Search Results (354 substrates found)
Gene name
Organism
Protein name
Aatk
Rat
Protein Aatk
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
D4ABZ3_RAT
- Accession #
- D4ABZ3
- Protein names
-
- Protein Aatk
- Gene names
-
- Aatk
- Description
-
N/A
- Links
-
Search Kinases of Aatk (Rat)
N/A
- ATP binding
- Rab protein signal transduction
- axonal growth cone
- brain development
- endoplasmic reticulum
- mitochondrion
- negative regulation of axon extension
- neuron apoptotic process
- peptidyl-tyrosine autophosphorylation
- perinuclear region of cytoplasm
- protein tyrosine kinase activity
- recycling endosome

Aatk
Mouse
Serine/threonine-protein kinase LMTK1
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
LMTK1_MOUSE
- Accession #
-
Q80YE4
- Protein names
-
- Serine/threonine-protein kinase LMTK1
- EC 2.7.11.1
- Apoptosis-associated tyrosine kinase
- AATYK
- Brain apoptosis-associated tyrosine kinase
- Lemur tyrosine kinase 1
- Gene names
-
- Aatk
- Aatyk
- Kiaa0641
- Lmr1
- Lmtk1
- Description
-
May be involved in neuronal differentiation (By similarity).
- Links
-
Search Kinases of Aatk (Mouse)
N/A
- ATP binding
- Rab protein signal transduction
- apoptotic process
- axonal growth cone
- brain development
- dendrite
- endoplasmic reticulum
- integral component of membrane
- negative regulation of axon extension
- neuron apoptotic process
- peptidyl-tyrosine autophosphorylation
- perinuclear region of cytoplasm
- protein autophosphorylation
- protein binding
- protein serine/threonine kinase activity
- protein tyrosine kinase activity
- recycling endosome

Abce1
Rat
ATP-binding cassette, sub-family E
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
D3ZD23_RAT
- Accession #
- D3ZD23
- Protein names
-
- ATP-binding cassette, sub-family E
- OABP, member 1
- Protein Abce1
- Gene names
-
- Abce1
- rCG_51692
- Description
-
N/A
- Links
-
Search Kinases of Abce1 (Rat)
N/A

Abi2
Rat
Protein Abi2
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
F1LYA6_RAT
- Accession #
- F1LYA6
- Protein names
-
- Protein Abi2
- Gene names
-
- Abi2
- Description
-
N/A
- Links
-
Search Kinases of Abi2 (Rat)
N/A

Acot9
Rat
Acyl-CoA thioesterase 9
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
Q5U2X8_RAT
- Accession #
- Q5U2X8
- Protein names
-
- Acyl-CoA thioesterase 9
- Protein Acot9
- Similar to acyl-CoA thioesterase, isoform CRA_b
- Gene names
-
- Acot9
- LOC302640
- rCG_36383
- Description
-
N/A
- Links
-
Search Kinases of Acot9 (Rat)
N/A
N/A

Actr3
Rat
Actin-related protein 3
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ARP3_RAT
- Accession #
-
Q4V7C7
- Protein names
-
- Actin-related protein 3
- Actin-like protein 3
- Gene names
-
- Actr3
- Arp3
- Description
-
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis (By similarity).
- Links
-
Search Kinases of Actr3 (Rat)
N/A
- ATP binding
- Golgi membrane
- asymmetric cell division
- cell leading edge
- cilium morphogenesis
- cytoplasm
- establishment or maintenance of cell polarity
- excitatory synapse
- hemidesmosome
- lamellipodium
- meiotic cytokinesis
- podosome
- positive regulation of actin filament polymerization
- positive regulation of dendrite morphogenesis
- positive regulation of filopodium assembly
- positive regulation of lamellipodium assembly
- positive regulation of neuron differentiation
- protein binding
- regulation of myosin II filament organization
- response to antibiotic
- response to carbohydrate
- spindle localization

ADD2
Human
Beta-adducin
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ADDB_HUMAN
- Accession #
-
P35612
- Protein names
-
- Beta-adducin
- Erythrocyte adducin subunit beta
- Gene names
-
- ADD2
- ADDB
- Description
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.
- Links
-
Search Kinases of ADD2 (Human)
N/A
- F-actin capping protein complex
- actin binding
- actin cytoskeleton organization
- actin filament binding
- actin filament bundle assembly
- barbed-end actin filament capping
- cytoplasmic membrane-bounded vesicle
- hemopoiesis
- plasma membrane
- positive regulation of protein binding
- protein complex assembly
- protein heterodimerization activity
- protein homodimerization activity
- spectrin binding
- structural molecule activity

AGAP2
Human
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
AGAP2_HUMAN
- Accession #
-
Q99490
- Protein names
-
- Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
- AGAP-2
- Centaurin-gamma-1
- Cnt-g1
- GTP-binding and GTPase-activating protein 2
- GGAP2
- Phosphatidylinositol 3-kinase enhancer
- PIKE
- Gene names
-
- AGAP2
- CENTG1
- KIAA0167
- Description
-
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
- Links
-
Search Kinases of AGAP2 (Human)
- ARF GTPase activator activity
- GTP binding
- axon guidance
- mitochondrion
- negative regulation of neuron apoptotic process
- negative regulation of protein catabolic process
- nucleolus
- nucleus
- protein binding
- protein transport
- regulation of ARF GTPase activity
- small GTPase mediated signal transduction
- zinc ion binding

Agap2
Rat
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
AGAP2_RAT
- Accession #
-
Q8CGU4
- Protein names
-
- Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
- AGAP-2
- Centaurin-gamma-1
- Cnt-g1
- Phosphatidylinositol 3-kinase enhancer
- PIKE
- Gene names
-
- Agap2
- Centg1
- Description
-
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. Aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase.
- Links
-
Search Kinases of Agap2 (Rat)
- ARF GTPase activator activity
- GTP binding
- cytosol
- mammary gland alveolus development
- mitochondrion
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- negative regulation of neuron apoptotic process
- nucleolus
- nucleus
- positive regulation of JAK-STAT cascade
- positive regulation of mammary gland epithelial cell proliferation
- positive regulation of phosphatidylinositol 3-kinase signaling
- positive regulation of protein kinase activity
- positive regulation of transcription from RNA polymerase II promoter
- protein binding
- protein kinase activator activity
- protein kinase binding
- regulation of ARF GTPase activity
- small GTPase mediated signal transduction
- zinc ion binding

Ager
Rat
Advanced glycosylation end product-specific receptor
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
RAGE_RAT
- Accession #
-
Q63495
- Protein names
-
- Advanced glycosylation end product-specific receptor
- Receptor for advanced glycosylation end products
- Gene names
-
- Ager
- Rage
- Description
-
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides (By similarity). Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.
- Links
-
Search Kinases of Ager (Rat)
N/A
- JAK-STAT cascade
- S100 protein binding
- advanced glycation end-product receptor activity
- axon
- basal plasma membrane
- brain development
- calcium ion homeostasis
- cell surface
- cellular response to fatty acid
- cellular response to glucose stimulus
- cellular response to hydrogen peroxide
- cellular response to organic cyclic compound
- cytoplasm
- cytosol
- extracellular space
- glycoprotein metabolic process
- heterocycle metabolic process
- high mobility group box 1 binding
- inflammatory response
- integral component of membrane
- lung development
- negative regulation of cell adhesion
- negative regulation of collagen biosynthetic process
- negative regulation of endothelial cell migration
- negative regulation of endothelial cell proliferation
- negative regulation of protein phosphorylation
- neuron projection development
- neuronal cell body
- osteoblast proliferation
- plasma membrane
- positive regulation of apoptotic process
- positive regulation of autophagy
- positive regulation of cell migration
- positive regulation of endothelial cell apoptotic process
- positive regulation of epithelial to mesenchymal transition
- positive regulation of fibroblast migration
- positive regulation of fibroblast proliferation
- positive regulation of gene expression
- positive regulation of inflammatory response
- positive regulation of neuron apoptotic process
- positive regulation of neuron death
- positive regulation of potassium ion transmembrane transporter activity
- positive regulation of protein phosphorylation
- positive regulation of reactive oxygen species metabolic process
- positive regulation of smooth muscle cell migration
- positive regulation of smooth muscle cell proliferation
- positive regulation of type B pancreatic cell apoptotic process
- protein binding
- response to activity
- response to drug
- response to fructose
- response to hyperoxia
- response to methylglyoxal
- response to selenite ion
- response to vitamin A
- transdifferentiation

Ahsg
Rat
Alpha-2-HS-glycoprotein
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
FETUA_RAT
- Accession #
-
P24090
- Protein names
-
- Alpha-2-HS-glycoprotein
- 59 kDa bone sialic acid-containing protein
- BSP
- Fetuin-A
- Glycoprotein PP63
- Gene names
-
- Ahsg
- Fetua
- Description
-
Could inhibit both insulin-receptor tyrosine kinase activity and insulin-stimulated receptor autophosphorylation and, concomitantly, antagonize the mitogenic effect of the hormone in cultured rat hepatoma cells.
- Links
-
Search Kinases of Ahsg (Rat)
N/A
- acute-phase response
- cellular response to insulin stimulus
- cerebral cortex development
- cysteine-type endopeptidase inhibitor activity
- extracellular matrix
- extracellular space
- kinase inhibitor activity
- male gonad development
- negative regulation of bone mineralization
- negative regulation of cell growth
- negative regulation of insulin receptor signaling pathway
- negative regulation of phosphorylation
- negative regulation of protein tyrosine kinase activity
- organ regeneration
- positive regulation of bone resorption
- positive regulation of phagocytosis
- protein complex
- protein complex assembly
- receptor signaling protein tyrosine kinase inhibitor activity
- regulation of inflammatory response

Aldoa
Rat
Fructose-bisphosphate aldolase A
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ALDOA_RAT
- Accession #
-
P05065
- Protein names
-
- Fructose-bisphosphate aldolase A
- EC 4.1.2.13
- Muscle-type aldolase
- Gene names
-
- Aldoa
- Description
-
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).
- Links
-
Search Kinases of Aldoa (Rat)

Aldoc
Rat
Fructose-bisphosphate aldolase C
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ALDOC_RAT
- Accession #
-
P09117
- Protein names
-
- Fructose-bisphosphate aldolase C
- EC 4.1.2.13
- Brain-type aldolase
- Gene names
-
- Aldoc
- Description
-
N/A
- Links
-
Search Kinases of Aldoc (Rat)
- aging
- apoptotic process
- axon
- cytoplasm
- fructose 1,6-bisphosphate metabolic process
- fructose-bisphosphate aldolase activity
- glycolytic process
- mitochondrion
- organ regeneration
- protein binding
- protein heterotetramerization
- protein homotetramerization
- response to hypoxia
- response to organic cyclic compound
- response to organonitrogen compound

Ampd3
Rat
AMP deaminase 3
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
F1M7Q5_RAT
- Accession #
- F1M7Q5
- Protein names
-
- AMP deaminase 3
- Adenosine monophosphate deaminase 3, isoform CRA_c
- Gene names
-
- Ampd3
- rCG_39800
- Description
-
N/A
- Links
-
Search Kinases of Ampd3 (Rat)
N/A

AMPH
Human
Amphiphysin
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
AMPH_HUMAN
- Accession #
-
P49418
- Protein names
-
- Amphiphysin
- Gene names
-
- AMPH
- AMPH1
- Description
-
May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.
- Links
-
Search Kinases of AMPH (Human)

Amph
Rat
Amphiphysin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
AMPH_RAT
- Accession #
-
O08838
- Protein names
-
- Amphiphysin
- Gene names
-
- Amph
- Amph1
- Description
-
May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton (By similarity).
- Links
-
Search Kinases of Amph (Rat)

Ank1
Rat
Ankyrin 1, erythroid
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
D3Z9Z0_RAT
- Accession #
- D3Z9Z0
- Protein names
-
- Ankyrin 1, erythroid
- Protein Ank1
- Gene names
-
- Ank1
- rCG_43073
- Description
-
N/A
- Links
-
Search Kinases of Ank1 (Rat)
- A band
- ER to Golgi vesicle-mediated transport
- M band
- Z disc
- axolemma
- cortical cytoskeleton
- erythrocyte development
- monovalent inorganic cation transport
- neuron projection
- nucleus
- plasma membrane
- porphyrin-containing compound biosynthetic process
- positive regulation of organelle organization
- postsynaptic membrane
- protein binding
- protein targeting to plasma membrane
- sarcolemma
- sarcoplasmic reticulum
- spectrin-associated cytoskeleton

Ank2
Rat
Protein Ank2
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
F1LM42_RAT
- Accession #
- F1LM42
- Protein names
-
- Protein Ank2
- Gene names
-
- Ank2
- Description
-
N/A
- Links
-
Search Kinases of Ank2 (Rat)
N/A
- M band
- SA node cell action potential
- T-tubule
- T-tubule organization
- Z disc
- atrial cardiac muscle cell action potential
- atrial septum development
- basolateral plasma membrane
- cardiac muscle contraction
- cellular calcium ion homeostasis
- costamere
- cytoskeleton
- integral component of plasma membrane
- intercalated disc
- ion channel binding
- membrane raft
- nervous system development
- neuron projection
- paranodal junction assembly
- perinuclear region of cytoplasm
- plasma membrane
- positive regulation of calcium ion transmembrane transporter activity
- positive regulation of calcium ion transport
- positive regulation of cation channel activity
- positive regulation of gene expression
- positive regulation of potassium ion transmembrane transporter activity
- positive regulation of potassium ion transport
- potassium channel regulator activity
- protein binding
- protein kinase binding
- protein localization to M-band
- protein localization to T-tubule
- protein localization to cell surface
- protein localization to endoplasmic reticulum
- protein stabilization
- protein targeting to plasma membrane
- regulation of cardiac muscle cell membrane potential
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
- regulation of heart rate by cardiac conduction
- regulation of ventricular cardiac muscle cell membrane repolarization
- response to methylmercury
- structural constituent of cytoskeleton
- ventricular cardiac muscle cell action potential

Ank3
Rat
Ankyrin-3
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ANK3_RAT
- Accession #
-
O70511
- Protein names
-
- Ankyrin-3
- ANK-3
- Ankyrin-G
- Gene names
-
- Ank3
- Description
-
Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity).
- Links
-
Search Kinases of Ank3 (Rat)
- T-tubule
- Z disc
- axon initial segment
- cadherin binding
- cell surface
- costamere
- cytoskeletal protein binding
- dendrite
- intercalated disc
- ion channel binding
- membrane assembly
- neuromuscular junction
- neuromuscular junction development
- neuron projection
- node of Ranvier
- plasma membrane
- positive regulation of cation channel activity
- positive regulation of cell communication by electrical coupling
- positive regulation of gene expression
- positive regulation of homotypic cell-cell adhesion
- positive regulation of membrane depolarization during cardiac muscle cell action potential
- positive regulation of membrane potential
- positive regulation of protein targeting to membrane
- positive regulation of sodium ion transmembrane transporter activity
- positive regulation of sodium ion transport
- postsynaptic membrane
- protein binding
- protein binding, bridging
- protein localization to plasma membrane
- regulation of potassium ion transport
- sarcolemma
- sarcoplasmic reticulum
- signal transduction
- spectrin binding
- spectrin-associated cytoskeleton

Ankrd34a
Rat
Ankyrin repeat domain-containing protein 34A
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
AN34A_RAT
- Accession #
-
Q5BJT1
- Protein names
-
- Ankyrin repeat domain-containing protein 34A
- Gene names
-
- Ankrd34a
- Description
-
N/A
- Links
-
Search Kinases of Ankrd34a (Rat)
N/A
