KANPHOS_Str

Search Results (75 substrates found)

Displaying 1 - 20 of 75 Items
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Gene name
Organism
Protein name
AHNAK
Human
Neuroblast differentiation-associated protein AHNAK
ARHGAP21
Human
Rho GTPase-activating protein 21
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
RHG21_HUMAN
Accession #
Q5T5U3
Protein names
  • Rho GTPase-activating protein 21
  • Rho GTPase-activating protein 10
  • Rho-type GTPase-activating protein 21
Gene names
  • ARHGAP21
  • ARHGAP10
  • KIAA1424
Description
Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.
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Search Kinases of ARHGAP21 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
ATM
Human
Serine-protein kinase ATM
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ATM_HUMAN
Accession #
Q13315
Protein names
  • Serine-protein kinase ATM
  • EC 2.7.11.1
  • Ataxia telangiectasia mutated
  • A-T mutated
Gene names
  • ATM
Description
Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.
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Search Kinases of ATM (Human)
Gene Ontology Terms (46)
Phosphorylation Site Information
AURKB
Human
Aurora kinase B
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
AURKB_HUMAN
Accession #
Q96GD4
Protein names
  • Aurora kinase B
  • EC 2.7.11.1
  • Aurora 1
  • Aurora- and IPL1-like midbody-associated protein 1
  • AIM-1
  • Aurora/IPL1-related kinase 2
  • ARK-2
  • Aurora-related kinase 2
  • STK-1
  • Serine/threonine-protein kinase 12
  • Serine/threonine-protein kinase 5
  • Serine/threonine-protein kinase aurora-B
Gene names
  • AURKB
  • AIK2
  • AIM1
  • AIRK2
  • ARK2
  • STK1
  • STK12
  • STK5
Description
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin, and histone H3. A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between GSG2 and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGOL1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes.
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Search Kinases of AURKB (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
BIRC5
Human
Baculoviral IAP repeat-containing protein 5
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
BIRC5_HUMAN
Accession #
O15392
Protein names
  • Baculoviral IAP repeat-containing protein 5
  • Apoptosis inhibitor 4
  • Apoptosis inhibitor survivin
Gene names
  • BIRC5
  • API4
  • IAP4
Description
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.
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Search Kinases of BIRC5 (Human)
Phosphorylation Site Information
CASC5
Human
Protein CASC5
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CASC5_HUMAN
Accession #
Q8NG31
Protein names
  • Protein CASC5
  • ALL1-fused gene from chromosome 15q14 protein
  • AF15q14
  • Bub-linking kinetochore protein
  • Blinkin
  • Cancer susceptibility candidate gene 5 protein
  • Cancer/testis antigen 29
  • CT29
  • Kinetochore-null protein 1
  • Protein D40/AF15q14
Gene names
  • CASC5
  • KIAA1570
  • KNL1
Description
Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.
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Search Kinases of CASC5 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
CBX5
Human
Chromobox protein homolog 5
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CBX5_HUMAN
Accession #
P45973
Protein names
  • Chromobox protein homolog 5
  • Antigen p25
  • Heterochromatin protein 1 homolog alpha
  • HP1 alpha
Gene names
  • CBX5
  • HP1A
Description
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
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Search Kinases of CBX5 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
CCDC86
Human
Coiled-coil domain-containing protein 86
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CCD86_HUMAN
Accession #
Q9H6F5
Protein names
  • Coiled-coil domain-containing protein 86
  • Cytokine-induced protein with coiled-coil domain
Gene names
  • CCDC86
  • CYCLON
Description
N/A
Links

Search Kinases of CCDC86 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
CDCA5
Human
Sororin
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CDCA5_HUMAN
Accession #
Q96FF9
Protein names
  • Sororin
  • Cell division cycle-associated protein 5
  • p35
Gene names
  • CDCA5
Description
Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair.
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Search Kinases of CDCA5 (Human)
KEGG Pathways (1)
Phosphorylation Site Information
CDCA8
Human
Borealin
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
BOREA_HUMAN
Accession #
Q53HL2
Protein names
  • Borealin
  • Cell division cycle-associated protein 8
  • Dasra-B
  • hDasra-B
  • Pluripotent embryonic stem cell-related gene 3 protein
Gene names
  • CDCA8
  • PESCRG3
Description
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
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Search Kinases of CDCA8 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
CENPA
Human
Histone H3-like centromeric protein A
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CENPA_HUMAN
Accession #
P49450
Protein names
  • Histone H3-like centromeric protein A
  • Centromere autoantigen A
  • Centromere protein A
  • CENP-A
Gene names
  • CENPA
Description
Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).
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Search Kinases of CENPA (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
CKAP2
Human
Cytoskeleton-associated protein 2
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CKAP2_HUMAN
Accession #
Q8WWK9
Protein names
  • Cytoskeleton-associated protein 2
  • CTCL tumor antigen se20-10
  • Tumor- and microtubule-associated protein
Gene names
  • CKAP2
  • LB1
  • TMAP
Description
Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity).
Links

Search Kinases of CKAP2 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
COBLL1
Human
Cordon-bleu protein-like 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
COBL1_HUMAN
Accession #
Q53SF7
Protein names
  • Cordon-bleu protein-like 1
Gene names
  • COBLL1
  • KIAA0977
Description
N/A
Links

Search Kinases of COBLL1 (Human)
KEGG Pathways (0)
N/A
Gene Ontology Terms (1)
Phosphorylation Site Information
DDA1
Human
DET1- and DDB1-associated protein 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
DDA1_HUMAN
Accession #
Q9BW61
Protein names
  • DET1- and DDB1-associated protein 1
  • Placenta cross-immune reaction antigen 1
  • PCIA-1
Gene names
  • DDA1
  • C19orf58
  • PCIA1
Description
May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins.
Links

Search Kinases of DDA1 (Human)
KEGG Pathways (0)
N/A
Gene Ontology Terms (0)
N/A
Phosphorylation Site Information
DDX3X
Human
ATP-dependent RNA helicase DDX3X
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
DDX3X_HUMAN
Accession #
O00571
Protein names
  • ATP-dependent RNA helicase DDX3X
  • EC 3.6.4.13
  • DEAD box protein 3, X-chromosomal
  • DEAD box, X isoform
  • Helicase-like protein 2
  • HLP2
Gene names
  • DDX3X
  • DBX
  • DDX3
Description
Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can enhance transcription from the CDKN1A/WAF1 promoter in a SP1-dependent manner. Found associated with the E-cadherin promoter and can down-regulate transcription from the promoter. Involved in regulation of translation initiation. Proposed to be involved in positive regulation of translation such as of cyclin E1/CCNE1 mRNA and specifically of mRNAs containing complex secondary structures in their 5'UTRs; these functions seem to require RNA helicase activity. Specifically promotes translation of a subset of viral and cellular mRNAs carrying a 5'proximal stem-loop structure in their 5'UTRs and cooperates with the eIF4F complex. Proposed to act prior to 43S ribosomal scanning and to locally destabilize these RNA structures to allow recognition of the mRNA cap or loading onto the 40S subunit. After association with 40S ribosomal subunits seems to be involved in the functional assembly of 80S ribosomes; the function seems to cover translation of mRNAs with structured and non-structured 5'UTRs and is independent of RNA helicase activity. Also proposed to inhibit cap-dependent translation by competetive interaction with EIF4E which can block the EIF4E:EIF4G complex formation. Proposed to be involved in stress response and stress granule assembly; the function is independent of RNA helicase activity and seems to involve association with EIF4E. May be involved in nuclear export of specific mRNAs but not in bulk mRNA export via interactions with XPO1 and NXF1. Also associates with polyadenylated mRNAs independently of NXF1. Associates with spliced mRNAs in an exon junction complex (EJC)-dependent manner and seems not to be directly involved in splicing. May be involved in nuclear mRNA export by association with DDX5 and regulating its nuclear location. Involved in innate immune signaling promoting the production of type I interferon (IFN-alpha and IFN-beta); proposed to act as viral RNA sensor, signaling intermediate and transcriptional coactivator. Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, plays a role of scaffolding adapter that links IKBKE and IRF3 and coordinates their activation. Also found associated with IFNB promoters; the function is independent of IRF3. Can bind to viral RNAs and via association with MAVS/IPS1 and DDX58/RIG-I is thought to induce signaling in early stages of infection. Involved in regulation of apoptosis. May be required for activation of the intrinsic but inhibit activation of the extrinsic apoptotic pathway. Acts as an antiapoptotic protein through association with GSK3A/B and BIRC2 in an apoptosis antagonizing signaling complex; activation of death receptors promotes caspase-dependent cleavage of BIRC2 and DDX3X and relieves the inhibition. May be involved in mitotic chromosome segregation. Appears to be a prime target for viral manipulations. Hepatitis B virus (HBV) polymerase and possibly vaccinia virus (VACV) protein K7 inhibit IFNB induction probably by dissociating DDX3X from TBK1 or IKBKE. Is involved in hepatitis C virus (HCV) replication; the function may involve the association with HCV core protein. HCV core protein inhibits the IPS1-dependent function in viral RNA sensing and may switch the function from a INFB inducing to a HCV replication mode. Involved in HIV-1 replication. Acts as a cofactor for XPO1-mediated nuclear export of incompletely spliced HIV-1 Rev RNAs.
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Search Kinases of DDX3X (Human)
Gene Ontology Terms (51)
Phosphorylation Site Information
DDX52
Human
Probable ATP-dependent RNA helicase DDX52
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
DDX52_HUMAN
Accession #
Q9Y2R4
Protein names
  • Probable ATP-dependent RNA helicase DDX52
  • EC 3.6.4.13
  • ATP-dependent RNA helicase ROK1-like
  • DEAD box protein 52
Gene names
  • DDX52
  • ROK1
  • HUSSY-19
Description
N/A
Links

Search Kinases of DDX52 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
DES
Human
Desmin
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
DESM_HUMAN
Accession #
P17661
Protein names
  • Desmin
Gene names
  • DES
Description
Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.
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Search Kinases of DES (Human)
Phosphorylation Site Information
DIAPH2
Human
DIAPH2 protein
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
Q17R91_HUMAN
Accession #
Q17R91
Protein names
  • DIAPH2 protein
Gene names
  • DIAPH2
Description
N/A
Links

Search Kinases of DIAPH2 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
DSN1
Human
Kinetochore-associated protein DSN1 homolog
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
DSN1_HUMAN
Accession #
Q9H410
Protein names
  • Kinetochore-associated protein DSN1 homolog
Gene names
  • DSN1
  • C20orf172
  • MIS13
Description
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.
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Search Kinases of DSN1 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
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