Search Results (640 substrates found)
Gene name
Organism
Protein name
2010300C02Rik
Mouse
Protein 2010300C02Rik
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
E9Q3M9_MOUSE
- Accession #
- E9Q3M9
- Protein names
-
- Protein 2010300C02Rik
- Gene names
-
- 2010300C02Rik
- Description
-
N/A
- Links
-
Search Kinases of 2010300C02Rik (Mouse)
N/A
N/A

A6NN6
Human
Putative UPF0633 protein MGC21881
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
U633A_HUMAN
- Accession #
- A6NN06
- Protein names
-
- Putative UPF0633 protein MGC21881
- Gene names
-
- A6NN6
- Description
-
N/A
- Links
-
Search Kinases of A6NN6 (Human)
N/A
N/A

Aak1
Mouse
AP2-associated protein kinase 1
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
AAK1_MOUSE
- Accession #
-
Q3UHJ0
- Protein names
-
- AP2-associated protein kinase 1
- EC 2.7.11.1
- Adaptor-associated kinase 1
- Gene names
-
- Aak1
- Kiaa1048
- Description
-
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (By similarity).
- Links
-
Search Kinases of Aak1 (Mouse)
N/A
- AP-2 adaptor complex binding
- ATP binding
- Notch binding
- cell leading edge
- clathrin-coated vesicle
- coated pit
- endocytosis
- extrinsic component of plasma membrane
- positive regulation of Notch signaling pathway
- protein autophosphorylation
- protein phosphorylation
- protein serine/threonine kinase activity
- protein stabilization
- regulation of clathrin-mediated endocytosis
- regulation of protein localization
- terminal bouton

Abl1
Mouse
Tyrosine-protein kinase ABL1
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
ABL1_MOUSE
- Accession #
-
P00520
- Protein names
-
- Tyrosine-protein kinase ABL1
- EC 2.7.10.2
- Abelson murine leukemia viral oncogene homolog 1
- Abelson tyrosine-protein kinase 1
- Proto-oncogene c-Abl
- p150
- Gene names
-
- Abl1
- Abl
- Description
-
Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-191' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
- Links
-
Search Kinases of Abl1 (Mouse)
- ATP binding
- DNA binding
- DNA damage induced protein phosphorylation
- DNA repair
- actin cytoskeleton organization
- apoptotic process
- autophagy
- cell adhesion
- cell leading edge
- cellular response to DNA damage stimulus
- cytoplasm
- cytoskeleton
- cytosol
- endocytosis
- kinase activity
- magnesium ion binding
- manganese ion binding
- mitochondrion
- negative regulation of protein serine/threonine kinase activity
- non-membrane spanning protein tyrosine kinase activity
- nucleolus
- nucleus
- peptidyl-tyrosine phosphorylation
- perinuclear region of cytoplasm
- platelet-derived growth factor receptor signaling pathway
- positive regulation of apoptotic process
- positive regulation of oxidoreductase activity
- positive regulation of peptidyl-tyrosine phosphorylation
- proline-rich region binding
- protein binding
- protein domain specific binding
- protein kinase activity
- protein tyrosine kinase activity
- regulation of cell cycle
- regulation of response to DNA damage stimulus
- signal transduction in response to DNA damage

Abl2
Mouse
Abelson tyrosine-protein kinase 2
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
F8VQH0_MOUSE
- Accession #
- F8VQH0
- Protein names
-
- Abelson tyrosine-protein kinase 2
- Gene names
-
- Abl2
- Description
-
N/A
- Links
-
Search Kinases of Abl2 (Mouse)
- ATP binding
- actin cytoskeleton
- actin filament bundle assembly
- actin filament organization
- cellular response to retinoic acid
- cytoplasmic membrane-bounded vesicle
- magnesium ion binding
- manganese ion binding
- non-membrane spanning protein tyrosine kinase activity
- positive regulation of neuron projection development
- positive regulation of oxidoreductase activity

Ablim1
Mouse
Actin-binding LIM protein 1
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
E9Q9Q7_MOUSE
- Accession #
- E9Q9Q7
- Protein names
-
- Actin-binding LIM protein 1
- Gene names
-
- Ablim1
- Description
-
N/A
- Links
-
Search Kinases of Ablim1 (Mouse)
N/A

ABT1
Human
Activator of basal transcription 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ABT1_HUMAN
- Accession #
-
Q9ULW3
- Protein names
-
- Activator of basal transcription 1
- hABT1
- Basal transcriptional activator
- Gene names
-
- ABT1
- Description
-
Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity).
- Links
-
Search Kinases of ABT1 (Human)
N/A

Adam22
Mouse
Disintegrin and metalloproteinase domain-containing protein 22
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
D3YUP9_MOUSE
- Accession #
- D3YUP9
- Protein names
-
- Disintegrin and metalloproteinase domain-containing protein 22
- Gene names
-
- Adam22
- Description
-
N/A
- Links
-
Search Kinases of Adam22 (Mouse)
N/A

Add1
Rat
Alpha-adducin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ADDA_RAT
- Accession #
-
Q63028
- Protein names
-
- Alpha-adducin
- Erythrocyte adducin subunit alpha
- Gene names
-
- Add1
- Description
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
- Links
-
Search Kinases of Add1 (Rat)
N/A
- F-actin capping protein complex
- T cell receptor binding
- actin filament bundle assembly
- barbed-end actin filament capping
- cell morphogenesis
- cell volume homeostasis
- cellular response to retinoic acid
- cytoskeleton organization
- dendrite
- dendritic spine
- erythrocyte differentiation
- hemoglobin metabolic process
- homeostasis of number of cells within a tissue
- in utero embryonic development
- ion transport
- multicellular organism growth
- negative regulation of actin filament polymerization
- nucleus
- perinuclear region of cytoplasm
- plasma membrane
- positive regulation of angiogenesis
- positive regulation of endocytosis
- positive regulation of protein binding
- postsynaptic density
- protein binding
- structural molecule activity
- synapse

ADD1
Human
Alpha-adducin
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ADDA_HUMAN
- Accession #
-
P35611
- Protein names
-
- Alpha-adducin
- Erythrocyte adducin subunit alpha
- Gene names
-
- ADD1
- ADDA
- Description
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
- Links
-
Search Kinases of ADD1 (Human)
N/A
- F-actin capping protein complex
- actin binding
- actin cytoskeleton organization
- actin filament binding
- actin filament bundle assembly
- activation of signaling protein activity involved in unfolded protein response
- apoptotic process
- barbed-end actin filament capping
- cell morphogenesis
- cell volume homeostasis
- cellular component disassembly involved in execution phase of apoptosis
- cellular protein metabolic process
- cellular response to retinoic acid
- cytosol
- dendritic spine
- endoplasmic reticulum unfolded protein response
- erythrocyte differentiation
- hemoglobin metabolic process
- homeostasis of number of cells within a tissue
- in utero embryonic development
- intermediate filament cytoskeleton
- multicellular organism growth
- nucleus
- perinuclear region of cytoplasm
- plasma membrane
- poly(A) RNA binding
- positive regulation of angiogenesis
- positive regulation of endocytosis
- positive regulation of protein binding
- postsynaptic density
- protein heterodimerization activity
- protein homodimerization activity
- spectrin binding
- structural molecule activity
- transcription factor binding

Add1
Mouse
Adducin 1
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
Q8K232_MOUSE
- Accession #
- Q8K232
- Protein names
-
- Adducin 1
- Alpha
- Gene names
-
- Add1
- Description
-
N/A
- Links
-
Search Kinases of Add1 (Mouse)
N/A

Add2
Rat
Beta-adducin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
F8WFS9_RAT
- Accession #
- F8WFS9
- Protein names
-
- Beta-adducin
- Gene names
-
- Add2
- Description
-
N/A
- Links
-
Search Kinases of Add2 (Rat)
N/A

Add2
Mouse
Beta-adducin
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
ADDB_MOUSE
- Accession #
-
Q9QYB8
- Protein names
-
- Beta-adducin
- Add97
- Erythrocyte adducin subunit beta
- Gene names
-
- Add2
- Description
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity).
- Links
-
Search Kinases of Add2 (Mouse)
N/A

Add3
Rat
Adducin 3
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
G3V9D7_RAT
- Accession #
- G3V9D7
- Protein names
-
- Adducin 3
- Gamma, isoform CRA_a
- Gamma-adducin
- Gene names
-
- Add3
- rCG_57421
- Description
-
N/A
- Links
-
Search Kinases of Add3 (Rat)
N/A

Add3
Mouse
Gamma-adducin
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
ADDG_MOUSE
- Accession #
-
Q9QYB5
- Protein names
-
- Gamma-adducin
- Adducin-like protein 70
- Gene names
-
- Add3
- Addl
- Description
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
- Links
-
Search Kinases of Add3 (Mouse)
N/A

Agap2
Mouse
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
AGAP2_MOUSE
- Accession #
-
Q3UHD9
- Protein names
-
- Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
- AGAP-2
- Centaurin-gamma-1
- Cnt-g1
- Phosphatidylinositol 3-kinase enhancer
- PIKE
- Gene names
-
- Agap2
- Centg1
- Kiaa0167
- Description
-
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. Aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase (By similarity).
- Links
-
Search Kinases of Agap2 (Mouse)
- ARF GTPase activator activity
- GTP binding
- mammary gland alveolus development
- mitochondrion
- negative regulation of apoptotic process
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- nucleolus
- positive regulation of JAK-STAT cascade
- positive regulation of mammary gland epithelial cell proliferation
- positive regulation of transcription from RNA polymerase II promoter
- protein binding
- protein kinase activator activity
- regulation of ARF GTPase activity
- small GTPase mediated signal transduction
- zinc ion binding

Agfg1
Mouse
Arf-GAP domain and FG repeat-containing protein 1
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
AGFG1_MOUSE
- Accession #
-
Q8K2K6
- Protein names
-
- Arf-GAP domain and FG repeat-containing protein 1
- HIV-1 Rev-binding protein homolog
- Nucleoporin-like protein RIP
- Gene names
-
- Agfg1
- Hrb
- Rip
- Description
-
Required for vesicle docking or fusion during acrosome biogenesis. May play a role in RNA trafficking or localization.
- Links
-
Search Kinases of Agfg1 (Mouse)
- ARF GTPase activator activity
- DNA binding
- acrosome assembly
- cell projection
- cytoplasmic membrane-bounded vesicle
- intermediate filament organization
- multicellular organismal development
- neuronal cell body
- nucleus
- regulation of ARF GTPase activity
- spermatid nucleus differentiation
- transport
- zinc ion binding

ALKBH1
Human
Alkylated DNA repair protein alkB homolog 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ALKB1_HUMAN
- Accession #
-
Q13686
- Protein names
-
- Alkylated DNA repair protein alkB homolog 1
- EC 1.14.11.33
- Alpha-ketoglutarate-dependent dioxygenase ABH1
- DNA lyase ABH1
- EC 4.2.99.18
- DNA oxidative demethylase ALKBH1
- Gene names
-
- ALKBH1
- ABH
- ABH1
- ALKBH
- Description
-
Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron.
- Links
-
Search Kinases of ALKBH1 (Human)
N/A
- DNA catabolic process, endonucleolytic
- DNA dealkylation involved in DNA repair
- DNA demethylation
- DNA repair
- DNA-(apurinic or apyrimidinic site) lyase activity
- RNA repair
- chemoattractant activity
- developmental growth
- ferrous iron binding
- in utero embryonic development
- methylcytosine dioxygenase activity
- mitochondrion
- negative regulation of neuron apoptotic process
- neuron migration
- neuron projection development
- nuclear euchromatin
- oxidative demethylation
- placenta development

ALKBH3
Human
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ALKB3_HUMAN
- Accession #
-
Q96Q83
- Protein names
-
- Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
- EC 1.14.11.-
- Alkylated DNA repair protein alkB homolog 3
- DEPC-1
- Prostate cancer antigen 1
- Gene names
-
- ALKBH3
- ABH3
- DEPC1
- Description
-
Dioxygenase that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron.
- Links
-
Search Kinases of ALKBH3 (Human)
N/A

Als2
Mouse
Alsin
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
ALS2_MOUSE
- Accession #
-
Q920R0
- Protein names
-
- Alsin
- Amyotrophic lateral sclerosis 2 protein homolog
- Gene names
-
- Als2
- Description
-
May act as a GTPase regulator (By similarity). Controls survival and growth of spinal motoneurons (By similarity).
- Links
-
Search Kinases of Als2 (Mouse)
- Rab GTPase binding
- Rab guanyl-nucleotide exchange factor activity
- Rac guanyl-nucleotide exchange factor activity
- behavioral fear response
- cytoplasm
- cytosol
- dendrite
- dendritic spine
- early endosome
- endosomal transport
- growth cone
- lamellipodium
- locomotory behavior
- neuromuscular junction development
- neuron projection morphogenesis
- positive regulation of Rac GTPase activity
- positive regulation of protein kinase activity
- postsynaptic density
- protein binding
- protein complex
- protein homodimerization activity
- protein localization
- protein serine/threonine kinase activator activity
- receptor recycling
- regulation of Rab GTPase activity
- regulation of Rac GTPase activity
- regulation of endosome size
- response to oxidative stress
- ruffle
- synaptic transmission, glutamatergic
- vesicle
- vesicle organization
