KANPHOS_Str

Search Results (141 substrates found)

Displaying 1 - 20 of 141 Items
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Gene name
Organism
Protein name
Acot11
Rat
Protein Acot11
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
F1LX28_RAT
Accession #
F1LX28
Protein names
  • Protein Acot11
  • Fragment
Gene names
  • Acot11
Description
N/A
Links

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Gene Ontology Terms (2)
Phosphorylation Site Information
Add2
Rat
Beta-adducin
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
F8WFS9_RAT
Accession #
F8WFS9
Protein names
  • Beta-adducin
Gene names
  • Add2
Description
N/A
Links

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Ak5
Rat
Protein Ak5
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
M0R7U1_RAT
Accession #
M0R7U1
Protein names
  • Protein Ak5
  • RCG28422
Gene names
  • Ak5
  • rCG_28422
Description
N/A
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Ambp
Rat
Protein AMBP [Cleaved into: Alpha-1-microglobulin; Inter-alpha-trypsin inhibitor light chain
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
AMBP_RAT
Accession #
Q64240
Protein names
  • Protein AMBP [Cleaved into: Alpha-1-microglobulin
  • Inter-alpha-trypsin inhibitor light chain
  • ITI-LC
  • Bikunin
  • HI-30
  • Trypstatin]
Gene names
  • Ambp
  • Itil
Description
Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization (By similarity).Trypstatin is a trypsin inhibitor. It inhibits blood coagulation factor Xa and tryptase about 100-fold more rapidly than porcine pancreatic trypsin and chymase.
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Ankrd63
Rat
Protein Ankrd63
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
D3ZKY6_RAT
Accession #
D3ZKY6
Protein names
  • Protein Ankrd63
Gene names
  • Ankrd63
Description
N/A
Links

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Ap2m1
Rat
AP-2 complex subunit mu
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
AP2M1_RAT
Accession #
P84092
Protein names
  • AP-2 complex subunit mu
  • AP-2 mu chain
  • Adaptor protein complex AP-2 subunit mu
  • Adaptor-related protein complex 2 subunit mu
  • Clathrin assembly protein complex 2 mu medium chain
  • Clathrin coat assembly protein AP50
  • Clathrin coat-associated protein AP50
  • Mu2-adaptin
  • Plasma membrane adaptor AP-2 50 kDa protein
Gene names
  • Ap2m1
Description
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 mu subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs. The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at 'Tyr-156' in membrane-associated AP-2. The membrane-specific phosphorylation event appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (By similarity). Plays a role in endocytosis of frizzled family members upon Wnt signaling.
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Arhgap35
Rat
Rho GTPase-activating protein 35
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
RHG35_RAT
Accession #
P81128
Protein names
  • Rho GTPase-activating protein 35
  • GAP-associated protein p190
  • Glucocorticoid receptor DNA-binding factor 1
Gene names
  • Arhgap35
  • Grlf1
Description
Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor (By similarity).
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ARL6IP4
Human
ADP-ribosylation factor-like protein 6-interacting protein 4
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
AR6P4_HUMAN
Accession #
Q66PJ3
Protein names
  • ADP-ribosylation factor-like protein 6-interacting protein 4
  • ARL-6-interacting protein 4
  • Aip-4
  • HSP-975
  • HSVI-binding protein
  • SR-15
  • SRp25
  • SR-25
  • Splicing factor SRrp37
Gene names
  • ARL6IP4
Description
Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site. In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA.
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Atp5a1
Rat
ATP synthase subunit alpha
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
F1LP05_RAT
Accession #
F1LP05
Protein names
  • ATP synthase subunit alpha
Gene names
  • Atp5a1
Description
Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity).
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Brsk1
Rat
Serine/threonine-protein kinase BRSK1
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
BRSK1_RAT
Accession #
B2DD29
Protein names
  • Serine/threonine-protein kinase BRSK1
  • EC 2.7.11.1
  • EC 2.7.11.26
  • Brain-specific serine/threonine-protein kinase 1
  • BR serine/threonine-protein kinase 1
  • Serine/threonine-protein kinase SAD-B
Gene names
  • Brsk1
  • Sadb
Description
Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-523' and 'Ser-573'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C (By similarity). In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1.
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Brsk2
Rat
Serine/threonine-protein kinase BRSK2
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
BRSK2_RAT
Accession #
D3ZML2
Protein names
  • Serine/threonine-protein kinase BRSK2
  • EC 2.7.11.1
  • EC 2.7.11.26
  • Brain-specific serine/threonine-protein kinase 2
  • BR serine/threonine-protein kinase 2
  • Serine/threonine-protein kinase SAD-A
Gene names
  • Brsk2
  • Sada
Description
Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-523' and 'Ser-573'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-175 can inhibit insulin secretion, BRSK2 phosphorylated at Thr-261 can promote insulin secretion. Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmatic reticulum (ER) stress (By similarity).
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C11orf63
Human
Uncharacterized protein C11orf63
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CK063_HUMAN
Accession #
Q6NUN7
Protein names
  • Uncharacterized protein C11orf63
Gene names
  • C11orf63
Description
N/A
Links

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C1orf174
Human
UPF0688 protein C1orf174
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CA174_HUMAN
Accession #
Q8IYL3
Protein names
  • UPF0688 protein C1orf174
Gene names
  • C1orf174
Description
N/A
Links

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Gene Ontology Terms (1)
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Camkk1
Rat
Calcium/calmodulin-dependent protein kinase kinase 1
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
F1LQD2_RAT
Accession #
F1LQD2
Protein names
  • Calcium/calmodulin-dependent protein kinase kinase 1
  • Calcium/calmodulin-dependent protein kinase kinase 1, alpha
Gene names
  • Camkk1
  • rCG_35534
Description
N/A
Links

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Cct2
Rat
T-complex protein 1 subunit beta
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
TCPB_RAT
Accession #
Q5XIM9
Protein names
  • T-complex protein 1 subunit beta
  • TCP-1-beta
  • CCT-beta
Gene names
  • Cct2
  • Cctb
Description
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).
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Cct6a
Rat
Chaperonin containing Tcp1, subunit 6A
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
Q3MHS9_RAT
Accession #
Q3MHS9
Protein names
  • Chaperonin containing Tcp1, subunit 6A
  • Zeta 1
  • Chaperonin subunit 6a
  • Zeta
  • Protein Cct6a
Gene names
  • Cct6a
  • rCG_21714
Description
N/A
Links

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Cdk18
Rat
Cyclin-dependent kinase 18
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
CKD18_RAT
Accession #
O35832
Protein names
  • Cyclin-dependent kinase 18
  • EC 2.7.11.22
  • Cell division protein kinase 18
  • PCTAIRE-motif protein kinase 3
  • Serine/threonine-protein kinase PCTAIRE-3
Gene names
  • Cdk18
  • Pctaire3
  • Pctk3
Description
May play a role in signal transduction cascades in terminally differentiated cells.
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Crmp1
Rat
Dihydropyrimidinase-related protein 1
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
DPYL1_RAT
Accession #
Q62950
Protein names
  • Dihydropyrimidinase-related protein 1
  • DRP-1
  • Collapsin response mediator protein 1
  • CRMP-1
Gene names
  • Crmp1
  • Dpysl1
Description
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis (By similarity).
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