Search Results (72 substrates found)
Gene name
Organism
Protein name
Acaca
Mouse
Acetyl-CoA carboxylase 1
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
ACACA_MOUSE
- Accession #
-
Q5SWU9
- Protein names
-
- Acetyl-CoA carboxylase 1
- ACC1
- EC 6.4.1.2
- ACC-alpha
- Acetyl-CoA carboxylase 265 [Includes: Biotin carboxylase
- EC 6.3.4.14]
- Gene names
-
- Acaca
- Acac
- Gm738
- Description
-
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (By similarity).
- Links
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Search Kinases of Acaca (Mouse)
- ATP binding
- acetyl-CoA carboxylase activity
- acetyl-CoA metabolic process
- biotin carboxylase activity
- cytosol
- fatty acid biosynthetic process
- lipid homeostasis
- lipid metabolic process
- malonyl-CoA biosynthetic process
- metal ion binding
- mitochondrion
- multicellular organismal protein metabolic process
- protein binding
- protein homotetramerization
- tissue homeostasis

Acaca
Rat
Acetyl-CoA carboxylase 1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ACACA_RAT
- Accession #
-
P11497
- Protein names
-
- Acetyl-CoA carboxylase 1
- ACC1
- EC 6.4.1.2
- ACC-alpha [Includes: Biotin carboxylase
- EC 6.3.4.14]
- Gene names
-
- Acaca
- Acac
- Description
-
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
- Links
-
Search Kinases of Acaca (Rat)
- ATP binding
- acetyl-CoA carboxylase activity
- acetyl-CoA metabolic process
- biotin binding
- biotin carboxylase activity
- cytosol
- fatty acid biosynthetic process
- kinase binding
- malonyl-CoA biosynthetic process
- metal ion binding
- protein homotetramerization
- response to drug
- response to organic cyclic compound

ACACA
Human
Acetyl-CoA carboxylase 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ACACA_HUMAN
- Accession #
-
Q13085
- Protein names
-
- Acetyl-CoA carboxylase 1
- ACC1
- EC 6.4.1.2
- ACC-alpha [Includes: Biotin carboxylase
- EC 6.3.4.14]
- Gene names
-
- ACACA
- ACAC
- ACC1
- ACCA
- Description
-
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
- Links
-
Search Kinases of ACACA (Human)
- ATP binding
- acetyl-CoA carboxylase activity
- acetyl-CoA metabolic process
- biotin carboxylase activity
- biotin metabolic process
- carnitine shuttle
- cellular lipid metabolic process
- cytosol
- energy reserve metabolic process
- extracellular vesicular exosome
- fatty acid biosynthetic process
- lipid homeostasis
- long-chain fatty-acyl-CoA biosynthetic process
- malonyl-CoA biosynthetic process
- metal ion binding
- mitochondrion
- multicellular organismal protein metabolic process
- positive regulation of cellular metabolic process
- protein binding
- protein homotetramerization
- small molecule metabolic process
- tissue homeostasis
- triglyceride biosynthetic process
- vitamin metabolic process
- water-soluble vitamin metabolic process

ACACB
Human
Acetyl-CoA carboxylase 2
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ACACB_HUMAN
- Accession #
-
O00763
- Protein names
-
- Acetyl-CoA carboxylase 2
- EC 6.4.1.2
- ACC-beta [Includes: Biotin carboxylase
- EC 6.3.4.14]
- Gene names
-
- ACACB
- ACC2
- ACCB
- Description
-
ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
- Links
-
Search Kinases of ACACB (Human)
- ATP binding
- acetyl-CoA carboxylase activity
- acetyl-CoA metabolic process
- biotin binding
- biotin carboxylase activity
- biotin metabolic process
- carnitine shuttle
- cellular lipid metabolic process
- cytosol
- endomembrane system
- energy reserve metabolic process
- fatty acid biosynthetic process
- malonyl-CoA biosynthetic process
- metal ion binding
- mitochondrial outer membrane
- positive regulation of cellular metabolic process
- protein binding
- protein homotetramerization
- response to drug
- response to organic cyclic compound
- small molecule metabolic process
- vitamin metabolic process
- water-soluble vitamin metabolic process

BAIAP2
Human
Brain-specific angiogenesis inhibitor 1-associated protein 2
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
BAIP2_HUMAN
- Accession #
-
Q9UQB8
- Protein names
-
- Brain-specific angiogenesis inhibitor 1-associated protein 2
- BAI-associated protein 2
- BAI1-associated protein 2
- Protein BAP2
- Fas ligand-associated factor 3
- FLAF3
- Insulin receptor substrate p53/p58
- IRS-58
- IRSp53/58
- Insulin receptor substrate protein of 53 kDa
- IRSp53
- Insulin receptor substrate p53
- Gene names
-
- BAIAP2
- Description
-
Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
- Links
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Search Kinases of BAIAP2 (Human)
- Fc-gamma receptor signaling pathway involved in phagocytosis
- actin crosslink formation
- actin filament bundle assembly
- axonogenesis
- cytoplasm
- cytoskeletal adaptor activity
- cytoskeleton
- cytosol
- dendrite development
- extracellular vesicular exosome
- filopodium
- filopodium assembly
- identical protein binding
- innate immune response
- insulin receptor signaling pathway
- neuron projection
- plasma membrane
- proline-rich region binding
- protein C-terminus binding
- protein binding
- regulation of actin cytoskeleton organization
- regulation of cell shape
- regulation of synaptic plasticity
- response to bacterium
- ruffle

CDC27
Human
Cell division cycle protein 27 homolog
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CDC27_HUMAN
- Accession #
-
P30260
- Protein names
-
- Cell division cycle protein 27 homolog
- Anaphase-promoting complex subunit 3
- APC3
- CDC27 homolog
- CDC27Hs
- H-NUC
- Gene names
-
- CDC27
- ANAPC3
- D0S1430E
- D17S978E
- Description
-
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
- Links
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Search Kinases of CDC27 (Human)
- anaphase-promoting complex
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
- cell proliferation
- centrosome
- cytoplasm
- cytosol
- metaphase/anaphase transition of mitotic cell cycle
- mitotic cell cycle
- mitotic spindle assembly checkpoint
- negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
- nucleoplasm
- nucleus
- positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
- protein K11-linked ubiquitination
- protein binding
- protein phosphatase binding
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
- spindle

Cdkn1b
Mouse
Cyclin-dependent kinase inhibitor 1B
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
CDN1B_MOUSE
- Accession #
-
P46414
- Protein names
-
- Cyclin-dependent kinase inhibitor 1B
- Cyclin-dependent kinase inhibitor p27
- p27Kip1
- Gene names
-
- Cdkn1b
- Description
-
Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of cyclin D-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
- Links
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Search Kinases of Cdkn1b (Mouse)
- Cell cycle
- Chronic myeloid leukemia
- Epstein-Barr virus infection
- ErbB signaling pathway
- FoxO signaling pathway
- HIF-1 signaling pathway
- Hepatitis B
- Measles
- MicroRNAs in cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Prostate cancer
- Small cell lung cancer
- Transcriptional misregulation in cancer
- Viral carcinogenesis
- G1/S transition of mitotic cell cycle
- autophagic cell death
- cell cycle arrest
- cellular response to antibiotic
- cellular response to lithium ion
- cellular response to organic cyclic compound
- cyclin-dependent protein serine/threonine kinase inhibitor activity
- cysteine-type endopeptidase activator activity involved in apoptotic process
- cytoplasm
- cytosol
- endosome
- inner ear development
- mitotic cell cycle arrest
- negative regulation of apoptotic process
- negative regulation of cell growth
- negative regulation of cell proliferation
- negative regulation of cellular component movement
- negative regulation of cyclin-dependent protein serine/threonine kinase activity
- negative regulation of epithelial cell proliferation
- negative regulation of epithelial cell proliferation involved in prostate gland development
- negative regulation of mitotic cell cycle
- negative regulation of transcription, DNA-templated
- nucleus
- positive regulation of cell death
- positive regulation of cell proliferation
- positive regulation of microtubule polymerization
- positive regulation of protein catabolic process
- potassium ion transport
- protein binding
- protein complex
- response to amino acid
- response to cadmium ion
- response to drug
- response to estradiol
- response to glucose
- response to hypoxia
- response to peptide hormone
- sensory perception of sound

CDKN1B
Human
Cyclin-dependent kinase inhibitor 1B
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CDN1B_HUMAN
- Accession #
-
P46527
- Protein names
-
- Cyclin-dependent kinase inhibitor 1B
- Cyclin-dependent kinase inhibitor p27
- p27Kip1
- Gene names
-
- CDKN1B
- KIP1
- Description
-
Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
- Links
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Search Kinases of CDKN1B (Human)
- Cell cycle
- Chronic myeloid leukemia
- Epstein-Barr virus infection
- ErbB signaling pathway
- FoxO signaling pathway
- HIF-1 signaling pathway
- Hepatitis B
- Measles
- MicroRNAs in cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Prostate cancer
- Small cell lung cancer
- Transcriptional misregulation in cancer
- Viral carcinogenesis
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- Fc-epsilon receptor signaling pathway
- G1/S transition of mitotic cell cycle
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- autophagic cell death
- cell cycle arrest
- cellular response to antibiotic
- cellular response to lithium ion
- cellular response to organic cyclic compound
- cyclin-dependent protein serine/threonine kinase inhibitor activity
- cytoplasm
- cytosol
- endosome
- epidermal growth factor receptor signaling pathway
- fibroblast growth factor receptor signaling pathway
- innate immune response
- inner ear development
- mitotic cell cycle
- mitotic cell cycle arrest
- negative regulation of apoptotic process
- negative regulation of cell growth
- negative regulation of cell proliferation
- negative regulation of cellular component movement
- negative regulation of cyclin-dependent protein serine/threonine kinase activity
- negative regulation of epithelial cell proliferation involved in prostate gland development
- negative regulation of kinase activity
- negative regulation of mitotic cell cycle
- negative regulation of phosphorylation
- negative regulation of transcription, DNA-templated
- neurotrophin TRK receptor signaling pathway
- nucleoplasm
- nucleus
- phosphatidylinositol-mediated signaling
- positive regulation of cell death
- positive regulation of cell proliferation
- positive regulation of microtubule polymerization
- positive regulation of protein catabolic process
- potassium ion transport
- protein binding
- protein complex
- protein phosphatase binding
- regulation of cyclin-dependent protein serine/threonine kinase activity
- response to amino acid
- response to cadmium ion
- response to drug
- response to estradiol
- response to glucose
- response to hypoxia
- response to peptide hormone
- sensory perception of sound
- transforming growth factor beta receptor, cytoplasmic mediator activity

CFTR
Human
Cystic fibrosis transmembrane conductance regulator
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CFTR_HUMAN
- Accession #
-
P13569
- Protein names
-
- Cystic fibrosis transmembrane conductance regulator
- CFTR
- ATP-binding cassette sub-family C member 7
- Channel conductance-controlling ATPase
- EC 3.6.3.49
- cAMP-dependent chloride channel
- Gene names
-
- CFTR
- ABCC7
- Description
-
Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
- Links
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Search Kinases of CFTR (Human)
- ATP binding
- ATP-binding and phosphorylation-dependent chloride channel activity
- PDZ domain binding
- apical plasma membrane
- basolateral plasma membrane
- bicarbonate transmembrane transporter activity
- cell surface
- cellular response to cAMP
- cellular response to hormone stimulus
- channel-conductance-controlling ATPase activity
- chloride channel activity
- chloride channel complex
- chloride channel inhibitor activity
- chloride transmembrane transport
- chloride transmembrane transporter activity
- cholesterol biosynthetic process
- cholesterol transport
- cytoplasmic vesicle membrane
- early endosome
- early endosome membrane
- enzyme binding
- extracellular vesicular exosome
- intracellular pH elevation
- iodide transport
- lung development
- membrane hyperpolarization
- microvillus
- plasma membrane
- positive regulation of vasodilation
- positive regulation of voltage-gated chloride channel activity
- protein binding
- protein complex
- respiratory gaseous exchange
- response to cytokine
- response to drug
- response to estrogen
- response to peptide hormone
- sperm capacitation
- transepithelial chloride transport
- transmembrane transport
- transport
- vasodilation
- water transport

Cry1
Mouse
Cryptochrome-1
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
CRY1_MOUSE
- Accession #
-
P97784
- Protein names
-
- Cryptochrome-1
- Gene names
-
- Cry1
- Description
-
Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. More potent transcriptional repressor in cerebellum and liver than CRY2, though more effective in lengthening the period of the SCN oscillator. On its side, CRY2 seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY2, is dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. Interacts with CLOCK:BMAL1 independently of PER proteins and is found at CLOCK:BMAL1-bound sites, suggesting that CRY may act as a molecular gatekeeper to maintain CLOCK:BMAL1 in a poised and repressed state until the proper time for transcriptional activation. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1. May repress circadian target genes expression in collaboration with HDAC1 and HDAC2 through histone deacetylation. Mediates the clock-control activation of ATR and modulates ATR-mediated DNA damage checkpoint. In liver, mediates circadian regulation of cAMP signaling and gluconeogenesis by binding to membrane-coupled G proteins and blocking glucagon-mediated increases in intracellular cAMP concentrations and CREB1 phosphorylation. Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4.
- Links
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Search Kinases of Cry1 (Mouse)
- DNA damage induced protein phosphorylation
- DNA photolyase activity
- DNA repair
- circadian regulation of gene expression
- circadian rhythm
- core promoter binding
- cytosol
- double-stranded DNA binding
- entrainment of circadian clock by photoperiod
- gluconeogenesis
- glucose homeostasis
- histone deacetylase binding
- kinase binding
- lipid storage
- mitochondrion
- negative regulation of G-protein coupled receptor protein signaling pathway
- negative regulation of circadian rhythm
- negative regulation of glucocorticoid receptor signaling pathway
- negative regulation of glucocorticoid secretion
- negative regulation of protein ubiquitination
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-templated
- nuclear hormone receptor binding
- nucleoplasm
- nucleotide binding
- nucleus
- photoreceptor activity
- protein binding
- protein kinase binding
- protein-chromophore linkage
- regulation of DNA damage checkpoint
- regulation of circadian rhythm
- response to glucagon
- response to insulin
- transcription factor binding
- transcription factor binding transcription factor activity
- transcription, DNA-templated
- ubiquitin binding

CSNK1E
Human
Casein kinase I isoform epsilon
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
KC1E_HUMAN
- Accession #
-
P49674
- Protein names
-
- Casein kinase I isoform epsilon
- CKI-epsilon
- CKIe
- EC 2.7.11.1
- Gene names
-
- CSNK1E
- Description
-
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.
- Links
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Search Kinases of CSNK1E (Human)
- ATP binding
- DNA repair
- G2/M transition of mitotic cell cycle
- cellular protein localization
- circadian regulation of gene expression
- cytosol
- mitotic cell cycle
- negative regulation of Wnt signaling pathway
- nucleus
- poly(A) RNA binding
- positive regulation of canonical Wnt signaling pathway
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- protein binding
- protein kinase activity
- protein phosphorylation
- protein serine/threonine kinase activity
- regulation of circadian rhythm
- ribonucleoprotein complex
- signal transduction

CTBP1
Human
C-terminal-binding protein 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CTBP1_HUMAN
- Accession #
-
Q13363
- Protein names
-
- C-terminal-binding protein 1
- CtBP1
- EC 1.1.1.-
- Gene names
-
- CTBP1
- CTBP
- Description
-
Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.
- Links
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Search Kinases of CTBP1 (Human)
- Golgi organization
- NAD binding
- RNA polymerase II transcription corepressor activity
- cytosol
- negative regulation of cell proliferation
- negative regulation of histone H4 acetylation
- negative regulation of histone acetylation
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-templated
- nucleus
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
- positive regulation of histone deacetylation
- protein C-terminus binding
- protein binding
- protein domain specific binding
- protein phosphorylation
- regulation of cell cycle
- regulation of transcription by chromatin organization
- repressing transcription factor binding
- sequence-specific DNA binding transcription factor activity
- transcription factor binding
- transcription factor complex
- transcriptional repressor complex
- viral genome replication
- white fat cell differentiation

EEF2K
Human
Eukaryotic elongation factor 2 kinase
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
EF2K_HUMAN
- Accession #
-
O00418
- Protein names
-
- Eukaryotic elongation factor 2 kinase
- eEF-2 kinase
- eEF-2K
- EC 2.7.11.20
- Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase
- Gene names
-
- EEF2K
- Description
-
Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.
- Links
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Search Kinases of EEF2K (Human)
- ATP binding
- calcium ion binding
- calmodulin binding
- cytoplasm
- cytosol
- elongation factor-2 kinase activity
- insulin receptor signaling pathway
- protein autophosphorylation
- protein kinase activity
- regulation of protein autophosphorylation
- translation factor activity, nucleic acid binding
- translational elongation

EP300
Human
Histone acetyltransferase p300
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
EP300_HUMAN
- Accession #
-
Q09472
- Protein names
-
- Histone acetyltransferase p300
- p300 HAT
- EC 2.3.1.48
- E1A-associated protein p300
- Gene names
-
- EP300
- P300
- Description
-
Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity. Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity. Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter.
- Links
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Search Kinases of EP300 (Human)
- Adherens junction
- Cell cycle
- Epstein-Barr virus infection
- FoxO signaling pathway
- HIF-1 signaling pathway
- HTLV-I infection
- Hepatitis B
- Herpes simplex infection
- Huntington's disease
- Influenza A
- Jak-STAT signaling pathway
- Long-term potentiation
- Melanogenesis
- MicroRNAs in cancer
- Notch signaling pathway
- Pathways in cancer
- Prostate cancer
- Renal cell carcinoma
- TGF-beta signaling pathway
- Thyroid hormone signaling pathway
- Tuberculosis
- Viral carcinogenesis
- Wnt signaling pathway
- cAMP signaling pathway
- DNA binding
- G2/M transition of mitotic cell cycle
- N-terminal peptidyl-lysine acetylation
- Notch signaling pathway
- RNA polymerase II activating transcription factor binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- acetyltransferase activity
- activating transcription factor binding
- androgen receptor binding
- antigen binding
- apoptotic process
- beta-catenin binding
- cellular response to hydrogen peroxide
- cellular response to hypoxia
- cellular response to organic cyclic compound
- chromatin
- chromatin DNA binding
- chromatin binding
- chromatin organization
- circadian rhythm
- core promoter binding
- cytoplasm
- digestive tract development
- heart development
- histone H2B acetylation
- histone H4 acetylation
- histone acetyltransferase activity
- histone acetyltransferase complex
- innate immune response
- internal peptidyl-lysine acetylation
- internal protein amino acid acetylation
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
- liver development
- lung development
- lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
- mitotic cell cycle
- negative regulation of transcription from RNA polymerase II promoter
- nervous system development
- nuclear hormone receptor binding
- nucleoplasm
- nucleus
- organ morphogenesis
- positive regulation by host of viral transcription
- positive regulation of DNA binding
- positive regulation of axon extension
- positive regulation of cell death
- positive regulation of cell size
- positive regulation of collagen biosynthetic process
- positive regulation of glycoprotein biosynthetic process
- positive regulation of protein binding
- positive regulation of protein import into nucleus, translocation
- positive regulation of protein phosphorylation
- positive regulation of protein secretion
- positive regulation of proteolysis
- positive regulation of sarcomere organization
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of translation
- positive regulation of type I interferon production
- protein binding
- protein kinase B signaling
- protein-DNA complex
- protein-DNA complex assembly
- regulation of androgen receptor signaling pathway
- regulation of angiotensin metabolic process
- regulation of cell cycle
- regulation of transcription from RNA polymerase II promoter in response to hypoxia
- regulation of transcription, DNA-templated
- regulation of tubulin deacetylation
- response to calcium ion
- response to cobalt ion
- response to drug
- response to estrogen
- response to ethanol
- response to fatty acid
- response to glucocorticoid
- response to glucose
- response to hypoxia
- response to retinoic acid
- response to tumor necrosis factor
- skeletal muscle tissue development
- somitogenesis
- transcription coactivator activity
- transcription factor binding
- transcription factor complex
- transcription, DNA-templated
- transferase activity, transferring acyl groups
- viral process
- zinc ion binding

FOXO3
Human
Forkhead box protein O3
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
FOXO3_HUMAN
- Accession #
-
O43524
- Protein names
-
- Forkhead box protein O3
- AF6q21 protein
- Forkhead in rhabdomyosarcoma-like 1
- Gene names
-
- FOXO3
- FKHRL1
- FOXO3A
- Description
-
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
- Links
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Search Kinases of FOXO3 (Human)
- DNA binding
- DNA binding, bending
- DNA damage response, signal transduction by p53 class mediator
- Fc-epsilon receptor signaling pathway
- antral ovarian follicle growth
- cellular response to DNA damage stimulus
- cellular response to oxidative stress
- chromatin DNA binding
- core promoter binding
- cytoplasm
- cytosol
- epidermal growth factor receptor signaling pathway
- extrinsic apoptotic signaling pathway in absence of ligand
- fibroblast growth factor receptor signaling pathway
- glucose homeostasis
- initiation of primordial ovarian follicle growth
- innate immune response
- insulin receptor signaling pathway
- membrane
- negative regulation of transcription from RNA polymerase II promoter
- neurotrophin TRK receptor signaling pathway
- nucleoplasm
- nucleus
- oocyte maturation
- ovulation from ovarian follicle
- pattern specification process
- phosphatidylinositol-mediated signaling
- positive regulation of erythrocyte differentiation
- positive regulation of neuron apoptotic process
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription, DNA-templated
- protein binding
- protein kinase binding
- regulation of cell proliferation
- regulation of transcription from RNA polymerase II promoter
- regulation of translation
- sequence-specific DNA binding
- sequence-specific DNA binding transcription factor activity
- tissue development
- transcription, DNA-templated

Gabbr1
Rat
Gamma-aminobutyric acid type B receptor subunit 1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
GABR1_RAT
- Accession #
-
Q9Z0U4
- Protein names
-
- Gamma-aminobutyric acid type B receptor subunit 1
- GABA-B receptor 1
- GABA-B-R1
- GABA-BR1
- GABABR1
- Gb1
- Gene names
-
- Gabbr1
- Description
-
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
- Links
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Search Kinases of Gabbr1 (Rat)
- G-protein coupled GABA receptor activity
- G-protein coupled receptor heterodimeric complex
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- axolemma
- cell junction
- dendritic shaft
- dendritic spine
- endoplasmic reticulum membrane
- extracellular space
- gamma-aminobutyric acid signaling pathway
- integral component of plasma membrane
- intracellular membrane-bounded organelle
- membrane raft
- mitochondrial membrane
- negative regulation of adenylate cyclase activity
- negative regulation of cell proliferation
- negative regulation of dopamine secretion
- negative regulation of epinephrine secretion
- negative regulation of gamma-aminobutyric acid secretion
- negative regulation of synaptic transmission
- neuron projection
- neuronal cell body
- osteoblast differentiation
- positive regulation of glutamate secretion
- positive regulation of growth hormone secretion
- postsynaptic membrane
- protein binding
- regulation of cAMP biosynthetic process
- regulation of glutamate secretion
- response to ethanol
- response to nicotine
- synaptic vesicle
- transcription factor binding

Gabbr2
Rat
Gamma-aminobutyric acid type B receptor subunit 2
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
GABR2_RAT
- Accession #
-
O88871
- Protein names
-
- Gamma-aminobutyric acid type B receptor subunit 2
- GABA-B receptor 2
- GABA-B-R2
- GABA-BR2
- GABABR2
- Gb2
- G-protein coupled receptor 51
- Gene names
-
- Gabbr2
- Gpr51
- Description
-
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
- Links
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Search Kinases of Gabbr2 (Rat)

GBF1
Human
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
GBF1_HUMAN
- Accession #
-
Q92538
- Protein names
-
- Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
- BFA-resistant GEF 1
- Gene names
-
- GBF1
- KIAA0248
- Description
-
Promotes guanine-nucleotide exchange on ARF5. Promotes the activation of ARF5 through replacement of GDP with GTP (By similarity).
- Links
-
Search Kinases of GBF1 (Human)
- ARF guanyl-nucleotide exchange factor activity
- COPI coating of Golgi vesicle
- Golgi apparatus
- Golgi membrane
- Golgi stack
- cis-Golgi network
- endoplasmic reticulum lumen
- membrane organization
- mitochondrion
- peroxisome
- post-Golgi vesicle-mediated transport
- protein binding
- regulation of ARF protein signal transduction
- regulation of GTPase activity
- retrograde vesicle-mediated transport, Golgi to ER
- trans-Golgi network
- vesicle-mediated transport
- viral process

GFPT1
Human
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
GFPT1_HUMAN
- Accession #
-
Q06210
- Protein names
-
- Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
- EC 2.6.1.16
- D-fructose-6-phosphate amidotransferase 1
- Glutamine:fructose-6-phosphate amidotransferase 1
- GFAT 1
- GFAT1
- Hexosephosphate aminotransferase 1
- Gene names
-
- GFPT1
- GFAT
- GFPT
- Description
-
Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1.
- Links
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Search Kinases of GFPT1 (Human)
- UDP-N-acetylglucosamine biosynthetic process
- activation of signaling protein activity involved in unfolded protein response
- amino acid binding
- carbohydrate binding
- carbohydrate biosynthetic process
- cellular protein metabolic process
- cellular response to insulin stimulus
- circadian regulation of gene expression
- cytosol
- dolichol-linked oligosaccharide biosynthetic process
- endoplasmic reticulum unfolded protein response
- energy reserve metabolic process
- extracellular vesicular exosome
- fructose 6-phosphate metabolic process
- glucosamine biosynthetic process
- glutamine metabolic process
- glutamine-fructose-6-phosphate transaminase (isomerizing) activity
- negative regulation of glycogen biosynthetic process
- post-translational protein modification
- protein N-linked glycosylation via asparagine
- protein homotetramerization
- response to sucrose

HAS2
Human
Hyaluronan synthase 2
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
HYAS2_HUMAN
- Accession #
-
Q92819
- Protein names
-
- Hyaluronan synthase 2
- EC 2.4.1.212
- Hyaluronate synthase 2
- Hyaluronic acid synthase 2
- HA synthase 2
- Gene names
-
- HAS2
- Description
-
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity).
- Links
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Search Kinases of HAS2 (Human)
N/A
- atrioventricular canal development
- bone morphogenesis
- cellular response to fluid shear stress
- cellular response to interleukin-1
- cellular response to platelet-derived growth factor stimulus
- cellular response to tumor necrosis factor
- endocardial cushion to mesenchymal transition
- extracellular matrix assembly
- extracellular polysaccharide biosynthetic process
- hyaluronan biosynthetic process
- hyaluronan synthase activity
- integral component of plasma membrane
- kidney development
- positive regulation of cell migration
- positive regulation of cell proliferation
- positive regulation of monocyte aggregation
- positive regulation of urine volume
- renal water absorption
- vasculogenesis
