KANPHOS_Str

Search Results (719 substrates found)

Displaying 1 - 20 of 719 Items
items per page
Order by
/36 page
 
Gene name
Organism
Protein name
2010300C02Rik
Mouse
Protein 2010300C02Rik
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
F7B0R9_MOUSE
Accession #
F7B0R9
Protein names
  • Protein 2010300C02Rik
  • Fragment
Gene names
  • 2010300C02Rik
Description
N/A
Links

Search Kinases of 2010300C02Rik (Mouse)
KEGG Pathways (0)
N/A
Gene Ontology Terms (0)
N/A
Phosphorylation Site Information
2010300C02Rik
Mouse
Protein 2010300C02Rik
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
E9Q3M9_MOUSE
Accession #
E9Q3M9
Protein names
  • Protein 2010300C02Rik
Gene names
  • 2010300C02Rik
Description
N/A
Links

Search Kinases of 2010300C02Rik (Mouse)
KEGG Pathways (0)
N/A
Gene Ontology Terms (0)
N/A
Phosphorylation Site Information
A8KX7
Human
cDNA FLJ75103, highly similar to Homo sapiens protein tyrosine phosphatase domain containing 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
A8K0X7_HUMAN
Accession #
A8K0X7
Protein names
  • cDNA FLJ75103, highly similar to Homo sapiens protein tyrosine phosphatase domain containing 1
  • PTPDC1, transcript variant 1, mRNA
Gene names
  • A8KX7
Description
N/A
Links

Search Kinases of A8KX7 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Aak1
Rat
AP2-associated protein kinase 1
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
AAK1_RAT
Accession #
P0C1X8
Protein names
  • AP2-associated protein kinase 1
  • EC 2.7.11.1
  • Adaptor-associated kinase 1
Gene names
  • Aak1
Description
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.
Links

Search Kinases of Aak1 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Aak1
Mouse
AP2-associated protein kinase 1
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
AAK1_MOUSE
Accession #
Q3UHJ0
Protein names
  • AP2-associated protein kinase 1
  • EC 2.7.11.1
  • Adaptor-associated kinase 1
Gene names
  • Aak1
  • Kiaa1048
Description
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (By similarity).
Links

Search Kinases of Aak1 (Mouse)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
ABI1
Human
Abl interactor 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ABI1_HUMAN
Accession #
Q8IZP0
Protein names
  • Abl interactor 1
  • Abelson interactor 1
  • Abi-1
  • Abl-binding protein 4
  • AblBP4
  • Eps8 SH3 domain-binding protein
  • Eps8-binding protein
  • Nap1-binding protein
  • Nap1BP
  • Spectrin SH3 domain-binding protein 1
  • e3B1
Gene names
  • ABI1
  • SSH3BP1
Description
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.
Links

Search Kinases of ABI1 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Abi2
Mouse
Abi2 protein
acdh-1
Nematode
Protein ACDH-1, isoform a
Substrate Information
Organism
Nematode (Caenorhabditis elegans)
Uniprot ID
H2KZG6_CAEEL
Accession #
H2KZG6
Protein names
  • Protein ACDH-1, isoform a
Gene names
  • acdh-1
  • C55B7.4
  • CELE_C55B7.4
Description
N/A
Links

Search Kinases of acdh-1 (Nematode)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
aco-2
Nematode
Probable aconitate hydratase, mitochondrial
Substrate Information
Organism
Nematode (Caenorhabditis elegans)
Uniprot ID
ACON_CAEEL
Accession #
P34455
Protein names
  • Probable aconitate hydratase, mitochondrial
  • Aconitase
  • EC 4.2.1.3
  • Citrate hydro-lyase
Gene names
  • aco-2
  • F54H12.1
Description
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity).
Links

Search Kinases of aco-2 (Nematode)
Phosphorylation Site Information
act-5
Nematode
Protein ACT-5
Substrate Information
Organism
Nematode (Caenorhabditis elegans)
Uniprot ID
O45815_CAEEL
Accession #
O45815
Protein names
  • Protein ACT-5
Gene names
  • act-5
  • CELE_T25C8.2
  • T25C8.2
Description
N/A
Links

Search Kinases of act-5 (Nematode)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Actg1
Mouse
Gamma actin-like protein
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
Q9QZ83_MOUSE
Accession #
Q9QZ83
Protein names
  • Gamma actin-like protein
Gene names
  • Actg1
  • Actl
Description
N/A
Links

Search Kinases of Actg1 (Mouse)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
ADAM17
Human
Disintegrin and metalloproteinase domain-containing protein 17
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ADA17_HUMAN
Accession #
P78536
Protein names
  • Disintegrin and metalloproteinase domain-containing protein 17
  • ADAM 17
  • EC 3.4.24.86
  • Snake venom-like protease
  • TNF-alpha convertase
  • TNF-alpha-converting enzyme
  • CD antigen CD156b
Gene names
  • ADAM17
  • CSVP
  • TACE
Description
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
Links

Search Kinases of ADAM17 (Human)
Gene Ontology Terms (57)
Phosphorylation Site Information
Adam17
Mouse
Disintegrin and metalloproteinase domain-containing protein 17
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
ADA17_MOUSE
Accession #
Q9Z0F8
Protein names
  • Disintegrin and metalloproteinase domain-containing protein 17
  • ADAM 17
  • EC 3.4.24.86
  • TNF-alpha convertase
  • TNF-alpha-converting enzyme
  • CD antigen CD156b
Gene names
  • Adam17
  • Tace
Description
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Plays a role in the proteolytic processing of ACE2 (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called notch extracellular truncation (NEXT).
Links

Search Kinases of Adam17 (Mouse)
Phosphorylation Site Information
Add2
Mouse
Beta-adducin
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
ADDB_MOUSE
Accession #
Q9QYB8
Protein names
  • Beta-adducin
  • Add97
  • Erythrocyte adducin subunit beta
Gene names
  • Add2
Description
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity).
Links

Search Kinases of Add2 (Mouse)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Aebp1
Mouse
Adipocyte enhancer-binding protein 1
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
AEBP1_MOUSE
Accession #
Q640N1
Protein names
  • Adipocyte enhancer-binding protein 1
  • AE-binding protein 1
  • Aortic carboxypeptidase-like protein
Gene names
  • Aebp1
  • Aclp
Description
Isoform 2 may positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. Isoform 2 may also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.
Links

Search Kinases of Aebp1 (Mouse)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
AFF4
Human
AF4/FMR2 family member 4
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
AFF4_HUMAN
Accession #
Q9UHB7
Protein names
  • AF4/FMR2 family member 4
  • ALL1-fused gene from chromosome 5q31 protein
  • Protein AF-5q31
  • Major CDK9 elongation factor-associated protein
Gene names
  • AFF4
  • AF5Q31
  • MCEF
  • HSPC092
Description
Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression.
Links

Search Kinases of AFF4 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Agap2
Mouse
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
AGAP2_MOUSE
Accession #
Q3UHD9
Protein names
  • Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
  • AGAP-2
  • Centaurin-gamma-1
  • Cnt-g1
  • Phosphatidylinositol 3-kinase enhancer
  • PIKE
Gene names
  • Agap2
  • Centg1
  • Kiaa0167
Description
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. Aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase (By similarity).
Links

Search Kinases of Agap2 (Mouse)
Phosphorylation Site Information
/36 page