Search Results (208 substrates found)
Gene name
Organism
Protein name
Acsbg1
Rat
Long-chain-fatty-acid--CoA ligase ACSBG1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ACBG1_RAT
- Accession #
-
Q924N5
- Protein names
-
- Long-chain-fatty-acid--CoA ligase ACSBG1
- EC 6.2.1.3
- Acyl-CoA synthetase bubblegum family member 1
- Gonadotropin-regulated long chain acyl CoA synthetase
- GR-LACS
- Gene names
-
- Acsbg1
- Grlacs
- Description
-
Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. {ECO:0000269|PubMed:11381125}.
- Links
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Search Kinases of Acsbg1 (Rat)
- ATP binding
- CoA-ligase activity
- cytoplasm
- cytoplasmic vesicle
- endoplasmic reticulum
- long-chain fatty acid biosynthetic process
- long-chain fatty acid metabolic process
- long-chain fatty acid-CoA ligase activity
- ovarian follicle atresia
- plasma membrane
- response to glucocorticoid
- very long-chain fatty acid metabolic process
- very long-chain fatty acid-CoA ligase activity

ADD2
Human
Beta-adducin
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ADDB_HUMAN
- Accession #
-
P35612
- Protein names
-
- Beta-adducin
- Erythrocyte adducin subunit beta
- Gene names
-
- ADD2
- ADDB
- Description
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. {ECO:0000269|PubMed:18347014}.
- Links
-
Search Kinases of ADD2 (Human)
N/A
- F-actin capping protein complex
- actin binding
- actin cytoskeleton organization
- actin filament binding
- actin filament bundle assembly
- barbed-end actin filament capping
- calmodulin binding
- cytoplasmic vesicle
- cytoskeleton
- cytosol
- hemopoiesis
- leukocyte migration
- leukocyte tethering or rolling
- plasma membrane
- plasma membrane raft
- positive regulation of protein binding
- postsynaptic density
- protein heterodimerization activity
- protein homodimerization activity
- protein kinase binding
- protein-containing complex assembly
- spectrin binding
- structural constituent of cytoskeleton
- synapse assembly
- transmembrane transport

Afap1
Rat
Actin filament-associated protein 1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
G3V6Z3_RAT
- Accession #
- G3V6Z3
- Protein names
-
- Actin filament-associated protein 1
- RCG36144, isoform CRA_b
- Gene names
-
- Afap1
- rCG_36144
- Description
-
N/A
- Links
-
Search Kinases of Afap1 (Rat)
N/A

Ahsg
Rat
Alpha-2-HS-glycoprotein
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
FETUA_RAT
- Accession #
-
P24090
- Protein names
-
- Alpha-2-HS-glycoprotein
- 59 kDa bone sialic acid-containing protein
- BSP
- Fetuin-A
- Glycoprotein PP63
- Gene names
-
- Ahsg
- Fetua
- Description
-
Could inhibit both insulin-receptor tyrosine kinase activity and insulin-stimulated receptor autophosphorylation and, concomitantly, antagonize the mitogenic effect of the hormone in cultured rat hepatoma cells.
- Links
-
Search Kinases of Ahsg (Rat)
N/A
- acute-phase response
- animal organ regeneration
- cellular response to insulin stimulus
- cerebral cortex development
- collagen-containing extracellular matrix
- cysteine-type endopeptidase inhibitor activity
- endopeptidase inhibitor activity
- extracellular matrix
- extracellular region
- extracellular space
- kinase inhibitor activity
- male gonad development
- negative regulation of bone mineralization
- negative regulation of cell growth
- negative regulation of endopeptidase activity
- negative regulation of insulin receptor signaling pathway
- ossification
- positive regulation of bone resorption
- positive regulation of phagocytosis
- protein-containing complex
- protein-containing complex assembly
- receptor signaling protein tyrosine kinase inhibitor activity
- regulation of inflammatory response

AMPH
Human
Amphiphysin
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
AMPH_HUMAN
- Accession #
-
P49418
- Protein names
-
- Amphiphysin
- Gene names
-
- AMPH
- AMPH1
- Description
-
May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.
- Links
-
Search Kinases of AMPH (Human)

Apex1
Mouse
DNA-
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
APEX1_MOUSE
- Accession #
-
P28352
- Protein names
-
- DNA-
- apurinic or apyrimidinic site
- EC 3.1.-.-
- APEX nuclease
- APEN
- Apurinic-apyrimidinic endonuclease 1
- AP endonuclease 1
- REF-1
- Redox factor-1
- Gene names
-
- Apex1
- Ape
- Apex
- Ref1
- Description
-
Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB. Plays a role in the protection from granzymes-mediated cellular repair leading to cell death. Also involved in the DNA cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression. Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance. Acts also as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA. Binds DNA and RNA. {ECO:0000269|PubMed:18025127, ECO:0000269|PubMed:19556307}.
- Links
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Search Kinases of Apex1 (Mouse)
- 3'-5' exonuclease activity
- DNA binding
- DNA demethylation
- DNA recombination
- DNA repair
- DNA-(apurinic or apyrimidinic site) endonuclease activity
- NF-kappaB binding
- RNA binding
- aging
- base-excision repair
- cell redox homeostasis
- cellular response to cAMP
- cellular response to hydrogen peroxide
- cellular response to peptide hormone stimulus
- centrosome
- chromatin DNA binding
- cytoplasm
- damaged DNA binding
- double-stranded DNA 3'-5' exodeoxyribonuclease activity
- double-stranded DNA exodeoxyribonuclease activity
- double-stranded telomeric DNA binding
- endoplasmic reticulum
- endoribonuclease activity
- metal ion binding
- mitochondrion
- negative regulation of smooth muscle cell migration
- nuclear speck
- nucleolus
- nucleoplasm
- nucleus
- oxidoreductase activity
- perinuclear region of cytoplasm
- phosphodiesterase I activity
- phosphoric diester hydrolase activity
- positive regulation of G1/S transition of mitotic cell cycle
- positive regulation of transcription by RNA polymerase II
- protein-containing complex binding
- regulation of apoptotic process
- regulation of mRNA stability
- site-specific endodeoxyribonuclease activity, specific for altered base
- telomere maintenance
- telomere maintenance via base-excision repair
- transcription coactivator activity
- transcription regulator complex

AR
Human
Androgen receptor
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ANDR_HUMAN
- Accession #
-
P10275
- Protein names
-
- Androgen receptor
- Dihydrotestosterone receptor
- Nuclear receptor subfamily 3 group C member 4
- Gene names
-
- AR
- DHTR
- NR3C4
- Description
-
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.
- Links
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Search Kinases of AR (Human)
- ATPase binding
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- Leydig cell differentiation
- POU domain binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- RNA polymerase II general transcription initiation factor binding
- activation of prostate induction by androgen receptor signaling pathway
- androgen binding
- androgen receptor signaling pathway
- animal organ formation
- beta-catenin binding
- cell-cell signaling
- cellular response to estrogen stimulus
- cellular response to steroid hormone stimulus
- cellular response to testosterone stimulus
- chromatin
- chromatin binding
- cytoplasm
- cytosol
- enzyme binding
- epithelial cell differentiation involved in prostate gland development
- epithelial cell morphogenesis
- in utero embryonic development
- intracellular estrogen receptor signaling pathway
- intracellular receptor signaling pathway
- intracellular steroid hormone receptor signaling pathway
- lateral sprouting involved in mammary gland duct morphogenesis
- male genitalia morphogenesis
- male gonad development
- male somatic sex determination
- mammary gland alveolus development
- morphogenesis of an epithelial fold
- multicellular organism growth
- negative regulation of cell population proliferation
- negative regulation of epithelial cell proliferation
- negative regulation of extrinsic apoptotic signaling pathway
- negative regulation of integrin biosynthetic process
- negative regulation of transcription by RNA polymerase II
- nuclear receptor activity
- nuclear speck
- nucleoplasm
- nucleus
- plasma membrane
- positive regulation of MAPK cascade
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of cell differentiation
- positive regulation of cell population proliferation
- positive regulation of epithelial cell proliferation involved in prostate gland development
- positive regulation of gene expression
- positive regulation of insulin-like growth factor receptor signaling pathway
- positive regulation of integrin biosynthetic process
- positive regulation of intracellular estrogen receptor signaling pathway
- positive regulation of phosphorylation
- positive regulation of transcription by RNA polymerase II
- positive regulation of transcription by RNA polymerase III
- positive regulation of transcription, DNA-templated
- prostate gland epithelium morphogenesis
- prostate gland growth
- protein deubiquitination
- protein-containing complex
- regulation of androgen receptor signaling pathway
- regulation of developmental growth
- regulation of protein localization to plasma membrane
- regulation of systemic arterial blood pressure
- regulation of transcription by RNA polymerase II
- seminiferous tubule development
- signal transduction
- signaling receptor binding
- single fertilization
- spermatogenesis
- steroid binding
- tertiary branching involved in mammary gland duct morphogenesis
- transcription cis-regulatory region binding
- transcription factor binding
- transcription initiation from RNA polymerase II promoter
- zinc ion binding

Arid1a
Rat
AT-rich interaction domain 1A
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
D4A3E3_RAT
- Accession #
-
D4A3E3
- Protein names
-
- AT-rich interaction domain 1A
- Gene names
-
- Arid1a
- Description
-
N/A
- Links
-
Search Kinases of Arid1a (Rat)
N/A
- DNA binding
- SWI/SNF complex
- androgen receptor signaling pathway
- brahma complex
- cardiac chamber development
- cardiac muscle cell differentiation
- chromatin
- chromatin organization
- chromatin remodeling
- embryo implantation
- forebrain development
- formation of primary germ layer
- gastrulation
- glucocorticoid receptor signaling pathway
- intracellular estrogen receptor signaling pathway
- nBAF complex
- negative regulation of transcription by RNA polymerase II
- neural tube closure
- npBAF complex
- nuclear receptor binding
- nucleoplasm
- nucleosome disassembly
- obsolete heterochromatin maintenance
- optic cup formation involved in camera-type eye development
- placenta blood vessel development
- positive regulation of transcription, DNA-templated
- regulation of transcription by RNA polymerase II
- stem cell population maintenance
- toxin transport

Ash1l
Rat
ASH1-like histone lysine methyltransferase
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
D3ZKH4_RAT
- Accession #
-
D3ZKH4
- Protein names
-
- ASH1-like histone lysine methyltransferase
- Gene names
-
- Ash1l
- Description
-
N/A
- Links
-
Search Kinases of Ash1l (Rat)
N/A
- DNA binding
- Golgi apparatus
- chromatin binding
- decidualization
- flagellated sperm motility
- histone H3-K36 dimethylation
- histone H3-K4 methylation
- histone methyltransferase activity (H3-K36 specific)
- histone methyltransferase activity (H3-K4 specific)
- histone methyltransferase activity (H3-K9 specific)
- metal ion binding
- negative regulation of I-kappaB kinase/NF-kappaB signaling
- negative regulation of MAPK cascade
- negative regulation of acute inflammatory response
- negative regulation of inflammatory response
- nucleoplasm
- positive regulation of transcription by RNA polymerase II
- post-embryonic development
- regulation of gene expression
- sebaceous gland development
- single fertilization
- skeletal system development
- tarsal gland development
- uterine gland development
- uterus morphogenesis

ATAT1
Human
Alpha-tubulin N-acetyltransferase 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
B7Z4Q7_HUMAN
- Accession #
- B7Z4Q7
- Protein names
-
- Alpha-tubulin N-acetyltransferase 1
- Alpha-TAT
- Alpha-TAT1
- TAT
- EC 2.3.1.108
- Acetyltransferase mec-17 homolog
- Gene names
-
- ATAT1
- MEC17
- Description
-
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. {ECO:0000256|HAMAP-Rule:MF_03130}.
- Links
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Search Kinases of ATAT1 (Human)
N/A

ATM
Human
Serine-protein kinase ATM
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ATM_HUMAN
- Accession #
-
Q13315
- Protein names
-
- Serine-protein kinase ATM
- EC 2.7.11.1
- Ataxia telangiectasia mutated
- A-T mutated
- Gene names
-
- ATM
- Description
-
Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:9843217, PubMed:9733515, PubMed:10550055, PubMed:10766245, PubMed:10839545, PubMed:10910365, PubMed:10802669, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:30612738, PubMed:30886146). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response. Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). {ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}.
- Links
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Search Kinases of ATM (Human)
- 1-phosphatidylinositol-3-kinase activity
- ATP binding
- DNA binding
- DNA damage checkpoint signaling
- DNA damage induced protein phosphorylation
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- DNA double-strand break processing
- DNA repair complex
- DNA replication
- DNA-dependent protein kinase activity
- V(D)J recombination
- brain development
- cellular response to DNA damage stimulus
- cellular response to X-ray
- cellular response to gamma radiation
- cellular response to nitrosative stress
- cellular response to retinoic acid
- cytoplasm
- cytoplasmic vesicle
- cytosol
- determination of adult lifespan
- double-strand break repair
- double-strand break repair via homologous recombination
- double-strand break repair via nonhomologous end joining
- establishment of RNA localization to telomere
- establishment of protein-containing complex localization to telomere
- female meiotic nuclear division
- heart development
- histone mRNA catabolic process
- histone phosphorylation
- identical protein binding
- intracellular membrane-bounded organelle
- intrinsic apoptotic signaling pathway in response to DNA damage
- lipoprotein catabolic process
- male meiotic nuclear division
- meiotic telomere clustering
- mitotic spindle assembly checkpoint signaling
- multicellular organism growth
- negative regulation of B cell proliferation
- negative regulation of TORC1 signaling
- negative regulation of telomere capping
- neuron apoptotic process
- nucleolus
- nucleoplasm
- nucleus
- oocyte development
- ovarian follicle development
- peptidyl-serine autophosphorylation
- peptidyl-serine phosphorylation
- peroxisomal matrix
- pexophagy
- positive regulation of DNA catabolic process
- positive regulation of DNA damage response, signal transduction by p53 class mediator
- positive regulation of apoptotic process
- positive regulation of cell adhesion
- positive regulation of cell migration
- positive regulation of gene expression
- positive regulation of histone phosphorylation
- positive regulation of neuron apoptotic process
- positive regulation of telomerase catalytic core complex assembly
- positive regulation of telomere maintenance via telomerase
- positive regulation of telomere maintenance via telomere lengthening
- positive regulation of transcription by RNA polymerase II
- post-embryonic development
- pre-B cell allelic exclusion
- protein N-terminus binding
- protein autophosphorylation
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- protein-containing complex binding
- reciprocal meiotic recombination
- regulation of apoptotic process
- regulation of autophagy
- regulation of cellular response to gamma radiation
- regulation of cellular response to heat
- regulation of microglial cell activation
- regulation of signal transduction by p53 class mediator
- regulation of telomere maintenance via telomerase
- replicative senescence
- response to hypoxia
- response to ionizing radiation
- signal transduction
- somitogenesis
- spindle
- telomere maintenance
- thymus development

Atp5f1b
Rat
ATP synthase subunit beta
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
G3V6D3_RAT
- Accession #
- G3V6D3
- Protein names
-
- ATP synthase subunit beta
- EC 7.1.2.2
- Gene names
-
- Atp5f1b
- Atp5b
- rCG_42467
- Description
-
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. {ECO:0000256|ARBA:ARBA00003086}.; Produces ATP from ADP in the presence of a proton gradient across the membrane. {ECO:0000256|RuleBase:RU003553}.
- Links
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Search Kinases of Atp5f1b (Rat)
N/A
- ATP binding
- MHC class I protein binding
- angiogenesis
- angiostatin binding
- cell surface
- cellular response to interleukin-7
- lipid metabolic process
- mitochondrial ATP synthesis coupled proton transport
- mitochondrial nucleoid
- mitochondrial proton-transporting ATP synthase complex
- negative regulation of cell adhesion involved in substrate-bound cell migration
- plasma membrane
- positive regulation of blood vessel endothelial cell migration
- proton-transporting ATP synthase activity, rotational mechanism
- proton-transporting ATP synthase complex, catalytic core F(1)
- proton-transporting ATPase activity, rotational mechanism
- regulation of intracellular pH

Axin1
Mouse
Axin-1
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
AXIN1_MOUSE
- Accession #
-
O35625
- Protein names
-
- Axin-1
- Axis inhibition protein 1
- Protein Fused
- Gene names
-
- Axin1
- Axin
- Fu
- Description
-
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (By similarity). Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. {ECO:0000250, ECO:0000269|PubMed:12223491, ECO:0000269|PubMed:15526030, ECO:0000269|PubMed:17681137}.
- Links
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Search Kinases of Axin1 (Mouse)
- Alzheimer disease
- Basal cell carcinoma
- Breast cancer
- Colorectal cancer
- Cushing syndrome
- Endometrial cancer
- Gastric cancer
- Hepatocellular carcinoma
- Hippo signaling pathway
- Human papillomavirus infection
- Pathways in cancer
- Pathways of neurodegeneration
- Signaling pathways regulating pluripotency of stem cells
- Wnt signaling pathway
- I-SMAD binding
- R-SMAD binding
- SMAD binding
- Wnt signaling pathway
- Wnt signalosome
- activation of protein kinase activity
- apoptotic process
- armadillo repeat domain binding
- axial mesoderm development
- axial mesoderm formation
- beta-catenin binding
- beta-catenin destruction complex
- canonical Wnt signaling pathway
- cell cortex
- cell periphery
- cellular protein-containing complex assembly
- cytoplasm
- cytoplasmic microtubule organization
- cytoplasmic vesicle
- cytosol
- dorsal/ventral axis specification
- dorsal/ventral pattern formation
- enzyme binding
- genetic imprinting
- head development
- identical protein binding
- in utero embryonic development
- lateral plasma membrane
- microtubule cytoskeleton
- molecular adaptor activity
- negative regulation of Wnt signaling pathway
- negative regulation of canonical Wnt signaling pathway
- negative regulation of fat cell differentiation
- negative regulation of gene expression
- negative regulation of protein metabolic process
- negative regulation of transcription elongation from RNA polymerase II promoter
- nucleocytoplasmic transport
- nucleus
- p53 binding
- perinuclear region of cytoplasm
- plasma membrane
- positive regulation of JNK cascade
- positive regulation of JUN kinase activity
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of peptidyl-threonine phosphorylation
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of protein catabolic process
- positive regulation of protein kinase activity
- positive regulation of protein phosphorylation
- positive regulation of protein ubiquitination
- positive regulation of transcription, DNA-templated
- positive regulation of transforming growth factor beta receptor signaling pathway
- positive regulation of ubiquitin-dependent protein catabolic process
- positive regulation of ubiquitin-protein transferase activity
- post-anal tail morphogenesis
- postsynaptic density
- protein C-terminus binding
- protein catabolic process
- protein domain specific binding
- protein homodimerization activity
- protein kinase binding
- protein polyubiquitination
- protein self-association
- protein-containing complex
- regulation of canonical Wnt signaling pathway
- regulation of protein phosphorylation
- sensory perception of sound
- signaling receptor binding
- signaling receptor complex adaptor activity
- ubiquitin protein ligase binding

AXIN1
Human
Axin-1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
AXIN1_HUMAN
- Accession #
-
O15169
- Protein names
-
- Axin-1
- Axis inhibition protein 1
- hAxin
- Gene names
-
- AXIN1
- AXIN
- Description
-
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684, ECO:0000269|PubMed:27098453}.
- Links
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Search Kinases of AXIN1 (Human)
- Alzheimer disease
- Basal cell carcinoma
- Breast cancer
- Colorectal cancer
- Cushing syndrome
- Endometrial cancer
- Gastric cancer
- Hepatocellular carcinoma
- Hippo signaling pathway
- Human papillomavirus infection
- Pathways in cancer
- Pathways of neurodegeneration
- Signaling pathways regulating pluripotency of stem cells
- Wnt signaling pathway
- I-SMAD binding
- SMAD binding
- Wnt signaling pathway
- activation of protein kinase activity
- apoptotic process
- armadillo repeat domain binding
- beta-catenin binding
- beta-catenin destruction complex
- beta-catenin destruction complex assembly
- beta-catenin destruction complex disassembly
- cell periphery
- cellular protein-containing complex assembly
- cytoplasm
- cytoplasmic vesicle
- cytosol
- enzyme binding
- identical protein binding
- lateral plasma membrane
- molecular adaptor activity
- multicellular organism development
- negative regulation of canonical Wnt signaling pathway
- nucleus
- perinuclear region of cytoplasm
- positive regulation of JNK cascade
- positive regulation of canonical Wnt signaling pathway
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of peptidyl-threonine phosphorylation
- positive regulation of protein catabolic process
- positive regulation of protein phosphorylation
- positive regulation of protein ubiquitination
- positive regulation of transcription, DNA-templated
- positive regulation of ubiquitin-dependent protein catabolic process
- positive regulation of ubiquitin-protein transferase activity
- protein homodimerization activity
- protein kinase binding
- regulation of Wnt signaling pathway
- regulation of intracellular estrogen receptor signaling pathway
- signaling adaptor activity
- signaling receptor complex adaptor activity
- ubiquitin protein ligase binding

Bcan
Rat
Brevican core protein
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
G3V8G4_RAT
- Accession #
- G3V8G4
- Protein names
-
- Brevican core protein
- Brevican, isoform CRA_a
- Gene names
-
- Bcan
- LOC100910284
- rCG_62833
- Description
-
N/A
- Links
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Search Kinases of Bcan (Rat)
N/A

Bcl2
Mouse
Apoptosis regulator Bcl-2
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
BCL2_MOUSE
- Accession #
-
P10417
- Protein names
-
- Apoptosis regulator Bcl-2
- Gene names
-
- Bcl2
- Bcl-2
- Description
-
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). {ECO:0000269|PubMed:17418785}.
- Links
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Search Kinases of Bcl2 (Mouse)
- AGE
- Adrenergic signaling in cardiomyocytes
- Amyotrophic lateral sclerosis
- Apoptosis
- Autophagy
- Chemical carcinogenesis
- Cholinergic synapse
- Colorectal cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Epstein
- Estrogen signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- Gastric cancer
- HIF
- Hedgehog signaling pathway
- Hepatitis B
- Herpes simplex virus 1 infection
- Human immunodeficiency virus 1 infection
- JAK
- Lipid and atherosclerosis
- Measles
- MicroRNAs in cancer
- NF
- NOD
- Necroptosis
- Neurotrophin signaling pathway
- PI3K
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration
- Platinum drug resistance
- Prostate cancer
- Protein processing in endoplasmic reticulum
- Salmonella infection
- Small cell lung cancer
- Sphingolipid signaling pathway
- Toxoplasmosis
- Tuberculosis
- p53 signaling pathway
- B cell differentiation
- B cell homeostasis
- B cell lineage commitment
- B cell proliferation
- B cell receptor signaling pathway
- BH domain binding
- BH3 domain binding
- CD8-positive, alpha-beta T cell lineage commitment
- T cell differentiation
- T cell differentiation in thymus
- T cell homeostasis
- T cell lineage commitment
- actin filament organization
- animal organ morphogenesis
- apoptotic mitochondrial changes
- apoptotic process
- axon regeneration
- axonogenesis
- behavioral fear response
- branching involved in ureteric bud morphogenesis
- cell aging
- cell morphogenesis
- cell population proliferation
- cell-cell adhesion
- cellular calcium ion homeostasis
- cellular response to DNA damage stimulus
- cellular response to glucose starvation
- cellular response to hypoxia
- cellular response to organic substance
- channel activity
- channel inhibitor activity
- cochlear nucleus development
- cytoplasm
- cytosol
- defense response to virus
- developmental growth
- developmental pigmentation
- digestive tract morphogenesis
- ear development
- endoplasmic reticulum
- endoplasmic reticulum calcium ion homeostasis
- endoplasmic reticulum membrane
- extrinsic apoptotic signaling pathway in absence of ligand
- extrinsic apoptotic signaling pathway via death domain receptors
- focal adhesion assembly
- gland morphogenesis
- glomerulus development
- hair follicle morphogenesis
- hemopoiesis
- homeostasis of number of cells within a tissue
- identical protein binding
- immune system development
- intrinsic apoptotic signaling pathway in response to DNA damage
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- intrinsic apoptotic signaling pathway in response to oxidative stress
- kidney development
- leukocyte homeostasis
- lymphocyte homeostasis
- lymphoid progenitor cell differentiation
- male gonad development
- melanin metabolic process
- melanocyte differentiation
- membrane
- mesenchymal cell development
- metanephros development
- mitochondrial crista
- mitochondrial membrane
- mitochondrial outer membrane
- mitochondrion
- myelin sheath
- negative regulation of G1/S transition of mitotic cell cycle
- negative regulation of anoikis
- negative regulation of apoptotic process
- negative regulation of apoptotic signaling pathway
- negative regulation of autophagy
- negative regulation of calcium ion transport into cytosol
- negative regulation of cardiac muscle cell apoptotic process
- negative regulation of cell growth
- negative regulation of cell migration
- negative regulation of cell population proliferation
- negative regulation of cellular pH reduction
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- negative regulation of intrinsic apoptotic signaling pathway
- negative regulation of mitotic cell cycle
- negative regulation of myeloid cell apoptotic process
- negative regulation of neuron apoptotic process
- negative regulation of ossification
- negative regulation of osteoblast proliferation
- negative regulation of reactive oxygen species metabolic process
- negative regulation of retinal cell programmed cell death
- neuron apoptotic process
- nuclear membrane
- nucleoplasm
- nucleus
- oocyte development
- organ growth
- ossification
- ovarian follicle development
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- perinuclear region of cytoplasm
- pigment granule organization
- pigmentation
- pore complex
- positive regulation of B cell proliferation
- positive regulation of catalytic activity
- positive regulation of cell growth
- positive regulation of cell population proliferation
- positive regulation of developmental pigmentation
- positive regulation of melanocyte differentiation
- positive regulation of multicellular organism growth
- positive regulation of neuron maturation
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of skeletal muscle fiber development
- positive regulation of smooth muscle cell migration
- post-embryonic development
- protease binding
- protein dephosphorylation
- protein heterodimerization activity
- protein homodimerization activity
- protein phosphatase 2A binding
- protein phosphatase binding
- protein polyubiquitination
- protein-containing complex
- protein-containing complex binding
- reactive oxygen species metabolic process
- regulation of apoptotic process
- regulation of autophagy
- regulation of calcium ion transport
- regulation of catalytic activity
- regulation of cell cycle
- regulation of cell-matrix adhesion
- regulation of developmental pigmentation
- regulation of gene expression
- regulation of glycoprotein biosynthetic process
- regulation of growth
- regulation of mitochondrial membrane permeability
- regulation of mitochondrial membrane potential
- regulation of nitrogen utilization
- regulation of programmed cell death
- regulation of protein localization
- regulation of protein stability
- regulation of transmembrane transporter activity
- regulation of viral genome replication
- release of cytochrome c from mitochondria
- renal system process
- response to UV-B
- response to cytokine
- response to ethanol
- response to gamma radiation
- response to glucocorticoid
- response to hydrogen peroxide
- response to iron ion
- response to ischemia
- response to nicotine
- response to oxidative stress
- response to steroid hormone
- response to toxic substance
- sequence-specific DNA binding
- spleen development
- thymus development
- transcription factor binding
- ubiquitin protein ligase binding
- ureteric bud development

BRSK1
Human
Serine/threonine-protein kinase BRSK1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
BRSK1_HUMAN
- Accession #
-
Q8TDC3
- Protein names
-
- Serine/threonine-protein kinase BRSK1
- EC 2.7.11.1
- Brain-selective kinase 1
- EC 2.7.11.26
- Brain-specific serine/threonine-protein kinase 1
- BR serine/threonine-protein kinase 1
- Serine/threonine-protein kinase SAD-B
- Synapses of Amphids Defective homolog 1
- SAD1 homolog
- hSAD1
- Gene names
-
- BRSK1
- KIAA1811
- SAD1
- SADB
- Description
-
Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15150265, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311}.
- Links
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Search Kinases of BRSK1 (Human)
N/A
- ATP binding
- G2/M transition of mitotic cell cycle
- associative learning
- axonogenesis
- cell junction
- cellular response to DNA damage stimulus
- cellular response to glucose starvation
- centrosome
- centrosome duplication
- cytoplasm
- distal axon
- establishment of cell polarity
- gamma-tubulin binding
- intracellular signal transduction
- magnesium ion binding
- microtubule cytoskeleton organization involved in establishment of planar polarity
- mitotic G2 DNA damage checkpoint signaling
- neuron differentiation
- neurotransmitter secretion
- nucleoplasm
- nucleus
- peptidyl-serine phosphorylation
- presynaptic active zone
- protein kinase binding
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- regulation of axonogenesis
- regulation of neuron projection development
- regulation of synaptic plasticity
- regulation of synaptic vesicle clustering
- response to UV
- synaptic vesicle
- synaptic vesicle cycle
- tau protein binding
- tau-protein kinase activity

Cacna1b
Rat
Voltage-dependent N-type calcium channel subunit alpha-1B
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
CAC1B_RAT
- Accession #
-
Q02294
- Protein names
-
- Voltage-dependent N-type calcium channel subunit alpha-1B
- Brain calcium channel III
- BIII
- Calcium channel, L type, alpha-1 polypeptide isoform 5
- Voltage-gated calcium channel subunit alpha Cav2.2
- Gene names
-
- Cacna1b
- Cach5
- Cacnl1a5
- Description
-
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (PubMed:1317580). They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. {ECO:0000269|PubMed:1317580}.
- Links
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Search Kinases of Cacna1b (Rat)
N/A
- ATP binding
- Schaffer collateral - CA1 synapse
- axon terminus
- calcium ion binding
- calcium ion import
- calcium ion transmembrane transport
- calcium ion transport
- chemical synaptic transmission
- dendrite
- dendritic shaft
- glutamatergic synapse
- high voltage-gated calcium channel activity
- locomotory behavior
- membrane
- modulation of chemical synaptic transmission
- neuron projection
- neuronal cell body
- neurotransmitter secretion
- plasma membrane
- positive regulation of neurotransmitter secretion
- protein C-terminus binding
- protein phosphatase 2A binding
- protein-containing complex
- regulation of blood pressure
- regulation of calcium ion transport
- regulation of heart contraction
- regulation of ion transmembrane transport
- response to amyloid-beta
- response to ethanol
- response to organic cyclic compound
- response to pain
- response to testosterone
- sensory perception of pain
- voltage-gated calcium channel activity
- voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
- voltage-gated calcium channel complex

Cacna1c
Mouse
Voltage-dependent L-type calcium channel subunit alpha-1C
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
CAC1C_MOUSE
- Accession #
-
Q01815
- Protein names
-
- Voltage-dependent L-type calcium channel subunit alpha-1C
- Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle
- MELC-CC
- Mouse brain class C
- MBC
- Voltage-gated calcium channel subunit alpha Cav1.2
- Gene names
-
- Cacna1c
- Cach2
- Cacn2
- Cacnl1a1
- Cchl1a1
- Description
-
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:14609949, PubMed:18586882, PubMed:21216955, PubMed:25368181, PubMed:28119464). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:21216955). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:14609949, PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). {ECO:0000250|UniProtKB:P15381, ECO:0000269|PubMed:14609949, ECO:0000269|PubMed:18586882, ECO:0000269|PubMed:21216955, ECO:0000269|PubMed:25368181, ECO:0000269|PubMed:28119464, ECO:0000305}.
- Links
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Search Kinases of Cacna1c (Mouse)
- Adrenergic signaling in cardiomyocytes
- Aldosterone synthesis and secretion
- Alzheimer disease
- Amphetamine addiction
- Arrhythmogenic right ventricular cardiomyopathy
- Calcium signaling pathway
- Cardiac muscle contraction
- Chemical carcinogenesis
- Cholinergic synapse
- Circadian entrainment
- Cortisol synthesis and secretion
- Cushing syndrome
- Dilated cardiomyopathy
- Dopaminergic synapse
- GABAergic synapse
- Glutamatergic synapse
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hypertrophic cardiomyopathy
- Insulin secretion
- Long
- MAPK signaling pathway
- Oxytocin signaling pathway
- Pathways of neurodegeneration
- Prion disease
- Renin secretion
- Retrograde endocannabinoid signaling
- Serotonergic synapse
- Taste transduction
- Type II diabetes mellitus
- Vascular smooth muscle contraction
- cAMP signaling pathway
- cGMP
- L-type voltage-gated calcium channel complex
- T-tubule
- Z disc
- adult walking behavior
- alpha-actinin binding
- calcium ion import
- calcium ion import across plasma membrane
- calcium ion transmembrane transport
- calcium ion transmembrane transport via high voltage-gated calcium channel
- calcium ion transport
- calcium ion transport into cytosol
- calcium-ion regulated exocytosis
- calmodulin binding
- camera-type eye development
- cardiac conduction
- cardiac muscle cell action potential involved in contraction
- caveolar macromolecular signaling complex
- cell communication involved in cardiac conduction
- cell surface
- cellular calcium ion homeostasis
- chemical synaptic transmission
- cytoplasm
- dendrite
- dendritic shaft
- embryonic forelimb morphogenesis
- enzyme binding
- glucose homeostasis
- glutamatergic synapse
- growth hormone secretion
- heart development
- high voltage-gated calcium channel activity
- immune system development
- insulin secretion
- integral component of membrane
- integral component of plasma membrane
- integral component of postsynaptic membrane
- integral component of presynaptic membrane
- membrane
- membrane depolarization during AV node cell action potential
- membrane depolarization during atrial cardiac muscle cell action potential
- membrane depolarization during cardiac muscle cell action potential
- metal ion binding
- neuronal cell body
- perikaryon
- plasma membrane
- positive regulation of adenylate cyclase activity
- positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
- positive regulation of cytosolic calcium ion concentration
- postsynaptic density
- postsynaptic density membrane
- postsynaptic membrane
- presynaptic membrane
- protein domain specific binding
- protein phosphatase 2A binding
- protein-containing complex
- regulation of blood pressure
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
- regulation of heart rate by cardiac conduction
- regulation of organ growth
- regulation of vasoconstriction
- regulation of ventricular cardiac muscle cell action potential
- sarcolemma
- smooth muscle contraction
- smooth muscle contraction involved in micturition
- translation initiation factor binding
- transmembrane transporter binding
- visual learning
- voltage-gated calcium channel activity
- voltage-gated calcium channel activity involved in AV node cell action potential
- voltage-gated calcium channel activity involved in cardiac muscle cell action potential
- voltage-gated calcium channel complex
- voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential

Camkk1
Rat
Calcium/calmodulin-dependent protein kinase kinase 1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
F1LQD2_RAT
- Accession #
- F1LQD2
- Protein names
-
- Calcium/calmodulin-dependent protein kinase kinase 1
- Calcium/calmodulin-dependent protein kinase kinase 1, alpha
- Gene names
-
- Camkk1
- rCG_35534
- Description
-
N/A
- Links
-
Search Kinases of Camkk1 (Rat)
N/A
