KANPHOS_Str

Search Results (149 substrates found)

Displaying 1 - 20 of 149 Items
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Gene name
Organism
Protein name
abcf-3
Nematode
Protein ABCF-3
Substrate Information
Organism
Nematode (Caenorhabditis elegans)
Uniprot ID
Q20306_CAEEL
Accession #
Q20306
Protein names
  • Protein ABCF-3
Gene names
  • abcf-3
  • CELE_F42A10.1
  • F42A10.1
Description
N/A
Links

Search Kinases of abcf-3 (Nematode)
KEGG Pathways (0)
N/A
Gene Ontology Terms (2)
Phosphorylation Site Information
abts-1
Nematode
Protein ABTS-1, isoform c
Substrate Information
Organism
Nematode (Caenorhabditis elegans)
Uniprot ID
B3WFV9_CAEEL
Accession #
B3WFV9
Protein names
  • Protein ABTS-1, isoform c
Gene names
  • abts-1
  • CELE_F52B5.1
  • F52B5.1
Description
N/A
Links

Search Kinases of abts-1 (Nematode)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
ADAM17
Human
Disintegrin and metalloproteinase domain-containing protein 17
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ADA17_HUMAN
Accession #
P78536
Protein names
  • Disintegrin and metalloproteinase domain-containing protein 17
  • ADAM 17
  • EC 3.4.24.86
  • Snake venom-like protease
  • TNF-alpha convertase
  • TNF-alpha-converting enzyme
  • CD antigen CD156b
Gene names
  • ADAM17
  • CSVP
  • TACE
Description
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
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Search Kinases of ADAM17 (Human)
Gene Ontology Terms (57)
Phosphorylation Site Information
ADAP1
Human
Arf-GAP with dual PH domain-containing protein 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ADAP1_HUMAN
Accession #
O75689
Protein names
  • Arf-GAP with dual PH domain-containing protein 1
  • Centaurin-alpha-1
  • Cnt-a1
  • Putative MAPK-activating protein PM25
Gene names
  • ADAP1
  • CENTA1
Description
GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).
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Search Kinases of ADAP1 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
agef-1
Nematode
Protein AGEF-1, isoform a
Substrate Information
Organism
Nematode (Caenorhabditis elegans)
Uniprot ID
G5EFH7_CAEEL
Accession #
G5EFH7
Protein names
  • Protein AGEF-1, isoform a
Gene names
  • agef-1
  • CELE_Y6B3A.1
  • Y6B3A.1
Description
N/A
Links

Search Kinases of agef-1 (Nematode)
KEGG Pathways (1)
Phosphorylation Site Information
Aicda
Mouse
Single-stranded DNA cytosine deaminase
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
AICDA_MOUSE
Accession #
Q9WVE0
Protein names
  • Single-stranded DNA cytosine deaminase
  • EC 3.5.4.38
  • Activation-induced cytidine deaminase
  • Cytidine aminohydrolase
Gene names
  • Aicda
  • Aid
Description
Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
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Search Kinases of Aicda (Mouse)
Phosphorylation Site Information
Akt1
Rat
RAC-alpha serine/threonine-protein kinase
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
AKT1_RAT
Accession #
P47196
Protein names
  • RAC-alpha serine/threonine-protein kinase
  • EC 2.7.11.1
  • Protein kinase B
  • PKB
  • Protein kinase B alpha
  • PKB alpha
  • RAC-PK-alpha
Gene names
  • Akt1
Description
AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development. Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation. Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation (By similarity). Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity. Phosphorylation of BAD stimulates its pro-apoptotic activity (By similarity). Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53 (By similarity).AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation.
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Search Kinases of Akt1 (Rat)
KEGG Pathways (61)
Gene Ontology Terms (86)
Phosphorylation Site Information
ATF2
Human
Cyclic AMP-dependent transcription factor ATF-2
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ATF2_HUMAN
Accession #
P15336
Protein names
  • Cyclic AMP-dependent transcription factor ATF-2
  • cAMP-dependent transcription factor ATF-2
  • EC 2.3.1.48
  • Activating transcription factor 2
  • Cyclic AMP-responsive element-binding protein 2
  • CREB-2
  • cAMP-responsive element-binding protein 2
  • HB16
  • Histone acetyltransferase ATF2
  • cAMP response element-binding protein CRE-BP1
Gene names
  • ATF2
  • CREB2
  • CREBP1
Description
Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.
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Search Kinases of ATF2 (Human)
Gene Ontology Terms (48)
Phosphorylation Site Information
B0334.3
Nematode
Protein B0334.3, isoform a
Substrate Information
Organism
Nematode (Caenorhabditis elegans)
Uniprot ID
Q17474_CAEEL
Accession #
Q17474
Protein names
  • Protein B0334.3, isoform a
Gene names
  • B0334.3
  • CELE_B0334.3
Description
N/A
Links

Search Kinases of B0334.3 (Nematode)
KEGG Pathways (1)
Phosphorylation Site Information
BAD
Human
Bcl2-associated agonist of cell death
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
BAD_HUMAN
Accession #
Q92934
Protein names
  • Bcl2-associated agonist of cell death
  • BAD
  • Bcl-2-binding component 6
  • Bcl-2-like protein 8
  • Bcl2-L-8
  • Bcl-xL/Bcl-2-associated death promoter
  • Bcl2 antagonist of cell death
Gene names
  • BAD
  • BBC6
  • BCL2L8
Description
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
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Search Kinases of BAD (Human)
Gene Ontology Terms (67)
Phosphorylation Site Information
C17G10.1
Nematode
Protein C17G10.1
Substrate Information
Organism
Nematode (Caenorhabditis elegans)
Uniprot ID
Q09973_CAEEL
Accession #
Q09973
Protein names
  • Protein C17G10.1
Gene names
  • C17G10.1
  • CELE_C17G10.1
Description
N/A
Links

Search Kinases of C17G10.1 (Nematode)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
C28H8.3
Nematode
Uncharacterized helicase C28H8.3
Substrate Information
Organism
Nematode (Caenorhabditis elegans)
Uniprot ID
YP93_CAEEL
Accession #
Q09475
Protein names
  • Uncharacterized helicase C28H8.3
  • EC 3.6.4.-
Gene names
  • C28H8.3
Description
N/A
Links

Search Kinases of C28H8.3 (Nematode)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
C44B7.10
Nematode
Protein C44B7.10
Substrate Information
Organism
Nematode (Caenorhabditis elegans)
Uniprot ID
Q18599_CAEEL
Accession #
Q18599
Protein names
  • Protein C44B7.10
Gene names
  • C44B7.10
  • CELE_C44B7.10
Description
N/A
Links

Search Kinases of C44B7.10 (Nematode)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
C46G7.2
Nematode
Protein C46G7.2
Substrate Information
Organism
Nematode (Caenorhabditis elegans)
Uniprot ID
O02141_CAEEL
Accession #
O02141
Protein names
  • Protein C46G7.2
Gene names
  • C46G7.2
  • CELE_C46G7.2
Description
N/A
Links

Search Kinases of C46G7.2 (Nematode)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Cacna1b
Rat
Voltage-dependent N-type calcium channel subunit alpha-1B
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
CAC1B_RAT
Accession #
Q02294
Protein names
  • Voltage-dependent N-type calcium channel subunit alpha-1B
  • Brain calcium channel III
  • BIII
  • Calcium channel, L type, alpha-1 polypeptide isoform 5
  • Voltage-gated calcium channel subunit alpha Cav2.2
Gene names
  • Cacna1b
  • Cach5
  • Cacnl1a5
Description
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.
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Search Kinases of Cacna1b (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Cacna1d
Rat
Voltage-dependent L-type calcium channel subunit alpha-1D
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
CAC1D_RAT
Accession #
P27732
Protein names
  • Voltage-dependent L-type calcium channel subunit alpha-1D
  • Calcium channel, L type, alpha-1 polypeptide, isoform 2
  • Rat brain class D
  • RBD
  • Voltage-gated calcium channel subunit alpha Cav1.3
Gene names
  • Cacna1d
  • Cach3
  • Cacn4
  • Cacnl1a2
  • Cchl1a2
Description
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
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Search Kinases of Cacna1d (Rat)
Phosphorylation Site Information
cct-1
Nematode
T-complex protein 1 subunit alpha
Substrate Information
Organism
Nematode (Caenorhabditis elegans)
Uniprot ID
TCPA_CAEEL
Accession #
P41988
Protein names
  • T-complex protein 1 subunit alpha
  • TCP-1-alpha
  • CCT-alpha
Gene names
  • cct-1
  • tcp-1
  • T05C12.7
Description
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.
Links

Search Kinases of cct-1 (Nematode)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Cdyl
Rat
Chromodomain Y-like protein
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
CDYL_RAT
Accession #
Q6AYK9
Protein names
  • Chromodomain Y-like protein
  • CDY-like
  • EC 2.3.1.48
Gene names
  • Cdyl
Description
Acts as a RE1-silencing transcription factor (REST) corepressor that facilitates histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Required for chromatin targeting and maximal enzymatic activity of polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes. Has histone acetyltransferase activity. May play a role in histone hyperacetylation during spermatid maturation (By similarity).
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Search Kinases of Cdyl (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
CELE_D2045.2
Nematode
Protein D2045.2
Substrate Information
Organism
Nematode (Caenorhabditis elegans)
Uniprot ID
Q18983_CAEEL
Accession #
Q18983
Protein names
  • Protein D2045.2
Gene names
  • CELE_D2045.2
  • D2045.2
Description
N/A
Links

Search Kinases of CELE_D2045.2 (Nematode)
KEGG Pathways (0)
N/A
Gene Ontology Terms (0)
N/A
Phosphorylation Site Information
CELE_F32B5.1
Nematode
Protein F32B5.1
Substrate Information
Organism
Nematode (Caenorhabditis elegans)
Uniprot ID
O01854_CAEEL
Accession #
O01854
Protein names
  • Protein F32B5.1
Gene names
  • CELE_F32B5.1
  • F32B5.1
Description
N/A
Links

Search Kinases of CELE_F32B5.1 (Nematode)
KEGG Pathways (0)
N/A
Gene Ontology Terms (2)
Phosphorylation Site Information
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