KANPHOS_Str

Search Results (369 substrates found)

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Gene name
Organism
Protein name
Acacb
Rat
Protein Acacb
ADD2
Human
Beta-adducin
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ADDB_HUMAN
Accession #
P35612
Protein names
  • Beta-adducin
  • Erythrocyte adducin subunit beta
Gene names
  • ADD2
  • ADDB
Description
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.
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KEGG Pathways (0)
N/A
Phosphorylation Site Information
Add2
Rat
Beta-adducin
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
F8WFS9_RAT
Accession #
F8WFS9
Protein names
  • Beta-adducin
Gene names
  • Add2
Description
N/A
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Search Kinases of Add2 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Add2
Rat
Beta-adducin
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ADDB_RAT
Accession #
Q05764
Protein names
  • Beta-adducin
  • Adducin-63
  • Erythrocyte adducin subunit beta
Gene names
  • Add2
Description
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity).
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KEGG Pathways (0)
N/A
Phosphorylation Site Information
Agap2
Rat
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
AGAP2_RAT
Accession #
Q8CGU4
Protein names
  • Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
  • AGAP-2
  • Centaurin-gamma-1
  • Cnt-g1
  • Phosphatidylinositol 3-kinase enhancer
  • PIKE
Gene names
  • Agap2
  • Centg1
Description
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. Aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase.
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Phosphorylation Site Information
Ahsg
Rat
Alpha-2-HS-glycoprotein
Amph
Rat
Amphiphysin
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
AMPH_RAT
Accession #
O08838
Protein names
  • Amphiphysin
Gene names
  • Amph
  • Amph1
Description
May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton (By similarity).
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Phosphorylation Site Information
Ankrd34a
Rat
Ankyrin repeat domain-containing protein 34A
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
AN34A_RAT
Accession #
Q5BJT1
Protein names
  • Ankyrin repeat domain-containing protein 34A
Gene names
  • Ankrd34a
Description
N/A
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Search Kinases of Ankrd34a (Rat)
KEGG Pathways (0)
N/A
Gene Ontology Terms (1)
Phosphorylation Site Information
Ankrd63
Rat
Protein Ankrd63
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
D3ZKY6_RAT
Accession #
D3ZKY6
Protein names
  • Protein Ankrd63
Gene names
  • Ankrd63
Description
N/A
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Search Kinases of Ankrd63 (Rat)
KEGG Pathways (0)
N/A
Gene Ontology Terms (0)
N/A
Phosphorylation Site Information
Ap2m1
Rat
AP-2 complex subunit mu
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
AP2M1_RAT
Accession #
P84092
Protein names
  • AP-2 complex subunit mu
  • AP-2 mu chain
  • Adaptor protein complex AP-2 subunit mu
  • Adaptor-related protein complex 2 subunit mu
  • Clathrin assembly protein complex 2 mu medium chain
  • Clathrin coat assembly protein AP50
  • Clathrin coat-associated protein AP50
  • Mu2-adaptin
  • Plasma membrane adaptor AP-2 50 kDa protein
Gene names
  • Ap2m1
Description
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 mu subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs. The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at 'Tyr-156' in membrane-associated AP-2. The membrane-specific phosphorylation event appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (By similarity). Plays a role in endocytosis of frizzled family members upon Wnt signaling.
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Ap3d1
Rat
AP-3 complex subunit delta
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
B5DFK6_RAT
Accession #
B5DFK6
Protein names
  • AP-3 complex subunit delta
Gene names
  • Ap3d1
  • rCG_29405
Description
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane (By similarity).
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Search Kinases of Ap3d1 (Rat)
KEGG Pathways (1)
Phosphorylation Site Information
APC
Human
Adenomatous polyposis coli protein
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
APC_HUMAN
Accession #
P25054
Protein names
  • Adenomatous polyposis coli protein
  • Protein APC
  • Deleted in polyposis 2.5
Gene names
  • APC
  • DP2.5
Description
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
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Gene Ontology Terms (70)
Phosphorylation Site Information
App
Rat
Amyloid beta A4 protein
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
A4_RAT
Accession #
P08592
Protein names
  • Amyloid beta A4 protein
  • ABPP
  • APP
  • Alzheimer disease amyloid A4 protein homolog
  • Amyloidogenic glycoprotein
  • AG [Cleaved into: N-APP
  • Soluble APP-alpha
  • S-APP-alpha
  • Soluble APP-beta
  • S-APP-beta
  • C99
  • Beta-amyloid protein 42
  • Beta-APP42
  • Beta-amyloid protein 40
  • Beta-APP40
  • C83
  • P3
  • 42
Gene names
  • App
Description
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). May be involved in copper homeostasis/oxidative stress through copper ion reduction. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV (By similarity). The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1 (By similarity).Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Binds transient metals such as copper, zinc and iron. Rat and mouse beta-amyloid peptides bind only weakly transient metals and have little reducing activity due to substitutions of transient metal chelating residues. Beta-APP42 may activate mononuclear phagocytes in the brain and elicits inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Also bind GPC1 in lipid rafts (By similarity).Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain.The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis (By similarity).N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6) (By similarity).
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Search Kinases of App (Rat)
Gene Ontology Terms (61)
Phosphorylation Site Information
Arhgef2
Rat
Rho guanine nucleotide exchange factor 2
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ARHG2_RAT
Accession #
Q5FVC2
Protein names
  • Rho guanine nucleotide exchange factor 2
  • Guanine nucleotide exchange factor H1
  • GEF-H1
Gene names
  • Arhgef2
Description
Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2 (By similarity).
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Search Kinases of Arhgef2 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Arhgef7
Rat
PAK-interacting exchange factor
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
Q52NK0_RAT
Accession #
Q52NK0
Protein names
  • PAK-interacting exchange factor
  • Rho guanine nucleotide exchange factor 7
  • Rho guanine nucleotide exchange factor 7, isoform CRA_c
Gene names
  • Arhgef7
  • rCG_43127
Description
N/A
Links

Search Kinases of Arhgef7 (Rat)
Phosphorylation Site Information
ARNTL
Human
Aryl hydrocarbon receptor nuclear translocator-like protein 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
BMAL1_HUMAN
Accession #
O00327
Protein names
  • Aryl hydrocarbon receptor nuclear translocator-like protein 1
  • Basic-helix-loop-helix-PAS protein MOP3
  • Brain and muscle ARNT-like 1
  • Class E basic helix-loop-helix protein 5
  • bHLHe5
  • Member of PAS protein 3
  • PAS domain-containing protein 3
  • bHLH-PAS protein JAP3
Gene names
  • ARNTL
  • BHLHE5
  • BMAL1
  • MOP3
  • PASD3
Description
Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. ARNTL/BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART. The CLOCK-ARNTL/BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1 and also genes implicated in glucose and lipid metabolism. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The NPAS2-ARNTL/BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina.
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Search Kinases of ARNTL (Human)
Gene Ontology Terms (40)
Phosphorylation Site Information
Atp5a1
Rat
ATP synthase subunit alpha
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
F1LP05_RAT
Accession #
F1LP05
Protein names
  • ATP synthase subunit alpha
Gene names
  • Atp5a1
Description
Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity).
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Search Kinases of Atp5a1 (Rat)
KEGG Pathways (0)
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Phosphorylation Site Information
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