KANPHOS_Str

Search Results (51 substrates found)

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Gene name
Organism
Protein name
ADAM17
Human
Disintegrin and metalloproteinase domain-containing protein 17
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ADA17_HUMAN
Accession #
P78536
Protein names
  • Disintegrin and metalloproteinase domain-containing protein 17
  • ADAM 17
  • EC 3.4.24.86
  • Snake venom-like protease
  • TNF-alpha convertase
  • TNF-alpha-converting enzyme
  • CD antigen CD156b
Gene names
  • ADAM17
  • CSVP
  • TACE
Description
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:12441351). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (PubMed:26876177, PubMed:28060820). {ECO:0000250|UniProtKB:Q9Z0F8, ECO:0000269|PubMed:12441351, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:24226769, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:28060820, ECO:0000269|PubMed:9034191}.
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Search Kinases of ADAM17 (Human)
Gene Ontology Terms (64)
Phosphorylation Site Information
ADAP1
Human
Arf-GAP with dual PH domain-containing protein 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ADAP1_HUMAN
Accession #
O75689
Protein names
  • Arf-GAP with dual PH domain-containing protein 1
  • Centaurin-alpha-1
  • Cnt-a1
  • Putative MAPK-activating protein PM25
Gene names
  • ADAP1
  • CENTA1
Description
GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). {ECO:0000269|PubMed:10448098, ECO:0000303|PubMed:10333475, ECO:0000305}.
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Search Kinases of ADAP1 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Aicda
Mouse
Single-stranded DNA cytosine deaminase
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
AICDA_MOUSE
Accession #
Q9WVE0
Protein names
  • Single-stranded DNA cytosine deaminase
  • EC 3.5.4.38
  • Activation-induced cytidine deaminase
  • AID
  • Cytidine aminohydrolase
Gene names
  • Aicda
  • Aid
Description
Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. {ECO:0000269|PubMed:12692563, ECO:0000269|PubMed:23803409}.
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Search Kinases of Aicda (Mouse)
Phosphorylation Site Information
Akt1
Rat
RAC-alpha serine/threonine-protein kinase
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
AKT1_RAT
Accession #
P47196
Protein names
  • RAC-alpha serine/threonine-protein kinase
  • EC 2.7.11.1
  • Protein kinase B
  • PKB
  • Protein kinase B alpha
  • PKB alpha
  • RAC-PK-alpha
Gene names
  • Akt1
Description
AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis (PubMed:11882383, PubMed:21620960, PubMed:21432781). This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates (PubMed:11882383, PubMed:21620960, PubMed:21432781). Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported (PubMed:11882383, PubMed:21620960, PubMed:21432781). AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface (PubMed:9632753, PubMed:10400692). Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling (By similarity). Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport (By similarity). AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven (By similarity). AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1 (By similarity). AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis (PubMed:12107176). Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis (By similarity). Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity (PubMed:15546921). The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth (By similarity). AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I) (By similarity). AKT mediates the antiapoptotic effects of IGF-I (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (By similarity). May be involved in the regulation of the placental development (By similarity). Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation. Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation. Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity. Phosphorylation of BAD stimulates its pro-apoptotic activity. Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53. Phosphorylates palladin (PALLD), modulating cytoskeletal organization and cell motility. Phosphorylates prohibitin (PHB), playing an important role in cell metabolism and proliferation. Phosphorylates CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation (By similarity). Phosphorylates PCK1 at 'Ser-90', reducing the binding affinity of PCK1 to oxaloacetate and changing PCK1 into an atypical protein kinase activity using GTP as donor (By similarity). Also acts as an activator of TMEM175 potassium channel activity in response to growth factors: forms the lysoK(GF) complex together with TMEM175 and acts by promoting TMEM175 channel activation, independently of its protein kinase activity (By similarity). {ECO:0000250|UniProtKB:P31749, ECO:0000250|UniProtKB:P31750, ECO:0000269|PubMed:10400692, ECO:0000269|PubMed:12107176, ECO:0000269|PubMed:15546921, ECO:0000269|PubMed:9632753, ECO:0000303|PubMed:11882383, ECO:0000303|PubMed:21432781, ECO:0000303|PubMed:21620960}.
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Search Kinases of Akt1 (Rat)
KEGG Pathways (95)
Gene Ontology Terms (162)
Phosphorylation Site Information
ATF2
Human
Cyclic AMP-dependent transcription factor ATF-2
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ATF2_HUMAN
Accession #
P15336
Protein names
  • Cyclic AMP-dependent transcription factor ATF-2
  • cAMP-dependent transcription factor ATF-2
  • Activating transcription factor 2
  • Cyclic AMP-responsive element-binding protein 2
  • CREB-2
  • cAMP-responsive element-binding protein 2
  • HB16
  • cAMP response element-binding protein CRE-BP1
Gene names
  • ATF2
  • CREB2
  • CREBP1
Description
Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro (PubMed:10821277). In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. {ECO:0000269|PubMed:10821277, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:18397884, ECO:0000269|PubMed:22304920}.
Links

Search Kinases of ATF2 (Human)
Gene Ontology Terms (46)
Phosphorylation Site Information
BAD
Human
Bcl2-associated agonist of cell death
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
BAD_HUMAN
Accession #
Q92934
Protein names
  • Bcl2-associated agonist of cell death
  • BAD
  • Bcl-2-binding component 6
  • Bcl-2-like protein 8
  • Bcl2-L-8
  • Bcl-xL/Bcl-2-associated death promoter
  • Bcl2 antagonist of cell death
Gene names
  • BAD
  • BBC6
  • BCL2L8
Description
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. {ECO:0000250}.
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Search Kinases of BAD (Human)
Gene Ontology Terms (67)
Phosphorylation Site Information
Cacna1b
Rat
Voltage-dependent N-type calcium channel subunit alpha-1B
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
CAC1B_RAT
Accession #
Q02294
Protein names
  • Voltage-dependent N-type calcium channel subunit alpha-1B
  • Brain calcium channel III
  • BIII
  • Calcium channel, L type, alpha-1 polypeptide isoform 5
  • Voltage-gated calcium channel subunit alpha Cav2.2
Gene names
  • Cacna1b
  • Cach5
  • Cacnl1a5
Description
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (PubMed:1317580). They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. {ECO:0000269|PubMed:1317580}.
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Search Kinases of Cacna1b (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Cacna1d
Rat
Voltage-dependent L-type calcium channel subunit alpha-1D
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
CAC1D_RAT
Accession #
P27732
Protein names
  • Voltage-dependent L-type calcium channel subunit alpha-1D
  • Calcium channel, L type, alpha-1 polypeptide, isoform 2
  • Rat brain class D
  • RBD
  • Voltage-gated calcium channel subunit alpha Cav1.3
Gene names
  • Cacna1d
  • Cach3
  • Cacn4
  • Cacnl1a2
  • Cchl1a2
Description
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. {ECO:0000269|PubMed:17050707}.
Links

Search Kinases of Cacna1d (Rat)
KEGG Pathways (0)
N/A
Gene Ontology Terms (49)
Phosphorylation Site Information
CREB1
Human
Cyclic AMP-responsive element-binding protein 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CREB1_HUMAN
Accession #
P16220
Protein names
  • Cyclic AMP-responsive element-binding protein 1
  • CREB-1
  • cAMP-responsive element-binding protein 1
Gene names
  • CREB1
Description
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
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Search Kinases of CREB1 (Human)
Gene Ontology Terms (71)
Phosphorylation Site Information
CTNND1
Human
Catenin delta-1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CTND1_HUMAN
Accession #
O60716
Protein names
  • Catenin delta-1
  • Cadherin-associated Src substrate
  • CAS
  • p120 catenin
  • p120(ctn
  • p120(cas
Gene names
  • CTNND1
  • KIAA0384
Description
Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476). {ECO:0000269|PubMed:10207085, ECO:0000269|PubMed:14610055, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:20371349}.
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Search Kinases of CTNND1 (Human)
Phosphorylation Site Information
FBXW7
Human
F-box/WD repeat-containing protein 7
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
FBXW7_HUMAN
Accession #
Q969H0
Protein names
  • F-box/WD repeat-containing protein 7
  • Archipelago homolog
  • hAgo
  • F-box and WD-40 domain-containing protein 7
  • F-box protein FBX30
  • SEL-10
  • hCdc4
Gene names
  • FBXW7
  • FBW7
  • FBX30
  • SEL10
Description
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:22748924, PubMed:17434132, PubMed:26976582, PubMed:28727686). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923, PubMed:22748924, PubMed:29149593, PubMed:25775507, PubMed:28007894, PubMed:26976582, PubMed:28727686). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (By similarity). Involved in bone homeostasis and negative regulation of osteoclast differentiation (PubMed:29149593). Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination (PubMed:27238018). {ECO:0000250|UniProtKB:Q8VBV4, ECO:0000269|PubMed:11565034, ECO:0000269|PubMed:11585921, ECO:0000269|PubMed:14739463, ECO:0000269|PubMed:15103331, ECO:0000269|PubMed:17434132, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:22748924, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:26976582, ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:28007894, ECO:0000269|PubMed:28727686, ECO:0000269|PubMed:29149593, ECO:0000305|PubMed:12354302}.
Links

Search Kinases of FBXW7 (Human)
Gene Ontology Terms (58)
Phosphorylation Site Information
FGFR1
Human
Fibroblast growth factor receptor 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
FGFR1_HUMAN
Accession #
P11362
Protein names
  • Fibroblast growth factor receptor 1
  • FGFR-1
  • EC 2.7.10.1
  • Basic fibroblast growth factor receptor 1
  • BFGFR
  • bFGF-R-1
  • Fms-like tyrosine kinase 2
  • FLT-2
  • N-sam
  • Proto-oncogene c-Fgr
  • CD antigen CD331
Gene names
  • FGFR1
  • BFGFR
  • CEK
  • FGFBR
  • FLG
  • FLT2
  • HBGFR
Description
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. {ECO:0000250|UniProtKB:P16092, ECO:0000269|PubMed:10830168, ECO:0000269|PubMed:11353842, ECO:0000269|PubMed:12181353, ECO:0000269|PubMed:1379697, ECO:0000269|PubMed:1379698, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19261810, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:20133753, ECO:0000269|PubMed:20139426, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:8622701, ECO:0000269|PubMed:8663044}.
Links

Search Kinases of FGFR1 (Human)
Gene Ontology Terms (46)
Phosphorylation Site Information
Gabrg2
Mouse
Gamma-aminobutyric acid receptor subunit gamma-2
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
GBRG2_MOUSE
Accession #
P22723
Protein names
  • Gamma-aminobutyric acid receptor subunit gamma-2
  • GABA(A
Gene names
  • Gabrg2
Description
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:27129275). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:27129275). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (PubMed:27129275). The alpha1/beta2/gamma2 receptor, alpha2/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (PubMed:27129275). Functions also as histamine receptor and mediates cellular responses to histamine (PubMed:18281286). {ECO:0000269|PubMed:18281286, ECO:0000269|PubMed:27129275}.
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Search Kinases of Gabrg2 (Mouse)
Phosphorylation Site Information
Gja1
Rat
Gap junction alpha-1 protein
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
CXA1_RAT
Accession #
P08050
Protein names
  • Gap junction alpha-1 protein
  • Connexin-43
  • Cx43
  • Gap junction 43 kDa heart protein
Gene names
  • Gja1
  • Cxn-43
Description
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization (PubMed:15181016). Plays an essential role in gap junction communication in the ventricles (By similarity). {ECO:0000250|UniProtKB:P23242, ECO:0000269|PubMed:15181016}.
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Search Kinases of Gja1 (Rat)
Gene Ontology Terms (139)
Phosphorylation Site Information
GJA1
Human
Gap junction alpha-1 protein
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CXA1_HUMAN
Accession #
P17302
Protein names
  • Gap junction alpha-1 protein
  • Connexin-43
  • Cx43
  • Gap junction 43 kDa heart protein
Gene names
  • GJA1
  • GJAL
Description
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). {ECO:0000250|UniProtKB:P08050, ECO:0000250|UniProtKB:P23242}.
Links

Search Kinases of GJA1 (Human)
Gene Ontology Terms (103)
Phosphorylation Site Information
GNAI2
Human
Guanine nucleotide-binding protein G
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
GNAI2_HUMAN
Accession #
P04899
Protein names
  • Guanine nucleotide-binding protein G
  • i
  • Adenylate cyclase-inhibiting G alpha protein
Gene names
  • GNAI2
  • GNAI2B
Description
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. {ECO:0000269|PubMed:17635935}.; [Isoform sGi2]: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. {ECO:0000269|PubMed:17550964}.
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Search Kinases of GNAI2 (Human)
Gene Ontology Terms (50)
Phosphorylation Site Information
Gng12
Mouse
Guanine nucleotide-binding protein G
IQGAP1
Human
Ras GTPase-activating-like protein IQGAP1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
IQGA1_HUMAN
Accession #
P46940
Protein names
  • Ras GTPase-activating-like protein IQGAP1
  • p195
Gene names
  • IQGAP1
  • KIAA0051
Description
Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). {ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}.
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Search Kinases of IQGAP1 (Human)
Gene Ontology Terms (55)
Phosphorylation Site Information
Irs1
Mouse
Insulin receptor substrate 1
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
IRS1_MOUSE
Accession #
P35569
Protein names
  • Insulin receptor substrate 1
  • IRS-1
Gene names
  • Irs1
  • Irs-1
Description
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). {ECO:0000250}.
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Search Kinases of Irs1 (Mouse)
Gene Ontology Terms (46)
Phosphorylation Site Information
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