Search Results (907 substrates found)
Gene name
Organism
Protein name
A8KAD6
Human
cDNA FLJ77616, highly similar to Homo sapiens CWF19-like 2, cell cycle control
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
A8KAD6_HUMAN
- Accession #
- A8KAD6
- Protein names
-
- cDNA FLJ77616, highly similar to Homo sapiens CWF19-like 2, cell cycle control
- CWF19L2, mRNA
- Gene names
-
- A8KAD6
- Description
-
N/A
- Links
-
Search Kinases of A8KAD6 (Human)
N/A

Aanat
Rat
Serotonin N-acetyltransferase
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
SNAT_RAT
- Accession #
-
Q64666
- Protein names
-
- Serotonin N-acetyltransferase
- Serotonin acetylase
- EC 2.3.1.87
- Aralkylamine N-acetyltransferase
- AA-NAT
- Gene names
-
- Aanat
- Snat
- Description
-
Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.
- Links
-
Search Kinases of Aanat (Rat)
- 14-3-3 protein binding
- N-terminal protein amino acid acetylation
- aralkylamine N-acetyltransferase activity
- arylamine N-acetyltransferase activity
- cellular response to cAMP
- circadian rhythm
- cytoplasm
- entrainment of circadian clock by photoperiod
- melatonin biosynthetic process
- perinuclear region of cytoplasm
- photoperiodism
- response to cAMP
- response to calcium ion
- response to copper ion
- response to corticosterone
- response to cytokine
- response to insulin
- response to light stimulus
- response to organic cyclic compound
- response to prostaglandin E
- response to zinc ion

ABCB1
Human
Multidrug resistance protein 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
MDR1_HUMAN
- Accession #
-
P08183
- Protein names
-
- Multidrug resistance protein 1
- EC 3.6.3.44
- ATP-binding cassette sub-family B member 1
- P-glycoprotein 1
- CD antigen CD243
- Gene names
-
- ABCB1
- MDR1
- PGY1
- Description
-
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
- Links
-
Search Kinases of ABCB1 (Human)
- ATP binding
- ATPase activity, coupled to transmembrane movement of substances
- G2/M transition of mitotic cell cycle
- cell surface
- drug transmembrane transport
- extracellular vesicular exosome
- integral component of membrane
- membrane
- plasma membrane
- protein binding
- response to drug
- small molecule metabolic process
- stem cell proliferation
- transmembrane transport
- transport
- transporter activity
- xenobiotic-transporting ATPase activity

ABCB7
Human
ATP-binding cassette sub-family B member 7, mitochondrial
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ABCB7_HUMAN
- Accession #
-
O75027
- Protein names
-
- ATP-binding cassette sub-family B member 7, mitochondrial
- ATP-binding cassette transporter 7
- ABC transporter 7 protein
- Gene names
-
- ABCB7
- ABC7
- Description
-
Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins.
- Links
-
Search Kinases of ABCB7 (Human)

ABCF1
Human
ATP-binding cassette sub-family F member 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ABCF1_HUMAN
- Accession #
-
Q8NE71
- Protein names
-
- ATP-binding cassette sub-family F member 1
- ATP-binding cassette 50
- TNF-alpha-stimulated ABC protein
- Gene names
-
- ABCF1
- ABC50
- Description
-
Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis.
- Links
-
Search Kinases of ABCF1 (Human)
N/A
- ATP binding
- ATPase activity
- cytoplasm
- inflammatory response
- nuclear envelope
- nucleoplasm
- poly(A) RNA binding
- polysomal ribosome
- positive regulation of translation
- protein binding
- ribosome
- ribosome binding
- translation
- translation activator activity
- translation factor activity, nucleic acid binding
- translational initiation

ACAP1
Human
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ACAP1_HUMAN
- Accession #
-
Q15027
- Protein names
-
- Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
- Centaurin-beta-1
- Cnt-b1
- Gene names
-
- ACAP1
- CENTB1
- KIAA0050
- Description
-
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.
- Links
-
Search Kinases of ACAP1 (Human)

Aco1
Rat
Cytoplasmic aconitate hydratase
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ACOC_RAT
- Accession #
-
Q63270
- Protein names
-
- Cytoplasmic aconitate hydratase
- Aconitase
- EC 4.2.1.3
- Citrate hydro-lyase
- Iron regulatory protein 1
- IRP1
- Iron-responsive element-binding protein 1
- IRE-BP 1
- Gene names
-
- Aco1
- Ireb1
- Irebp
- Description
-
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding (By similarity).Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity).
- Links
-
Search Kinases of Aco1 (Rat)
- 4 iron, 4 sulfur cluster binding
- Golgi apparatus
- aconitate hydratase activity
- cellular iron ion homeostasis
- citrate metabolic process
- cytoplasm
- cytosol
- endoplasmic reticulum
- intracellular membrane-bounded organelle
- iron-responsive element binding
- iron-sulfur cluster binding
- mRNA 5'-UTR binding
- mRNA binding
- metal ion binding
- regulation of translation
- response to iron(II) ion
- tricarboxylic acid cycle

ACO1
Human
Cytoplasmic aconitate hydratase
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ACOC_HUMAN
- Accession #
-
P21399
- Protein names
-
- Cytoplasmic aconitate hydratase
- Aconitase
- EC 4.2.1.3
- Citrate hydro-lyase
- Ferritin repressor protein
- Iron regulatory protein 1
- IRP1
- Iron-responsive element-binding protein 1
- IRE-BP 1
- Gene names
-
- ACO1
- IREB1
- Description
-
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity).
- Links
-
Search Kinases of ACO1 (Human)
- 4 iron, 4 sulfur cluster binding
- Golgi apparatus
- RNA binding
- aconitate hydratase activity
- cellular iron ion homeostasis
- citrate metabolic process
- cytoplasm
- cytosol
- endoplasmic reticulum
- extracellular vesicular exosome
- intestinal absorption
- iron-responsive element binding
- metal ion binding
- mitochondrion
- post-embryonic development
- protein binding
- regulation of translation
- response to iron(II) ion
- tricarboxylic acid cycle

ADAM17
Human
Disintegrin and metalloproteinase domain-containing protein 17
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ADA17_HUMAN
- Accession #
-
P78536
- Protein names
-
- Disintegrin and metalloproteinase domain-containing protein 17
- ADAM 17
- EC 3.4.24.86
- Snake venom-like protease
- TNF-alpha convertase
- TNF-alpha-converting enzyme
- CD antigen CD156b
- Gene names
-
- ADAM17
- CSVP
- TACE
- Description
-
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
- Links
-
Search Kinases of ADAM17 (Human)
- B cell differentiation
- JAK-STAT cascade involved in growth hormone signaling pathway
- Notch binding
- Notch receptor processing
- Notch signaling pathway
- PDZ domain binding
- PMA-inducible membrane protein ectodomain proteolysis
- T cell differentiation in thymus
- actin cytoskeleton
- apical plasma membrane
- apoptotic process
- apoptotic signaling pathway
- cell adhesion
- cell adhesion mediated by integrin
- cell motility
- cell surface
- collagen catabolic process
- cytoplasm
- epidermal growth factor receptor signaling pathway
- epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
- extracellular matrix disassembly
- extracellular matrix organization
- germinal center formation
- integral component of plasma membrane
- integrin binding
- interleukin-6 receptor binding
- membrane protein ectodomain proteolysis
- membrane protein intracellular domain proteolysis
- membrane raft
- metalloendopeptidase activity
- metallopeptidase activity
- negative regulation of interleukin-8 production
- negative regulation of transforming growth factor beta receptor signaling pathway
- neurotrophin TRK receptor signaling pathway
- neutrophil mediated immunity
- plasma membrane
- positive regulation of T cell chemotaxis
- positive regulation of cell growth
- positive regulation of cell migration
- positive regulation of cell proliferation
- positive regulation of cellular component movement
- positive regulation of chemokine production
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
- positive regulation of epidermal growth factor-activated receptor activity
- positive regulation of leukocyte chemotaxis
- positive regulation of protein phosphorylation
- positive regulation of transforming growth factor beta receptor signaling pathway
- protein binding
- proteolysis
- regulation of mast cell apoptotic process
- response to drug
- response to high density lipoprotein particle
- response to hypoxia
- response to lipopolysaccharide
- spleen development
- wound healing, spreading of epidermal cells
- zinc ion binding

ADAP1
Human
Arf-GAP with dual PH domain-containing protein 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ADAP1_HUMAN
- Accession #
-
O75689
- Protein names
-
- Arf-GAP with dual PH domain-containing protein 1
- Centaurin-alpha-1
- Cnt-a1
- Putative MAPK-activating protein PM25
- Gene names
-
- ADAP1
- CENTA1
- Description
-
GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).
- Links
-
Search Kinases of ADAP1 (Human)
N/A
- ARF GTPase activator activity
- cell surface receptor signaling pathway
- cytoplasm
- inositol 1,3,4,5 tetrakisphosphate binding
- nucleus
- phosphatidylinositol-3,4,5-trisphosphate binding
- plasma membrane
- positive regulation of GTPase activity
- protein binding
- regulation of ARF GTPase activity
- regulation of GTPase activity
- zinc ion binding

ADAP2
Human
Arf-GAP with dual PH domain-containing protein 2
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ADAP2_HUMAN
- Accession #
-
Q9NPF8
- Protein names
-
- Arf-GAP with dual PH domain-containing protein 2
- Centaurin-alpha-2
- Cnt-a2
- Gene names
-
- ADAP2
- CENTA2
- Description
-
GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity.
- Links
-
Search Kinases of ADAP2 (Human)
N/A
- ARF GTPase activator activity
- cytoplasm
- heart development
- inositol 1,3,4,5 tetrakisphosphate binding
- mitochondrial envelope
- phosphatidylinositol-3,4,5-trisphosphate binding
- phosphatidylinositol-3,4-bisphosphate binding
- phosphatidylinositol-4,5-bisphosphate binding
- plasma membrane
- protein binding
- protein binding, bridging
- regulation of ARF GTPase activity
- zinc ion binding

ADARB1
Human
Double-stranded RNA-specific editase 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
RED1_HUMAN
- Accession #
-
P78563
- Protein names
-
- Double-stranded RNA-specific editase 1
- EC 3.5.4.37
- RNA-editing deaminase 1
- RNA-editing enzyme 1
- dsRNA adenosine deaminase
- Gene names
-
- ADARB1
- ADAR2
- DRADA2
- RED1
- Description
-
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis.
- Links
-
Search Kinases of ADARB1 (Human)
N/A
- RNA binding
- RNA processing
- adenosine deaminase activity
- adenosine to inosine editing
- base conversion or substitution editing
- defense response to virus
- double-stranded RNA adenosine deaminase activity
- double-stranded RNA binding
- gene expression
- innate immune response
- mRNA binding
- mRNA modification
- mRNA processing
- metal ion binding
- negative regulation of cell migration
- negative regulation of cell proliferation
- negative regulation of protein kinase activity by regulation of protein phosphorylation
- nucleolus
- nucleoplasm
- nucleus
- poly(A) RNA binding
- positive regulation of viral genome replication
- protein binding
- regulation of cell cycle

Adcy2
Rat
Adenylate cyclase type 2
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ADCY2_RAT
- Accession #
-
P26769
- Protein names
-
- Adenylate cyclase type 2
- EC 4.6.1.1
- ATP pyrophosphate-lyase 2
- Adenylate cyclase type II
- Adenylyl cyclase 2
- Gene names
-
- Adcy2
- Description
-
This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.
- Links
-
Search Kinases of Adcy2 (Rat)
- Adrenergic signaling in cardiomyocytes
- Bile secretion
- Calcium signaling pathway
- Chemokine signaling pathway
- Cholinergic synapse
- Circadian entrainment
- Dilated cardiomyopathy
- Estrogen signaling pathway
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glutamatergic synapse
- GnRH signaling pathway
- HTLV-I infection
- Inflammatory mediator regulation of TRP channels
- Insulin secretion
- Melanogenesis
- Morphine addiction
- Oocyte meiosis
- Ovarian steroidogenesis
- Oxytocin signaling pathway
- Pancreatic secretion
- Pathways in cancer
- Platelet activation
- Progesterone-mediated oocyte maturation
- Purine metabolism
- Rap1 signaling pathway
- Retrograde endocannabinoid signaling
- Salivary secretion
- Thyroid hormone synthesis
- Vascular smooth muscle contraction
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- ATP binding
- G-protein beta/gamma-subunit complex binding
- adenylate cyclase activity
- adenylate cyclase binding
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- cAMP biosynthetic process
- calcium- and calmodulin-responsive adenylate cyclase activity
- cytoplasm
- dendrite
- integral component of membrane
- intracellular
- intracellular signal transduction
- membrane
- membrane raft
- metal ion binding
- plasma membrane
- protein binding
- protein complex
- protein heterodimerization activity

Add1
Rat
Alpha-adducin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ADDA_RAT
- Accession #
-
Q63028
- Protein names
-
- Alpha-adducin
- Erythrocyte adducin subunit alpha
- Gene names
-
- Add1
- Description
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
- Links
-
Search Kinases of Add1 (Rat)
N/A
- F-actin capping protein complex
- T cell receptor binding
- actin filament bundle assembly
- barbed-end actin filament capping
- cell morphogenesis
- cell volume homeostasis
- cellular response to retinoic acid
- cytoskeleton organization
- dendrite
- dendritic spine
- erythrocyte differentiation
- hemoglobin metabolic process
- homeostasis of number of cells within a tissue
- in utero embryonic development
- ion transport
- multicellular organism growth
- negative regulation of actin filament polymerization
- nucleus
- perinuclear region of cytoplasm
- plasma membrane
- positive regulation of angiogenesis
- positive regulation of endocytosis
- positive regulation of protein binding
- postsynaptic density
- protein binding
- structural molecule activity
- synapse

ADD1
Human
Alpha-adducin
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ADDA_HUMAN
- Accession #
-
P35611
- Protein names
-
- Alpha-adducin
- Erythrocyte adducin subunit alpha
- Gene names
-
- ADD1
- ADDA
- Description
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
- Links
-
Search Kinases of ADD1 (Human)
N/A
- F-actin capping protein complex
- actin binding
- actin cytoskeleton organization
- actin filament binding
- actin filament bundle assembly
- activation of signaling protein activity involved in unfolded protein response
- apoptotic process
- barbed-end actin filament capping
- cell morphogenesis
- cell volume homeostasis
- cellular component disassembly involved in execution phase of apoptosis
- cellular protein metabolic process
- cellular response to retinoic acid
- cytosol
- dendritic spine
- endoplasmic reticulum unfolded protein response
- erythrocyte differentiation
- hemoglobin metabolic process
- homeostasis of number of cells within a tissue
- in utero embryonic development
- intermediate filament cytoskeleton
- multicellular organism growth
- nucleus
- perinuclear region of cytoplasm
- plasma membrane
- poly(A) RNA binding
- positive regulation of angiogenesis
- positive regulation of endocytosis
- positive regulation of protein binding
- postsynaptic density
- protein heterodimerization activity
- protein homodimerization activity
- spectrin binding
- structural molecule activity
- transcription factor binding

ADD2
Human
Beta-adducin
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ADDB_HUMAN
- Accession #
-
P35612
- Protein names
-
- Beta-adducin
- Erythrocyte adducin subunit beta
- Gene names
-
- ADD2
- ADDB
- Description
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.
- Links
-
Search Kinases of ADD2 (Human)
N/A
- F-actin capping protein complex
- actin binding
- actin cytoskeleton organization
- actin filament binding
- actin filament bundle assembly
- barbed-end actin filament capping
- cytoplasmic membrane-bounded vesicle
- hemopoiesis
- plasma membrane
- positive regulation of protein binding
- protein complex assembly
- protein heterodimerization activity
- protein homodimerization activity
- spectrin binding
- structural molecule activity

Add2
Rat
Beta-adducin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ADDB_RAT
- Accession #
-
Q05764
- Protein names
-
- Beta-adducin
- Adducin-63
- Erythrocyte adducin subunit beta
- Gene names
-
- Add2
- Description
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity).
- Links
-
Search Kinases of Add2 (Rat)
N/A

Add3
Rat
Gamma-adducin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ADDG_RAT
- Accession #
-
Q62847
- Protein names
-
- Gamma-adducin
- Adducin-like protein 70
- Protein kinase C-binding protein 35H
- Gene names
-
- Add3
- Description
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
- Links
-
Search Kinases of Add3 (Rat)
N/A

Adrbk1
Rat
Beta-adrenergic receptor kinase 1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ARBK1_RAT
- Accession #
-
P26817
- Protein names
-
- Beta-adrenergic receptor kinase 1
- Beta-ARK-1
- EC 2.7.11.15
- G-protein-coupled receptor kinase 2
- Gene names
-
- Adrbk1
- Grk2
- Description
-
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them.
- Links
-
Search Kinases of Adrbk1 (Rat)
- ATP binding
- G-protein coupled receptor kinase activity
- G-protein coupled receptor signaling pathway
- aging
- apical plasma membrane
- axon
- basolateral plasma membrane
- beta-adrenergic receptor kinase activity
- caveola
- cytoplasm
- dendritic shaft
- dendritic spine
- desensitization of G-protein coupled receptor protein signaling pathway
- follicle-stimulating hormone signaling pathway
- negative regulation of G-protein coupled receptor protein signaling pathway
- positive regulation of catecholamine secretion
- protein binding
- protein phosphorylation
- response to hydrogen peroxide
- response to organic cyclic compound
- response to oxidative stress
- synapse
- termination of G-protein coupled receptor signaling pathway

ADRBK1
Human
Beta-adrenergic receptor kinase 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ARBK1_HUMAN
- Accession #
-
P25098
- Protein names
-
- Beta-adrenergic receptor kinase 1
- Beta-ARK-1
- EC 2.7.11.15
- G-protein coupled receptor kinase 2
- Gene names
-
- ADRBK1
- BARK
- BARK1
- GRK2
- Description
-
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
- Links
-
Search Kinases of ADRBK1 (Human)
- ATP binding
- Edg-2 lysophosphatidic acid receptor binding
- G-protein coupled acetylcholine receptor signaling pathway
- G-protein coupled receptor kinase activity
- activation of phospholipase C activity
- alpha-2A adrenergic receptor binding
- beta-adrenergic receptor kinase activity
- cardiac muscle contraction
- cytoplasm
- cytosol
- desensitization of G-protein coupled receptor protein signaling pathway
- epidermal growth factor receptor signaling pathway
- fibroblast growth factor receptor signaling pathway
- heart development
- innate immune response
- membrane
- negative regulation of striated muscle contraction
- negative regulation of the force of heart contraction by chemical signal
- neurotrophin TRK receptor signaling pathway
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- plasma membrane
- positive regulation of catecholamine secretion
- protein binding
- protein kinase activity
- receptor internalization
- signal transduction
- tachykinin receptor signaling pathway
- termination of G-protein coupled receptor signaling pathway
