Search Results (719 substrates found)
Gene name
Organism
Protein name
2010300C02Rik
Mouse
Protein 2010300C02Rik
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
F7B0R9_MOUSE
- Accession #
- F7B0R9
- Protein names
-
- Protein 2010300C02Rik
- Fragment
- Gene names
-
- 2010300C02Rik
- Description
-
N/A
- Links
-
Search Kinases of 2010300C02Rik (Mouse)
N/A
N/A

2010300C02Rik
Mouse
Protein 2010300C02Rik
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
E9Q3M9_MOUSE
- Accession #
- E9Q3M9
- Protein names
-
- Protein 2010300C02Rik
- Gene names
-
- 2010300C02Rik
- Description
-
N/A
- Links
-
Search Kinases of 2010300C02Rik (Mouse)
N/A
N/A

A8KX7
Human
cDNA FLJ75103, highly similar to Homo sapiens protein tyrosine phosphatase domain containing 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
A8K0X7_HUMAN
- Accession #
- A8K0X7
- Protein names
-
- cDNA FLJ75103, highly similar to Homo sapiens protein tyrosine phosphatase domain containing 1
- PTPDC1, transcript variant 1, mRNA
- Gene names
-
- A8KX7
- Description
-
N/A
- Links
-
Search Kinases of A8KX7 (Human)
N/A

Aak1
Rat
AP2-associated protein kinase 1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
AAK1_RAT
- Accession #
-
P0C1X8
- Protein names
-
- AP2-associated protein kinase 1
- EC 2.7.11.1
- Adaptor-associated kinase 1
- Gene names
-
- Aak1
- Description
-
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.
- Links
-
Search Kinases of Aak1 (Rat)
N/A
- AP-2 adaptor complex binding
- ATP binding
- Notch binding
- cell leading edge
- clathrin complex
- coated pit
- endocytosis
- extrinsic component of plasma membrane
- positive regulation of Notch signaling pathway
- protein autophosphorylation
- protein phosphorylation
- protein serine/threonine kinase activity
- protein stabilization
- regulation of clathrin-mediated endocytosis
- regulation of protein localization
- terminal bouton

Aak1
Mouse
AP2-associated protein kinase 1
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
AAK1_MOUSE
- Accession #
-
Q3UHJ0
- Protein names
-
- AP2-associated protein kinase 1
- EC 2.7.11.1
- Adaptor-associated kinase 1
- Gene names
-
- Aak1
- Kiaa1048
- Description
-
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (By similarity).
- Links
-
Search Kinases of Aak1 (Mouse)
N/A
- AP-2 adaptor complex binding
- ATP binding
- Notch binding
- cell leading edge
- clathrin-coated vesicle
- coated pit
- endocytosis
- extrinsic component of plasma membrane
- positive regulation of Notch signaling pathway
- protein autophosphorylation
- protein phosphorylation
- protein serine/threonine kinase activity
- protein stabilization
- regulation of clathrin-mediated endocytosis
- regulation of protein localization
- terminal bouton

ABI1
Human
Abl interactor 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ABI1_HUMAN
- Accession #
-
Q8IZP0
- Protein names
-
- Abl interactor 1
- Abelson interactor 1
- Abi-1
- Abl-binding protein 4
- AblBP4
- Eps8 SH3 domain-binding protein
- Eps8-binding protein
- Nap1-binding protein
- Nap1BP
- Spectrin SH3 domain-binding protein 1
- e3B1
- Gene names
-
- ABI1
- SSH3BP1
- Description
-
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.
- Links
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Search Kinases of ABI1 (Human)
N/A
- Fc-gamma receptor signaling pathway involved in phagocytosis
- SCAR complex
- actin polymerization or depolymerization
- cell junction
- cellular component movement
- cytoskeletal protein binding
- cytosol
- endoplasmic reticulum
- extracellular vesicular exosome
- filopodium
- growth cone
- innate immune response
- intracellular
- lamellipodium
- lamellipodium morphogenesis
- megakaryocyte development
- negative regulation of cell proliferation
- nucleus
- peptidyl-tyrosine phosphorylation
- postsynaptic density
- postsynaptic membrane
- protein binding
- protein complex binding
- protein tyrosine kinase activator activity
- somitogenesis
- transmembrane receptor protein tyrosine kinase signaling pathway

Abi2
Mouse
Abi2 protein
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
Q6AXD2_MOUSE
- Accession #
- Q6AXD2
- Protein names
-
- Abi2 protein
- Gene names
-
- Abi2
- Description
-
N/A
- Links
-
Search Kinases of Abi2 (Mouse)

Abl2
Mouse
Abelson tyrosine-protein kinase 2
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
F8VQH0_MOUSE
- Accession #
- F8VQH0
- Protein names
-
- Abelson tyrosine-protein kinase 2
- Gene names
-
- Abl2
- Description
-
N/A
- Links
-
Search Kinases of Abl2 (Mouse)
- ATP binding
- actin cytoskeleton
- actin filament bundle assembly
- actin filament organization
- cellular response to retinoic acid
- cytoplasmic membrane-bounded vesicle
- magnesium ion binding
- manganese ion binding
- non-membrane spanning protein tyrosine kinase activity
- positive regulation of neuron projection development
- positive regulation of oxidoreductase activity

acdh-1
Nematode
Protein ACDH-1, isoform a
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
H2KZG6_CAEEL
- Accession #
- H2KZG6
- Protein names
-
- Protein ACDH-1, isoform a
- Gene names
-
- acdh-1
- C55B7.4
- CELE_C55B7.4
- Description
-
N/A
- Links
-
Search Kinases of acdh-1 (Nematode)
N/A

aco-2
Nematode
Probable aconitate hydratase, mitochondrial
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
ACON_CAEEL
- Accession #
- P34455
- Protein names
-
- Probable aconitate hydratase, mitochondrial
- Aconitase
- EC 4.2.1.3
- Citrate hydro-lyase
- Gene names
-
- aco-2
- F54H12.1
- Description
-
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity).
- Links
-
Search Kinases of aco-2 (Nematode)

act-5
Nematode
Protein ACT-5
- Organism
- Nematode (Caenorhabditis elegans)
- Uniprot ID
-
O45815_CAEEL
- Accession #
- O45815
- Protein names
-
- Protein ACT-5
- Gene names
-
- act-5
- CELE_T25C8.2
- T25C8.2
- Description
-
N/A
- Links
-
Search Kinases of act-5 (Nematode)
N/A

Actg1
Mouse
Gamma actin-like protein
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
Q9QZ83_MOUSE
- Accession #
- Q9QZ83
- Protein names
-
- Gamma actin-like protein
- Gene names
-
- Actg1
- Actl
- Description
-
N/A
- Links
-
Search Kinases of Actg1 (Mouse)
N/A

ADAM17
Human
Disintegrin and metalloproteinase domain-containing protein 17
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ADA17_HUMAN
- Accession #
-
P78536
- Protein names
-
- Disintegrin and metalloproteinase domain-containing protein 17
- ADAM 17
- EC 3.4.24.86
- Snake venom-like protease
- TNF-alpha convertase
- TNF-alpha-converting enzyme
- CD antigen CD156b
- Gene names
-
- ADAM17
- CSVP
- TACE
- Description
-
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
- Links
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Search Kinases of ADAM17 (Human)
- B cell differentiation
- JAK-STAT cascade involved in growth hormone signaling pathway
- Notch binding
- Notch receptor processing
- Notch signaling pathway
- PDZ domain binding
- PMA-inducible membrane protein ectodomain proteolysis
- T cell differentiation in thymus
- actin cytoskeleton
- apical plasma membrane
- apoptotic process
- apoptotic signaling pathway
- cell adhesion
- cell adhesion mediated by integrin
- cell motility
- cell surface
- collagen catabolic process
- cytoplasm
- epidermal growth factor receptor signaling pathway
- epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
- extracellular matrix disassembly
- extracellular matrix organization
- germinal center formation
- integral component of plasma membrane
- integrin binding
- interleukin-6 receptor binding
- membrane protein ectodomain proteolysis
- membrane protein intracellular domain proteolysis
- membrane raft
- metalloendopeptidase activity
- metallopeptidase activity
- negative regulation of interleukin-8 production
- negative regulation of transforming growth factor beta receptor signaling pathway
- neurotrophin TRK receptor signaling pathway
- neutrophil mediated immunity
- plasma membrane
- positive regulation of T cell chemotaxis
- positive regulation of cell growth
- positive regulation of cell migration
- positive regulation of cell proliferation
- positive regulation of cellular component movement
- positive regulation of chemokine production
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
- positive regulation of epidermal growth factor-activated receptor activity
- positive regulation of leukocyte chemotaxis
- positive regulation of protein phosphorylation
- positive regulation of transforming growth factor beta receptor signaling pathway
- protein binding
- proteolysis
- regulation of mast cell apoptotic process
- response to drug
- response to high density lipoprotein particle
- response to hypoxia
- response to lipopolysaccharide
- spleen development
- wound healing, spreading of epidermal cells
- zinc ion binding

Adam17
Mouse
Disintegrin and metalloproteinase domain-containing protein 17
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
ADA17_MOUSE
- Accession #
-
Q9Z0F8
- Protein names
-
- Disintegrin and metalloproteinase domain-containing protein 17
- ADAM 17
- EC 3.4.24.86
- TNF-alpha convertase
- TNF-alpha-converting enzyme
- CD antigen CD156b
- Gene names
-
- Adam17
- Tace
- Description
-
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Plays a role in the proteolytic processing of ACE2 (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called notch extracellular truncation (NEXT).
- Links
-
Search Kinases of Adam17 (Mouse)
- B cell differentiation
- Notch binding
- Notch receptor processing
- Notch signaling pathway
- PMA-inducible membrane protein ectodomain proteolysis
- T cell differentiation in thymus
- actin cytoskeleton
- apical plasma membrane
- cell adhesion mediated by integrin
- cell motility
- cell surface
- cell-cell junction
- cytoplasm
- epidermal growth factor receptor signaling pathway
- epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
- extracellular region
- focal adhesion
- germinal center formation
- integral component of plasma membrane
- membrane protein ectodomain proteolysis
- membrane raft
- metalloendopeptidase activity
- metallopeptidase activity
- negative regulation of interleukin-8 production
- plasma membrane
- positive regulation of T cell chemotaxis
- positive regulation of cell growth
- positive regulation of cell proliferation
- positive regulation of cellular component movement
- positive regulation of chemokine production
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
- positive regulation of transforming growth factor beta receptor signaling pathway
- protein binding
- proteolysis
- regulation of mast cell apoptotic process
- response to drug
- response to high density lipoprotein particle
- response to hypoxia
- response to lipopolysaccharide
- ruffle membrane
- spleen development
- wound healing, spreading of epidermal cells
- zinc ion binding

Add1
Rat
Alpha-adducin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ADDA_RAT
- Accession #
-
Q63028
- Protein names
-
- Alpha-adducin
- Erythrocyte adducin subunit alpha
- Gene names
-
- Add1
- Description
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
- Links
-
Search Kinases of Add1 (Rat)
N/A
- F-actin capping protein complex
- T cell receptor binding
- actin filament bundle assembly
- barbed-end actin filament capping
- cell morphogenesis
- cell volume homeostasis
- cellular response to retinoic acid
- cytoskeleton organization
- dendrite
- dendritic spine
- erythrocyte differentiation
- hemoglobin metabolic process
- homeostasis of number of cells within a tissue
- in utero embryonic development
- ion transport
- multicellular organism growth
- negative regulation of actin filament polymerization
- nucleus
- perinuclear region of cytoplasm
- plasma membrane
- positive regulation of angiogenesis
- positive regulation of endocytosis
- positive regulation of protein binding
- postsynaptic density
- protein binding
- structural molecule activity
- synapse

Add2
Mouse
Beta-adducin
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
ADDB_MOUSE
- Accession #
-
Q9QYB8
- Protein names
-
- Beta-adducin
- Add97
- Erythrocyte adducin subunit beta
- Gene names
-
- Add2
- Description
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity).
- Links
-
Search Kinases of Add2 (Mouse)
N/A

Adrbk1
Rat
Beta-adrenergic receptor kinase 1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ARBK1_RAT
- Accession #
-
P26817
- Protein names
-
- Beta-adrenergic receptor kinase 1
- Beta-ARK-1
- EC 2.7.11.15
- G-protein-coupled receptor kinase 2
- Gene names
-
- Adrbk1
- Grk2
- Description
-
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them.
- Links
-
Search Kinases of Adrbk1 (Rat)
- ATP binding
- G-protein coupled receptor kinase activity
- G-protein coupled receptor signaling pathway
- aging
- apical plasma membrane
- axon
- basolateral plasma membrane
- beta-adrenergic receptor kinase activity
- caveola
- cytoplasm
- dendritic shaft
- dendritic spine
- desensitization of G-protein coupled receptor protein signaling pathway
- follicle-stimulating hormone signaling pathway
- negative regulation of G-protein coupled receptor protein signaling pathway
- positive regulation of catecholamine secretion
- protein binding
- protein phosphorylation
- response to hydrogen peroxide
- response to organic cyclic compound
- response to oxidative stress
- synapse
- termination of G-protein coupled receptor signaling pathway

Aebp1
Mouse
Adipocyte enhancer-binding protein 1
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
AEBP1_MOUSE
- Accession #
-
Q640N1
- Protein names
-
- Adipocyte enhancer-binding protein 1
- AE-binding protein 1
- Aortic carboxypeptidase-like protein
- Gene names
-
- Aebp1
- Aclp
- Description
-
Isoform 2 may positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. Isoform 2 may also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.
- Links
-
Search Kinases of Aebp1 (Mouse)
N/A

AFF4
Human
AF4/FMR2 family member 4
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
AFF4_HUMAN
- Accession #
-
Q9UHB7
- Protein names
-
- AF4/FMR2 family member 4
- ALL1-fused gene from chromosome 5q31 protein
- Protein AF-5q31
- Major CDK9 elongation factor-associated protein
- Gene names
-
- AFF4
- AF5Q31
- MCEF
- HSPC092
- Description
-
Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression.
- Links
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Search Kinases of AFF4 (Human)
N/A

Agap2
Mouse
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
AGAP2_MOUSE
- Accession #
-
Q3UHD9
- Protein names
-
- Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
- AGAP-2
- Centaurin-gamma-1
- Cnt-g1
- Phosphatidylinositol 3-kinase enhancer
- PIKE
- Gene names
-
- Agap2
- Centg1
- Kiaa0167
- Description
-
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. Aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase (By similarity).
- Links
-
Search Kinases of Agap2 (Mouse)
- ARF GTPase activator activity
- GTP binding
- mammary gland alveolus development
- mitochondrion
- negative regulation of apoptotic process
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- nucleolus
- positive regulation of JAK-STAT cascade
- positive regulation of mammary gland epithelial cell proliferation
- positive regulation of transcription from RNA polymerase II promoter
- protein binding
- protein kinase activator activity
- regulation of ARF GTPase activity
- small GTPase mediated signal transduction
- zinc ion binding
