Search Results (3 substrates found)
Gene name
Organism
Protein name
Dcx
Mouse
Neuronal migration protein doublecortin
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
DCX_MOUSE
- Accession #
-
O88809
- Protein names
-
- Neuronal migration protein doublecortin
- Doublin
- Lissencephalin-X
- Lis-X
- Gene names
-
- Dcx
- Dcn
- Description
-
Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May participate along with PAFAH1B1/LIS-1 in a distinct overlapping signaling pathway that promotes neuronal migration (By similarity).
- Links
-
Search Kinases of Dcx (Mouse)
N/A

MAPT
Human
Microtubule-associated protein tau
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
TAU_HUMAN
- Accession #
-
P10636
- Protein names
-
- Microtubule-associated protein tau
- Neurofibrillary tangle protein
- Paired helical filament-tau
- PHF-tau
- Gene names
-
- MAPT
- MAPTL
- MTBT1
- TAU
- Description
-
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
- Links
-
Search Kinases of MAPT (Human)
- SH3 domain binding
- adult walking behavior
- apolipoprotein binding
- apoptotic process
- axon
- axon cargo transport
- axon extension
- cellular component disassembly involved in execution phase of apoptosis
- cytosol
- enzyme binding
- generation of neurons
- growth cone
- lipoprotein particle binding
- microtubule
- microtubule associated complex
- microtubule binding
- microtubule cytoskeleton organization
- mitochondrion transport along microtubule
- negative regulation of intracellular transport
- neuron migration
- nuclear periphery
- plasma membrane
- positive regulation of axon extension
- positive regulation of microtubule polymerization
- protein binding
- regulation of autophagy
- regulation of microtubule polymerization
- regulation of microtubule-based movement
- structural constituent of cytoskeleton
- tubulin complex

Mapt
Rat
Microtubule-associated protein tau
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
TAU_RAT
- Accession #
-
P19332
- Protein names
-
- Microtubule-associated protein tau
- Neurofibrillary tangle protein
- Paired helical filament-tau
- PHF-tau
- Gene names
-
- Mapt
- Mtapt
- Tau
- Description
-
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
- Links
-
Search Kinases of Mapt (Rat)
N/A
- apoptotic process
- axon
- axonal growth cone
- brain development
- cytosol
- enzyme binding
- female pregnancy
- growth cone
- intrinsic apoptotic signaling pathway in response to oxidative stress
- microtubule
- microtubule binding
- microtubule cytoskeleton organization
- microtubule-based process
- neuron differentiation
- neuron projection
- plasma membrane
- positive regulation of axon extension
- positive regulation of microtubule polymerization
- protein binding
- protein domain specific binding
- protein kinase binding
- response to nutrient
- response to organic substance
- tubulin complex
