Search Results (51 substrates found)
Gene name
Organism
Protein name
ADAM17
Human
Disintegrin and metalloproteinase domain-containing protein 17
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ADA17_HUMAN
- Accession #
-
P78536
- Protein names
-
- Disintegrin and metalloproteinase domain-containing protein 17
- ADAM 17
- EC 3.4.24.86
- Snake venom-like protease
- TNF-alpha convertase
- TNF-alpha-converting enzyme
- CD antigen CD156b
- Gene names
-
- ADAM17
- CSVP
- TACE
- Description
-
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:12441351). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (PubMed:26876177, PubMed:28060820). {ECO:0000250|UniProtKB:Q9Z0F8, ECO:0000269|PubMed:12441351, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:24226769, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:28060820, ECO:0000269|PubMed:9034191}.
- Links
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Search Kinases of ADAM17 (Human)
- B cell differentiation
- Golgi membrane
- Notch binding
- Notch receptor processing
- Notch signaling pathway
- PDZ domain binding
- SH3 domain binding
- T cell differentiation in thymus
- actin cytoskeleton
- amyloid precursor protein catabolic process
- apical plasma membrane
- cell adhesion
- cell adhesion mediated by integrin
- cell motility
- cell surface
- cellular response to high density lipoprotein particle stimulus
- cytoplasm
- cytosol
- defense response to Gram-positive bacterium
- endopeptidase activity
- endoplasmic reticulum lumen
- epidermal growth factor receptor signaling pathway
- germinal center formation
- integral component of plasma membrane
- integrin binding
- interleukin-6 receptor binding
- membrane
- membrane protein ectodomain proteolysis
- membrane protein intracellular domain proteolysis
- membrane raft
- metal ion binding
- metalloendopeptidase activity
- metalloendopeptidase activity involved in amyloid precursor protein catabolic process
- metallopeptidase activity
- negative regulation of cold-induced thermogenesis
- negative regulation of inflammatory response to antigenic stimulus
- negative regulation of transforming growth factor beta receptor signaling pathway
- neutrophil mediated immunity
- peptidase activity
- plasma membrane
- positive regulation of G1/S transition of mitotic cell cycle
- positive regulation of T cell chemotaxis
- positive regulation of blood vessel endothelial cell migration
- positive regulation of cell growth
- positive regulation of cell migration
- positive regulation of cell population proliferation
- positive regulation of cellular component movement
- positive regulation of chemokine production
- positive regulation of cyclin-dependent protein serine/threonine kinase activity
- positive regulation of epidermal growth factor-activated receptor activity
- positive regulation of leukocyte chemotaxis
- positive regulation of protein phosphorylation
- positive regulation of transforming growth factor beta receptor signaling pathway
- positive regulation of tumor necrosis factor-mediated signaling pathway
- positive regulation of vascular endothelial cell proliferation
- protein processing
- proteolysis
- receptor transactivation
- regulation of mast cell apoptotic process
- response to hypoxia
- response to lipopolysaccharide
- spleen development
- tumor necrosis factor-mediated signaling pathway
- wound healing, spreading of epidermal cells

ADAP1
Human
Arf-GAP with dual PH domain-containing protein 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ADAP1_HUMAN
- Accession #
-
O75689
- Protein names
-
- Arf-GAP with dual PH domain-containing protein 1
- Centaurin-alpha-1
- Cnt-a1
- Putative MAPK-activating protein PM25
- Gene names
-
- ADAP1
- CENTA1
- Description
-
GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). {ECO:0000269|PubMed:10448098, ECO:0000303|PubMed:10333475, ECO:0000305}.
- Links
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Search Kinases of ADAP1 (Human)
N/A
- GTPase activator activity
- cell surface receptor signaling pathway
- cytoplasm
- cytosol
- inositol 1,3,4,5 tetrakisphosphate binding
- intracellular membrane-bounded organelle
- metal ion binding
- nucleus
- phosphatidylinositol bisphosphate binding
- phosphatidylinositol-3,4,5-trisphosphate binding
- plasma membrane
- regulation of GTPase activity

Aicda
Mouse
Single-stranded DNA cytosine deaminase
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
AICDA_MOUSE
- Accession #
-
Q9WVE0
- Protein names
-
- Single-stranded DNA cytosine deaminase
- EC 3.5.4.38
- Activation-induced cytidine deaminase
- AID
- Cytidine aminohydrolase
- Gene names
-
- Aicda
- Aid
- Description
-
Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. {ECO:0000269|PubMed:12692563, ECO:0000269|PubMed:23803409}.
- Links
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Search Kinases of Aicda (Mouse)
- DNA cytosine deamination
- DNA demethylation
- P-body
- RNA binding
- cellular response to lipopolysaccharide
- cytidine deaminase activity
- cytidine deamination
- cytidine to uridine editing
- cytoplasm
- defense response to bacterium
- defense response to virus
- deoxycytidine deaminase activity
- identical protein binding
- isotype switching
- mRNA processing
- negative regulation of DNA methylation-dependent heterochromatin assembly
- negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
- negative regulation of transposition
- nucleus
- protein-containing complex
- regulation of nuclear cell cycle DNA replication
- somatic diversification of immunoglobulins
- somatic hypermutation of immunoglobulin genes
- ubiquitin protein ligase binding
- zinc ion binding

Akt1
Rat
RAC-alpha serine/threonine-protein kinase
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
AKT1_RAT
- Accession #
-
P47196
- Protein names
-
- RAC-alpha serine/threonine-protein kinase
- EC 2.7.11.1
- Protein kinase B
- PKB
- Protein kinase B alpha
- PKB alpha
- RAC-PK-alpha
- Gene names
-
- Akt1
- Description
-
AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis (PubMed:11882383, PubMed:21620960, PubMed:21432781). This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates (PubMed:11882383, PubMed:21620960, PubMed:21432781). Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported (PubMed:11882383, PubMed:21620960, PubMed:21432781). AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface (PubMed:9632753, PubMed:10400692). Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling (By similarity). Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport (By similarity). AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven (By similarity). AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1 (By similarity). AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis (PubMed:12107176). Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis (By similarity). Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity (PubMed:15546921). The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth (By similarity). AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I) (By similarity). AKT mediates the antiapoptotic effects of IGF-I (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (By similarity). May be involved in the regulation of the placental development (By similarity). Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation. Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation. Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity. Phosphorylation of BAD stimulates its pro-apoptotic activity. Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53. Phosphorylates palladin (PALLD), modulating cytoskeletal organization and cell motility. Phosphorylates prohibitin (PHB), playing an important role in cell metabolism and proliferation. Phosphorylates CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation (By similarity). Phosphorylates PCK1 at 'Ser-90', reducing the binding affinity of PCK1 to oxaloacetate and changing PCK1 into an atypical protein kinase activity using GTP as donor (By similarity). Also acts as an activator of TMEM175 potassium channel activity in response to growth factors: forms the lysoK(GF) complex together with TMEM175 and acts by promoting TMEM175 channel activation, independently of its protein kinase activity (By similarity). {ECO:0000250|UniProtKB:P31749, ECO:0000250|UniProtKB:P31750, ECO:0000269|PubMed:10400692, ECO:0000269|PubMed:12107176, ECO:0000269|PubMed:15546921, ECO:0000269|PubMed:9632753, ECO:0000303|PubMed:11882383, ECO:0000303|PubMed:21432781, ECO:0000303|PubMed:21620960}.
- Links
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Search Kinases of Akt1 (Rat)
- AGE
- AMPK signaling pathway
- Acute myeloid leukemia
- Adipocytokine signaling pathway
- Adrenergic signaling in cardiomyocytes
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy
- B cell receptor signaling pathway
- Breast cancer
- C
- Carbohydrate digestion and absorption
- Cellular senescence
- Central carbon metabolism in cancer
- Chagas disease
- Chemical carcinogenesis
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- Diabetic cardiomyopathy
- Dopaminergic synapse
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- Epstein
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- Gastric cancer
- Glioma
- Glucagon signaling pathway
- GnRH secretion
- Growth hormone synthesis, secretion and action
- HIF
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Herpes simplex virus 1 infection
- Human T
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Influenza A
- Insulin resistance
- Insulin signaling pathway
- JAK
- Kaposi sarcoma
- Lipid and atherosclerosis
- Longevity regulating pathway
- MAPK signaling pathway
- Measles
- Melanoma
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non
- Osteoclast differentiation
- PD
- PI3K
- Pancreatic cancer
- Pathways in cancer
- Phospholipase D signaling pathway
- Platelet activation
- Platinum drug resistance
- Progesterone
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renal cell carcinoma
- Salmonella infection
- Signaling pathways regulating pluripotency of stem cells
- Small cell lung cancer
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Thyroid hormone signaling pathway
- Toll
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
- cAMP signaling pathway
- cGMP
- mTOR signaling pathway
- 14-3-3 protein binding
- ATP binding
- GTPase activating protein binding
- I-kappaB kinase/NF-kappaB signaling
- NIK/NF-kappaB signaling
- activation-induced cell death of T cells
- aging
- apoptotic mitochondrial changes
- apoptotic process
- calmodulin binding
- carbohydrate transport
- cell migration involved in sprouting angiogenesis
- cell projection organization
- cell-cell junction
- cellular response to DNA damage stimulus
- cellular response to cadmium ion
- cellular response to decreased oxygen levels
- cellular response to epidermal growth factor stimulus
- cellular response to granulocyte macrophage colony-stimulating factor stimulus
- cellular response to growth factor stimulus
- cellular response to hypoxia
- cellular response to insulin stimulus
- cellular response to mechanical stimulus
- cellular response to nerve growth factor stimulus
- cellular response to organic cyclic compound
- cellular response to oxidised low-density lipoprotein particle stimulus
- cellular response to peptide
- cellular response to prostaglandin E stimulus
- cellular response to reactive oxygen species
- cellular response to tumor necrosis factor
- cellular response to vascular endothelial growth factor stimulus
- ciliary basal body
- cytoplasm
- cytosol
- enzyme binding
- epidermal growth factor receptor signaling pathway
- establishment of protein localization to mitochondrion
- execution phase of apoptosis
- gene expression
- germ cell development
- glucose homeostasis
- glucose metabolic process
- glycogen biosynthetic process
- glycogen cell differentiation involved in embryonic placenta development
- glycogen metabolic process
- hyaluronan metabolic process
- identical protein binding
- inflammatory response
- insulin receptor signaling pathway
- insulin-like growth factor receptor signaling pathway
- interleukin-18-mediated signaling pathway
- intracellular signal transduction
- kinase activity
- labyrinthine layer blood vessel development
- lipopolysaccharide-mediated signaling pathway
- maintenance of protein location in mitochondrion
- maternal placenta development
- mitochondrion
- negative regulation of JNK cascade
- negative regulation of apoptotic process
- negative regulation of autophagy
- negative regulation of calcium import into the mitochondrion
- negative regulation of cell size
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of endopeptidase activity
- negative regulation of fatty acid beta-oxidation
- negative regulation of gene expression
- negative regulation of intrinsic apoptotic signaling pathway
- negative regulation of leukocyte cell-cell adhesion
- negative regulation of long-chain fatty acid import across plasma membrane
- negative regulation of lymphocyte migration
- negative regulation of protein binding
- negative regulation of protein kinase activity
- negative regulation of protein ubiquitination
- negative regulation of proteolysis
- negative regulation of release of cytochrome c from mitochondria
- negative regulation of superoxide anion generation
- nitric-oxide synthase regulator activity
- nucleoplasm
- nucleus
- osteoblast differentiation
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- peripheral nervous system myelin maintenance
- phosphatidylinositol 3-kinase signaling
- phosphatidylinositol-3,4,5-trisphosphate binding
- phosphatidylinositol-3,4-bisphosphate binding
- phosphorylation
- plasma membrane
- positive regulation of DNA-binding transcription factor activity
- positive regulation of G1/S transition of mitotic cell cycle
- positive regulation of I-kappaB phosphorylation
- positive regulation of apoptotic process
- positive regulation of blood vessel endothelial cell migration
- positive regulation of cell growth
- positive regulation of cell population proliferation
- positive regulation of cellular protein metabolic process
- positive regulation of cyclin-dependent protein serine/threonine kinase activity
- positive regulation of endodeoxyribonuclease activity
- positive regulation of endothelial cell migration
- positive regulation of endothelial cell proliferation
- positive regulation of fat cell differentiation
- positive regulation of fibroblast migration
- positive regulation of gene expression
- positive regulation of glucose import
- positive regulation of glucose metabolic process
- positive regulation of glycogen biosynthetic process
- positive regulation of lipid biosynthetic process
- positive regulation of mitochondrial membrane potential
- positive regulation of nitric oxide biosynthetic process
- positive regulation of nitric-oxide synthase activity
- positive regulation of organ growth
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of protein localization to cell surface
- positive regulation of protein localization to nucleus
- positive regulation of protein localization to plasma membrane
- positive regulation of protein phosphorylation
- positive regulation of smooth muscle cell proliferation
- positive regulation of sodium ion transport
- positive regulation of transcription by RNA polymerase II
- positive regulation of transcription, DNA-templated
- positive regulation of vasoconstriction
- potassium channel activator activity
- protein catabolic process
- protein homodimerization activity
- protein import into nucleus
- protein kinase B signaling
- protein kinase C binding
- protein kinase activity
- protein kinase binding
- protein phosphatase 2A binding
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- protein serine/threonine/tyrosine kinase activity
- protein ubiquitination
- protein-containing complex
- regulation of aerobic respiration
- regulation of apoptotic process
- regulation of cell migration
- regulation of glycogen biosynthetic process
- regulation of myelination
- regulation of neuron projection development
- regulation of protein localization
- regulation of translation
- response to UV-A
- response to fluid shear stress
- response to food
- response to growth hormone
- response to hormone
- response to insulin-like growth factor stimulus
- response to ischemia
- response to organic substance
- response to oxidative stress
- signal transduction
- sphingosine-1-phosphate receptor signaling pathway
- spinal cord development
- spindle
- striated muscle cell differentiation
- translation
- vesicle

ATF2
Human
Cyclic AMP-dependent transcription factor ATF-2
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ATF2_HUMAN
- Accession #
-
P15336
- Protein names
-
- Cyclic AMP-dependent transcription factor ATF-2
- cAMP-dependent transcription factor ATF-2
- Activating transcription factor 2
- Cyclic AMP-responsive element-binding protein 2
- CREB-2
- cAMP-responsive element-binding protein 2
- HB16
- cAMP response element-binding protein CRE-BP1
- Gene names
-
- ATF2
- CREB2
- CREBP1
- Description
-
Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:22304920}.
- Links
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Search Kinases of ATF2 (Human)
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Aldosterone synthesis and secretion
- Amphetamine addiction
- Chemical carcinogenesis
- Cocaine addiction
- Cortisol synthesis and secretion
- Cushing syndrome
- Dopaminergic synapse
- Estrogen signaling pathway
- Glucagon signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human T
- Human cytomegalovirus infection
- Insulin secretion
- Longevity regulating pathway
- MAPK signaling pathway
- PI3K
- Parathyroid hormone synthesis, secretion and action
- Prion disease
- Relaxin signaling pathway
- TNF signaling pathway
- Thermogenesis
- Thyroid hormone synthesis
- Viral carcinogenesis
- cGMP
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- H2B histone acetyltransferase activity
- H4 histone acetyltransferase activity
- H4 histone acetyltransferase complex
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- adipose tissue development
- amelogenesis
- cAMP response element binding
- cAMP response element binding protein binding
- cellular response to DNA damage stimulus
- cellular response to amino acid starvation
- chromatin
- chromatin binding
- cis-regulatory region sequence-specific DNA binding
- cytoplasm
- fat cell differentiation
- histone H2B acetylation
- histone H4 acetylation
- metal ion binding
- mitochondrial outer membrane
- mitotic intra-S DNA damage checkpoint signaling
- negative regulation of angiogenesis
- negative regulation of epithelial cell proliferation
- negative regulation of transcription by RNA polymerase II
- nucleoplasm
- nucleus
- outflow tract morphogenesis
- positive regulation of DNA-binding transcription factor activity
- positive regulation of cardiac muscle myoblast proliferation
- positive regulation of gene expression
- positive regulation of mitochondrial membrane permeability involved in apoptotic process
- positive regulation of neuron apoptotic process
- positive regulation of transcription by RNA polymerase II
- positive regulation of transforming growth factor beta2 production
- protein kinase binding
- protein-containing complex binding
- regulation of DNA-binding transcription factor activity
- regulation of transcription by RNA polymerase II
- regulation of transcription, DNA-templated
- response to osmotic stress
- response to water deprivation
- sequence-specific double-stranded DNA binding
- site of double-strand break

BAD
Human
Bcl2-associated agonist of cell death
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
BAD_HUMAN
- Accession #
-
Q92934
- Protein names
-
- Bcl2-associated agonist of cell death
- BAD
- Bcl-2-binding component 6
- Bcl-2-like protein 8
- Bcl2-L-8
- Bcl-xL/Bcl-2-associated death promoter
- Bcl2 antagonist of cell death
- Gene names
-
- BAD
- BBC6
- BCL2L8
- Description
-
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. {ECO:0000250}.
- Links
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Search Kinases of BAD (Human)
- Acute myeloid leukemia
- Alzheimer disease
- Amyotrophic lateral sclerosis
- Apoptosis
- Autophagy
- Chemical carcinogenesis
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Colorectal cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Herpes simplex virus 1 infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Insulin signaling pathway
- Lipid and atherosclerosis
- Measles
- Melanoma
- Neurotrophin signaling pathway
- Non
- PI3K
- Pancreatic cancer
- Pathways in cancer
- Pathways of neurodegeneration
- Platinum drug resistance
- Prion disease
- Prostate cancer
- Ras signaling pathway
- Renal cell carcinoma
- Thyroid hormone signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Viral carcinogenesis
- cAMP signaling pathway
- cGMP
- 14-3-3 protein binding
- ADP metabolic process
- ATP metabolic process
- activation of cysteine-type endopeptidase activity
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- apoptotic process
- cellular response to chromate
- cellular response to hypoxia
- cellular response to lipid
- cellular response to mechanical stimulus
- cellular response to nicotine
- cerebral cortex development
- cysteine-type endopeptidase activator activity involved in apoptotic process
- cytokine-mediated signaling pathway
- cytosol
- extrinsic apoptotic signaling pathway
- extrinsic apoptotic signaling pathway in absence of ligand
- extrinsic apoptotic signaling pathway via death domain receptors
- glucose catabolic process
- glucose homeostasis
- intrinsic apoptotic signaling pathway
- intrinsic apoptotic signaling pathway in response to DNA damage
- lipid binding
- mitochondrial outer membrane
- mitochondrion
- phospholipid binding
- pore complex assembly
- positive regulation of B cell differentiation
- positive regulation of T cell differentiation
- positive regulation of apoptotic process
- positive regulation of apoptotic process by virus
- positive regulation of autophagy
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- positive regulation of epithelial cell proliferation
- positive regulation of glucokinase activity
- positive regulation of granulosa cell apoptotic process
- positive regulation of insulin secretion
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
- positive regulation of intrinsic apoptotic signaling pathway
- positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
- positive regulation of mitochondrial membrane potential
- positive regulation of neuron death
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
- positive regulation of proteolysis
- positive regulation of release of cytochrome c from mitochondria
- positive regulation of type B pancreatic cell development
- protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
- protein kinase B binding
- protein kinase binding
- protein phosphatase 2B binding
- protein phosphatase binding
- regulation of mitochondrial membrane permeability
- release of cytochrome c from mitochondria
- response to amino acid
- response to benzene
- response to calcium ion
- response to estradiol
- response to ethanol
- response to glucocorticoid
- response to glucose
- response to hydrogen peroxide
- response to oleic acid
- response to progesterone
- response to testosterone
- spermatogenesis
- suppression by virus of host apoptotic process
- type B pancreatic cell proliferation

Cacna1b
Rat
Voltage-dependent N-type calcium channel subunit alpha-1B
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
CAC1B_RAT
- Accession #
-
Q02294
- Protein names
-
- Voltage-dependent N-type calcium channel subunit alpha-1B
- Brain calcium channel III
- BIII
- Calcium channel, L type, alpha-1 polypeptide isoform 5
- Voltage-gated calcium channel subunit alpha Cav2.2
- Gene names
-
- Cacna1b
- Cach5
- Cacnl1a5
- Description
-
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (PubMed:1317580). They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. {ECO:0000269|PubMed:1317580}.
- Links
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Search Kinases of Cacna1b (Rat)
N/A
- ATP binding
- Schaffer collateral - CA1 synapse
- axon terminus
- calcium ion binding
- calcium ion import
- calcium ion transmembrane transport
- calcium ion transport
- chemical synaptic transmission
- dendrite
- dendritic shaft
- glutamatergic synapse
- high voltage-gated calcium channel activity
- locomotory behavior
- membrane
- modulation of chemical synaptic transmission
- neuron projection
- neuronal cell body
- neurotransmitter secretion
- plasma membrane
- positive regulation of neurotransmitter secretion
- protein C-terminus binding
- protein phosphatase 2A binding
- protein-containing complex
- regulation of blood pressure
- regulation of calcium ion transport
- regulation of heart contraction
- regulation of ion transmembrane transport
- response to amyloid-beta
- response to ethanol
- response to organic cyclic compound
- response to pain
- response to testosterone
- sensory perception of pain
- voltage-gated calcium channel activity
- voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
- voltage-gated calcium channel complex

Cacna1d
Rat
Voltage-dependent L-type calcium channel subunit alpha-1D
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
CAC1D_RAT
- Accession #
-
P27732
- Protein names
-
- Voltage-dependent L-type calcium channel subunit alpha-1D
- Calcium channel, L type, alpha-1 polypeptide, isoform 2
- Rat brain class D
- RBD
- Voltage-gated calcium channel subunit alpha Cav1.3
- Gene names
-
- Cacna1d
- Cach3
- Cacn4
- Cacnl1a2
- Cchl1a2
- Description
-
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. {ECO:0000269|PubMed:17050707}.
- Links
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Search Kinases of Cacna1d (Rat)
N/A
- L-type voltage-gated calcium channel complex
- PDZ domain binding
- Z disc
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway
- aging
- alpha-actinin binding
- ankyrin binding
- apical plasma membrane
- calcium channel activity
- calcium ion import
- calcium ion transmembrane transport
- calcium ion transport
- calcium-mediated signaling
- cardiac muscle cell action potential involved in contraction
- cell surface
- cellular response to amyloid-beta
- cochlear hair cell ribbon synapse
- cytoplasm
- dendrite
- dendrite membrane
- heart development
- high voltage-gated calcium channel activity
- integral component of presynaptic active zone membrane
- membrane depolarization during SA node cell action potential
- membrane depolarization during cardiac muscle cell action potential
- memory
- metal ion binding
- metal ion transport
- neuronal cell body
- nucleus
- plasma membrane
- positive regulation of CREB transcription factor activity
- positive regulation of adenylate cyclase activity
- positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
- positive regulation of calcium ion transport
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
- regulation of atrial cardiac muscle cell membrane repolarization
- regulation of calcium ion transport
- regulation of heart rate by cardiac conduction
- regulation of potassium ion transmembrane transport
- regulation of potassium ion transmembrane transporter activity
- response to estradiol
- sarcolemma
- sensory perception of sound
- voltage-gated calcium channel activity
- voltage-gated calcium channel activity involved SA node cell action potential
- voltage-gated calcium channel activity involved in cardiac muscle cell action potential
- voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
- voltage-gated calcium channel complex

CREB1
Human
Cyclic AMP-responsive element-binding protein 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CREB1_HUMAN
- Accession #
-
P16220
- Protein names
-
- Cyclic AMP-responsive element-binding protein 1
- CREB-1
- cAMP-responsive element-binding protein 1
- Gene names
-
- CREB1
- Description
-
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
- Links
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Search Kinases of CREB1 (Human)
- AMPK signaling pathway
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Aldosterone synthesis and secretion
- Amphetamine addiction
- Antigen processing and presentation
- Chemical carcinogenesis
- Cholinergic synapse
- Circadian entrainment
- Circadian rhythm
- Cocaine addiction
- Cortisol synthesis and secretion
- Cushing syndrome
- Dopaminergic synapse
- Estrogen signaling pathway
- Glucagon signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human T
- Human cytomegalovirus infection
- Human papillomavirus infection
- Huntington disease
- Insulin resistance
- Insulin secretion
- Kaposi sarcoma
- Longevity regulating pathway
- Melanogenesis
- Osteoclast differentiation
- PI3K
- Parathyroid hormone synthesis, secretion and action
- Prion disease
- Prostate cancer
- Relaxin signaling pathway
- Renin secretion
- TNF signaling pathway
- Thermogenesis
- Thyroid hormone synthesis
- Tuberculosis
- Vasopressin
- Viral carcinogenesis
- cAMP signaling pathway
- cGMP
- ATF4-CREB1 transcription factor complex
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- Hsp70 protein binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- aging
- arrestin family protein binding
- axon
- axonogenesis
- cAMP response element binding
- cellular response to fatty acid
- cellular response to hepatocyte growth factor stimulus
- cellular response to insulin-like growth factor stimulus
- cellular response to leukemia inhibitory factor
- cellular response to nerve growth factor stimulus
- cellular response to platelet-derived growth factor stimulus
- cellular response to retinoic acid
- cellular response to zinc ion
- chemotaxis to arachidonic acid
- chromatin
- circadian rhythm
- enzyme binding
- euchromatin
- histone acetyltransferase binding
- identical protein binding
- lactation
- lung saccule development
- memory
- mitochondrial matrix
- negative regulation of gene expression
- negative regulation of inflammatory response to antigenic stimulus
- negative regulation of neuron death
- negative regulation of transcription by competitive promoter binding
- nucleoplasm
- nucleus
- pituitary gland development
- positive regulation of RNA polymerase II transcription preinitiation complex assembly
- positive regulation of apoptotic process
- positive regulation of cardiac muscle tissue development
- positive regulation of fat cell differentiation
- positive regulation of hormone secretion
- positive regulation of lipid biosynthetic process
- positive regulation of long-term synaptic potentiation
- positive regulation of multicellular organism growth
- positive regulation of osteoclast differentiation
- positive regulation of transcription by RNA polymerase II
- positive regulation of transcription, DNA-templated
- positive regulation of transforming growth factor beta3 production
- protein phosphorylation
- protein stabilization
- regulation of cell size
- regulation of circadian rhythm
- regulation of fibroblast proliferation
- regulation of glial cell proliferation
- regulation of transcription by RNA polymerase II
- response to L-glutamate
- response to activity
- response to glucagon
- response to hypoxia
- response to nicotine
- response to organic substance
- secretory granule organization
- sequence-specific double-stranded DNA binding
- signal transduction
- transcription by RNA polymerase II
- transcription regulator complex
- transforming growth factor beta receptor signaling pathway
- type I pneumocyte differentiation
- viral process
- visual learning

CTNND1
Human
Catenin delta-1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CTND1_HUMAN
- Accession #
-
O60716
- Protein names
-
- Catenin delta-1
- Cadherin-associated Src substrate
- CAS
- p120 catenin
- p120(ctn
- p120(cas
- Gene names
-
- CTNND1
- KIAA0384
- Description
-
Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:20371349}.
- Links
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Search Kinases of CTNND1 (Human)
- Schaffer collateral - CA1 synapse
- Wnt signaling pathway
- adherens junction
- adherens junction organization
- brain development
- cadherin binding
- catenin complex
- cell-cell adhesion
- cell-cell adhesion mediated by cadherin
- cell-cell junction
- cell-cell junction assembly
- cytoplasm
- cytosol
- dendritic spine
- entry of bacterium into host cell
- extracellular exosome
- glutamatergic synapse
- growth cone
- hippocampal mossy fiber to CA3 synapse
- lamellipodium
- midbody
- negative regulation of canonical Wnt signaling pathway
- nucleus
- plasma membrane
- postsynaptic density, intracellular component
- presynaptic active zone cytoplasmic component
- protein kinase binding
- protein stabilization
- regulation of postsynaptic membrane neurotransmitter receptor levels
- signaling receptor binding
- zonula adherens

FBXW7
Human
F-box/WD repeat-containing protein 7
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
FBXW7_HUMAN
- Accession #
-
Q969H0
- Protein names
-
- F-box/WD repeat-containing protein 7
- Archipelago homolog
- hAgo
- F-box and WD-40 domain-containing protein 7
- F-box protein FBX30
- SEL-10
- hCdc4
- Gene names
-
- FBXW7
- FBW7
- FBX30
- SEL10
- Description
-
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:22748924, PubMed:17434132, PubMed:26976582, PubMed:28727686). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923, PubMed:22748924, PubMed:29149593, PubMed:25775507, PubMed:28007894, PubMed:26976582, PubMed:28727686). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (By similarity). Involved in bone homeostasis and negative regulation of osteoclast differentiation (PubMed:29149593). Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination (PubMed:27238018). {ECO:0000250|UniProtKB:Q8VBV4, ECO:0000269|PubMed:11565034, ECO:0000269|PubMed:11585921, ECO:0000269|PubMed:14739463, ECO:0000269|PubMed:15103331, ECO:0000269|PubMed:17434132, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:22748924, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:26976582, ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:28007894, ECO:0000269|PubMed:28727686, ECO:0000269|PubMed:29149593, ECO:0000305|PubMed:12354302}.
- Links
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Search Kinases of FBXW7 (Human)
- Golgi apparatus
- Notch signaling pathway
- Parkin-FBXW7-Cul1 ubiquitin ligase complex
- SCF ubiquitin ligase complex
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- cellular response to DNA damage stimulus
- cellular response to UV
- cyclin binding
- cytoplasm
- cytosol
- endoplasmic reticulum
- identical protein binding
- lipid homeostasis
- lung development
- mitochondrion
- negative regulation of Notch signaling pathway
- negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
- negative regulation of SREBP signaling pathway
- negative regulation of gene expression
- negative regulation of hepatocyte proliferation
- negative regulation of osteoclast development
- negative regulation of triglyceride biosynthetic process
- nucleolus
- nucleoplasm
- nucleus
- perinuclear region of cytoplasm
- phosphothreonine residue binding
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of epidermal growth factor-activated receptor activity
- positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
- positive regulation of proteasomal protein catabolic process
- positive regulation of protein targeting to mitochondrion
- positive regulation of protein ubiquitination
- positive regulation of ubiquitin-dependent protein catabolic process
- positive regulation of ubiquitin-protein transferase activity
- post-translational protein modification
- proteasome-mediated ubiquitin-dependent protein catabolic process
- protein destabilization
- protein polyubiquitination
- protein stabilization
- protein ubiquitination
- protein-containing complex
- protein-macromolecule adaptor activity
- regulation of autophagy of mitochondrion
- regulation of cell cycle G1/S phase transition
- regulation of cell migration involved in sprouting angiogenesis
- regulation of circadian rhythm
- regulation of lipid storage
- regulation of protein localization
- rhythmic process
- sister chromatid cohesion
- ubiquitin binding
- ubiquitin protein ligase binding
- ubiquitin recycling
- ubiquitin-protein transferase activator activity
- vasculature development
- vasculogenesis
- viral process

FGFR1
Human
Fibroblast growth factor receptor 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
FGFR1_HUMAN
- Accession #
-
P11362
- Protein names
-
- Fibroblast growth factor receptor 1
- FGFR-1
- EC 2.7.10.1
- Basic fibroblast growth factor receptor 1
- BFGFR
- bFGF-R-1
- Fms-like tyrosine kinase 2
- FLT-2
- N-sam
- Proto-oncogene c-Fgr
- CD antigen CD331
- Gene names
-
- FGFR1
- BFGFR
- CEK
- FGFBR
- FLG
- FLT2
- HBGFR
- Description
-
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. {ECO:0000250|UniProtKB:P16092, ECO:0000269|PubMed:10830168, ECO:0000269|PubMed:11353842, ECO:0000269|PubMed:12181353, ECO:0000269|PubMed:1379697, ECO:0000269|PubMed:1379698, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19261810, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:20133753, ECO:0000269|PubMed:20139426, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:8622701, ECO:0000269|PubMed:8663044}.
- Links
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Search Kinases of FGFR1 (Human)
- Adherens junction
- Breast cancer
- Calcium signaling pathway
- Central carbon metabolism in cancer
- MAPK signaling pathway
- Melanoma
- PI3K
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Signaling pathways regulating pluripotency of stem cells
- Thermogenesis
- ATP binding
- MAPK cascade
- cell migration
- chordate embryonic development
- cytoplasmic vesicle
- cytosol
- epithelial to mesenchymal transition
- extracellular region
- fibroblast growth factor binding
- fibroblast growth factor receptor signaling pathway
- fibroblast growth factor-activated receptor activity
- heparin binding
- identical protein binding
- integral component of membrane
- integral component of plasma membrane
- multicellular organism development
- neuron migration
- nucleus
- peptidyl-tyrosine phosphorylation
- phosphatidylinositol-mediated signaling
- plasma membrane
- positive regulation of MAP kinase activity
- positive regulation of MAPK cascade
- positive regulation of blood vessel endothelial cell migration
- positive regulation of cell differentiation
- positive regulation of cell population proliferation
- positive regulation of endothelial cell chemotaxis to fibroblast growth factor
- positive regulation of kinase activity
- positive regulation of neuron differentiation
- positive regulation of phosphatidylinositol 3-kinase signaling
- positive regulation of phospholipase C activity
- positive regulation of phospholipase activity
- positive regulation of protein kinase B signaling
- positive regulation of vascular endothelial cell proliferation
- protein autophosphorylation
- protein homodimerization activity
- protein phosphorylation
- protein tyrosine kinase activity
- receptor complex
- receptor-receptor interaction
- regulation of cell differentiation
- regulation of extrinsic apoptotic signaling pathway in absence of ligand
- skeletal system development
- skeletal system morphogenesis
- transmembrane receptor protein tyrosine kinase activity
- transmembrane receptor protein tyrosine kinase signaling pathway

Gabrg2
Rat
GABA
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
Q6PW52_RAT
- Accession #
- Q6PW52
- Protein names
-
- GABA
- A
- Gamma-aminobutyric acid receptor subunit gamma-2
- Gene names
-
- Gabrg2
- rCG_33820
- Description
-
N/A
- Links
-
Search Kinases of Gabrg2 (Rat)
N/A
- GABA-A receptor activity
- GABA-A receptor complex
- GABA-ergic synapse
- GABA-gated chloride ion channel activity
- adult behavior
- axon
- cellular response to histamine
- chloride channel complex
- chloride transmembrane transport
- cytoplasmic vesicle membrane
- gamma-aminobutyric acid signaling pathway
- inhibitory synapse assembly
- integral component of plasma membrane
- post-embryonic development
- postsynaptic membrane
- transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

Gabrg2
Mouse
Gamma-aminobutyric acid receptor subunit gamma-2
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
GBRG2_MOUSE
- Accession #
-
P22723
- Protein names
-
- Gamma-aminobutyric acid receptor subunit gamma-2
- GABA(A
- Gene names
-
- Gabrg2
- Description
-
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:27129275). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:27129275). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (PubMed:27129275). The alpha1/beta2/gamma2 receptor, alpha2/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (PubMed:27129275). Functions also as histamine receptor and mediates cellular responses to histamine (PubMed:18281286). {ECO:0000269|PubMed:18281286, ECO:0000269|PubMed:27129275}.
- Links
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Search Kinases of Gabrg2 (Mouse)
- GABA receptor complex
- GABA-A receptor activity
- GABA-A receptor complex
- GABA-ergic synapse
- GABA-gated chloride ion channel activity
- adult behavior
- axon
- cellular response to histamine
- chemical synaptic transmission
- chloride channel activity
- chloride channel complex
- chloride transmembrane transport
- cytoplasm
- cytoplasmic vesicle membrane
- dendrite membrane
- gamma-aminobutyric acid signaling pathway
- glutamatergic synapse
- inhibitory extracellular ligand-gated ion channel activity
- inhibitory synapse
- inhibitory synapse assembly
- integral component of plasma membrane
- integral component of postsynaptic specialization membrane
- ion transmembrane transport
- nervous system process
- neuron projection
- neurotransmitter receptor activity
- post-embryonic development
- postsynapse
- regulation of membrane potential
- regulation of postsynaptic membrane potential
- signal transduction
- synapse
- synaptic transmission, GABAergic
- transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

Gja1
Rat
Gap junction alpha-1 protein
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
CXA1_RAT
- Accession #
-
P08050
- Protein names
-
- Gap junction alpha-1 protein
- Connexin-43
- Cx43
- Gap junction 43 kDa heart protein
- Gene names
-
- Gja1
- Cxn-43
- Description
-
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization (PubMed:15181016). Plays an essential role in gap junction communication in the ventricles (By similarity). {ECO:0000250|UniProtKB:P23242, ECO:0000269|PubMed:15181016}.
- Links
-
Search Kinases of Gja1 (Rat)
- ATP transport
- Golgi apparatus
- Golgi membrane
- Golgi-associated vesicle membrane
- PDZ domain binding
- SH3 domain binding
- T cell activation
- T cell proliferation
- adult heart development
- apical plasma membrane
- apoptotic process
- atrial ventricular junction remodeling
- beta-catenin binding
- beta-tubulin binding
- blood vessel morphogenesis
- bone development
- bone remodeling
- cardiac conduction
- cell communication
- cell communication by chemical coupling
- cell communication by electrical coupling
- cell junction
- cell-cell contact zone
- cell-cell junction
- cell-cell junction organization
- cell-cell signaling
- cellular protein localization
- cellular response to amyloid-beta
- cellular response to mechanical stimulus
- cellular response to pH
- cellular response to parathyroid hormone stimulus
- chronic inflammatory response
- connexin binding
- connexin complex
- contractile fiber
- cytoplasm
- cytosol
- decidualization
- disordered domain specific binding
- early endosome
- efflux transmembrane transporter activity
- embryonic digit morphogenesis
- embryonic heart tube development
- endoplasmic reticulum membrane
- endosome
- endothelium development
- epididymis development
- epithelial cell maturation
- establishment of mitotic spindle orientation
- export across plasma membrane
- fascia adherens
- gap junction
- gap junction assembly
- gap junction channel activity
- gap junction channel activity involved in cell communication by electrical coupling
- gap junction hemi-channel activity
- glutamate secretion
- glutathione transmembrane transporter activity
- heart development
- heart looping
- in utero embryonic development
- integral component of plasma membrane
- intercalated disc
- intermediate filament
- ion transmembrane transport
- ion transmembrane transporter activity
- late endosome
- lateral plasma membrane
- lens development in camera-type eye
- lysosome
- maintenance of protein localization in endoplasmic reticulum
- male gonad development
- membrane
- membrane raft
- microtubule-based transport
- milk ejection reflex
- mitochondrial outer membrane
- mitochondrion
- multivesicular body
- negative regulation of DNA biosynthetic process
- negative regulation of cardiac muscle cell proliferation
- negative regulation of cell growth
- negative regulation of cell population proliferation
- negative regulation of endothelial cell proliferation
- negative regulation of gene expression
- negative regulation of gonadotropin secretion
- negative regulation of trophoblast cell migration
- negative regulation of wound healing
- neuron migration
- neuron projection morphogenesis
- nucleoplasm
- osteoblast differentiation
- plasma membrane
- positive regulation of behavioral fear response
- positive regulation of cell communication by chemical coupling
- positive regulation of cold-induced thermogenesis
- positive regulation of cytosolic calcium ion concentration
- positive regulation of gene expression
- positive regulation of glomerular filtration
- positive regulation of insulin secretion
- positive regulation of mesodermal cell differentiation
- positive regulation of morphogenesis of an epithelium
- positive regulation of protein catabolic process
- positive regulation of stem cell proliferation
- positive regulation of striated muscle tissue development
- positive regulation of vascular associated smooth muscle cell proliferation
- positive regulation of vasoconstriction
- protein domain specific binding
- protein tyrosine kinase binding
- protein-containing complex
- regulation of apoptotic process
- regulation of atrial cardiac muscle cell membrane depolarization
- regulation of bicellular tight junction assembly
- regulation of bone mineralization
- regulation of bone remodeling
- regulation of calcium ion transport
- regulation of cell communication by electrical coupling
- regulation of heart contraction
- regulation of transmembrane transporter activity
- regulation of ventricular cardiac muscle cell membrane depolarization
- regulation of ventricular cardiac muscle cell membrane repolarization
- response to estradiol
- response to fluid shear stress
- response to glucose
- response to ischemia
- response to lipopolysaccharide
- response to pH
- response to peptide hormone
- response to retinoic acid
- scaffold protein binding
- signal transduction
- signaling receptor binding
- skeletal muscle tissue regeneration
- spermatogenesis
- tight junction
- transmembrane transport
- tubulin binding
- vascular transport
- xenobiotic transport

GJA1
Human
Gap junction alpha-1 protein
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CXA1_HUMAN
- Accession #
-
P17302
- Protein names
-
- Gap junction alpha-1 protein
- Connexin-43
- Cx43
- Gap junction 43 kDa heart protein
- Gene names
-
- GJA1
- GJAL
- Description
-
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). {ECO:0000250|UniProtKB:P08050, ECO:0000250|UniProtKB:P23242}.
- Links
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Search Kinases of GJA1 (Human)
- ATP transport
- Golgi apparatus
- Golgi membrane
- Golgi-associated vesicle membrane
- PDZ domain binding
- SH3 domain binding
- alpha-tubulin binding
- apical plasma membrane
- apoptotic process
- atrial cardiac muscle cell action potential
- beta-catenin binding
- bone development
- bone remodeling
- cardiac conduction system development
- cell communication by electrical coupling
- cell communication by electrical coupling involved in cardiac conduction
- cell junction
- cell-cell contact zone
- cell-cell signaling
- cellular protein localization
- cellular response to amyloid-beta
- cellular response to mechanical stimulus
- cellular response to parathyroid hormone stimulus
- chronic inflammatory response
- connexin binding
- connexin complex
- cytoplasm
- decidualization
- disordered domain specific binding
- early endosome
- efflux transmembrane transporter activity
- endoplasmic reticulum membrane
- endothelium development
- epididymis development
- establishment of mitotic spindle orientation
- export across plasma membrane
- fascia adherens
- focal adhesion
- gap junction
- gap junction assembly
- gap junction channel activity
- gap junction channel activity involved in cardiac conduction electrical coupling
- gap junction channel activity involved in cell communication by electrical coupling
- gap junction hemi-channel activity
- glutamate secretion
- glutathione transmembrane transporter activity
- integral component of plasma membrane
- intercalated disc
- intracellular membrane-bounded organelle
- ion transmembrane transport
- ion transmembrane transporter activity
- lysosome
- maintenance of blood-brain barrier
- maintenance of protein localization in endoplasmic reticulum
- membrane raft
- microtubule-based transport
- mitochondrial outer membrane
- mitochondrion
- multivesicular body
- negative regulation of DNA biosynthetic process
- negative regulation of cardiac muscle cell proliferation
- negative regulation of cell growth
- negative regulation of endothelial cell proliferation
- negative regulation of gonadotropin secretion
- negative regulation of trophoblast cell migration
- negative regulation of wound healing
- neuron projection morphogenesis
- nucleoplasm
- nucleus
- plasma membrane
- positive regulation of I-kappaB kinase/NF-kappaB signaling
- positive regulation of behavioral fear response
- positive regulation of cell communication by chemical coupling
- positive regulation of cold-induced thermogenesis
- positive regulation of cytosolic calcium ion concentration
- positive regulation of gene expression
- positive regulation of glomerular filtration
- positive regulation of insulin secretion
- positive regulation of mesodermal cell differentiation
- positive regulation of morphogenesis of an epithelium
- positive regulation of protein catabolic process
- positive regulation of stem cell proliferation
- positive regulation of vascular associated smooth muscle cell proliferation
- positive regulation of vasoconstriction
- regulation of apoptotic process
- regulation of bicellular tight junction assembly
- regulation of calcium ion transport
- regulation of cell communication by electrical coupling
- regulation of transmembrane transporter activity
- response to estradiol
- response to fluid shear stress
- response to glucose
- response to ischemia
- response to lipopolysaccharide
- response to pH
- response to peptide hormone
- response to retinoic acid
- signal transduction
- spermatogenesis
- tight junction
- tubulin binding
- vascular transport
- xenobiotic transport

GNAI2
Human
Guanine nucleotide-binding protein G
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
GNAI2_HUMAN
- Accession #
-
P04899
- Protein names
-
- Guanine nucleotide-binding protein G
- i
- Adenylate cyclase-inhibiting G alpha protein
- Gene names
-
- GNAI2
- GNAI2B
- Description
-
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. {ECO:0000269|PubMed:17635935}.; [Isoform sGi2]: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. {ECO:0000269|PubMed:17550964}.
- Links
-
Search Kinases of GNAI2 (Human)
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Apelin signaling pathway
- Axon guidance
- Chagas disease
- Chemical carcinogenesis
- Chemokine signaling pathway
- Cholinergic synapse
- Circadian entrainment
- Cocaine addiction
- Cushing syndrome
- Dopaminergic synapse
- Estrogen signaling pathway
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glutamatergic synapse
- Growth hormone synthesis, secretion and action
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Leukocyte transendothelial migration
- Long
- Melanogenesis
- Morphine addiction
- Oxytocin signaling pathway
- Parathyroid hormone synthesis, secretion and action
- Parkinson disease
- Pathways in cancer
- Pertussis
- Platelet activation
- Progesterone
- Rap1 signaling pathway
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renin secretion
- Retrograde endocannabinoid signaling
- Serotonergic synapse
- Sphingolipid signaling pathway
- Toxoplasmosis
- cAMP signaling pathway
- cGMP
- G protein-coupled acetylcholine receptor signaling pathway
- G protein-coupled adenosine receptor signaling pathway
- G protein-coupled receptor binding
- G protein-coupled receptor signaling pathway
- G-protein beta/gamma-subunit complex binding
- GTP binding
- GTPase activity
- adenylate cyclase-activating G protein-coupled receptor signaling pathway
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway
- cell body
- cell cycle
- cell division
- cell population proliferation
- centrosome
- cytoplasm
- cytosol
- dendrite
- extracellular exosome
- extracellular vesicle
- gamma-aminobutyric acid signaling pathway
- heterotrimeric G-protein complex
- membrane
- membrane raft
- metal ion binding
- midbody
- negative regulation of adenylate cyclase activity
- negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
- negative regulation of apoptotic signaling pathway
- negative regulation of calcium ion-dependent exocytosis
- negative regulation of protein tyrosine phosphatase activity
- negative regulation of synaptic transmission
- nucleoplasm
- plasma membrane
- platelet activation
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of NAD(P)H oxidase activity
- positive regulation of cell migration
- positive regulation of cell population proliferation
- positive regulation of insulin receptor signaling pathway
- positive regulation of neural precursor cell proliferation
- positive regulation of renal sodium excretion
- positive regulation of superoxide anion generation
- positive regulation of urine volume
- positive regulation of vascular associated smooth muscle cell proliferation
- protein folding
- regulation of calcium ion transport
- response to nutrient
- signal transduction
- synapse

Gng12
Mouse
Guanine nucleotide-binding protein G
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
GBG12_MOUSE
- Accession #
-
Q9DAS9
- Protein names
-
- Guanine nucleotide-binding protein G
- I
- S
- O
- Gene names
-
- Gng12
- Description
-
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
- Links
-
Search Kinases of Gng12 (Mouse)
- Alcoholism
- Apelin signaling pathway
- Chemokine signaling pathway
- Cholinergic synapse
- Circadian entrainment
- Dopaminergic synapse
- GABAergic synapse
- Glutamatergic synapse
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Kaposi sarcoma
- MAPK signaling pathway
- Morphine addiction
- PI3K
- Pathways in cancer
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Serotonergic synapse

IQGAP1
Human
Ras GTPase-activating-like protein IQGAP1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
IQGA1_HUMAN
- Accession #
-
P46940
- Protein names
-
- Ras GTPase-activating-like protein IQGAP1
- p195
- Gene names
-
- IQGAP1
- KIAA0051
- Description
-
Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}.
- Links
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Search Kinases of IQGAP1 (Human)
- GTPase activator activity
- GTPase inhibitor activity
- MAP-kinase scaffold activity
- S100 protein binding
- actin filament
- actin filament binding
- axon
- cadherin binding
- calcium ion binding
- calmodulin binding
- cell migration
- cellular response to calcium ion
- cellular response to epidermal growth factor stimulus
- cytoplasm
- cytoplasmic ribonucleoprotein granule
- cytosol
- epidermal growth factor receptor signaling pathway
- extracellular exosome
- extrinsic component of cytoplasmic side of plasma membrane
- focal adhesion
- glomerular visceral epithelial cell development
- growth cone
- membrane raft
- microtubule
- midbody
- mitogen-activated protein kinase binding
- molecular adaptor activity
- neuron projection
- neuron projection extension
- neutrophil degranulation
- nucleus
- phosphatidylinositol-3,4,5-trisphosphate binding
- plasma membrane
- positive regulation of MAP kinase activity
- positive regulation of MAPK cascade
- positive regulation of dendrite development
- positive regulation of focal adhesion assembly
- positive regulation of peptidyl-tyrosine autophosphorylation
- positive regulation of protein kinase activity
- positive regulation of protein localization
- positive regulation of vascular associated smooth muscle cell migration
- protein domain specific binding
- protein kinase binding
- protein phosphatase binding
- protein serine/threonine kinase activator activity
- protein-containing complex
- regulation of actin cytoskeleton organization
- regulation of mitotic cell cycle
- response to angiotensin
- ruffle
- secretory granule membrane
- signal transduction
- slit diaphragm
- small GTPase binding
- viral process

Irs1
Mouse
Insulin receptor substrate 1
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
IRS1_MOUSE
- Accession #
-
P35569
- Protein names
-
- Insulin receptor substrate 1
- IRS-1
- Gene names
-
- Irs1
- Irs-1
- Description
-
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). {ECO:0000250}.
- Links
-
Search Kinases of Irs1 (Mouse)
- AMPK signaling pathway
- Adipocytokine signaling pathway
- Aldosterone
- Alzheimer disease
- Autophagy
- Diabetic cardiomyopathy
- FoxO signaling pathway
- Growth hormone synthesis, secretion and action
- Insulin resistance
- Insulin signaling pathway
- Longevity regulating pathway
- MicroRNAs in cancer
- Neurotrophin signaling pathway
- Non
- PI3K
- Regulation of lipolysis in adipocytes
- Type II diabetes mellitus
- cGMP
- mTOR signaling pathway
- SH2 domain binding
- caveola
- cellular response to fatty acid
- cellular response to insulin stimulus
- ciliary basal body
- cytoplasm
- cytosol
- insulin receptor binding
- insulin receptor complex
- insulin receptor signaling pathway
- insulin-like growth factor receptor binding
- insulin-like growth factor receptor signaling pathway
- intracellular membrane-bounded organelle
- lipid catabolic process
- mammary gland development
- negative regulation of insulin receptor signaling pathway
- negative regulation of insulin secretion
- negative regulation of somatostatin secretion
- nucleoplasm
- nucleus
- phosphatidylinositol 3-kinase binding
- phosphatidylinositol 3-kinase signaling
- phosphotyrosine residue binding
- plasma membrane
- positive regulation of cell migration
- positive regulation of fatty acid beta-oxidation
- positive regulation of glucagon secretion
- positive regulation of glucose import
- positive regulation of glucose metabolic process
- positive regulation of glycogen biosynthetic process
- positive regulation of insulin receptor signaling pathway
- positive regulation of mesenchymal cell proliferation
- positive regulation of phosphatidylinositol 3-kinase activity
- positive regulation of phosphorylation
- protein domain specific binding
- protein kinase B signaling
- protein kinase C binding
- protein kinase binding
- protein localization to nucleus
- protein-containing complex binding
- regulation of gene expression
- response to caffeine
- response to insulin
- response to peptide hormone
- signaling receptor complex adaptor activity
- transmembrane receptor protein tyrosine kinase adaptor activity
