Search Results (141 substrates found)
Gene name
Organism
Protein name
Acot11
Rat
Protein Acot11
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
F1LX28_RAT
- Accession #
- F1LX28
- Protein names
-
- Protein Acot11
- Fragment
- Gene names
-
- Acot11
- Description
-
N/A
- Links
-
Search Kinases of Acot11 (Rat)
N/A

Add2
Rat
Beta-adducin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
F8WFS9_RAT
- Accession #
- F8WFS9
- Protein names
-
- Beta-adducin
- Gene names
-
- Add2
- Description
-
N/A
- Links
-
Search Kinases of Add2 (Rat)
N/A

Ak5
Rat
Protein Ak5
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
M0R7U1_RAT
- Accession #
- M0R7U1
- Protein names
-
- Protein Ak5
- RCG28422
- Gene names
-
- Ak5
- rCG_28422
- Description
-
N/A
- Links
-
Search Kinases of Ak5 (Rat)

Ambp
Rat
Protein AMBP [Cleaved into: Alpha-1-microglobulin; Inter-alpha-trypsin inhibitor light chain
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
AMBP_RAT
- Accession #
- Q64240
- Protein names
-
- Protein AMBP [Cleaved into: Alpha-1-microglobulin
- Inter-alpha-trypsin inhibitor light chain
- ITI-LC
- Bikunin
- HI-30
- Trypstatin]
- Gene names
-
- Ambp
- Itil
- Description
-
Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization (By similarity).Trypstatin is a trypsin inhibitor. It inhibits blood coagulation factor Xa and tryptase about 100-fold more rapidly than porcine pancreatic trypsin and chymase.
- Links
-
Search Kinases of Ambp (Rat)
N/A
- IgA binding
- cell surface
- extracellular space
- heme binding
- intracellular membrane-bounded organelle
- negative regulation of endopeptidase activity
- plasma membrane
- protein catabolic process
- protein homodimerization activity
- protein-chromophore linkage
- serine-type endopeptidase inhibitor activity
- small molecule binding

Ankrd63
Rat
Protein Ankrd63
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
D3ZKY6_RAT
- Accession #
- D3ZKY6
- Protein names
-
- Protein Ankrd63
- Gene names
-
- Ankrd63
- Description
-
N/A
- Links
-
Search Kinases of Ankrd63 (Rat)
N/A
N/A

Ap2m1
Rat
AP-2 complex subunit mu
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
AP2M1_RAT
- Accession #
- P84092
- Protein names
-
- AP-2 complex subunit mu
- AP-2 mu chain
- Adaptor protein complex AP-2 subunit mu
- Adaptor-related protein complex 2 subunit mu
- Clathrin assembly protein complex 2 mu medium chain
- Clathrin coat assembly protein AP50
- Clathrin coat-associated protein AP50
- Mu2-adaptin
- Plasma membrane adaptor AP-2 50 kDa protein
- Gene names
-
- Ap2m1
- Description
-
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 mu subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs. The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at 'Tyr-156' in membrane-associated AP-2. The membrane-specific phosphorylation event appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (By similarity). Plays a role in endocytosis of frizzled family members upon Wnt signaling.
- Links
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Search Kinases of Ap2m1 (Rat)

Arhgap35
Rat
Rho GTPase-activating protein 35
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
RHG35_RAT
- Accession #
-
P81128
- Protein names
-
- Rho GTPase-activating protein 35
- GAP-associated protein p190
- Glucocorticoid receptor DNA-binding factor 1
- Gene names
-
- Arhgap35
- Grlf1
- Description
-
Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor (By similarity).
- Links
-
Search Kinases of Arhgap35 (Rat)
N/A

ARL6IP4
Human
ADP-ribosylation factor-like protein 6-interacting protein 4
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
AR6P4_HUMAN
- Accession #
-
Q66PJ3
- Protein names
-
- ADP-ribosylation factor-like protein 6-interacting protein 4
- ARL-6-interacting protein 4
- Aip-4
- HSP-975
- HSVI-binding protein
- SR-15
- SRp25
- SR-25
- Splicing factor SRrp37
- Gene names
-
- ARL6IP4
- Description
-
Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site. In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA.
- Links
-
Search Kinases of ARL6IP4 (Human)
N/A

Atp5a1
Rat
ATP synthase subunit alpha
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
F1LP05_RAT
- Accession #
- F1LP05
- Protein names
-
- ATP synthase subunit alpha
- Gene names
-
- Atp5a1
- Description
-
Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity).
- Links
-
Search Kinases of Atp5a1 (Rat)
N/A
- ATP binding
- ATP hydrolysis coupled proton transport
- ATP synthesis coupled proton transport
- embryo development
- lipid metabolic process
- mitochondrial inner membrane
- proton-transporting ATP synthase activity, rotational mechanism
- proton-transporting ATP synthase complex, catalytic core F(1)
- proton-transporting ATPase activity, rotational mechanism

Atp5b
Rat
ATP synthase subunit beta
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
G3V6D3_RAT
- Accession #
- G3V6D3
- Protein names
-
- ATP synthase subunit beta
- EC 3.6.3.14
- Gene names
-
- Atp5b
- rCG_42467
- Description
-
Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity).
- Links
-
Search Kinases of Atp5b (Rat)
N/A
- ATP binding
- ATP hydrolysis coupled proton transport
- ATP synthesis coupled proton transport
- angiogenesis
- cell surface
- lipid metabolic process
- mitochondrial nucleoid
- mitochondrial proton-transporting ATP synthase complex
- negative regulation of cell adhesion involved in substrate-bound cell migration
- plasma membrane
- proton-transporting ATP synthase activity, rotational mechanism
- proton-transporting ATP synthase complex, catalytic core F(1)
- proton-transporting ATPase activity, rotational mechanism
- regulation of intracellular pH

Braf
Rat
Protein Braf
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
F1M9C3_RAT
- Accession #
-
F1M9C3
- Protein names
-
- Protein Braf
- Gene names
-
- Braf
- Description
-
N/A
- Links
-
Search Kinases of Braf (Rat)
N/A
- ATP binding
- MAP kinase kinase kinase activity
- MAPK cascade
- activation of MAPKK activity
- calcium ion binding
- cellular response to calcium ion
- cytoplasm
- membrane
- mitogen-activated protein kinase kinase binding
- negative regulation of neuron apoptotic process
- neuron projection
- nucleus
- plasma membrane
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of gene expression
- positive regulation of peptidyl-serine phosphorylation
- protein binding
- protein heterodimerization activity
- protein heterooligomerization
- protein phosphorylation
- protein serine/threonine kinase activity
- response to cAMP
- response to epidermal growth factor
- response to peptide hormone

Brsk1
Rat
Serine/threonine-protein kinase BRSK1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
BRSK1_RAT
- Accession #
- B2DD29
- Protein names
-
- Serine/threonine-protein kinase BRSK1
- EC 2.7.11.1
- EC 2.7.11.26
- Brain-specific serine/threonine-protein kinase 1
- BR serine/threonine-protein kinase 1
- Serine/threonine-protein kinase SAD-B
- Gene names
-
- Brsk1
- Sadb
- Description
-
Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-523' and 'Ser-573'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C (By similarity). In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1.
- Links
-
Search Kinases of Brsk1 (Rat)
N/A
- ATP binding
- G2 DNA damage checkpoint
- axonogenesis
- cell junction
- centrosome
- centrosome duplication
- establishment of cell polarity
- gamma-tubulin binding
- magnesium ion binding
- neurotransmitter secretion
- nucleus
- plasma membrane
- protein autophosphorylation
- protein binding
- protein serine/threonine kinase activity
- response to UV
- synaptic vesicle
- tau-protein kinase activity

Brsk2
Rat
Serine/threonine-protein kinase BRSK2
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
BRSK2_RAT
- Accession #
-
D3ZML2
- Protein names
-
- Serine/threonine-protein kinase BRSK2
- EC 2.7.11.1
- EC 2.7.11.26
- Brain-specific serine/threonine-protein kinase 2
- BR serine/threonine-protein kinase 2
- Serine/threonine-protein kinase SAD-A
- Gene names
-
- Brsk2
- Sada
- Description
-
Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-523' and 'Ser-573'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-175 can inhibit insulin secretion, BRSK2 phosphorylated at Thr-261 can promote insulin secretion. Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmatic reticulum (ER) stress (By similarity).
- Links
-
Search Kinases of Brsk2 (Rat)
N/A
- ATP binding
- G2 DNA damage checkpoint
- apoptotic process
- axonogenesis
- cellular response to DNA damage stimulus
- cytoplasm
- endoplasmic reticulum
- establishment of cell polarity
- exocytosis
- metal ion binding
- microtubule organizing center
- mitotic nuclear division
- nucleus
- perinuclear region of cytoplasm
- protein phosphorylation
- protein serine/threonine kinase activity
- response to UV
- tau-protein kinase activity

C11orf63
Human
Uncharacterized protein C11orf63
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CK063_HUMAN
- Accession #
-
Q6NUN7
- Protein names
-
- Uncharacterized protein C11orf63
- Gene names
-
- C11orf63
- Description
-
N/A
- Links
-
Search Kinases of C11orf63 (Human)
N/A
N/A

C1orf174
Human
UPF0688 protein C1orf174
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CA174_HUMAN
- Accession #
-
Q8IYL3
- Protein names
-
- UPF0688 protein C1orf174
- Gene names
-
- C1orf174
- Description
-
N/A
- Links
-
Search Kinases of C1orf174 (Human)
N/A

Camkk1
Rat
Calcium/calmodulin-dependent protein kinase kinase 1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
F1LQD2_RAT
- Accession #
- F1LQD2
- Protein names
-
- Calcium/calmodulin-dependent protein kinase kinase 1
- Calcium/calmodulin-dependent protein kinase kinase 1, alpha
- Gene names
-
- Camkk1
- rCG_35534
- Description
-
N/A
- Links
-
Search Kinases of Camkk1 (Rat)

Cct2
Rat
T-complex protein 1 subunit beta
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
TCPB_RAT
- Accession #
- Q5XIM9
- Protein names
-
- T-complex protein 1 subunit beta
- TCP-1-beta
- CCT-beta
- Gene names
-
- Cct2
- Cctb
- Description
-
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).
- Links
-
Search Kinases of Cct2 (Rat)
N/A

Cct6a
Rat
Chaperonin containing Tcp1, subunit 6A
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
Q3MHS9_RAT
- Accession #
- Q3MHS9
- Protein names
-
- Chaperonin containing Tcp1, subunit 6A
- Zeta 1
- Chaperonin subunit 6a
- Zeta
- Protein Cct6a
- Gene names
-
- Cct6a
- rCG_21714
- Description
-
N/A
- Links
-
Search Kinases of Cct6a (Rat)
N/A

Cdk18
Rat
Cyclin-dependent kinase 18
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
CKD18_RAT
- Accession #
-
O35832
- Protein names
-
- Cyclin-dependent kinase 18
- EC 2.7.11.22
- Cell division protein kinase 18
- PCTAIRE-motif protein kinase 3
- Serine/threonine-protein kinase PCTAIRE-3
- Gene names
-
- Cdk18
- Pctaire3
- Pctk3
- Description
-
May play a role in signal transduction cascades in terminally differentiated cells.
- Links
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Search Kinases of Cdk18 (Rat)
N/A

Crmp1
Rat
Dihydropyrimidinase-related protein 1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
DPYL1_RAT
- Accession #
-
Q62950
- Protein names
-
- Dihydropyrimidinase-related protein 1
- DRP-1
- Collapsin response mediator protein 1
- CRMP-1
- Gene names
-
- Crmp1
- Dpysl1
- Description
-
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis (By similarity).
- Links
-
Search Kinases of Crmp1 (Rat)
N/A
