KANPHOS_Str

Search Results (640 substrates found)

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Gene name
Organism
Protein name
2010300C02Rik
Mouse
Protein 2010300C02Rik
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
E9Q3M9_MOUSE
Accession #
E9Q3M9
Protein names
  • Protein 2010300C02Rik
Gene names
  • 2010300C02Rik
Description
N/A
Links

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KEGG Pathways (0)
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Gene Ontology Terms (0)
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Phosphorylation Site Information
A6NN6
Human
Putative UPF0633 protein MGC21881
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
U633A_HUMAN
Accession #
A6NN06
Protein names
  • Putative UPF0633 protein MGC21881
Gene names
  • A6NN6
Description
N/A
Links

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Aak1
Mouse
AP2-associated protein kinase 1
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
AAK1_MOUSE
Accession #
Q3UHJ0
Protein names
  • AP2-associated protein kinase 1
  • EC 2.7.11.1
  • Adaptor-associated kinase 1
Gene names
  • Aak1
  • Kiaa1048
Description
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (By similarity).
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Abl1
Mouse
Tyrosine-protein kinase ABL1
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
ABL1_MOUSE
Accession #
P00520
Protein names
  • Tyrosine-protein kinase ABL1
  • EC 2.7.10.2
  • Abelson murine leukemia viral oncogene homolog 1
  • Abelson tyrosine-protein kinase 1
  • Proto-oncogene c-Abl
  • p150
Gene names
  • Abl1
  • Abl
Description
Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-191' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
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Ablim1
Mouse
Actin-binding LIM protein 1
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
E9Q9Q7_MOUSE
Accession #
E9Q9Q7
Protein names
  • Actin-binding LIM protein 1
Gene names
  • Ablim1
Description
N/A
Links

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ABT1
Human
Activator of basal transcription 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ABT1_HUMAN
Accession #
Q9ULW3
Protein names
  • Activator of basal transcription 1
  • hABT1
  • Basal transcriptional activator
Gene names
  • ABT1
Description
Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity).
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Adam22
Mouse
Disintegrin and metalloproteinase domain-containing protein 22
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
D3YUP9_MOUSE
Accession #
D3YUP9
Protein names
  • Disintegrin and metalloproteinase domain-containing protein 22
Gene names
  • Adam22
Description
N/A
Links

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KEGG Pathways (0)
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Phosphorylation Site Information
ADD1
Human
Alpha-adducin
Add1
Mouse
Adducin 1
Add2
Mouse
Beta-adducin
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
ADDB_MOUSE
Accession #
Q9QYB8
Protein names
  • Beta-adducin
  • Add97
  • Erythrocyte adducin subunit beta
Gene names
  • Add2
Description
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity).
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Add2
Rat
Beta-adducin
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
F8WFS9_RAT
Accession #
F8WFS9
Protein names
  • Beta-adducin
Gene names
  • Add2
Description
N/A
Links

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Add3
Mouse
Gamma-adducin
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
ADDG_MOUSE
Accession #
Q9QYB5
Protein names
  • Gamma-adducin
  • Adducin-like protein 70
Gene names
  • Add3
  • Addl
Description
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
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Add3
Rat
Adducin 3
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
G3V9D7_RAT
Accession #
G3V9D7
Protein names
  • Adducin 3
  • Gamma, isoform CRA_a
  • Gamma-adducin
Gene names
  • Add3
  • rCG_57421
Description
N/A
Links

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Phosphorylation Site Information
Agap2
Mouse
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
AGAP2_MOUSE
Accession #
Q3UHD9
Protein names
  • Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
  • AGAP-2
  • Centaurin-gamma-1
  • Cnt-g1
  • Phosphatidylinositol 3-kinase enhancer
  • PIKE
Gene names
  • Agap2
  • Centg1
  • Kiaa0167
Description
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. Aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase (By similarity).
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Agfg1
Mouse
Arf-GAP domain and FG repeat-containing protein 1
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
AGFG1_MOUSE
Accession #
Q8K2K6
Protein names
  • Arf-GAP domain and FG repeat-containing protein 1
  • HIV-1 Rev-binding protein homolog
  • Nucleoporin-like protein RIP
Gene names
  • Agfg1
  • Hrb
  • Rip
Description
Required for vesicle docking or fusion during acrosome biogenesis. May play a role in RNA trafficking or localization.
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KEGG Pathways (1)
Phosphorylation Site Information
ALKBH1
Human
Alkylated DNA repair protein alkB homolog 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ALKB1_HUMAN
Accession #
Q13686
Protein names
  • Alkylated DNA repair protein alkB homolog 1
  • EC 1.14.11.33
  • Alpha-ketoglutarate-dependent dioxygenase ABH1
  • DNA lyase ABH1
  • EC 4.2.99.18
  • DNA oxidative demethylase ALKBH1
Gene names
  • ALKBH1
  • ABH
  • ABH1
  • ALKBH
Description
Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron.
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ALKBH3
Human
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ALKB3_HUMAN
Accession #
Q96Q83
Protein names
  • Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
  • EC 1.14.11.-
  • Alkylated DNA repair protein alkB homolog 3
  • DEPC-1
  • Prostate cancer antigen 1
Gene names
  • ALKBH3
  • ABH3
  • DEPC1
Description
Dioxygenase that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron.
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