Search Results (75 substrates found)
Gene name
Organism
Protein name
AHNAK
Human
Neuroblast differentiation-associated protein AHNAK
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
AHNK_HUMAN
- Accession #
-
Q09666
- Protein names
-
- Neuroblast differentiation-associated protein AHNAK
- Desmoyokin
- Gene names
-
- AHNAK
- PM227
- Description
-
May be required for neuronal cell differentiation.
- Links
-
Search Kinases of AHNAK (Human)
N/A
- S100 protein binding
- T-tubule
- actin cytoskeleton
- cell-cell contact zone
- costamere
- cytoplasm
- cytosol
- extracellular vesicular exosome
- lysosomal membrane
- nucleus
- plasma membrane
- poly(A) RNA binding
- protein binding
- protein oligomerization
- regulation of RNA splicing
- regulation of voltage-gated calcium channel activity
- sarcolemma
- structural molecule activity conferring elasticity
- vesicle

ARHGAP21
Human
Rho GTPase-activating protein 21
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
RHG21_HUMAN
- Accession #
-
Q5T5U3
- Protein names
-
- Rho GTPase-activating protein 21
- Rho GTPase-activating protein 10
- Rho-type GTPase-activating protein 21
- Gene names
-
- ARHGAP21
- ARHGAP10
- KIAA1424
- Description
-
Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.
- Links
-
Search Kinases of ARHGAP21 (Human)
N/A

ATM
Human
Serine-protein kinase ATM
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ATM_HUMAN
- Accession #
-
Q13315
- Protein names
-
- Serine-protein kinase ATM
- EC 2.7.11.1
- Ataxia telangiectasia mutated
- A-T mutated
- Gene names
-
- ATM
- Description
-
Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.
- Links
-
Search Kinases of ATM (Human)
- 1-phosphatidylinositol-3-kinase activity
- ATP binding
- DNA binding
- DNA damage induced protein phosphorylation
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- DNA repair
- DNA-dependent protein kinase activity
- brain development
- cell cycle arrest
- cellular response to DNA damage stimulus
- cellular response to gamma radiation
- cytoplasmic membrane-bounded vesicle
- double-strand break repair
- double-strand break repair via homologous recombination
- heart development
- histone mRNA catabolic process
- histone serine kinase activity
- intrinsic apoptotic signaling pathway in response to DNA damage
- lipoprotein catabolic process
- mitotic spindle assembly checkpoint
- negative regulation of B cell proliferation
- neuron apoptotic process
- nucleoplasm
- oocyte development
- peptidyl-serine phosphorylation
- phosphatidylinositol-3-phosphate biosynthetic process
- positive regulation of DNA damage response, signal transduction by p53 class mediator
- positive regulation of apoptotic process
- positive regulation of neuron apoptotic process
- pre-B cell allelic exclusion
- protein N-terminus binding
- protein autophosphorylation
- protein binding
- protein complex binding
- protein dimerization activity
- protein phosphorylation
- protein serine/threonine kinase activity
- reciprocal meiotic recombination
- replicative senescence
- response to hypoxia
- response to ionizing radiation
- signal transduction
- signal transduction involved in mitotic G2 DNA damage checkpoint
- somitogenesis
- spindle
- telomere maintenance

AURKB
Human
Aurora kinase B
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
AURKB_HUMAN
- Accession #
-
Q96GD4
- Protein names
-
- Aurora kinase B
- EC 2.7.11.1
- Aurora 1
- Aurora- and IPL1-like midbody-associated protein 1
- AIM-1
- Aurora/IPL1-related kinase 2
- ARK-2
- Aurora-related kinase 2
- STK-1
- Serine/threonine-protein kinase 12
- Serine/threonine-protein kinase 5
- Serine/threonine-protein kinase aurora-B
- Gene names
-
- AURKB
- AIK2
- AIM1
- AIRK2
- ARK2
- STK1
- STK12
- STK5
- Description
-
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin, and histone H3. A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between GSG2 and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGOL1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes.
- Links
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Search Kinases of AURKB (Human)
N/A
- ATP binding
- abscission
- aging
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
- attachment of spindle microtubules to kinetochore
- cell proliferation
- cellular response to UV
- chromocenter
- chromosome passenger complex
- cleavage furrow formation
- condensed chromosome, centromeric region
- condensed nuclear chromosome, centromeric region
- cytokinesis checkpoint
- cytosol
- histone H3-S28 phosphorylation
- histone modification
- histone serine kinase activity
- intercellular bridge
- metal ion binding
- midbody
- mitotic cell cycle
- negative regulation of B cell apoptotic process
- negative regulation of cytokinesis
- negative regulation of protein binding
- negative regulation of transcription from RNA polymerase II promoter
- nucleus
- positive regulation of cytokinesis
- protein autophosphorylation
- protein binding
- protein localization to kinetochore
- protein phosphorylation
- protein serine/threonine kinase activity
- protein serine/threonine/tyrosine kinase activity
- regulation of chromosome segregation
- spindle
- spindle checkpoint
- spindle midzone assembly involved in mitosis
- spindle stabilization

BIRC5
Human
Baculoviral IAP repeat-containing protein 5
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
BIRC5_HUMAN
- Accession #
-
O15392
- Protein names
-
- Baculoviral IAP repeat-containing protein 5
- Apoptosis inhibitor 4
- Apoptosis inhibitor survivin
- Gene names
-
- BIRC5
- API4
- IAP4
- Description
-
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.
- Links
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Search Kinases of BIRC5 (Human)
- G2/M transition of mitotic cell cycle
- Ran GTPase binding
- apoptotic process
- cell division
- centriole
- chaperone binding
- chromosome passenger complex
- chromosome segregation
- chromosome, centromeric region
- cobalt ion binding
- cofactor binding
- condensed chromosome kinetochore
- cysteine-type endopeptidase inhibitor activity
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process
- cytokinesis
- cytoplasm
- cytoplasmic microtubule
- cytosol
- enzyme binding
- establishment of chromosome localization
- identical protein binding
- interphase microtubule organizing center
- metal ion binding
- microtubule
- microtubule binding
- midbody
- mitotic cell cycle
- mitotic nuclear division
- negative regulation of apoptotic process
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of transcription, DNA-templated
- nuclear chromosome
- nucleus
- positive regulation of cell proliferation
- positive regulation of exit from mitosis
- positive regulation of mitotic cell cycle
- protein binding
- protein complex localization
- protein heterodimerization activity
- protein homodimerization activity
- protein phosphorylation
- spindle
- spindle checkpoint
- spindle microtubule
- transcription, DNA-templated
- tubulin binding
- zinc ion binding

CASC5
Human
Protein CASC5
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CASC5_HUMAN
- Accession #
-
Q8NG31
- Protein names
-
- Protein CASC5
- ALL1-fused gene from chromosome 15q14 protein
- AF15q14
- Bub-linking kinetochore protein
- Blinkin
- Cancer susceptibility candidate gene 5 protein
- Cancer/testis antigen 29
- CT29
- Kinetochore-null protein 1
- Protein D40/AF15q14
- Gene names
-
- CASC5
- KIAA1570
- KNL1
- Description
-
Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.
- Links
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Search Kinases of CASC5 (Human)
N/A
- CENP-A containing nucleosome assembly
- acrosomal vesicle
- acrosome assembly
- attachment of spindle microtubules to kinetochore
- condensed chromosome kinetochore
- cytoplasm
- cytosol
- extracellular vesicular exosome
- mitotic cell cycle
- mitotic nuclear division
- negative regulation of phosphatase activity
- nucleoplasm
- nucleosome assembly
- nucleus
- protein binding
- protein localization to kinetochore
- spindle assembly checkpoint

CBX5
Human
Chromobox protein homolog 5
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CBX5_HUMAN
- Accession #
-
P45973
- Protein names
-
- Chromobox protein homolog 5
- Antigen p25
- Heterochromatin protein 1 homolog alpha
- HP1 alpha
- Gene names
-
- CBX5
- HP1A
- Description
-
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
- Links
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Search Kinases of CBX5 (Human)
N/A
- blood coagulation
- chromatin binding
- chromocenter
- histone deacetylase complex
- histone methyltransferase complex
- kinetochore
- methylated histone binding
- negative regulation of transcription, DNA-templated
- nuclear envelope
- nuclear heterochromatin
- nuclear pericentric heterochromatin
- nucleolus
- nucleoplasm
- nucleus
- protein binding
- protein binding, bridging
- repressing transcription factor binding
- transcriptional repressor complex
- viral process

CCDC86
Human
Coiled-coil domain-containing protein 86
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CCD86_HUMAN
- Accession #
-
Q9H6F5
- Protein names
-
- Coiled-coil domain-containing protein 86
- Cytokine-induced protein with coiled-coil domain
- Gene names
-
- CCDC86
- CYCLON
- Description
-
N/A
- Links
-
Search Kinases of CCDC86 (Human)
N/A

CDCA5
Human
Sororin
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CDCA5_HUMAN
- Accession #
-
Q96FF9
- Protein names
-
- Sororin
- Cell division cycle-associated protein 5
- p35
- Gene names
-
- CDCA5
- Description
-
Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair.
- Links
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Search Kinases of CDCA5 (Human)
- G1/S transition of mitotic cell cycle
- chromatin binding
- chromosome
- chromosome, centromeric region
- cohesin complex
- cytoplasm
- cytosol
- double-strand break repair
- mitotic cell cycle
- mitotic chromosome condensation
- mitotic interphase
- mitotic metaphase plate congression
- mitotic nuclear division
- mitotic sister chromatid cohesion
- nuclear chromatin
- nucleoplasm
- nucleus
- plasma membrane
- protein binding
- regulation of cohesin localization to chromatin

CDCA8
Human
Borealin
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
BOREA_HUMAN
- Accession #
-
Q53HL2
- Protein names
-
- Borealin
- Cell division cycle-associated protein 8
- Dasra-B
- hDasra-B
- Pluripotent embryonic stem cell-related gene 3 protein
- Gene names
-
- CDCA8
- PESCRG3
- Description
-
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
- Links
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Search Kinases of CDCA8 (Human)
N/A

CENPA
Human
Histone H3-like centromeric protein A
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CENPA_HUMAN
- Accession #
-
P49450
- Protein names
-
- Histone H3-like centromeric protein A
- Centromere autoantigen A
- Centromere protein A
- CENP-A
- Gene names
-
- CENPA
- Description
-
Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).
- Links
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Search Kinases of CENPA (Human)
N/A
- CENP-A containing nucleosome assembly
- DNA binding
- chromatin binding
- chromosome, centromeric region
- condensed chromosome inner kinetochore
- condensed nuclear chromosome kinetochore
- condensed nuclear chromosome, centromeric region
- cytosol
- establishment of mitotic spindle orientation
- kinetochore assembly
- mitotic cell cycle
- nucleoplasm
- nucleosome
- nucleosome assembly
- nucleus
- protein binding
- protein localization to chromosome, centromeric region
- viral process

CKAP2
Human
Cytoskeleton-associated protein 2
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CKAP2_HUMAN
- Accession #
-
Q8WWK9
- Protein names
-
- Cytoskeleton-associated protein 2
- CTCL tumor antigen se20-10
- Tumor- and microtubule-associated protein
- Gene names
-
- CKAP2
- LB1
- TMAP
- Description
-
Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity).
- Links
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Search Kinases of CKAP2 (Human)
N/A

COBLL1
Human
Cordon-bleu protein-like 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
COBL1_HUMAN
- Accession #
- Q53SF7
- Protein names
-
- Cordon-bleu protein-like 1
- Gene names
-
- COBLL1
- KIAA0977
- Description
-
N/A
- Links
-
Search Kinases of COBLL1 (Human)
N/A

DDA1
Human
DET1- and DDB1-associated protein 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
DDA1_HUMAN
- Accession #
-
Q9BW61
- Protein names
-
- DET1- and DDB1-associated protein 1
- Placenta cross-immune reaction antigen 1
- PCIA-1
- Gene names
-
- DDA1
- C19orf58
- PCIA1
- Description
-
May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins.
- Links
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Search Kinases of DDA1 (Human)
N/A
N/A

DDX3X
Human
ATP-dependent RNA helicase DDX3X
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
DDX3X_HUMAN
- Accession #
-
O00571
- Protein names
-
- ATP-dependent RNA helicase DDX3X
- EC 3.6.4.13
- DEAD box protein 3, X-chromosomal
- DEAD box, X isoform
- Helicase-like protein 2
- HLP2
- Gene names
-
- DDX3X
- DBX
- DDX3
- Description
-
Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can enhance transcription from the CDKN1A/WAF1 promoter in a SP1-dependent manner. Found associated with the E-cadherin promoter and can down-regulate transcription from the promoter. Involved in regulation of translation initiation. Proposed to be involved in positive regulation of translation such as of cyclin E1/CCNE1 mRNA and specifically of mRNAs containing complex secondary structures in their 5'UTRs; these functions seem to require RNA helicase activity. Specifically promotes translation of a subset of viral and cellular mRNAs carrying a 5'proximal stem-loop structure in their 5'UTRs and cooperates with the eIF4F complex. Proposed to act prior to 43S ribosomal scanning and to locally destabilize these RNA structures to allow recognition of the mRNA cap or loading onto the 40S subunit. After association with 40S ribosomal subunits seems to be involved in the functional assembly of 80S ribosomes; the function seems to cover translation of mRNAs with structured and non-structured 5'UTRs and is independent of RNA helicase activity. Also proposed to inhibit cap-dependent translation by competetive interaction with EIF4E which can block the EIF4E:EIF4G complex formation. Proposed to be involved in stress response and stress granule assembly; the function is independent of RNA helicase activity and seems to involve association with EIF4E. May be involved in nuclear export of specific mRNAs but not in bulk mRNA export via interactions with XPO1 and NXF1. Also associates with polyadenylated mRNAs independently of NXF1. Associates with spliced mRNAs in an exon junction complex (EJC)-dependent manner and seems not to be directly involved in splicing. May be involved in nuclear mRNA export by association with DDX5 and regulating its nuclear location. Involved in innate immune signaling promoting the production of type I interferon (IFN-alpha and IFN-beta); proposed to act as viral RNA sensor, signaling intermediate and transcriptional coactivator. Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, plays a role of scaffolding adapter that links IKBKE and IRF3 and coordinates their activation. Also found associated with IFNB promoters; the function is independent of IRF3. Can bind to viral RNAs and via association with MAVS/IPS1 and DDX58/RIG-I is thought to induce signaling in early stages of infection. Involved in regulation of apoptosis. May be required for activation of the intrinsic but inhibit activation of the extrinsic apoptotic pathway. Acts as an antiapoptotic protein through association with GSK3A/B and BIRC2 in an apoptosis antagonizing signaling complex; activation of death receptors promotes caspase-dependent cleavage of BIRC2 and DDX3X and relieves the inhibition. May be involved in mitotic chromosome segregation. Appears to be a prime target for viral manipulations. Hepatitis B virus (HBV) polymerase and possibly vaccinia virus (VACV) protein K7 inhibit IFNB induction probably by dissociating DDX3X from TBK1 or IKBKE. Is involved in hepatitis C virus (HCV) replication; the function may involve the association with HCV core protein. HCV core protein inhibits the IPS1-dependent function in viral RNA sensing and may switch the function from a INFB inducing to a HCV replication mode. Involved in HIV-1 replication. Acts as a cofactor for XPO1-mediated nuclear export of incompletely spliced HIV-1 Rev RNAs.
- Links
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Search Kinases of DDX3X (Human)
- ATP binding
- ATP catabolic process
- ATP-dependent DNA helicase activity
- ATP-dependent RNA helicase activity
- ATPase activity
- DNA binding
- DNA duplex unwinding
- RNA binding
- RNA secondary structure unwinding
- RNA stem-loop binding
- cellular response to arsenic-containing substance
- cellular response to osmotic stress
- chromosome segregation
- cytoplasm
- cytoplasmic stress granule
- eukaryotic initiation factor 4E binding
- extracellular vesicular exosome
- extrinsic apoptotic signaling pathway via death domain receptors
- innate immune response
- intracellular signal transduction
- intrinsic apoptotic signaling pathway
- mRNA 5'-UTR binding
- mature ribosome assembly
- mitochondrial outer membrane
- negative regulation of apoptotic process
- negative regulation of cell growth
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of intrinsic apoptotic signaling pathway
- negative regulation of protein complex assembly
- negative regulation of translation
- nuclear speck
- nucleus
- poly(A) RNA binding
- poly(A) binding
- positive regulation of G1/S transition of mitotic cell cycle
- positive regulation of apoptotic process
- positive regulation of cell growth
- positive regulation of chemokine (C-C motif) ligand 5 production
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- positive regulation of interferon-beta production
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of translation
- positive regulation of translational initiation
- protein binding
- response to virus
- ribosomal small subunit binding
- stress granule assembly
- transcription factor binding
- transcription, DNA-templated
- translation initiation factor binding
- viral process

DDX52
Human
Probable ATP-dependent RNA helicase DDX52
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
DDX52_HUMAN
- Accession #
-
Q9Y2R4
- Protein names
-
- Probable ATP-dependent RNA helicase DDX52
- EC 3.6.4.13
- ATP-dependent RNA helicase ROK1-like
- DEAD box protein 52
- Gene names
-
- DDX52
- ROK1
- HUSSY-19
- Description
-
N/A
- Links
-
Search Kinases of DDX52 (Human)
N/A

DEK
Human
Protein DEK
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
DEK_HUMAN
- Accession #
-
P35659
- Protein names
-
- Protein DEK
- Gene names
-
- DEK
- Description
-
Involved in chromatin organization.
- Links
-
Search Kinases of DEK (Human)
N/A
- DNA binding
- chromatin modification
- histone binding
- nucleus
- poly(A) RNA binding
- regulation of double-strand break repair
- regulation of double-strand break repair via nonhomologous end joining
- regulation of transcription from RNA polymerase II promoter
- signal transduction
- transcription from RNA polymerase II promoter
- viral genome replication

DES
Human
Desmin
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
DESM_HUMAN
- Accession #
-
P17661
- Protein names
-
- Desmin
- Gene names
-
- DES
- Description
-
Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.
- Links
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Search Kinases of DES (Human)

DIAPH2
Human
DIAPH2 protein
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
Q17R91_HUMAN
- Accession #
- Q17R91
- Protein names
-
- DIAPH2 protein
- Gene names
-
- DIAPH2
- Description
-
N/A
- Links
-
Search Kinases of DIAPH2 (Human)
N/A

DSN1
Human
Kinetochore-associated protein DSN1 homolog
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
DSN1_HUMAN
- Accession #
-
Q9H410
- Protein names
-
- Kinetochore-associated protein DSN1 homolog
- Gene names
-
- DSN1
- C20orf172
- MIS13
- Description
-
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.
- Links
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Search Kinases of DSN1 (Human)
N/A
