Search Results (149 substrates found)
Gene name
Organism
Protein name
abcf-3
Nematode
Protein ABCF-3
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
Q20306_CAEEL
- Accession #
- Q20306
- Protein names
-
- Protein ABCF-3
- Gene names
-
- abcf-3
- CELE_F42A10.1
- F42A10.1
- Description
-
N/A
- Links
-
Search Kinases of abcf-3 (Nematode)
N/A

abts-1
Nematode
Protein ABTS-1, isoform c
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
B3WFV9_CAEEL
- Accession #
- B3WFV9
- Protein names
-
- Protein ABTS-1, isoform c
- Gene names
-
- abts-1
- CELE_F52B5.1
- F52B5.1
- Description
-
N/A
- Links
-
Search Kinases of abts-1 (Nematode)
N/A
- anion:anion antiporter activity
- chloride transmembrane transport
- chloride transmembrane transporter activity
- chloride transport
- inorganic anion exchanger activity
- integral component of plasma membrane
- regulation of synaptic transmission, GABAergic
- response to arsenic-containing substance
- synaptic transmission, cholinergic

ADAM17
Human
Disintegrin and metalloproteinase domain-containing protein 17
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ADA17_HUMAN
- Accession #
-
P78536
- Protein names
-
- Disintegrin and metalloproteinase domain-containing protein 17
- ADAM 17
- EC 3.4.24.86
- Snake venom-like protease
- TNF-alpha convertase
- TNF-alpha-converting enzyme
- CD antigen CD156b
- Gene names
-
- ADAM17
- CSVP
- TACE
- Description
-
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
- Links
-
Search Kinases of ADAM17 (Human)
- B cell differentiation
- JAK-STAT cascade involved in growth hormone signaling pathway
- Notch binding
- Notch receptor processing
- Notch signaling pathway
- PDZ domain binding
- PMA-inducible membrane protein ectodomain proteolysis
- T cell differentiation in thymus
- actin cytoskeleton
- apical plasma membrane
- apoptotic process
- apoptotic signaling pathway
- cell adhesion
- cell adhesion mediated by integrin
- cell motility
- cell surface
- collagen catabolic process
- cytoplasm
- epidermal growth factor receptor signaling pathway
- epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
- extracellular matrix disassembly
- extracellular matrix organization
- germinal center formation
- integral component of plasma membrane
- integrin binding
- interleukin-6 receptor binding
- membrane protein ectodomain proteolysis
- membrane protein intracellular domain proteolysis
- membrane raft
- metalloendopeptidase activity
- metallopeptidase activity
- negative regulation of interleukin-8 production
- negative regulation of transforming growth factor beta receptor signaling pathway
- neurotrophin TRK receptor signaling pathway
- neutrophil mediated immunity
- plasma membrane
- positive regulation of T cell chemotaxis
- positive regulation of cell growth
- positive regulation of cell migration
- positive regulation of cell proliferation
- positive regulation of cellular component movement
- positive regulation of chemokine production
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
- positive regulation of epidermal growth factor-activated receptor activity
- positive regulation of leukocyte chemotaxis
- positive regulation of protein phosphorylation
- positive regulation of transforming growth factor beta receptor signaling pathway
- protein binding
- proteolysis
- regulation of mast cell apoptotic process
- response to drug
- response to high density lipoprotein particle
- response to hypoxia
- response to lipopolysaccharide
- spleen development
- wound healing, spreading of epidermal cells
- zinc ion binding

ADAP1
Human
Arf-GAP with dual PH domain-containing protein 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ADAP1_HUMAN
- Accession #
-
O75689
- Protein names
-
- Arf-GAP with dual PH domain-containing protein 1
- Centaurin-alpha-1
- Cnt-a1
- Putative MAPK-activating protein PM25
- Gene names
-
- ADAP1
- CENTA1
- Description
-
GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).
- Links
-
Search Kinases of ADAP1 (Human)
N/A
- ARF GTPase activator activity
- cell surface receptor signaling pathway
- cytoplasm
- inositol 1,3,4,5 tetrakisphosphate binding
- nucleus
- phosphatidylinositol-3,4,5-trisphosphate binding
- plasma membrane
- positive regulation of GTPase activity
- protein binding
- regulation of ARF GTPase activity
- regulation of GTPase activity
- zinc ion binding

agef-1
Nematode
Protein AGEF-1, isoform a
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
G5EFH7_CAEEL
- Accession #
- G5EFH7
- Protein names
-
- Protein AGEF-1, isoform a
- Gene names
-
- agef-1
- CELE_Y6B3A.1
- Y6B3A.1
- Description
-
N/A
- Links
-
Search Kinases of agef-1 (Nematode)

Aicda
Mouse
Single-stranded DNA cytosine deaminase
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
AICDA_MOUSE
- Accession #
-
Q9WVE0
- Protein names
-
- Single-stranded DNA cytosine deaminase
- EC 3.5.4.38
- Activation-induced cytidine deaminase
- Cytidine aminohydrolase
- Gene names
-
- Aicda
- Aid
- Description
-
Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
- Links
-
Search Kinases of Aicda (Mouse)
- DNA demethylation
- cellular response to lipopolysaccharide
- cytidine deaminase activity
- cytidine deamination
- cytoplasm
- exosome (RNase complex)
- isotype switching
- mRNA processing
- negative regulation of methylation-dependent chromatin silencing
- nucleus
- protein binding
- somatic hypermutation of immunoglobulin genes
- zinc ion binding

Akt1
Rat
RAC-alpha serine/threonine-protein kinase
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
AKT1_RAT
- Accession #
-
P47196
- Protein names
-
- RAC-alpha serine/threonine-protein kinase
- EC 2.7.11.1
- Protein kinase B
- PKB
- Protein kinase B alpha
- PKB alpha
- RAC-PK-alpha
- Gene names
-
- Akt1
- Description
-
AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development. Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation. Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation (By similarity). Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity. Phosphorylation of BAD stimulates its pro-apoptotic activity (By similarity). Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53 (By similarity).AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation.
- Links
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Search Kinases of Akt1 (Rat)
- AMPK signaling pathway
- Acute myeloid leukemia
- Adipocytokine signaling pathway
- Adrenergic signaling in cardiomyocytes
- Apoptosis
- B cell receptor signaling pathway
- Carbohydrate digestion and absorption
- Central carbon metabolism in cancer
- Chagas disease (American trypanosomiasis)
- Chemokine signaling pathway
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- Dopaminergic synapse
- Endometrial cancer
- Epstein-Barr virus infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- FoxO signaling pathway
- Glioma
- HIF-1 signaling pathway
- HTLV-I infection
- Hepatitis B
- Hepatitis C
- Influenza A
- Insulin signaling pathway
- Jak-STAT signaling pathway
- MAPK signaling pathway
- Measles
- Melanoma
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease (NAFLD)
- Non-small cell lung cancer
- Osteoclast differentiation
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Platelet activation
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Renal cell carcinoma
- Signaling pathways regulating pluripotency of stem cells
- Small cell lung cancer
- T cell receptor signaling pathway
- TNF signaling pathway
- Thyroid hormone signaling pathway
- Tight junction
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- mTOR signaling pathway
- ATP binding
- activation-induced cell death of T cells
- aging
- anagen
- apoptotic mitochondrial changes
- cell projection organization
- cellular response to epidermal growth factor stimulus
- cellular response to hypoxia
- cellular response to insulin stimulus
- cellular response to mechanical stimulus
- cellular response to organic cyclic compound
- cytoplasm
- cytosol
- enzyme binding
- execution phase of apoptosis
- germ cell development
- glucose homeostasis
- glucose metabolic process
- glucose transport
- glycogen biosynthetic process
- glycogen cell differentiation involved in embryonic placenta development
- hyaluronan metabolic process
- inflammatory response
- insulin receptor signaling pathway
- insulin-like growth factor receptor signaling pathway
- labyrinthine layer blood vessel development
- maternal placenta development
- negative regulation of JNK cascade
- negative regulation of apoptotic process
- negative regulation of autophagy
- negative regulation of cell size
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of fatty acid beta-oxidation
- negative regulation of plasma membrane long-chain fatty acid transport
- negative regulation of protein kinase activity
- negative regulation of proteolysis
- negative regulation of release of cytochrome c from mitochondria
- nitric-oxide synthase regulator activity
- nucleoplasm
- nucleus
- osteoblast differentiation
- peptidyl-serine phosphorylation
- peripheral nervous system myelin maintenance
- phosphatidylinositol-3,4,5-trisphosphate binding
- phosphatidylinositol-3,4-bisphosphate binding
- phosphorylation
- plasma membrane
- positive regulation of apoptotic process
- positive regulation of blood vessel endothelial cell migration
- positive regulation of cell growth
- positive regulation of cellular protein metabolic process
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
- positive regulation of endothelial cell proliferation
- positive regulation of establishment of protein localization to plasma membrane
- positive regulation of fat cell differentiation
- positive regulation of glucose import
- positive regulation of glycogen biosynthetic process
- positive regulation of lipid biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of nitric-oxide synthase activity
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of sodium ion transport
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of vasoconstriction
- protein binding
- protein catabolic process
- protein import into nucleus, translocation
- protein kinase B signaling
- protein kinase C binding
- protein kinase activity
- protein phosphorylation
- protein serine/threonine kinase activity
- protein ubiquitination
- regulation of cell migration
- regulation of neuron projection development
- regulation of protein localization
- regulation of translation
- response to UV-A
- response to fluid shear stress
- response to food
- signal transduction
- spindle
- striated muscle cell differentiation
- translation

ATF2
Human
Cyclic AMP-dependent transcription factor ATF-2
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ATF2_HUMAN
- Accession #
-
P15336
- Protein names
-
- Cyclic AMP-dependent transcription factor ATF-2
- cAMP-dependent transcription factor ATF-2
- EC 2.3.1.48
- Activating transcription factor 2
- Cyclic AMP-responsive element-binding protein 2
- CREB-2
- cAMP-responsive element-binding protein 2
- HB16
- Histone acetyltransferase ATF2
- cAMP response element-binding protein CRE-BP1
- Gene names
-
- ATF2
- CREB2
- CREBP1
- Description
-
Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.
- Links
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Search Kinases of ATF2 (Human)
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Amphetamine addiction
- Cocaine addiction
- Dopaminergic synapse
- Epstein-Barr virus infection
- Estrogen signaling pathway
- HTLV-I infection
- Hepatitis B
- Influenza A
- Insulin secretion
- MAPK signaling pathway
- PI3K-Akt signaling pathway
- TNF signaling pathway
- Thyroid hormone synthesis
- Viral carcinogenesis
- cGMP-PKG signaling pathway
- MyD88-dependent toll-like receptor signaling pathway
- MyD88-independent toll-like receptor signaling pathway
- RNA polymerase II activating transcription factor binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- RNA polymerase II distal enhancer sequence-specific DNA binding
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
- RNA polymerase II transcription factor binding transcription factor activity
- TRIF-dependent toll-like receptor signaling pathway
- adipose tissue development
- cAMP response element binding
- cAMP response element binding protein binding
- cellular response to DNA damage stimulus
- chromatin binding
- chromatin organization
- cytoplasm
- fat cell differentiation
- histone acetylation
- histone acetyltransferase activity
- innate immune response
- intra-S DNA damage checkpoint
- metal ion binding
- mitochondrial outer membrane
- nucleoplasm
- nucleus
- outflow tract morphogenesis
- positive regulation of mitochondrial membrane permeability involved in apoptotic process
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of transforming growth factor beta2 production
- protein binding
- protein kinase binding
- regulation of sequence-specific DNA binding transcription factor activity
- regulation of transcription from RNA polymerase II promoter
- regulation of transcription, DNA-templated
- response to osmotic stress
- sequence-specific DNA binding transcription factor activity
- site of double-strand break
- stress-activated MAPK cascade
- toll-like receptor 10 signaling pathway
- toll-like receptor 2 signaling pathway
- toll-like receptor 3 signaling pathway
- toll-like receptor 4 signaling pathway
- toll-like receptor 5 signaling pathway
- toll-like receptor 9 signaling pathway
- toll-like receptor TLR1:TLR2 signaling pathway
- toll-like receptor TLR6:TLR2 signaling pathway
- toll-like receptor signaling pathway
- transcription coactivator activity
- transcription from RNA polymerase II promoter

B0334.3
Nematode
Protein B0334.3, isoform a
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
Q17474_CAEEL
- Accession #
- Q17474
- Protein names
-
- Protein B0334.3, isoform a
- Gene names
-
- B0334.3
- CELE_B0334.3
- Description
-
N/A
- Links
-
Search Kinases of B0334.3 (Nematode)

BAD
Human
Bcl2-associated agonist of cell death
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
BAD_HUMAN
- Accession #
-
Q92934
- Protein names
-
- Bcl2-associated agonist of cell death
- BAD
- Bcl-2-binding component 6
- Bcl-2-like protein 8
- Bcl2-L-8
- Bcl-xL/Bcl-2-associated death promoter
- Bcl2 antagonist of cell death
- Gene names
-
- BAD
- BBC6
- BCL2L8
- Description
-
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
- Links
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Search Kinases of BAD (Human)
- Acute myeloid leukemia
- Alzheimer's disease
- Amyotrophic lateral sclerosis (ALS)
- Apoptosis
- Chronic myeloid leukemia
- Colorectal cancer
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- Hepatitis B
- Hepatitis C
- Insulin signaling pathway
- Melanoma
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Prostate cancer
- Ras signaling pathway
- Thyroid hormone signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Viral carcinogenesis
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- ADP metabolic process
- ATP metabolic process
- Fc-epsilon receptor signaling pathway
- activation of cysteine-type endopeptidase activity
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- apoptotic process
- apoptotic signaling pathway
- cellular process regulating host cell cycle in response to virus
- cellular response to chromate
- cellular response to hypoxia
- cellular response to lipid
- cellular response to mechanical stimulus
- cellular response to nicotine
- cysteine-type endopeptidase activator activity involved in apoptotic process
- cytokine-mediated signaling pathway
- cytosol
- epidermal growth factor receptor signaling pathway
- extrinsic apoptotic signaling pathway
- extrinsic apoptotic signaling pathway in absence of ligand
- extrinsic apoptotic signaling pathway via death domain receptors
- fibroblast growth factor receptor signaling pathway
- glucose catabolic process
- glucose homeostasis
- innate immune response
- intrinsic apoptotic signaling pathway
- intrinsic apoptotic signaling pathway in response to DNA damage
- lipid binding
- mitochondrial outer membrane
- mitochondrion
- neurotrophin TRK receptor signaling pathway
- phosphatidylinositol-mediated signaling
- phospholipid binding
- pore complex assembly
- positive regulation of B cell differentiation
- positive regulation of T cell differentiation
- positive regulation of apoptotic process
- positive regulation of apoptotic process by virus
- positive regulation of autophagy
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- positive regulation of epithelial cell proliferation
- positive regulation of glucokinase activity
- positive regulation of insulin secretion
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
- positive regulation of intrinsic apoptotic signaling pathway
- positive regulation of mitochondrial membrane potential
- positive regulation of neuron death
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
- positive regulation of proteolysis
- positive regulation of release of cytochrome c from mitochondria
- positive regulation of type B pancreatic cell development
- protein binding
- protein kinase binding
- regulation of mitochondrial membrane permeability
- release of cytochrome c from mitochondria
- response to amino acid
- response to calcium ion
- response to drug
- response to estradiol
- response to ethanol
- response to glucocorticoid
- response to glucose
- response to hydrogen peroxide
- response to oleic acid
- response to progesterone
- response to testosterone
- suppression by virus of host apoptotic process
- type B pancreatic cell proliferation

C17G10.1
Nematode
Protein C17G10.1
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
Q09973_CAEEL
- Accession #
- Q09973
- Protein names
-
- Protein C17G10.1
- Gene names
-
- C17G10.1
- CELE_C17G10.1
- Description
-
N/A
- Links
-
Search Kinases of C17G10.1 (Nematode)
N/A

C28H8.3
Nematode
Uncharacterized helicase C28H8.3
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
YP93_CAEEL
- Accession #
- Q09475
- Protein names
-
- Uncharacterized helicase C28H8.3
- EC 3.6.4.-
- Gene names
-
- C28H8.3
- Description
-
N/A
- Links
-
Search Kinases of C28H8.3 (Nematode)
N/A

C44B7.10
Nematode
Protein C44B7.10
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
Q18599_CAEEL
- Accession #
- Q18599
- Protein names
-
- Protein C44B7.10
- Gene names
-
- C44B7.10
- CELE_C44B7.10
- Description
-
N/A
- Links
-
Search Kinases of C44B7.10 (Nematode)
N/A

C46G7.2
Nematode
Protein C46G7.2
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
O02141_CAEEL
- Accession #
- O02141
- Protein names
-
- Protein C46G7.2
- Gene names
-
- C46G7.2
- CELE_C46G7.2
- Description
-
N/A
- Links
-
Search Kinases of C46G7.2 (Nematode)
N/A

Cacna1b
Rat
Voltage-dependent N-type calcium channel subunit alpha-1B
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
CAC1B_RAT
- Accession #
-
Q02294
- Protein names
-
- Voltage-dependent N-type calcium channel subunit alpha-1B
- Brain calcium channel III
- BIII
- Calcium channel, L type, alpha-1 polypeptide isoform 5
- Voltage-gated calcium channel subunit alpha Cav2.2
- Gene names
-
- Cacna1b
- Cach5
- Cacnl1a5
- Description
-
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.
- Links
-
Search Kinases of Cacna1b (Rat)
N/A
- ATP binding
- axon terminus
- calcium ion binding
- calcium ion import
- calcium ion transport
- dendritic shaft
- high voltage-gated calcium channel activity
- membrane depolarization during action potential
- neuron projection
- neuronal cell body
- plasma membrane
- positive regulation of neurotransmitter secretion
- protein binding
- protein complex
- response to ethanol
- response to organic cyclic compound
- response to testosterone
- sensory perception of pain
- voltage-gated calcium channel activity
- voltage-gated calcium channel complex

Cacna1d
Rat
Voltage-dependent L-type calcium channel subunit alpha-1D
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
CAC1D_RAT
- Accession #
-
P27732
- Protein names
-
- Voltage-dependent L-type calcium channel subunit alpha-1D
- Calcium channel, L type, alpha-1 polypeptide, isoform 2
- Rat brain class D
- RBD
- Voltage-gated calcium channel subunit alpha Cav1.3
- Gene names
-
- Cacna1d
- Cach3
- Cacn4
- Cacnl1a2
- Cchl1a2
- Description
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Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
- Links
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Search Kinases of Cacna1d (Rat)
- Adrenergic signaling in cardiomyocytes
- Alzheimer's disease
- Amphetamine addiction
- Arrhythmogenic right ventricular cardiomyopathy (ARVC)
- Calcium signaling pathway
- Carbohydrate digestion and absorption
- Cardiac muscle contraction
- Cholinergic synapse
- Circadian entrainment
- Dilated cardiomyopathy
- Dopaminergic synapse
- GABAergic synapse
- Glutamatergic synapse
- GnRH signaling pathway
- Hypertrophic cardiomyopathy (HCM)
- Insulin secretion
- MAPK signaling pathway
- Oxytocin signaling pathway
- Retrograde endocannabinoid signaling
- Serotonergic synapse
- Type II diabetes mellitus
- Vascular smooth muscle contraction
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- ankyrin binding
- calcium ion transport
- membrane depolarization during cardiac muscle cell action potential
- metal ion binding
- protein binding
- regulation of calcium ion transport
- voltage-gated calcium channel activity
- voltage-gated calcium channel activity involved in cardiac muscle cell action potential
- voltage-gated calcium channel complex

cct-1
Nematode
T-complex protein 1 subunit alpha
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
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TCPA_CAEEL
- Accession #
- P41988
- Protein names
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- T-complex protein 1 subunit alpha
- TCP-1-alpha
- CCT-alpha
- Gene names
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- cct-1
- tcp-1
- T05C12.7
- Description
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Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.
- Links
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Search Kinases of cct-1 (Nematode)
N/A

Cdyl
Rat
Chromodomain Y-like protein
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
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CDYL_RAT
- Accession #
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Q6AYK9
- Protein names
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- Chromodomain Y-like protein
- CDY-like
- EC 2.3.1.48
- Gene names
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- Cdyl
- Description
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Acts as a RE1-silencing transcription factor (REST) corepressor that facilitates histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Required for chromatin targeting and maximal enzymatic activity of polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes. Has histone acetyltransferase activity. May play a role in histone hyperacetylation during spermatid maturation (By similarity).
- Links
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Search Kinases of Cdyl (Rat)
N/A

CELE_D2045.2
Nematode
Protein D2045.2
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
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Q18983_CAEEL
- Accession #
- Q18983
- Protein names
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- Protein D2045.2
- Gene names
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- CELE_D2045.2
- D2045.2
- Description
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N/A
- Links
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Search Kinases of CELE_D2045.2 (Nematode)
N/A
N/A

CELE_F32B5.1
Nematode
Protein F32B5.1
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
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O01854_CAEEL
- Accession #
- O01854
- Protein names
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- Protein F32B5.1
- Gene names
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- CELE_F32B5.1
- F32B5.1
- Description
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N/A
- Links
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Search Kinases of CELE_F32B5.1 (Nematode)
N/A
