Search Results (128 substrates found)
Gene name
Organism
Protein name
ADD2
Human
Beta-adducin
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ADDB_HUMAN
- Accession #
-
P35612
- Protein names
-
- Beta-adducin
- Erythrocyte adducin subunit beta
- Gene names
-
- ADD2
- ADDB
- Description
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. {ECO:0000269|PubMed:18347014}.
- Links
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Search Kinases of ADD2 (Human)
N/A
- F-actin capping protein complex
- actin binding
- actin cytoskeleton organization
- actin filament binding
- actin filament bundle assembly
- barbed-end actin filament capping
- calmodulin binding
- cytoplasmic vesicle
- cytoskeleton
- cytosol
- hemopoiesis
- leukocyte migration
- leukocyte tethering or rolling
- plasma membrane
- plasma membrane raft
- positive regulation of protein binding
- postsynaptic density
- protein heterodimerization activity
- protein homodimerization activity
- protein kinase binding
- protein-containing complex assembly
- spectrin binding
- structural constituent of cytoskeleton
- synapse assembly
- transmembrane transport

Add2
Rat
Beta-adducin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ADDB_RAT
- Accession #
-
Q05764
- Protein names
-
- Beta-adducin
- Adducin-63
- Erythrocyte adducin subunit beta
- Gene names
-
- Add2
- Description
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity). {ECO:0000250}.
- Links
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Search Kinases of Add2 (Rat)
N/A
- F-actin capping protein complex
- actin binding
- actin filament binding
- actin filament bundle assembly
- barbed-end actin filament capping
- calmodulin binding
- cytoplasmic vesicle
- cytoskeleton
- glutamatergic synapse
- hemopoiesis
- ion transport
- leukocyte migration
- leukocyte tethering or rolling
- membrane
- plasma membrane
- plasma membrane raft
- positive regulation of protein binding
- postsynapse
- postsynaptic density
- protein heterodimerization activity
- protein homodimerization activity
- protein kinase binding
- protein-containing complex assembly
- spectrin binding
- structural constituent of cytoskeleton
- synapse assembly

APC
Human
Adenomatous polyposis coli protein
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
APC_HUMAN
- Accession #
-
P25054
- Protein names
-
- Adenomatous polyposis coli protein
- Protein APC
- Deleted in polyposis 2.5
- Gene names
-
- APC
- DP2.5
- Description
-
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}.
- Links
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Search Kinases of APC (Human)
- Alzheimer disease
- Basal cell carcinoma
- Breast cancer
- Colorectal cancer
- Cushing syndrome
- Endometrial cancer
- Gastric cancer
- Hepatocellular carcinoma
- Hippo signaling pathway
- Human papillomavirus infection
- MicroRNAs in cancer
- Pathways in cancer
- Pathways of neurodegeneration
- Regulation of actin cytoskeleton
- Signaling pathways regulating pluripotency of stem cells
- Wnt signaling pathway
- Golgi apparatus
- Wnt signaling pathway
- Wnt signalosome
- adherens junction
- beta-catenin binding
- beta-catenin destruction complex
- beta-catenin destruction complex assembly
- beta-catenin destruction complex disassembly
- bicellular tight junction
- bicellular tight junction assembly
- catenin complex
- cell adhesion
- cell fate specification
- cell migration
- cellular response to DNA damage stimulus
- centrosome
- cytoplasm
- cytosol
- dynein complex binding
- gamma-catenin binding
- insulin receptor signaling pathway
- kinetochore
- lamellipodium
- lateral plasma membrane
- microtubule
- microtubule binding
- microtubule plus-end binding
- mitotic cytokinesis
- mitotic spindle assembly checkpoint signaling
- negative regulation of G1/S transition of mitotic cell cycle
- negative regulation of canonical Wnt signaling pathway
- negative regulation of cell population proliferation
- negative regulation of cyclin-dependent protein serine/threonine kinase activity
- negative regulation of microtubule depolymerization
- nervous system development
- nucleoplasm
- nucleus
- pattern specification process
- perinuclear region of cytoplasm
- plasma membrane
- positive regulation of apoptotic process
- positive regulation of cell death
- positive regulation of cell migration
- positive regulation of cold-induced thermogenesis
- positive regulation of protein catabolic process
- positive regulation of protein localization to centrosome
- positive regulation of pseudopodium assembly
- protein deubiquitination
- protein kinase binding
- protein kinase regulator activity
- protein-containing complex assembly
- regulation of attachment of spindle microtubules to kinetochore
- regulation of cell differentiation
- regulation of microtubule-based process
- ruffle membrane
- ubiquitin protein ligase binding

App
Rat
Amyloid-beta A4 protein
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
A4_RAT
- Accession #
-
P08592
- Protein names
-
- Amyloid-beta A4 protein
- ABPP
- APP
- Alzheimer disease amyloid A4 protein homolog
- Amyloid precursor protein
- Amyloid-beta precursor protein
- Amyloidogenic glycoprotein
- AG
- S-APP-alpha
- S-APP-beta
- Beta-secretase C-terminal fragment
- Beta-CTF
- Abeta42
- Beta-APP42
- Abeta40
- Beta-APP40
- Alpha-secretase C-terminal fragment
- Alpha-CTF
- 42
- 40
- Gamma-CTF(59
- Gamma-CTF(57
- Gamma-CTF(50
- Gene names
-
- App
- Description
-
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapes in axons (By similarity). May be involved in copper homeostasis/oxidative stress through copper ion reduction. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV (By similarity). The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1 (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P05067}.; Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Binds transient metals such as copper, zinc and iron. Rat and mouse amyloid-beta peptides bind only weakly transient metals and have little reducing activity due to substitutions of transient metal chelating residues. Amyloid-beta protein 42 may activate mononuclear phagocytes in the brain and elicits inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Also binds GPC1 in lipid rafts (By similarity). {ECO:0000250}.; Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain.; The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis. {ECO:0000250}.; N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). {ECO:0000250}.
- Links
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Search Kinases of App (Rat)
- COPII-coated ER to Golgi transport vesicle
- DNA binding
- Golgi apparatus
- Golgi-associated vesicle
- Notch signaling pathway
- PTB domain binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- adult locomotory behavior
- amyloid fibril formation
- antibacterial humoral response
- antifungal humoral response
- antimicrobial humoral immune response mediated by antimicrobial peptide
- apical part of cell
- astrocyte activation
- astrocyte activation involved in immune response
- astrocyte projection
- axo-dendritic transport
- axon
- axon midline choice point recognition
- axonogenesis
- cell adhesion
- cell surface
- cell-cell junction
- cellular copper ion homeostasis
- cellular process
- cellular response to amyloid-beta
- cellular response to cAMP
- cellular response to copper ion
- cellular response to manganese ion
- cellular response to nerve growth factor stimulus
- cellular response to norepinephrine stimulus
- cholesterol metabolic process
- ciliary rootlet
- clathrin-coated pit
- cognition
- collateral sprouting in absence of injury
- cytoplasm
- cytoplasmic vesicle
- defense response to Gram-negative bacterium
- defense response to Gram-positive bacterium
- dendrite development
- dendritic shaft
- dendritic spine
- early endosome
- endocytosis
- endosome
- enzyme binding
- extracellular matrix organization
- extracellular space
- forebrain development
- growth cone
- growth cone filopodium
- growth cone lamellipodium
- growth factor receptor binding
- heparin binding
- identical protein binding
- innate immune response
- integral component of membrane
- ionotropic glutamate receptor signaling pathway
- learning
- learning or memory
- locomotory behavior
- low-density lipoprotein particle receptor binding
- mRNA polyadenylation
- main axon
- mating behavior
- membrane
- membrane raft
- microglia development
- microglial cell activation
- modulation of age-related behavioral decline
- modulation of excitatory postsynaptic potential
- negative regulation of cell population proliferation
- negative regulation of gene expression
- negative regulation of long-term synaptic potentiation
- negative regulation of neuron differentiation
- neuromuscular junction
- neuromuscular process controlling balance
- neuron apoptotic process
- neuron projection
- neuron projection development
- neuron projection maintenance
- neuron remodeling
- nuclear envelope lumen
- obsolete activation of MAPK activity
- peptidase activator activity
- perikaryon
- perinuclear region of cytoplasm
- plasma membrane
- positive regulation of DNA-binding transcription factor activity
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of G2/M transition of mitotic cell cycle
- positive regulation of JNK cascade
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of NIK/NF-kappaB signaling
- positive regulation of T cell migration
- positive regulation of amyloid fibril formation
- positive regulation of chemokine production
- positive regulation of endothelin production
- positive regulation of gene expression
- positive regulation of glycolytic process
- positive regulation of inflammatory response
- positive regulation of interleukin-1 beta production
- positive regulation of interleukin-6 production
- positive regulation of long-term synaptic potentiation
- positive regulation of mitotic cell cycle
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of peptidyl-threonine phosphorylation
- positive regulation of phosphorylation
- positive regulation of protein binding
- positive regulation of protein metabolic process
- positive regulation of protein phosphorylation
- positive regulation of transcription by RNA polymerase II
- positive regulation of tumor necrosis factor production
- presynaptic active zone
- protein phosphorylation
- receptor complex
- recycling endosome
- regulation of epidermal growth factor-activated receptor activity
- regulation of gene expression
- regulation of long-term neuronal synaptic plasticity
- regulation of multicellular organism growth
- regulation of peptidyl-tyrosine phosphorylation
- regulation of presynapse assembly
- regulation of protein binding
- regulation of response to calcium ion
- regulation of spontaneous synaptic transmission
- regulation of synapse structure or activity
- regulation of translation
- response to interleukin-1
- response to lead ion
- response to oxidative stress
- response to radiation
- response to yeast
- rough endoplasmic reticulum
- serine-type endopeptidase inhibitor activity
- signaling receptor activator activity
- smooth endoplasmic reticulum
- smooth endoplasmic reticulum calcium ion homeostasis
- spindle midzone
- suckling behavior
- synapse
- synapse organization
- synaptic assembly at neuromuscular junction
- synaptic vesicle
- terminal bouton
- transition metal ion binding
- visual learning

ARNTL
Human
Aryl hydrocarbon receptor nuclear translocator-like protein 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
BMAL1_HUMAN
- Accession #
-
O00327
- Protein names
-
- Aryl hydrocarbon receptor nuclear translocator-like protein 1
- Basic-helix-loop-helix-PAS protein MOP3
- Brain and muscle ARNT-like 1
- Class E basic helix-loop-helix protein 5
- bHLHe5
- Member of PAS protein 3
- PAS domain-containing protein 3
- bHLH-PAS protein JAP3
- Gene names
-
- ARNTL
- BHLHE5
- BMAL1
- MOP3
- PASD3
- Description
-
Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. ARNTL/BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART and KLF11. The CLOCK-ARNTL/BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The NPAS2-ARNTL/BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The preferred binding motif for the CLOCK-ARNTL/BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking Ala residue in addition to the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while ARNTL binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-ARNTL/BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1 (PubMed:28985504). Plays a role in protecting against lethal sepsis by limiting the expression of immune checkpoint protein CD274 in macrophages in a PKM2-dependent manner (By similarity). Regulates the diurnal rhythms of skeletal muscle metabolism via transcriptional activation of genes promoting triglyceride synthesis (DGAT2) and metabolic efficiency (COQ10B) (By similarity). {ECO:0000250|UniProtKB:Q9WTL8, ECO:0000269|PubMed:11441146, ECO:0000269|PubMed:12738229, ECO:0000269|PubMed:18587630, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:23955654, ECO:0000269|PubMed:24005054, ECO:0000269|PubMed:28985504}.
- Links
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Search Kinases of ARNTL (Human)
- DNA binding
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription factor binding
- E-box binding
- Hsp90 protein binding
- PML body
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- aryl hydrocarbon receptor binding
- aryl hydrocarbon receptor complex
- chromatin
- chromatoid body
- circadian regulation of gene expression
- circadian rhythm
- intracellular membrane-bounded organelle
- negative regulation of TOR signaling
- negative regulation of cold-induced thermogenesis
- negative regulation of fat cell differentiation
- negative regulation of glucocorticoid receptor signaling pathway
- negative regulation of transcription, DNA-templated
- nucleoplasm
- nucleus
- oxidative stress-induced premature senescence
- positive regulation of canonical Wnt signaling pathway
- positive regulation of circadian rhythm
- positive regulation of protein acetylation
- positive regulation of skeletal muscle cell differentiation
- positive regulation of transcription by RNA polymerase II
- positive regulation of transcription, DNA-templated
- proteasome-mediated ubiquitin-dependent protein catabolic process
- protein dimerization activity
- regulation of cell cycle
- regulation of cellular senescence
- regulation of hair cycle
- regulation of insulin secretion
- regulation of neurogenesis
- regulation of transcription by RNA polymerase II
- regulation of transcription, DNA-templated
- regulation of type B pancreatic cell development
- response to redox state
- sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
- spermatogenesis
- transcription cis-regulatory region binding
- transcription regulator complex

ATXN3
Human
Ataxin-3
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ATX3_HUMAN
- Accession #
-
P54252
- Protein names
-
- Ataxin-3
- EC 3.4.19.12
- Machado-Joseph disease protein 1
- Spinocerebellar ataxia type 3 protein
- Gene names
-
- ATXN3
- ATX3
- MJD
- MJD1
- SCA3
- Description
-
Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:16118278). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). {ECO:0000250|UniProtKB:Q9CVD2, ECO:0000269|PubMed:12297501, ECO:0000269|PubMed:16118278, ECO:0000269|PubMed:17696782, ECO:0000269|PubMed:23625928, ECO:0000269|PubMed:28445460}.
- Links
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Search Kinases of ATXN3 (Human)
- ATPase binding
- Lys48-specific deubiquitinase activity
- Lys63-specific deubiquitinase activity
- actin cytoskeleton organization
- cellular response to heat
- cellular response to misfolded protein
- chemical synaptic transmission
- cytoplasm
- cytosol
- identical protein binding
- intermediate filament cytoskeleton organization
- microtubule cytoskeleton organization
- mitochondrial matrix
- mitochondrial membrane
- monoubiquitinated protein deubiquitination
- nervous system development
- nuclear inclusion body
- nuclear matrix
- nucleolus
- nucleoplasm
- nucleotide-excision repair
- nucleus
- plasma membrane
- positive regulation of ERAD pathway
- proteasome-mediated ubiquitin-dependent protein catabolic process
- protein K48-linked deubiquitination
- protein K63-linked deubiquitination
- protein deubiquitination
- protein localization to cytosolic proteasome complex involved in ERAD pathway
- protein quality control for misfolded or incompletely synthesized proteins
- regulation of cell-substrate adhesion
- synapse
- thiol-dependent deubiquitinase
- ubiquitin protein ligase binding
- ubiquitin-dependent protein catabolic process

Atxn3
Mouse
Ataxin-3
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
ATX3_MOUSE
- Accession #
-
Q9CVD2
- Protein names
-
- Ataxin-3
- EC 3.4.19.12
- Machado-Joseph disease protein 1 homolog
- Gene names
-
- Atxn3
- Mjd
- Description
-
Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (By similarity). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (PubMed:21855799). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (By similarity). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). {ECO:0000250|UniProtKB:P54252, ECO:0000269|PubMed:21855799, ECO:0000269|PubMed:28445460}.
- Links
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Search Kinases of Atxn3 (Mouse)
- ATPase binding
- Lys48-specific deubiquitinase activity
- Lys63-specific deubiquitinase activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- actin cytoskeleton organization
- cellular response to heat
- cellular response to misfolded protein
- cytoplasm
- cytosol
- exploration behavior
- histone H3 deacetylation
- histone deacetylase activity
- identical protein binding
- intermediate filament cytoskeleton organization
- microtubule cytoskeleton organization
- mitochondrial matrix
- mitochondrial membrane
- monoubiquitinated protein deubiquitination
- nuclear inclusion body
- nucleolus
- nucleoplasm
- nucleus
- plasma membrane
- positive regulation of ERAD pathway
- proteasome-mediated ubiquitin-dependent protein catabolic process
- protein K48-linked deubiquitination
- protein K63-linked deubiquitination
- protein deubiquitination
- protein localization to cytosolic proteasome complex involved in ERAD pathway
- protein quality control for misfolded or incompletely synthesized proteins
- regulation of cell-substrate adhesion
- thiol-dependent deubiquitinase
- ubiquitin protein ligase binding
- ubiquitin-dependent protein catabolic process

Axin1
Mouse
Axin-1
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
AXIN1_MOUSE
- Accession #
-
O35625
- Protein names
-
- Axin-1
- Axis inhibition protein 1
- Protein Fused
- Gene names
-
- Axin1
- Axin
- Fu
- Description
-
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (By similarity). Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. {ECO:0000250, ECO:0000269|PubMed:12223491, ECO:0000269|PubMed:15526030, ECO:0000269|PubMed:17681137}.
- Links
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Search Kinases of Axin1 (Mouse)
- Alzheimer disease
- Basal cell carcinoma
- Breast cancer
- Colorectal cancer
- Cushing syndrome
- Endometrial cancer
- Gastric cancer
- Hepatocellular carcinoma
- Hippo signaling pathway
- Human papillomavirus infection
- Pathways in cancer
- Pathways of neurodegeneration
- Signaling pathways regulating pluripotency of stem cells
- Wnt signaling pathway
- I-SMAD binding
- R-SMAD binding
- SMAD binding
- Wnt signaling pathway
- Wnt signalosome
- activation of protein kinase activity
- apoptotic process
- armadillo repeat domain binding
- axial mesoderm development
- axial mesoderm formation
- beta-catenin binding
- beta-catenin destruction complex
- canonical Wnt signaling pathway
- cell cortex
- cell periphery
- cellular protein-containing complex assembly
- cytoplasm
- cytoplasmic microtubule organization
- cytoplasmic vesicle
- cytosol
- dorsal/ventral axis specification
- dorsal/ventral pattern formation
- enzyme binding
- genetic imprinting
- head development
- identical protein binding
- in utero embryonic development
- lateral plasma membrane
- microtubule cytoskeleton
- molecular adaptor activity
- negative regulation of Wnt signaling pathway
- negative regulation of canonical Wnt signaling pathway
- negative regulation of fat cell differentiation
- negative regulation of gene expression
- negative regulation of protein metabolic process
- negative regulation of transcription elongation from RNA polymerase II promoter
- nucleocytoplasmic transport
- nucleus
- p53 binding
- perinuclear region of cytoplasm
- plasma membrane
- positive regulation of JNK cascade
- positive regulation of JUN kinase activity
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of peptidyl-threonine phosphorylation
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of protein catabolic process
- positive regulation of protein kinase activity
- positive regulation of protein phosphorylation
- positive regulation of protein ubiquitination
- positive regulation of transcription, DNA-templated
- positive regulation of transforming growth factor beta receptor signaling pathway
- positive regulation of ubiquitin-dependent protein catabolic process
- positive regulation of ubiquitin-protein transferase activity
- post-anal tail morphogenesis
- postsynaptic density
- protein C-terminus binding
- protein catabolic process
- protein domain specific binding
- protein homodimerization activity
- protein kinase binding
- protein polyubiquitination
- protein self-association
- protein-containing complex
- regulation of canonical Wnt signaling pathway
- regulation of protein phosphorylation
- sensory perception of sound
- signaling receptor binding
- signaling receptor complex adaptor activity
- ubiquitin protein ligase binding

BAX
Human
Apoptosis regulator BAX
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
BAX_HUMAN
- Accession #
-
Q07812
- Protein names
-
- Apoptosis regulator BAX
- Bcl-2-like protein 4
- Bcl2-L-4
- Gene names
-
- BAX
- BCL2L4
- Description
-
Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. {ECO:0000269|PubMed:10772918, ECO:0000269|PubMed:16113678, ECO:0000269|PubMed:18948948, ECO:0000269|PubMed:21199865, ECO:0000269|PubMed:21458670, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:8358790, ECO:0000269|PubMed:8521816}.
- Links
-
Search Kinases of BAX (Human)
- AGE
- Amyotrophic lateral sclerosis
- Apoptosis
- Basal cell carcinoma
- Breast cancer
- Chronic myeloid leukemia
- Colorectal cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- Epstein
- Gastric cancer
- Glioma
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Herpes simplex virus 1 infection
- Human T
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Huntington disease
- Influenza A
- Kaposi sarcoma
- Lipid and atherosclerosis
- Longevity regulating pathway
- Measles
- Melanoma
- Necroptosis
- Neurotrophin signaling pathway
- Non
- Pancreatic cancer
- Parkinson disease
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration
- Platinum drug resistance
- Prion disease
- Protein processing in endoplasmic reticulum
- Salmonella infection
- Shigellosis
- Small cell lung cancer
- Sphingolipid signaling pathway
- Thyroid cancer
- Transcriptional misregulation in cancer
- Tuberculosis
- Viral carcinogenesis
- p53 signaling pathway
- B cell apoptotic process
- B cell homeostasis
- B cell homeostatic proliferation
- B cell negative selection
- B cell receptor apoptotic signaling pathway
- BAK complex
- BAX complex
- BH3 domain binding
- Bcl-2 family protein complex
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- Hsp70 protein binding
- Sertoli cell proliferation
- T cell homeostatic proliferation
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
- activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
- apoptotic mitochondrial changes
- apoptotic process
- apoptotic process involved in blood vessel morphogenesis
- apoptotic process involved in embryonic digit morphogenesis
- apoptotic signaling pathway
- blood vessel remodeling
- cellular response to UV
- cellular response to unfolded protein
- cellular response to virus
- cerebral cortex development
- channel activity
- chaperone binding
- cytoplasm
- cytosol
- development of secondary sexual characteristics
- ectopic germ cell programmed cell death
- endoplasmic reticulum
- endoplasmic reticulum calcium ion homeostasis
- endoplasmic reticulum membrane
- establishment or maintenance of transmembrane electrochemical gradient
- extracellular exosome
- extrinsic apoptotic signaling pathway
- extrinsic apoptotic signaling pathway in absence of ligand
- extrinsic apoptotic signaling pathway via death domain receptors
- fertilization
- germ cell development
- glycosphingolipid metabolic process
- homeostasis of number of cells within a tissue
- hypothalamus development
- identical protein binding
- intrinsic apoptotic signaling pathway
- intrinsic apoptotic signaling pathway by p53 class mediator
- intrinsic apoptotic signaling pathway in response to DNA damage
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- kidney development
- lipid binding
- membrane
- mitochondrial fragmentation involved in apoptotic process
- mitochondrial fusion
- mitochondrial outer membrane
- mitochondrial permeability transition pore complex
- mitochondrion
- mitochondrion morphogenesis
- myeloid cell homeostasis
- negative regulation of apoptotic signaling pathway
- negative regulation of endoplasmic reticulum calcium ion concentration
- negative regulation of fibroblast proliferation
- negative regulation of mitochondrial membrane potential
- negative regulation of neuron apoptotic process
- negative regulation of peptidyl-serine phosphorylation
- negative regulation of protein binding
- neuron apoptotic process
- neuron migration
- nuclear envelope
- nucleus
- odontogenesis of dentin-containing tooth
- ovarian follicle development
- pore complex
- positive regulation of B cell apoptotic process
- positive regulation of IRE1-mediated unfolded protein response
- positive regulation of apoptotic DNA fragmentation
- positive regulation of apoptotic process
- positive regulation of apoptotic process involved in mammary gland involution
- positive regulation of developmental pigmentation
- positive regulation of endoplasmic reticulum unfolded protein response
- positive regulation of intrinsic apoptotic signaling pathway
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
- positive regulation of neuron apoptotic process
- positive regulation of protein-containing complex assembly
- positive regulation of release of cytochrome c from mitochondria
- positive regulation of release of sequestered calcium ion into cytosol
- post-embryonic camera-type eye morphogenesis
- protein heterodimerization activity
- protein homodimerization activity
- protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
- regulation of apoptotic process
- regulation of mammary gland epithelial cell proliferation
- regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
- regulation of mitochondrial membrane potential
- regulation of nitrogen utilization
- regulation of transcription initiation from RNA polymerase II promoter
- release of cytochrome c from mitochondria
- release of matrix enzymes from mitochondria
- response to axon injury
- response to gamma radiation
- response to salt stress
- response to toxic substance
- retina development in camera-type eye
- retinal cell programmed cell death
- spermatid differentiation
- thymocyte apoptotic process
- vagina development
- viral process

BCAM
Human
Basal cell adhesion molecule
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
BCAM_HUMAN
- Accession #
-
P50895
- Protein names
-
- Basal cell adhesion molecule
- Auberger B antigen
- B-CAM cell surface glycoprotein
- F8/G253 antigen
- Lutheran antigen
- Lutheran blood group glycoprotein
- CD antigen CD239
- Gene names
-
- BCAM
- LU
- MSK19
- Description
-
Laminin alpha-5 receptor. May mediate intracellular signaling. {ECO:0000269|PubMed:9616226}.
- Links
-
Search Kinases of BCAM (Human)
N/A
- cell adhesion
- cell-matrix adhesion
- collagen-containing extracellular matrix
- external side of plasma membrane
- extracellular exosome
- extracellular region
- integral component of plasma membrane
- laminin binding
- laminin receptor activity
- plasma membrane
- protein C-terminus binding
- signal transduction
- transmembrane signaling receptor activity

BCL2L1
Human
Bcl-2-like protein 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
B2CL1_HUMAN
- Accession #
-
Q07817
- Protein names
-
- Bcl-2-like protein 1
- Bcl2-L-1
- Apoptosis regulator Bcl-X
- Gene names
-
- BCL2L1
- BCL2L
- BCLX
- Description
-
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.; Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). {ECO:0000269|PubMed:17418785}.; Isoform Bcl-X(S) promotes apoptosis.
- Links
-
Search Kinases of BCL2L1 (Human)
- Amyotrophic lateral sclerosis
- Apoptosis
- Autophagy
- Chronic myeloid leukemia
- EGFR tyrosine kinase inhibitor resistance
- Hepatocellular carcinoma
- Herpes simplex virus 1 infection
- Human T
- Human immunodeficiency virus 1 infection
- JAK
- Lipid and atherosclerosis
- Measles
- Mitophagy
- NF
- NOD
- PI3K
- Pancreatic cancer
- Parkinson disease
- Pathways in cancer
- Pathways of neurodegeneration
- Platinum drug resistance
- Ras signaling pathway
- Shigellosis
- Small cell lung cancer
- Toxoplasmosis
- Transcriptional misregulation in cancer
- p53 signaling pathway
- BH3 domain binding
- Bcl-2 family protein complex
- MAPK cascade
- apoptotic mitochondrial changes
- centrosome
- cytokine-mediated signaling pathway
- cytoplasm
- cytosol
- defense response to virus
- endocytosis
- extrinsic apoptotic signaling pathway in absence of ligand
- identical protein binding
- integral component of membrane
- intrinsic apoptotic signaling pathway in response to DNA damage
- mitochondrial inner membrane
- mitochondrial matrix
- mitochondrial outer membrane
- mitochondrion
- mitotic cell cycle checkpoint signaling
- negative regulation of anoikis
- negative regulation of apoptotic process
- negative regulation of autophagy
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
- negative regulation of execution phase of apoptosis
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
- negative regulation of intrinsic apoptotic signaling pathway
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
- negative regulation of protein localization to plasma membrane
- negative regulation of release of cytochrome c from mitochondria
- nuclear membrane
- positive regulation of intrinsic apoptotic signaling pathway
- protein heterodimerization activity
- protein homodimerization activity
- protein kinase binding
- regulation of cytokinesis
- regulation of mitochondrial membrane permeability
- regulation of mitochondrial membrane potential
- release of cytochrome c from mitochondria
- response to cytokine
- suppression by virus of host apoptotic process
- synaptic vesicle membrane

BCL2L12
Human
Bcl-2-like protein 12
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
B2L12_HUMAN
- Accession #
-
Q9HB09
- Protein names
-
- Bcl-2-like protein 12
- Bcl2-L-12
- Bcl-2-related proline-rich protein
- Gene names
-
- BCL2L12
- BPR
- Description
-
N/A
- Links
-
Search Kinases of BCL2L12 (Human)
N/A
- apoptotic process
- inhibition of cysteine-type endopeptidase activity involved in apoptotic process
- membrane
- negative regulation of cellular senescence
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
- nucleus
- p53 binding
- positive regulation of transcription by RNA polymerase II
- regulation of extrinsic apoptotic signaling pathway

BCLAF1
Human
Bcl-2-associated transcription factor 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
BCLF1_HUMAN
- Accession #
-
Q9NYF8
- Protein names
-
- Bcl-2-associated transcription factor 1
- Btf
- BCLAF1 and THRAP3 family member 1
- Gene names
-
- BCLAF1
- BTF
- KIAA0164
- Description
-
Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}.
- Links
-
Search Kinases of BCLAF1 (Human)
N/A
- DNA binding
- RNA binding
- apoptotic process
- cellular response to leukemia inhibitory factor
- cytoplasm
- mediator complex
- negative regulation of transcription, DNA-templated
- nuclear speck
- nucleoplasm
- nucleus
- positive regulation of DNA-templated transcription, initiation
- positive regulation of apoptotic process
- positive regulation of intrinsic apoptotic signaling pathway
- positive regulation of response to DNA damage stimulus
- positive regulation of transcription by RNA polymerase II
- regulation of DNA-templated transcription in response to stress
- transcription coregulator activity

BORA
Human
Protein aurora borealis
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
BORA_HUMAN
- Accession #
-
Q6PGQ7
- Protein names
-
- Protein aurora borealis
- HsBora
- Gene names
-
- BORA
- C13orf34
- Description
-
Required for the activation of AURKA at the onset of mitosis. {ECO:0000269|PubMed:16890155}.
- Links
-
Search Kinases of BORA (Human)
N/A

CABYR
Human
Calcium-binding tyrosine phosphorylation-regulated protein
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CABYR_HUMAN
- Accession #
-
O75952
- Protein names
-
- Calcium-binding tyrosine phosphorylation-regulated protein
- Calcium-binding protein 86
- Cancer/testis antigen 88
- CT88
- Fibrousheathin II
- Fibrousheathin-2
- FSP-2
- Testis-specific calcium-binding protein CBP86
- Gene names
-
- CABYR
- CBP86
- FSP2
- Description
-
May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium.
- Links
-
Search Kinases of CABYR (Human)
N/A

CCND1
Human
G1/S-specific cyclin-D1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CCND1_HUMAN
- Accession #
-
P24385
- Protein names
-
- G1/S-specific cyclin-D1
- B-cell lymphoma 1 protein
- BCL-1
- BCL-1 oncogene
- PRAD1 oncogene
- Gene names
-
- CCND1
- BCL1
- PRAD1
- Description
-
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. {ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:16569215, ECO:0000269|PubMed:18417529, ECO:0000269|PubMed:9106657}.
- Links
-
Search Kinases of CCND1 (Human)
- AGE
- AMPK signaling pathway
- Acute myeloid leukemia
- Apelin signaling pathway
- Bladder cancer
- Breast cancer
- Cell cycle
- Cellular senescence
- Chemical carcinogenesis
- Chronic myeloid leukemia
- Colorectal cancer
- Cushing syndrome
- Endocrine resistance
- Endometrial cancer
- Epstein
- Focal adhesion
- FoxO signaling pathway
- Gastric cancer
- Glioma
- Hedgehog signaling pathway
- Hepatitis C
- Hepatocellular carcinoma
- Hippo signaling pathway
- Human T
- Human cytomegalovirus infection
- Human papillomavirus infection
- JAK
- Kaposi sarcoma
- Measles
- Melanoma
- MicroRNAs in cancer
- Non
- Oxytocin signaling pathway
- PI3K
- Pancreatic cancer
- Pathways in cancer
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Small cell lung cancer
- Thyroid cancer
- Thyroid hormone signaling pathway
- Tight junction
- Viral carcinogenesis
- Viral myocarditis
- Wnt signaling pathway
- p53 signaling pathway
- G1/S transition of mitotic cell cycle
- Leydig cell differentiation
- Wnt signaling pathway
- bicellular tight junction
- cell division
- cellular response to DNA damage stimulus
- cyclin-dependent protein kinase holoenzyme complex
- cyclin-dependent protein serine/threonine kinase regulator activity
- cytokine-mediated signaling pathway
- cytoplasm
- cytosol
- endoplasmic reticulum unfolded protein response
- enzyme binding
- fat cell differentiation
- histone deacetylase binding
- lactation
- liver regeneration
- mammary gland alveolus development
- mammary gland epithelial cell proliferation
- mitotic G1 DNA damage checkpoint signaling
- mitotic cell cycle phase transition
- negative regulation of epithelial cell differentiation
- negative regulation of transcription by RNA polymerase II
- nuclear membrane
- nucleoplasm
- nucleus
- positive regulation of G1/S transition of mitotic cell cycle
- positive regulation of G2/M transition of mitotic cell cycle
- positive regulation of cell cycle
- positive regulation of cyclin-dependent protein serine/threonine kinase activity
- positive regulation of mammary gland epithelial cell proliferation
- positive regulation of protein phosphorylation
- proline-rich region binding
- protein kinase activity
- protein kinase binding
- protein-containing complex binding
- re-entry into mitotic cell cycle
- regulation of cyclin-dependent protein serine/threonine kinase activity
- regulation of transcription initiation from RNA polymerase II promoter
- response to UV-A
- response to X-ray
- response to calcium ion
- response to corticosterone
- response to estradiol
- response to estrogen
- response to ethanol
- response to iron ion
- response to leptin
- response to magnesium ion
- response to organonitrogen compound
- response to vitamin E
- transcription corepressor activity
- transcription factor binding
- transcription repressor complex

Ccnd1
Mouse
G1/S-specific cyclin-D1
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
CCND1_MOUSE
- Accession #
-
P25322
- Protein names
-
- G1/S-specific cyclin-D1
- Gene names
-
- Ccnd1
- Cyl-1
- Description
-
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (By similarity). {ECO:0000250}.
- Links
-
Search Kinases of Ccnd1 (Mouse)
- AGE
- AMPK signaling pathway
- Acute myeloid leukemia
- Apelin signaling pathway
- Bladder cancer
- Breast cancer
- Cell cycle
- Cellular senescence
- Chemical carcinogenesis
- Chronic myeloid leukemia
- Colorectal cancer
- Cushing syndrome
- Endocrine resistance
- Endometrial cancer
- Epstein
- Focal adhesion
- FoxO signaling pathway
- Gastric cancer
- Glioma
- Hedgehog signaling pathway
- Hepatitis C
- Hepatocellular carcinoma
- Hippo signaling pathway
- Human T
- Human cytomegalovirus infection
- Human papillomavirus infection
- JAK
- Kaposi sarcoma
- Measles
- Melanoma
- MicroRNAs in cancer
- Non
- Oxytocin signaling pathway
- PI3K
- Pancreatic cancer
- Pathways in cancer
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Small cell lung cancer
- Thyroid cancer
- Thyroid hormone signaling pathway
- Tight junction
- Viral carcinogenesis
- Viral myocarditis
- Wnt signaling pathway
- p53 signaling pathway
- G1/S transition of mitotic cell cycle
- Leydig cell differentiation
- Wnt signaling pathway
- bicellular tight junction
- cell division
- cellular response to DNA damage stimulus
- cellular response to organic substance
- cyclin-dependent protein kinase holoenzyme complex
- cyclin-dependent protein serine/threonine kinase regulator activity
- cytoplasm
- cytosol
- endoplasmic reticulum unfolded protein response
- enzyme binding
- fat cell differentiation
- histone deacetylase binding
- kinase activity
- lactation
- liver regeneration
- mammary gland alveolus development
- mammary gland epithelial cell proliferation
- mitotic G1 DNA damage checkpoint signaling
- mitotic cell cycle phase transition
- negative regulation of epithelial cell differentiation
- negative regulation of transcription by RNA polymerase II
- nuclear membrane
- nucleoplasm
- nucleus
- positive regulation of G1/S transition of mitotic cell cycle
- positive regulation of G2/M transition of mitotic cell cycle
- positive regulation of cell population proliferation
- positive regulation of cyclin-dependent protein serine/threonine kinase activity
- positive regulation of mammary gland epithelial cell proliferation
- positive regulation of protein phosphorylation
- proline-rich region binding
- protein kinase activity
- protein kinase binding
- protein phosphorylation
- protein-containing complex binding
- re-entry into mitotic cell cycle
- regulation of G1/S transition of mitotic cell cycle
- regulation of cell cycle
- regulation of cyclin-dependent protein serine/threonine kinase activity
- response to UV-A
- response to X-ray
- response to calcium ion
- response to corticosterone
- response to estradiol
- response to estrogen
- response to ethanol
- response to iron ion
- response to leptin
- response to magnesium ion
- response to organonitrogen compound
- response to vitamin E
- transcription corepressor activity
- transcription factor binding
- transcription repressor complex

CCND2
Human
G1/S-specific cyclin-D2
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CCND2_HUMAN
- Accession #
-
P30279
- Protein names
-
- G1/S-specific cyclin-D2
- Gene names
-
- CCND2
- Description
-
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). {ECO:0000250}.
- Links
-
Search Kinases of CCND2 (Human)
- Cell cycle
- Cellular senescence
- Epstein
- Focal adhesion
- FoxO signaling pathway
- Hedgehog signaling pathway
- Hippo signaling pathway
- Human T
- Human papillomavirus infection
- JAK
- Measles
- MicroRNAs in cancer
- PI3K
- Pathways in cancer
- Prolactin signaling pathway
- Transcriptional misregulation in cancer
- Viral carcinogenesis
- Wnt signaling pathway
- p53 signaling pathway
- cell division
- chromatin
- cyclin-dependent protein kinase holoenzyme complex
- cyclin-dependent protein serine/threonine kinase regulator activity
- cytoplasm
- cytosol
- mitotic cell cycle phase transition
- negative regulation of apoptotic process
- nuclear membrane
- nucleolus
- nucleoplasm
- nucleus
- positive regulation of G1/S transition of mitotic cell cycle
- positive regulation of cell population proliferation
- positive regulation of cyclin-dependent protein serine/threonine kinase activity
- positive regulation of protein phosphorylation
- protein kinase binding
- regulation of cyclin-dependent protein serine/threonine kinase activity

CCND3
Human
G1/S-specific cyclin-D3
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CCND3_HUMAN
- Accession #
-
P30281
- Protein names
-
- G1/S-specific cyclin-D3
- Gene names
-
- CCND3
- Description
-
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. {ECO:0000269|PubMed:15358120}.
- Links
-
Search Kinases of CCND3 (Human)
- T cell proliferation
- cell division
- cyclin-dependent protein kinase holoenzyme complex
- cyclin-dependent protein serine/threonine kinase activity
- cyclin-dependent protein serine/threonine kinase regulator activity
- cytoplasm
- membrane
- mitotic cell cycle phase transition
- negative regulation of transcription by RNA polymerase II
- nucleoplasm
- nucleus
- positive regulation of G1/S transition of mitotic cell cycle
- positive regulation of cyclin-dependent protein serine/threonine kinase activity
- positive regulation of protein phosphorylation
- protein kinase binding
- regulation of cell population proliferation
- regulation of cyclin-dependent protein serine/threonine kinase activity
- regulation of insulin receptor signaling pathway
- signal transduction

CCNE1
Human
G1/S-specific cyclin-E1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CCNE1_HUMAN
- Accession #
-
P24864
- Protein names
-
- G1/S-specific cyclin-E1
- Gene names
-
- CCNE1
- CCNE
- Description
-
Essential for the control of the cell cycle at the G1/S (start) transition. {ECO:0000269|PubMed:7739542}.
- Links
-
Search Kinases of CCNE1 (Human)
- DNA replication initiation
- G1/S transition of mitotic cell cycle
- Wnt signaling pathway
- cell division
- centrosome
- cyclin E1-CDK2 complex
- cyclin-dependent protein kinase holoenzyme complex
- cyclin-dependent protein serine/threonine kinase regulator activity
- cytoplasm
- cytosol
- homologous chromosome pairing at meiosis
- kinase activity
- mitotic cell cycle phase transition
- negative regulation of transcription by RNA polymerase II
- nucleoplasm
- nucleus
- positive regulation of mesenchymal stem cell proliferation
- protein kinase binding
- protein phosphorylation
- regulation of cyclin-dependent protein serine/threonine kinase activity
- regulation of transcription involved in G1/S transition of mitotic cell cycle
- telomere maintenance
