Search Results (490 substrates found)
Gene name
Organism
Protein name
abcf-2
Nematode
Protein ABCF-2
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
G5EFG4_CAEEL
- Accession #
- G5EFG4
- Protein names
-
- Protein ABCF-2
- Gene names
-
- abcf-2
- CELE_T27E9.7
- T27E9.7
- Description
-
N/A
- Links
-
Search Kinases of abcf-2 (Nematode)
N/A

abcf-3
Nematode
Protein ABCF-3
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
Q20306_CAEEL
- Accession #
- Q20306
- Protein names
-
- Protein ABCF-3
- Gene names
-
- abcf-3
- CELE_F42A10.1
- F42A10.1
- Description
-
N/A
- Links
-
Search Kinases of abcf-3 (Nematode)
N/A

acdh-9
Nematode
Protein ACDH-9
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
Q95YB2_CAEEL
- Accession #
- Q95YB2
- Protein names
-
- Protein ACDH-9
- Gene names
-
- acdh-9
- CELE_F28A10.6
- F28A10.6
- Description
-
N/A
- Links
-
Search Kinases of acdh-9 (Nematode)

acp-6
Nematode
Protein ACP-6
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
Q9GUF2_CAEEL
- Accession #
- Q9GUF2
- Protein names
-
- Protein ACP-6
- Gene names
-
- acp-6
- CELE_Y73B6BL.24
- Y73B6BL.24
- Description
-
N/A
- Links
-
Search Kinases of acp-6 (Nematode)
N/A

Actg1
Rat
Actin, cytoplasmic 2
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ACTG_RAT
- Accession #
-
P63259
- Protein names
-
- Actin, cytoplasmic 2
- Gamma-actin [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]
- Gene names
-
- Actg1
- Actg
- Description
-
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
- Links
-
Search Kinases of Actg1 (Rat)
- Adherens junction
- Arrhythmogenic right ventricular cardiomyopathy (ARVC)
- Bacterial invasion of epithelial cells
- Dilated cardiomyopathy
- Focal adhesion
- Hippo signaling pathway
- Hypertrophic cardiomyopathy (HCM)
- Influenza A
- Leukocyte transendothelial migration
- Oxytocin signaling pathway
- Phagosome
- Platelet activation
- Proteoglycans in cancer
- Rap1 signaling pathway
- Regulation of actin cytoskeleton
- Salmonella infection
- Thyroid hormone signaling pathway
- Tight junction
- Viral myocarditis

Add1
Rat
Alpha-adducin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ADDA_RAT
- Accession #
-
Q63028
- Protein names
-
- Alpha-adducin
- Erythrocyte adducin subunit alpha
- Gene names
-
- Add1
- Description
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
- Links
-
Search Kinases of Add1 (Rat)
N/A
- F-actin capping protein complex
- T cell receptor binding
- actin filament bundle assembly
- barbed-end actin filament capping
- cell morphogenesis
- cell volume homeostasis
- cellular response to retinoic acid
- cytoskeleton organization
- dendrite
- dendritic spine
- erythrocyte differentiation
- hemoglobin metabolic process
- homeostasis of number of cells within a tissue
- in utero embryonic development
- ion transport
- multicellular organism growth
- negative regulation of actin filament polymerization
- nucleus
- perinuclear region of cytoplasm
- plasma membrane
- positive regulation of angiogenesis
- positive regulation of endocytosis
- positive regulation of protein binding
- postsynaptic density
- protein binding
- structural molecule activity
- synapse

Add2
Rat
Beta-adducin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
F8WFS9_RAT
- Accession #
- F8WFS9
- Protein names
-
- Beta-adducin
- Gene names
-
- Add2
- Description
-
N/A
- Links
-
Search Kinases of Add2 (Rat)
N/A

Add3
Rat
Gamma-adducin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ADDG_RAT
- Accession #
-
Q62847
- Protein names
-
- Gamma-adducin
- Adducin-like protein 70
- Protein kinase C-binding protein 35H
- Gene names
-
- Add3
- Description
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
- Links
-
Search Kinases of Add3 (Rat)
N/A

adr-1
Nematode
ADR-1C
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
Q8I8H1_CAEEL
- Accession #
- Q8I8H1
- Protein names
-
- ADR-1C
- Gene names
-
- adr-1
- Description
-
N/A
- Links
-
Search Kinases of adr-1 (Nematode)
N/A

air-2
Nematode
Aurora/IPL1-related protein kinase 2
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
AIR2_CAEEL
- Accession #
- O01427
- Protein names
-
- Aurora/IPL1-related protein kinase 2
- EC 2.7.11.1
- Serine/threonine-protein kinase aurora-B
- Gene names
-
- air-2
- stu-7
- B0207.4
- Description
-
Serine/threonine-protein kinase which mediates both meiotic and mitotic chromosome segregation. Required for histone H3 'Ser-10' phosphorylation. Phosphorylates tlk-1 at 'Ser-634', which enhances its activity. Phosphorylates zen-4 at 'Ser-680'.
- Links
-
Search Kinases of air-2 (Nematode)
N/A
- ATP binding
- ATPase binding
- chromatin modification
- chromosome condensation
- chromosome segregation
- condensed chromosome
- condensed nuclear chromosome
- cytokinesis, completion of separation
- cytoplasm
- establishment of protein localization
- kinesin binding
- meiotic nuclear division
- midbody
- multicellular organismal development
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- protein autophosphorylation
- protein binding
- protein kinase activity
- protein phosphorylation
- protein serine/threonine kinase activity
- regulation of actomyosin contractile ring contraction
- spindle
- spindle midzone
- spindle midzone assembly involved in mitosis

alg-1
Nematode
Protein ALG-1, isoform b
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
G5EES3_CAEEL
- Accession #
- G5EES3
- Protein names
-
- Protein ALG-1, isoform b
- Gene names
-
- alg-1
- CELE_F48F7.1
- F48F7.1
- Description
-
N/A
- Links
-
Search Kinases of alg-1 (Nematode)
N/A

alx-1
Nematode
Apoptosis-linked gene 2-interacting protein X 1
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
ALX1_CAEEL
- Accession #
- P34552
- Protein names
-
- Apoptosis-linked gene 2-interacting protein X 1
- Prion-like-
- Q/N-rich domain-bearing protein 58
- Protein YNK1
- Gene names
-
- alx-1
- pqn-58
- R10E12.1
- Description
-
Required for lin-12 degradation after it has been internalised in the vulval precursor cells.
- Links
-
Search Kinases of alx-1 (Nematode)

ama-1
Nematode
DNA-directed RNA polymerase II subunit RPB1
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
RPB1_CAEEL
- Accession #
- P16356
- Protein names
-
- DNA-directed RNA polymerase II subunit RPB1
- RNA polymerase II subunit B1
- EC 2.7.7.6
- DNA-directed RNA polymerase III largest subunit
- Gene names
-
- ama-1
- rpb-1
- F36A4.7
- Description
-
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing (By similarity).
- Links
-
Search Kinases of ama-1 (Nematode)
- DNA binding
- DNA-directed RNA polymerase II, core complex
- DNA-directed RNA polymerase activity
- RNA polymerase II activity
- embryo development ending in birth or egg hatching
- gastrulation
- mRNA transcription from RNA polymerase II promoter
- metal ion binding
- nucleus
- protein binding
- transcription, DNA-templated

Amph
Rat
Amphiphysin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
AMPH_RAT
- Accession #
-
O08838
- Protein names
-
- Amphiphysin
- Gene names
-
- Amph
- Amph1
- Description
-
May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton (By similarity).
- Links
-
Search Kinases of Amph (Rat)

Ankrd34a
Rat
Ankyrin repeat domain-containing protein 34A
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
AN34A_RAT
- Accession #
-
Q5BJT1
- Protein names
-
- Ankyrin repeat domain-containing protein 34A
- Gene names
-
- Ankrd34a
- Description
-
N/A
- Links
-
Search Kinases of Ankrd34a (Rat)
N/A

ant-1.1
Nematode
Protein ANT-1.1, isoform a
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
O45865_CAEEL
- Accession #
- O45865
- Protein names
-
- Protein ANT-1.1, isoform a
- Gene names
-
- ant-1.1
- CELE_T27E9.1
- T27E9.1
- Description
-
N/A
- Links
-
Search Kinases of ant-1.1 (Nematode)

Ap2m1
Rat
AP-2 complex subunit mu
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
AP2M1_RAT
- Accession #
- P84092
- Protein names
-
- AP-2 complex subunit mu
- AP-2 mu chain
- Adaptor protein complex AP-2 subunit mu
- Adaptor-related protein complex 2 subunit mu
- Clathrin assembly protein complex 2 mu medium chain
- Clathrin coat assembly protein AP50
- Clathrin coat-associated protein AP50
- Mu2-adaptin
- Plasma membrane adaptor AP-2 50 kDa protein
- Gene names
-
- Ap2m1
- Description
-
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 mu subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs. The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at 'Tyr-156' in membrane-associated AP-2. The membrane-specific phosphorylation event appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (By similarity). Plays a role in endocytosis of frizzled family members upon Wnt signaling.
- Links
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Search Kinases of Ap2m1 (Rat)

apb-1
Nematode
Protein APB-1, isoform a
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
Q9N4F3_CAEEL
- Accession #
- Q9N4F3
- Protein names
-
- Protein APB-1, isoform a
- Gene names
-
- apb-1
- CELE_Y71H2B.10
- Y71H2B.10
- Description
-
N/A
- Links
-
Search Kinases of apb-1 (Nematode)

Apob
Rat
Apolipoprotein B-100
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
APOB_RAT
- Accession #
-
Q7TMA5
- Protein names
-
- Apolipoprotein B-100
- Apo B-100 [Cleaved into: Apolipoprotein B-48
- Apo B-48]
- Gene names
-
- Apob
- Aa1064
- Ac1-060
- Description
-
Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.
- Links
-
Search Kinases of Apob (Rat)
- artery morphogenesis
- cellular response to prostaglandin stimulus
- cellular response to tumor necrosis factor
- cholesterol efflux
- cholesterol homeostasis
- cholesterol metabolic process
- cholesterol transporter activity
- cytoplasm
- endoplasmic reticulum
- extracellular space
- fertilization
- heparin binding
- in utero embryonic development
- intermediate-density lipoprotein particle
- intracellular membrane-bounded organelle
- lipid binding
- lipid metabolic process
- lipoprotein biosynthetic process
- lipoprotein catabolic process
- lipoprotein transport
- low-density lipoprotein particle
- low-density lipoprotein particle clearance
- low-density lipoprotein particle remodeling
- mature chylomicron
- nervous system development
- phospholipid binding
- positive regulation of cholesterol storage
- positive regulation of macrophage derived foam cell differentiation
- post-embryonic development
- protein binding
- regulation of cholesterol biosynthetic process
- response to carbohydrate
- response to lipopolysaccharide
- response to organic substance
- response to selenium ion
- response to virus
- sperm motility
- spermatogenesis
- triglyceride catabolic process
- triglyceride mobilization
- very-low-density lipoprotein particle
- vesicle lumen
- vesicle membrane

Arhgef7
Rat
Rho guanine nucleotide exchange factor 7
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ARHG7_RAT
- Accession #
-
O55043
- Protein names
-
- Rho guanine nucleotide exchange factor 7
- Beta-Pix
- PAK-interacting exchange factor beta
- Gene names
-
- Arhgef7
- Pak3bp
- Pixb
- Description
-
Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity).
- Links
-
Search Kinases of Arhgef7 (Rat)
- Rho guanyl-nucleotide exchange factor activity
- astrocyte cell migration
- cell cortex
- cytoplasm
- focal adhesion
- growth cone
- guanyl-nucleotide exchange factor activity
- lamellipodium
- lamellipodium assembly
- positive regulation of apoptotic process
- protein binding
- regulation of GTPase activity
- ruffle
- small GTPase mediated signal transduction
