KANPHOS_Str

Search Results (972 substrates found)

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Gene name
Organism
Protein name
2010300C02Rik
Mouse
Protein 2010300C02Rik
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
E9Q3M9_MOUSE
Accession #
E9Q3M9
Protein names
  • Protein 2010300C02Rik
Gene names
  • 2010300C02Rik
Description
N/A
Links

Search Kinases of 2010300C02Rik (Mouse)
KEGG Pathways (0)
N/A
Gene Ontology Terms (0)
N/A
Phosphorylation Site Information
5031439G07Rik
Mouse
Protein 5031439G07Rik
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
B1APX2_MOUSE
Accession #
B1APX2
Protein names
  • Protein 5031439G07Rik
Gene names
  • 5031439G07Rik
Description
N/A
Links

Search Kinases of 5031439G07Rik (Mouse)
KEGG Pathways (0)
N/A
Gene Ontology Terms (0)
N/A
Phosphorylation Site Information
A8KAD6
Human
cDNA FLJ77616, highly similar to Homo sapiens CWF19-like 2, cell cycle control
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
A8KAD6_HUMAN
Accession #
A8KAD6
Protein names
  • cDNA FLJ77616, highly similar to Homo sapiens CWF19-like 2, cell cycle control
  • CWF19L2, mRNA
Gene names
  • A8KAD6
Description
N/A
Links

Search Kinases of A8KAD6 (Human)
KEGG Pathways (0)
N/A
Gene Ontology Terms (1)
Phosphorylation Site Information
Aak1
Mouse
AP2-associated protein kinase 1
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
AAK1_MOUSE
Accession #
Q3UHJ0
Protein names
  • AP2-associated protein kinase 1
  • EC 2.7.11.1
  • Adaptor-associated kinase 1
Gene names
  • Aak1
  • Kiaa1048
Description
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (By similarity).
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Phosphorylation Site Information
Aanat
Rat
Serotonin N-acetyltransferase
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
SNAT_RAT
Accession #
Q64666
Protein names
  • Serotonin N-acetyltransferase
  • Serotonin acetylase
  • EC 2.3.1.87
  • Aralkylamine N-acetyltransferase
  • AA-NAT
Gene names
  • Aanat
  • Snat
Description
Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.
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Phosphorylation Site Information
ABCB1
Human
Multidrug resistance protein 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
MDR1_HUMAN
Accession #
P08183
Protein names
  • Multidrug resistance protein 1
  • EC 3.6.3.44
  • ATP-binding cassette sub-family B member 1
  • P-glycoprotein 1
  • CD antigen CD243
Gene names
  • ABCB1
  • MDR1
  • PGY1
Description
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
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Phosphorylation Site Information
ABCB7
Human
ATP-binding cassette sub-family B member 7, mitochondrial
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ABCB7_HUMAN
Accession #
O75027
Protein names
  • ATP-binding cassette sub-family B member 7, mitochondrial
  • ATP-binding cassette transporter 7
  • ABC transporter 7 protein
Gene names
  • ABCB7
  • ABC7
Description
Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins.
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KEGG Pathways (1)
Phosphorylation Site Information
ABCF1
Human
ATP-binding cassette sub-family F member 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ABCF1_HUMAN
Accession #
Q8NE71
Protein names
  • ATP-binding cassette sub-family F member 1
  • ATP-binding cassette 50
  • TNF-alpha-stimulated ABC protein
Gene names
  • ABCF1
  • ABC50
Description
Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis.
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KEGG Pathways (0)
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Phosphorylation Site Information
ACAP1
Human
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ACAP1_HUMAN
Accession #
Q15027
Protein names
  • Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
  • Centaurin-beta-1
  • Cnt-b1
Gene names
  • ACAP1
  • CENTB1
  • KIAA0050
Description
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.
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KEGG Pathways (1)
Phosphorylation Site Information
Aco1
Rat
Cytoplasmic aconitate hydratase
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ACOC_RAT
Accession #
Q63270
Protein names
  • Cytoplasmic aconitate hydratase
  • Aconitase
  • EC 4.2.1.3
  • Citrate hydro-lyase
  • Iron regulatory protein 1
  • IRP1
  • Iron-responsive element-binding protein 1
  • IRE-BP 1
Gene names
  • Aco1
  • Ireb1
  • Irebp
Description
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding (By similarity).Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity).
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Phosphorylation Site Information
ACO1
Human
Cytoplasmic aconitate hydratase
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ACOC_HUMAN
Accession #
P21399
Protein names
  • Cytoplasmic aconitate hydratase
  • Aconitase
  • EC 4.2.1.3
  • Citrate hydro-lyase
  • Ferritin repressor protein
  • Iron regulatory protein 1
  • IRP1
  • Iron-responsive element-binding protein 1
  • IRE-BP 1
Gene names
  • ACO1
  • IREB1
Description
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity).
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Phosphorylation Site Information
ADAM17
Human
Disintegrin and metalloproteinase domain-containing protein 17
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ADA17_HUMAN
Accession #
P78536
Protein names
  • Disintegrin and metalloproteinase domain-containing protein 17
  • ADAM 17
  • EC 3.4.24.86
  • Snake venom-like protease
  • TNF-alpha convertase
  • TNF-alpha-converting enzyme
  • CD antigen CD156b
Gene names
  • ADAM17
  • CSVP
  • TACE
Description
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
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Gene Ontology Terms (57)
Phosphorylation Site Information
ADAP1
Human
Arf-GAP with dual PH domain-containing protein 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ADAP1_HUMAN
Accession #
O75689
Protein names
  • Arf-GAP with dual PH domain-containing protein 1
  • Centaurin-alpha-1
  • Cnt-a1
  • Putative MAPK-activating protein PM25
Gene names
  • ADAP1
  • CENTA1
Description
GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).
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Phosphorylation Site Information
ADAP2
Human
Arf-GAP with dual PH domain-containing protein 2
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ADAP2_HUMAN
Accession #
Q9NPF8
Protein names
  • Arf-GAP with dual PH domain-containing protein 2
  • Centaurin-alpha-2
  • Cnt-a2
Gene names
  • ADAP2
  • CENTA2
Description
GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity.
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Phosphorylation Site Information
ADARB1
Human
Double-stranded RNA-specific editase 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
RED1_HUMAN
Accession #
P78563
Protein names
  • Double-stranded RNA-specific editase 1
  • EC 3.5.4.37
  • RNA-editing deaminase 1
  • RNA-editing enzyme 1
  • dsRNA adenosine deaminase
Gene names
  • ADARB1
  • ADAR2
  • DRADA2
  • RED1
Description
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis.
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Adcy2
Rat
Adenylate cyclase type 2
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ADCY2_RAT
Accession #
P26769
Protein names
  • Adenylate cyclase type 2
  • EC 4.6.1.1
  • ATP pyrophosphate-lyase 2
  • Adenylate cyclase type II
  • Adenylyl cyclase 2
Gene names
  • Adcy2
Description
This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.
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Phosphorylation Site Information
ADD1
Human
Alpha-adducin
Add2
Rat
Beta-adducin
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ADDB_RAT
Accession #
Q05764
Protein names
  • Beta-adducin
  • Adducin-63
  • Erythrocyte adducin subunit beta
Gene names
  • Add2
Description
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity).
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Phosphorylation Site Information
ADD2
Human
Beta-adducin
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ADDB_HUMAN
Accession #
P35612
Protein names
  • Beta-adducin
  • Erythrocyte adducin subunit beta
Gene names
  • ADD2
  • ADDB
Description
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.
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