KANPHOS_Str

Search Results (72 substrates found)

Displaying 1 - 20 of 72 Items
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Gene name
Organism
Protein name
Acaca
Mouse
Acetyl-CoA carboxylase 1
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
ACACA_MOUSE
Accession #
Q5SWU9
Protein names
  • Acetyl-CoA carboxylase 1
  • ACC1
  • EC 6.4.1.2
  • ACC-alpha
  • Acetyl-CoA carboxylase 265 [Includes: Biotin carboxylase
  • EC 6.3.4.14]
Gene names
  • Acaca
  • Acac
  • Gm738
Description
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (By similarity).
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Search Kinases of Acaca (Mouse)
Phosphorylation Site Information
Acaca
Rat
Acetyl-CoA carboxylase 1
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ACACA_RAT
Accession #
P11497
Protein names
  • Acetyl-CoA carboxylase 1
  • ACC1
  • EC 6.4.1.2
  • ACC-alpha [Includes: Biotin carboxylase
  • EC 6.3.4.14]
Gene names
  • Acaca
  • Acac
Description
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
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Search Kinases of Acaca (Rat)
Phosphorylation Site Information
BAIAP2
Human
Brain-specific angiogenesis inhibitor 1-associated protein 2
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
BAIP2_HUMAN
Accession #
Q9UQB8
Protein names
  • Brain-specific angiogenesis inhibitor 1-associated protein 2
  • BAI-associated protein 2
  • BAI1-associated protein 2
  • Protein BAP2
  • Fas ligand-associated factor 3
  • FLAF3
  • Insulin receptor substrate p53/p58
  • IRS-58
  • IRSp53/58
  • Insulin receptor substrate protein of 53 kDa
  • IRSp53
  • Insulin receptor substrate p53
Gene names
  • BAIAP2
Description
Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
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Search Kinases of BAIAP2 (Human)
Phosphorylation Site Information
CDC27
Human
Cell division cycle protein 27 homolog
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CDC27_HUMAN
Accession #
P30260
Protein names
  • Cell division cycle protein 27 homolog
  • Anaphase-promoting complex subunit 3
  • APC3
  • CDC27 homolog
  • CDC27Hs
  • H-NUC
Gene names
  • CDC27
  • ANAPC3
  • D0S1430E
  • D17S978E
Description
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
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Search Kinases of CDC27 (Human)
Phosphorylation Site Information
CDKN1B
Human
Cyclin-dependent kinase inhibitor 1B
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CDN1B_HUMAN
Accession #
P46527
Protein names
  • Cyclin-dependent kinase inhibitor 1B
  • Cyclin-dependent kinase inhibitor p27
  • p27Kip1
Gene names
  • CDKN1B
  • KIP1
Description
Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
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Search Kinases of CDKN1B (Human)
Gene Ontology Terms (51)
Phosphorylation Site Information
Cdkn1b
Mouse
Cyclin-dependent kinase inhibitor 1B
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
CDN1B_MOUSE
Accession #
P46414
Protein names
  • Cyclin-dependent kinase inhibitor 1B
  • Cyclin-dependent kinase inhibitor p27
  • p27Kip1
Gene names
  • Cdkn1b
Description
Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of cyclin D-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
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Search Kinases of Cdkn1b (Mouse)
Phosphorylation Site Information
CFTR
Human
Cystic fibrosis transmembrane conductance regulator
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CFTR_HUMAN
Accession #
P13569
Protein names
  • Cystic fibrosis transmembrane conductance regulator
  • CFTR
  • ATP-binding cassette sub-family C member 7
  • Channel conductance-controlling ATPase
  • EC 3.6.3.49
  • cAMP-dependent chloride channel
Gene names
  • CFTR
  • ABCC7
Description
Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
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Search Kinases of CFTR (Human)
Phosphorylation Site Information
Cry1
Mouse
Cryptochrome-1
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
CRY1_MOUSE
Accession #
P97784
Protein names
  • Cryptochrome-1
Gene names
  • Cry1
Description
Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. More potent transcriptional repressor in cerebellum and liver than CRY2, though more effective in lengthening the period of the SCN oscillator. On its side, CRY2 seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY2, is dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. Interacts with CLOCK:BMAL1 independently of PER proteins and is found at CLOCK:BMAL1-bound sites, suggesting that CRY may act as a molecular gatekeeper to maintain CLOCK:BMAL1 in a poised and repressed state until the proper time for transcriptional activation. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1. May repress circadian target genes expression in collaboration with HDAC1 and HDAC2 through histone deacetylation. Mediates the clock-control activation of ATR and modulates ATR-mediated DNA damage checkpoint. In liver, mediates circadian regulation of cAMP signaling and gluconeogenesis by binding to membrane-coupled G proteins and blocking glucagon-mediated increases in intracellular cAMP concentrations and CREB1 phosphorylation. Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4.
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Search Kinases of Cry1 (Mouse)
KEGG Pathways (1)
Phosphorylation Site Information
CSNK1E
Human
Casein kinase I isoform epsilon
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
KC1E_HUMAN
Accession #
P49674
Protein names
  • Casein kinase I isoform epsilon
  • CKI-epsilon
  • CKIe
  • EC 2.7.11.1
Gene names
  • CSNK1E
Description
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.
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Search Kinases of CSNK1E (Human)
Phosphorylation Site Information
CTBP1
Human
C-terminal-binding protein 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CTBP1_HUMAN
Accession #
Q13363
Protein names
  • C-terminal-binding protein 1
  • CtBP1
  • EC 1.1.1.-
Gene names
  • CTBP1
  • CTBP
Description
Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.
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Search Kinases of CTBP1 (Human)
Phosphorylation Site Information
EEF2K
Human
Eukaryotic elongation factor 2 kinase
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
EF2K_HUMAN
Accession #
O00418
Protein names
  • Eukaryotic elongation factor 2 kinase
  • eEF-2 kinase
  • eEF-2K
  • EC 2.7.11.20
  • Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase
Gene names
  • EEF2K
Description
Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.
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Search Kinases of EEF2K (Human)
Phosphorylation Site Information
EP300
Human
Histone acetyltransferase p300
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
EP300_HUMAN
Accession #
Q09472
Protein names
  • Histone acetyltransferase p300
  • p300 HAT
  • EC 2.3.1.48
  • E1A-associated protein p300
Gene names
  • EP300
  • P300
Description
Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity. Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity. Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter.
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Search Kinases of EP300 (Human)
Gene Ontology Terms (89)
Phosphorylation Site Information
FOXO3
Human
Forkhead box protein O3
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
FOXO3_HUMAN
Accession #
O43524
Protein names
  • Forkhead box protein O3
  • AF6q21 protein
  • Forkhead in rhabdomyosarcoma-like 1
Gene names
  • FOXO3
  • FKHRL1
  • FOXO3A
Description
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
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Search Kinases of FOXO3 (Human)
Phosphorylation Site Information
Gabbr1
Rat
Gamma-aminobutyric acid type B receptor subunit 1
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
GABR1_RAT
Accession #
Q9Z0U4
Protein names
  • Gamma-aminobutyric acid type B receptor subunit 1
  • GABA-B receptor 1
  • GABA-B-R1
  • GABA-BR1
  • GABABR1
  • Gb1
Gene names
  • Gabbr1
Description
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
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Search Kinases of Gabbr1 (Rat)
Phosphorylation Site Information
Gabbr2
Rat
Gamma-aminobutyric acid type B receptor subunit 2
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
GABR2_RAT
Accession #
O88871
Protein names
  • Gamma-aminobutyric acid type B receptor subunit 2
  • GABA-B receptor 2
  • GABA-B-R2
  • GABA-BR2
  • GABABR2
  • Gb2
  • G-protein coupled receptor 51
Gene names
  • Gabbr2
  • Gpr51
Description
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
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Search Kinases of Gabbr2 (Rat)
Phosphorylation Site Information
GBF1
Human
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
GBF1_HUMAN
Accession #
Q92538
Protein names
  • Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
  • BFA-resistant GEF 1
Gene names
  • GBF1
  • KIAA0248
Description
Promotes guanine-nucleotide exchange on ARF5. Promotes the activation of ARF5 through replacement of GDP with GTP (By similarity).
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Search Kinases of GBF1 (Human)
KEGG Pathways (1)
Phosphorylation Site Information
GFPT1
Human
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
GFPT1_HUMAN
Accession #
Q06210
Protein names
  • Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
  • EC 2.6.1.16
  • D-fructose-6-phosphate amidotransferase 1
  • Glutamine:fructose-6-phosphate amidotransferase 1
  • GFAT 1
  • GFAT1
  • Hexosephosphate aminotransferase 1
Gene names
  • GFPT1
  • GFAT
  • GFPT
Description
Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1.
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Search Kinases of GFPT1 (Human)
Phosphorylation Site Information
HAS2
Human
Hyaluronan synthase 2
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
HYAS2_HUMAN
Accession #
Q92819
Protein names
  • Hyaluronan synthase 2
  • EC 2.4.1.212
  • Hyaluronate synthase 2
  • Hyaluronic acid synthase 2
  • HA synthase 2
Gene names
  • HAS2
Description
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity).
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Search Kinases of HAS2 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
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