Search Results (98 substrates found)
Gene name
Organism
Protein name
abcf-3
Nematode
Protein ABCF-3
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
Q20306_CAEEL
- Accession #
- Q20306
- Protein names
-
- Protein ABCF-3
- Gene names
-
- abcf-3
- CELE_F42A10.1
- F42A10.1
- Description
-
N/A
- Links
-
Search Kinases of abcf-3 (Nematode)
N/A

Add1
Rat
Alpha-adducin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ADDA_RAT
- Accession #
-
Q63028
- Protein names
-
- Alpha-adducin
- Erythrocyte adducin subunit alpha
- Gene names
-
- Add1
- Description
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
- Links
-
Search Kinases of Add1 (Rat)
N/A
- F-actin capping protein complex
- T cell receptor binding
- actin filament bundle assembly
- barbed-end actin filament capping
- cell morphogenesis
- cell volume homeostasis
- cellular response to retinoic acid
- cytoskeleton organization
- dendrite
- dendritic spine
- erythrocyte differentiation
- hemoglobin metabolic process
- homeostasis of number of cells within a tissue
- in utero embryonic development
- ion transport
- multicellular organism growth
- negative regulation of actin filament polymerization
- nucleus
- perinuclear region of cytoplasm
- plasma membrane
- positive regulation of angiogenesis
- positive regulation of endocytosis
- positive regulation of protein binding
- postsynaptic density
- protein binding
- structural molecule activity
- synapse

Add2
Rat
Beta-adducin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
F8WFS9_RAT
- Accession #
- F8WFS9
- Protein names
-
- Beta-adducin
- Gene names
-
- Add2
- Description
-
N/A
- Links
-
Search Kinases of Add2 (Rat)
N/A

Add3
Rat
Gamma-adducin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ADDG_RAT
- Accession #
-
Q62847
- Protein names
-
- Gamma-adducin
- Adducin-like protein 70
- Protein kinase C-binding protein 35H
- Gene names
-
- Add3
- Description
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
- Links
-
Search Kinases of Add3 (Rat)
N/A

Ankrd34a
Rat
Ankyrin repeat domain-containing protein 34A
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
AN34A_RAT
- Accession #
-
Q5BJT1
- Protein names
-
- Ankyrin repeat domain-containing protein 34A
- Gene names
-
- Ankrd34a
- Description
-
N/A
- Links
-
Search Kinases of Ankrd34a (Rat)
N/A

Arhgef7
Rat
Rho guanine nucleotide exchange factor 7
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ARHG7_RAT
- Accession #
-
O55043
- Protein names
-
- Rho guanine nucleotide exchange factor 7
- Beta-Pix
- PAK-interacting exchange factor beta
- Gene names
-
- Arhgef7
- Pak3bp
- Pixb
- Description
-
Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity).
- Links
-
Search Kinases of Arhgef7 (Rat)
- Rho guanyl-nucleotide exchange factor activity
- astrocyte cell migration
- cell cortex
- cytoplasm
- focal adhesion
- growth cone
- guanyl-nucleotide exchange factor activity
- lamellipodium
- lamellipodium assembly
- positive regulation of apoptotic process
- protein binding
- regulation of GTPase activity
- ruffle
- small GTPase mediated signal transduction

Atp6v1d
Rat
ATPase, H+ transporting, V1 subunit D, isoform CRA_c
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
Q6P503_RAT
- Accession #
- Q6P503
- Protein names
-
- ATPase, H+ transporting, V1 subunit D, isoform CRA_c
- ATPase, H+ transporting, lysosomal V1 subunit D
- Protein Atp6v1d
- Gene names
-
- Atp6v1d
- rCG_61537
- Description
-
N/A
- Links
-
Search Kinases of Atp6v1d (Rat)

Bin1
Rat
Myc box-dependent-interacting protein 1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
BIN1_RAT
- Accession #
-
O08839
- Protein names
-
- Myc box-dependent-interacting protein 1
- Amphiphysin II
- Amphiphysin-like protein
- Bridging integrator 1
- Gene names
-
- Bin1
- Amph2
- Amphl
- Description
-
May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.
- Links
-
Search Kinases of Bin1 (Rat)
N/A
- GTPase binding
- I band
- T-tubule
- Z disc
- axon
- axon initial segment
- axon terminus
- cerebellar mossy fiber
- endocytosis
- lipid tube
- lipid tube assembly
- microtubule
- muscle cell differentiation
- node of Ranvier
- nucleus
- positive regulation of GTPase activity
- positive regulation of apoptotic process
- positive regulation of astrocyte differentiation
- positive regulation of endocytosis
- protein binding
- protein complex binding
- protein heterodimerization activity
- regulation of cell cycle arrest
- regulation of neuron differentiation
- synaptic vesicle
- varicosity

C15C6.3
Nematode
Protein C15C6.3
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
Q9XVT2_CAEEL
- Accession #
- Q9XVT2
- Protein names
-
- Protein C15C6.3
- Gene names
-
- C15C6.3
- CELE_C15C6.3
- Description
-
N/A
- Links
-
Search Kinases of C15C6.3 (Nematode)
N/A
N/A

Camkk1
Rat
Calcium/calmodulin-dependent protein kinase kinase 1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
KKCC1_RAT
- Accession #
-
P97756
- Protein names
-
- Calcium/calmodulin-dependent protein kinase kinase 1
- CaM-KK 1
- CaM-kinase kinase 1
- CaMKK 1
- EC 2.7.11.17
- CaM-kinase IV kinase
- Calcium/calmodulin-dependent protein kinase kinase alpha
- CaM-KK alpha
- CaM-kinase kinase alpha
- CaMKK alpha
- Gene names
-
- Camkk1
- Description
-
Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.
- Links
-
Search Kinases of Camkk1 (Rat)

Camkk1
Rat
Calcium/calmodulin-dependent protein kinase kinase 1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
F1LQD2_RAT
- Accession #
- F1LQD2
- Protein names
-
- Calcium/calmodulin-dependent protein kinase kinase 1
- Calcium/calmodulin-dependent protein kinase kinase 1, alpha
- Gene names
-
- Camkk1
- rCG_35534
- Description
-
N/A
- Links
-
Search Kinases of Camkk1 (Rat)

Camkk2
Rat
Calcium/calmodulin-dependent protein kinase kinase 2
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
KKCC2_RAT
- Accession #
-
O88831
- Protein names
-
- Calcium/calmodulin-dependent protein kinase kinase 2
- CaM-KK 2
- CaM-kinase kinase 2
- CaMKK 2
- EC 2.7.11.17
- Calcium/calmodulin-dependent protein kinase kinase beta
- CaM-KK beta
- CaM-kinase kinase beta
- CaMKK beta
- Gene names
-
- Camkk2
- Description
-
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1 and CAMK4. Phosphorylates CAMK1D (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals. May play a role in neurite growth. Isoform 2 may promote neurite elongation, while isoform 1 may promoter neurite branching.
- Links
-
Search Kinases of Camkk2 (Rat)

CELE_T23E7.2
Nematode
Protein T23E7.2, isoform a
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
H2KZS2_CAEEL
- Accession #
- H2KZS2
- Protein names
-
- Protein T23E7.2, isoform a
- Gene names
-
- CELE_T23E7.2
- T23E7.2
- Description
-
N/A
- Links
-
Search Kinases of CELE_T23E7.2 (Nematode)
N/A
N/A

CELE_Y71F9AL.9
Nematode
Protein Y71F9AL.9
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
Q9N4I3_CAEEL
- Accession #
- Q9N4I3
- Protein names
-
- Protein Y71F9AL.9
- Gene names
-
- CELE_Y71F9AL.9
- Y71F9AL.9
- Description
-
N/A
- Links
-
Search Kinases of CELE_Y71F9AL.9 (Nematode)
N/A
N/A

Cmas
Rat
N-acylneuraminate cytidylyltransferase
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
NEUA_RAT
- Accession #
- P69060
- Protein names
-
- N-acylneuraminate cytidylyltransferase
- EC 2.7.7.43
- CMP-N-acetylneuraminic acid synthase
- CMP-NeuNAc synthase
- Gene names
-
- Cmas
- Description
-
Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) (By similarity).
- Links
-
Search Kinases of Cmas (Rat)
N/A

cmk-1
Nematode
Calcium/calmodulin-dependent protein kinase type 1
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
CMK1_CAEEL
- Accession #
- Q9TXJ0
- Protein names
-
- Calcium/calmodulin-dependent protein kinase type 1
- EC 2.7.11.17
- CaM kinase I
- CaM-KI
- Gene names
-
- cmk-1
- K07A9.2
- Description
-
Calcium/calmodulin-dependent protein kinase belonging to a calcium-triggered signaling cascade which results in transcriptional activation, at least in part through phosphorylation of crh-1. Regulates gene expression, sensory morphology, and function of the AFD thermosensory neurons.
- Links
-
Search Kinases of cmk-1 (Nematode)
N/A
- ATP binding
- calcium- and calmodulin-dependent protein kinase complex
- calmodulin binding
- calmodulin-dependent protein kinase activity
- cytoplasm
- metal ion binding
- neuron projection morphogenesis
- nucleus
- positive regulation of CREB transcription factor activity
- positive regulation of transcription from RNA polymerase II promoter
- protein autophosphorylation
- protein phosphorylation
- regulation of neuron differentiation
- thermosensory behavior

Creb1
Rat
Cyclic AMP-responsive element-binding protein 1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
CREB1_RAT
- Accession #
-
P15337
- Protein names
-
- Cyclic AMP-responsive element-binding protein 1
- CREB-1
- cAMP-responsive element-binding protein 1
- Gene names
-
- Creb1
- Creb-1
- Description
-
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-117 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity).
- Links
-
Search Kinases of Creb1 (Rat)
- AMPK signaling pathway
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Amphetamine addiction
- Antigen processing and presentation
- Cholinergic synapse
- Circadian entrainment
- Circadian rhythm
- Cocaine addiction
- Dopaminergic synapse
- Estrogen signaling pathway
- HTLV-I infection
- Hepatitis B
- Huntington's disease
- Insulin secretion
- Melanogenesis
- Osteoclast differentiation
- PI3K-Akt signaling pathway
- Prostate cancer
- TNF signaling pathway
- Thyroid hormone synthesis
- Tuberculosis
- Vasopressin-regulated water reabsorption
- Viral carcinogenesis
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
- cell differentiation
- chromatin
- circadian rhythm
- double-stranded DNA binding
- histone acetyltransferase binding
- mitochondrion
- nuclear chromatin
- nucleoplasm
- nucleus
- positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of fat cell differentiation
- positive regulation of lipid biosynthetic process
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription, DNA-templated
- positive regulation of transforming growth factor beta3 production
- protein binding
- protein stabilization
- regulation of apoptotic process
- regulation of circadian rhythm
- response to glucagon
- sequence-specific DNA binding
- sequence-specific DNA binding transcription factor activity
- transcription factor binding
- transcription factor complex
- transcription from RNA polymerase II promoter
- transcription regulatory region DNA binding
- transforming growth factor beta receptor signaling pathway

Dlg5
Rat
Protein Dlg5
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
D4A3K3_RAT
- Accession #
- D4A3K3
- Protein names
-
- Protein Dlg5
- Gene names
-
- Dlg5
- Description
-
N/A
- Links
-
Search Kinases of Dlg5 (Rat)
N/A

Dnm1
Rat
Dynamin-1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
DYN1_RAT
- Accession #
-
P21575
- Protein names
-
- Dynamin-1
- EC 3.6.5.5
- B-dynamin
- D100
- Dynamin, brain
- Gene names
-
- Dnm1
- Dnm
- Description
-
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis (By similarity).
- Links
-
Search Kinases of Dnm1 (Rat)
- GTP binding
- GTPase activity
- Golgi apparatus
- endosome organization
- identical protein binding
- membrane coat
- microtubule
- nitric-oxide synthase binding
- plasma membrane
- protein C-terminus binding
- protein binding
- protein complex
- protein complex binding
- receptor internalization
- receptor-mediated endocytosis

Dnm1l
Rat
Dynamin-1-like protein
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
DNM1L_RAT
- Accession #
-
O35303
- Protein names
-
- Dynamin-1-like protein
- EC 3.6.5.5
- Dynamin-like protein
- Gene names
-
- Dnm1l
- Dlp1
- Description
-
Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues. Also required for mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution.
- Links
-
Search Kinases of Dnm1l (Rat)
- GTP binding
- GTP catabolic process
- GTPase activity
- Golgi apparatus
- cell junction
- coated pit
- cytosol
- dynamin polymerization involved in mitochondrial fission
- endocytosis
- lipid binding
- membrane fission involved in mitochondrial fission
- membrane fusion
- microtubule
- mitochondrial fission
- mitochondrial fragmentation involved in apoptotic process
- mitochondrial outer membrane
- mitochondrion
- mitochondrion morphogenesis
- necroptotic process
- perinuclear region of cytoplasm
- peroxisome
- peroxisome fission
- positive regulation of apoptotic process
- positive regulation of intrinsic apoptotic signaling pathway
- positive regulation of protein secretion
- positive regulation of release of cytochrome c from mitochondria
- protein binding
- protein homodimerization activity
- protein homotetramerization
- regulation of peroxisome organization
- regulation of protein oligomerization
- release of cytochrome c from mitochondria
- synaptic vesicle membrane
