disease
- Pathways in cancer
- Pathways of neurodegeneration
- Proteoglycans in cancer
- Tuberculosis
- Wnt signaling pathway
- cAMP signaling pathway
- ATP binding
- G1/S transition of mitotic cell cycle
- activation of meiosis involved in egg activation
- calcium ion transport
- calcium- and calmodulin-dependent protein kinase complex
- calmodulin binding
- calmodulin-dependent protein kinase activity
- cell projection morphogenesis
- cellular response to homocysteine
- cytoplasm
- cytosol
- dendrite
- glutamatergic synapse
- hippocampal neuron apoptotic process
- identical protein binding
- inhibitory G protein-coupled receptor phosphorylation
- long-term synaptic potentiation
- microtubule organizing center
- neuromuscular process controlling balance
- neuron projection
- peptidyl-serine phosphorylation
- perikaryon
- phospholipase binding
- positive regulation of apoptotic signaling pathway
- positive regulation of dendritic spine morphogenesis
- positive regulation of neuron projection development
- positive regulation of phospholipase A2 activity
- positive regulation of synapse maturation
- postsynaptic density
- protein autophosphorylation
- protein homodimerization activity
- protein kinase binding
- protein serine kinase activity
- protein serine/threonine kinase activity
- regulation of long-term neuronal synaptic plasticity
- regulation of neuron migration
- regulation of protein localization to plasma membrane
- regulation of synaptic transmission, cholinergic
- response to cadmium ion
- response to psychosocial stress
- sarcoplasmic reticulum membrane
- spindle midzone
- structural constituent of postsynaptic actin cytoskeleton

CAMK2D
Human
Calcium/calmodulin-dependent protein kinase type II subunit delta
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
KCC2D_HUMAN
- Accession #
-
Q13557
- Protein names
-
- Calcium/calmodulin-dependent protein kinase type II subunit delta
- CaM kinase II subunit delta
- CaMK-II subunit delta
- EC 2.7.11.17
- Gene names
-
- CAMK2D
- CAMKD
- Description
-
Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. {ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}.
- Links
-
Search Kinases of CAMK2D (Human)
- Adrenergic signaling in cardiomyocytes
- Aldosterone synthesis and secretion
- Amphetamine addiction
- Axon guidance
- Calcium signaling pathway
- Cholinergic synapse
- Circadian entrainment
- Cushing syndrome
- Diabetic cardiomyopathy
- Dopaminergic synapse
- ErbB signaling pathway
- Gastric acid secretion
- Glioma
- Glucagon signaling pathway
- GnRH signaling pathway
- HIF
- Inflammatory mediator regulation of TRP channels
- Insulin secretion
- Lipid and atherosclerosis
- Long
- Melanogenesis
- Necroptosis
- Neurotrophin signaling pathway
- Olfactory transduction
- Oocyte meiosis
- Oxytocin signaling pathway
- Parkinson disease
- Pathways in cancer
- Pathways of neurodegeneration
- Proteoglycans in cancer
- Tuberculosis
- Wnt signaling pathway
- cAMP signaling pathway
- ATP binding
- calcium- and calmodulin-dependent protein kinase complex
- calmodulin binding
- calmodulin-dependent protein kinase activity
- cardiac muscle cell contraction
- cellular response to calcium ion
- cytoplasm
- cytosol
- endocytic vesicle membrane
- endoplasmic reticulum calcium ion homeostasis
- identical protein binding
- interferon-gamma-mediated signaling pathway
- membrane
- negative regulation of sodium ion transmembrane transport
- negative regulation of sodium ion transmembrane transporter activity
- neuron projection
- nucleoplasm
- nucleus
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- positive regulation of cardiac muscle cell apoptotic process
- positive regulation of cardiac muscle hypertrophy
- protein autophosphorylation
- protein homodimerization activity
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
- regulation of cardiac muscle cell action potential
- regulation of cardiac muscle cell action potential involved in regulation of contraction
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
- regulation of cell communication by electrical coupling
- regulation of cell communication by electrical coupling involved in cardiac conduction
- regulation of cell growth
- regulation of cellular localization
- regulation of cellular response to heat
- regulation of heart contraction
- regulation of heart rate by cardiac conduction
- regulation of histone deacetylase activity
- regulation of membrane depolarization
- regulation of relaxation of cardiac muscle
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
- regulation of ryanodine-sensitive calcium-release channel activity
- regulation of the force of heart contraction
- regulation of transcription by RNA polymerase II
- relaxation of cardiac muscle
- sarcolemma
- sarcoplasmic reticulum membrane
- sodium channel inhibitor activity
- titin binding
- transmembrane transporter binding
