Search Results (441 substrates found)
Gene name
Organism
Protein name
A1i3
Rat
Alpha-1-inhibitor 3
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
A1I3_RAT
- Accession #
-
P14046
- Protein names
-
- Alpha-1-inhibitor 3
- Alpha-1-inhibitor 3 variant II
- Alpha-1-inhibitor III
- Gene names
-
- A1i3
- Description
-
Protease inhibitor with a wide spectrum of protein targets, which attaches through its thioester function.
- Links
-
Search Kinases of A1i3 (Rat)
N/A

Aacs
Rat
Acetoacetyl-CoA synthetase
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
AACS_RAT
- Accession #
-
Q9JMI1
- Protein names
-
- Acetoacetyl-CoA synthetase
- EC 6.2.1.16
- Gene names
-
- Aacs
- Description
-
Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development.
- Links
-
Search Kinases of Aacs (Rat)
- ATP binding
- acetoacetate-CoA ligase activity
- adipose tissue development
- butyrate-CoA ligase activity
- cellular response to cholesterol
- cellular response to glucose stimulus
- cellular response to testosterone stimulus
- cytosol
- fatty acid metabolic process
- liver development
- positive regulation of insulin secretion
- response to ethanol
- response to nutrient
- response to oleic acid
- response to organic cyclic compound
- response to organonitrogen compound
- response to purine-containing compound
- response to starvation
- white fat cell differentiation

Abat
Rat
4-aminobutyrate aminotransferase, mitochondrial
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
GABT_RAT
- Accession #
-
P50554
- Protein names
-
- 4-aminobutyrate aminotransferase, mitochondrial
- EC 2.6.1.19
- (S
- EC 2.6.1.22
- GABA aminotransferase
- GABA-AT
- Gamma-amino-N-butyrate transaminase
- GABA transaminase
- GABA-T
- L-AIBAT
- Gene names
-
- Abat
- Gabat
- Description
-
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
- Links
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Search Kinases of Abat (Rat)
- (S)-3-amino-2-methylpropionate transaminase activity
- 4-aminobutyrate transaminase activity
- 4-aminobutyrate transaminase complex
- 4-aminobutyrate:2-oxoglutarate transaminase activity
- aging
- behavioral response to cocaine
- cerebellum development
- copulation
- exploration behavior
- gamma-aminobutyric acid biosynthetic process
- gamma-aminobutyric acid catabolic process
- gamma-aminobutyric acid metabolic process
- identical protein binding
- iron-sulfur cluster binding
- locomotory behavior
- metal ion binding
- mitochondrial matrix
- mitochondrion
- negative regulation of blood pressure
- negative regulation of dopamine secretion
- negative regulation of gamma-aminobutyric acid secretion
- negative regulation of platelet aggregation
- neuron projection
- neurotransmitter catabolic process
- positive regulation of aspartate secretion
- positive regulation of dopamine metabolic process
- positive regulation of heat generation
- positive regulation of inhibitory postsynaptic potential
- positive regulation of insulin secretion
- positive regulation of prolactin secretion
- positive regulation of uterine smooth muscle contraction
- pyridoxal phosphate binding
- response to cocaine
- response to ethanol
- response to hypoxia
- response to iron ion
- response to nicotine
- succinate-semialdehyde dehydrogenase binding

Abce1
Rat
ATP-binding cassette subfamily E member 1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
D3ZD23_RAT
- Accession #
- D3ZD23
- Protein names
-
- ATP-binding cassette subfamily E member 1
- ATP-binding cassette, sub-family E (OABP
- Gene names
-
- Abce1
- rCG_51692
- Description
-
N/A
- Links
-
Search Kinases of Abce1 (Rat)
N/A
- ATP binding
- ATPase-coupled transmembrane transporter activity
- cytoplasm
- cytosol
- endoribonuclease inhibitor activity
- iron ion binding
- mitochondrion
- negative regulation of endoribonuclease activity
- ribosomal small subunit binding
- ribosomal subunit export from nucleus
- translational initiation
- translational termination

ABL1
Human
Tyrosine-protein kinase ABL1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ABL1_HUMAN
- Accession #
-
P00519
- Protein names
-
- Tyrosine-protein kinase ABL1
- EC 2.7.10.2
- Abelson murine leukemia viral oncogene homolog 1
- Abelson tyrosine-protein kinase 1
- Proto-oncogene c-Abl
- p150
- Gene names
-
- ABL1
- ABL
- JTK7
- Description
-
Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner. Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}.
- Links
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Search Kinases of ABL1 (Human)
- ATP binding
- B cell proliferation involved in immune response
- B cell receptor signaling pathway
- B-1 B cell homeostasis
- Bergmann glial cell differentiation
- DNA binding
- DNA conformation change
- DNA damage induced protein phosphorylation
- Fc-gamma receptor signaling pathway involved in phagocytosis
- SH2 domain binding
- SH3 domain binding
- T cell receptor signaling pathway
- actin cytoskeleton
- actin cytoskeleton organization
- actin filament binding
- actin filament branching
- actin monomer binding
- activated T cell proliferation
- activation of protein kinase C activity
- alpha-beta T cell differentiation
- autophagy
- bubble DNA binding
- cell leading edge
- cellular protein modification process
- cellular response to DNA damage stimulus
- cellular response to dopamine
- cellular response to hydrogen peroxide
- cellular response to lipopolysaccharide
- cellular response to oxidative stress
- cerebellum morphogenesis
- circulatory system development
- collateral sprouting
- cytoplasm
- cytosol
- dendrite
- endocytosis
- endothelial cell migration
- ephrin receptor binding
- epidermal growth factor receptor signaling pathway
- establishment of protein localization
- four-way junction DNA binding
- integrin-mediated signaling pathway
- intrinsic apoptotic signaling pathway in response to DNA damage
- kinase activity
- magnesium ion binding
- manganese ion binding
- microspike assembly
- mismatch repair
- mitochondrial depolarization
- mitochondrion
- mitogen-activated protein kinase binding
- mitotic cell cycle
- negative regulation of BMP signaling pathway
- negative regulation of ERK1 and ERK2 cascade
- negative regulation of I-kappaB kinase/NF-kappaB signaling
- negative regulation of cell-cell adhesion
- negative regulation of cellular senescence
- negative regulation of endothelial cell apoptotic process
- negative regulation of long-term synaptic potentiation
- negative regulation of mitotic cell cycle
- negative regulation of phospholipase C activity
- negative regulation of protein serine/threonine kinase activity
- negative regulation of ubiquitin-protein transferase activity
- neural tube closure
- neuroepithelial cell differentiation
- neuromuscular process controlling balance
- neuronal cell body
- neuropilin binding
- neuropilin signaling pathway
- nicotinate-nucleotide adenylyltransferase activity
- non-membrane spanning protein tyrosine kinase activity
- nuclear body
- nuclear membrane
- nucleolus
- nucleoplasm
- nucleus
- peptidyl-tyrosine autophosphorylation
- peptidyl-tyrosine phosphorylation
- perinuclear region of cytoplasm
- phosphotyrosine residue binding
- platelet-derived growth factor receptor-beta signaling pathway
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of I-kappaB kinase/NF-kappaB signaling
- positive regulation of Wnt signaling pathway, planar cell polarity pathway
- positive regulation of actin cytoskeleton reorganization
- positive regulation of actin filament binding
- positive regulation of apoptotic process
- positive regulation of blood vessel branching
- positive regulation of cell migration involved in sprouting angiogenesis
- positive regulation of cytosolic calcium ion concentration
- positive regulation of endothelial cell migration
- positive regulation of focal adhesion assembly
- positive regulation of interferon-gamma production
- positive regulation of interleukin-2 production
- positive regulation of microtubule binding
- positive regulation of mitotic cell cycle
- positive regulation of muscle cell differentiation
- positive regulation of neuron death
- positive regulation of osteoblast proliferation
- positive regulation of oxidoreductase activity
- positive regulation of peptidyl-tyrosine phosphorylation
- positive regulation of protein phosphorylation
- positive regulation of release of sequestered calcium ion into cytosol
- positive regulation of stress fiber assembly
- positive regulation of substrate adhesion-dependent cell spreading
- positive regulation of transcription by RNA polymerase II
- post-embryonic development
- postsynapse
- proline-rich region binding
- protein C-terminus binding
- protein autophosphorylation
- protein kinase C binding
- protein kinase activity
- protein phosphorylation
- protein tyrosine kinase activity
- protein-containing complex
- regulation of Cdc42 protein signal transduction
- regulation of T cell differentiation
- regulation of actin cytoskeleton organization
- regulation of actin cytoskeleton reorganization
- regulation of apoptotic process
- regulation of autophagy
- regulation of axon extension
- regulation of cell adhesion
- regulation of cell motility
- regulation of endocytosis
- regulation of extracellular matrix organization
- regulation of hematopoietic stem cell differentiation
- regulation of microtubule polymerization
- regulation of modification of synaptic structure
- regulation of response to DNA damage stimulus
- regulation of transcription, DNA-templated
- response to oxidative stress
- sequence-specific double-stranded DNA binding
- signal transduction in response to DNA damage
- spleen development
- substrate adhesion-dependent cell spreading
- syntaxin binding
- thymus development
- transcription coactivator activity
- transitional one stage B cell differentiation
- transmembrane receptor protein tyrosine kinase activity

Acadl
Rat
Long-chain specific acyl-CoA dehydrogenase, mitochondrial
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ACADL_RAT
- Accession #
-
P15650
- Protein names
-
- Long-chain specific acyl-CoA dehydrogenase, mitochondrial
- LCAD
- EC 1.3.8.8
- Gene names
-
- Acadl
- Description
-
Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:3968063). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:3968063). Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase can act on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains (PubMed:3968063, PubMed:15466478). {ECO:0000269|PubMed:15466478, ECO:0000269|PubMed:3968063, ECO:0000303|PubMed:3968063}.
- Links
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Search Kinases of Acadl (Rat)
- acyl-CoA dehydrogenase activity
- carnitine catabolic process
- carnitine metabolic process, CoA-linked
- cellular lipid catabolic process
- fatty acid beta-oxidation using acyl-CoA dehydrogenase
- fatty acid catabolic process
- fatty-acyl-CoA binding
- flavin adenine dinucleotide binding
- identical protein binding
- long-chain fatty acid catabolic process
- long-chain-acyl-CoA dehydrogenase activity
- mitochondrial matrix
- mitochondrial membrane
- mitochondrion
- negative regulation of fatty acid biosynthetic process
- negative regulation of fatty acid oxidation
- palmitoyl-CoA oxidase activity
- positive regulation of cold-induced thermogenesis
- regulation of cholesterol metabolic process
- response to cold
- temperature homeostasis

Aco2
Rat
Aconitate hydratase, mitochondrial
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ACON_RAT
- Accession #
-
Q9ER34
- Protein names
-
- Aconitate hydratase, mitochondrial
- Aconitase
- EC 4.2.1.3
- Citrate hydro-lyase
- Gene names
-
- Aco2
- Description
-
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250|UniProtKB:P16276}.
- Links
-
Search Kinases of Aco2 (Rat)

Acot7
Rat
Cytosolic acyl coenzyme A thioester hydrolase
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
BACH_RAT
- Accession #
-
Q64559
- Protein names
-
- Cytosolic acyl coenzyme A thioester hydrolase
- EC 3.1.2.2
- ACH1
- ACT
- Acyl-CoA thioesterase 7
- Brain acyl-CoA hydrolase
- BACH
- CTE-IIa
- CTE-IIb
- CTE-II
- LACH1
- Long chain acyl-CoA thioester hydrolase
- MTE-II
- Gene names
-
- Acot7
- Bach
- Description
-
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:7906114). Acyl-coenzyme A thioesterase 7/ACOT7 preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (PubMed:7906114). May play an important physiological function in brain (PubMed:7906114). {ECO:0000269|PubMed:7906114, ECO:0000303|PubMed:7906114}.
- Links
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Search Kinases of Acot7 (Rat)
- acyl-CoA hydrolase activity
- acyl-CoA metabolic process
- carboxylic ester hydrolase activity
- cell body
- coenzyme A biosynthetic process
- cytoplasm
- cytosol
- fatty acid catabolic process
- fatty acid metabolic process
- fatty-acyl-CoA binding
- identical protein binding
- long-chain fatty acyl-CoA binding
- long-chain fatty-acyl-CoA catabolic process
- medium-chain fatty acid biosynthetic process
- medium-chain fatty-acyl-CoA catabolic process
- myristoyl-CoA hydrolase activity
- neuron projection
- nucleoplasm
- palmitic acid biosynthetic process
- palmitoyl-CoA hydrolase activity
- protein homodimerization activity

Acsbg1
Rat
Long-chain-fatty-acid--CoA ligase ACSBG1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ACBG1_RAT
- Accession #
-
Q924N5
- Protein names
-
- Long-chain-fatty-acid--CoA ligase ACSBG1
- EC 6.2.1.3
- Acyl-CoA synthetase bubblegum family member 1
- Gonadotropin-regulated long chain acyl CoA synthetase
- GR-LACS
- Gene names
-
- Acsbg1
- Grlacs
- Description
-
Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. {ECO:0000269|PubMed:11381125}.
- Links
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Search Kinases of Acsbg1 (Rat)
- ATP binding
- CoA-ligase activity
- cytoplasm
- cytoplasmic vesicle
- endoplasmic reticulum
- long-chain fatty acid biosynthetic process
- long-chain fatty acid metabolic process
- long-chain fatty acid-CoA ligase activity
- ovarian follicle atresia
- plasma membrane
- response to glucocorticoid
- very long-chain fatty acid metabolic process
- very long-chain fatty acid-CoA ligase activity

Actn4
Rat
Alpha-actinin-4
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ACTN4_RAT
- Accession #
-
Q9QXQ0
- Protein names
-
- Alpha-actinin-4
- Non-muscle alpha-actinin 4
- Gene names
-
- Actn4
- Description
-
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA. {ECO:0000250|UniProtKB:O43707}.
- Links
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Search Kinases of Actn4 (Rat)
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- Z disc
- actin filament binding
- actin filament bundle assembly
- bicellular tight junction assembly
- calcium ion binding
- cell-cell junction
- chromatin DNA binding
- cortical cytoskeleton
- cytoplasm
- cytosol
- negative regulation of cellular component movement
- negative regulation of substrate adhesion-dependent cell spreading
- neuron projection
- nuclear body
- nuclear receptor coactivator activity
- nucleoside binding
- nucleus
- perinuclear region of cytoplasm
- peroxisome proliferator activated receptor signaling pathway
- positive regulation of NIK/NF-kappaB signaling
- positive regulation of cell migration
- positive regulation of cellular component movement
- positive regulation of pinocytosis
- protein N-terminus binding
- protein homodimerization activity
- protein localization to bicellular tight junction
- protein transport
- protein-containing complex
- protein-containing complex binding
- pseudopodium
- regulation of apoptotic process
- regulation of nucleic acid-templated transcription
- response to hypoxia
- retinoic acid receptor binding
- retinoic acid receptor signaling pathway
- ribonucleoprotein complex
- stress fiber
- transcription coactivator activity
- transmembrane transporter binding
- tumor necrosis factor-mediated signaling pathway
- vesicle transport along actin filament

Adap1
Rat
ArfGAP with dual PH domains 1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
O88768_RAT
- Accession #
- O88768
- Protein names
-
- ArfGAP with dual PH domains 1
- IP4/PIP3 binding protein
- Gene names
-
- Adap1
- Centa1
- Description
-
N/A
- Links
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Search Kinases of Adap1 (Rat)
N/A

Add1
Rat
Alpha-adducin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ADDA_RAT
- Accession #
-
Q63028
- Protein names
-
- Alpha-adducin
- Erythrocyte adducin subunit alpha
- Gene names
-
- Add1
- Description
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
- Links
-
Search Kinases of Add1 (Rat)
N/A
- F-actin capping protein complex
- T cell receptor binding
- actin filament binding
- actin filament bundle assembly
- adherens junction
- barbed-end actin filament capping
- calmodulin binding
- cell morphogenesis
- cell volume homeostasis
- cellular response to calcium ion
- cellular response to retinoic acid
- cytoplasm
- cytoskeleton
- cytoskeleton organization
- dendrite
- dendritic spine
- erythrocyte differentiation
- hemoglobin metabolic process
- homeostasis of number of cells within a tissue
- in utero embryonic development
- ion transport
- membrane
- multicellular organism growth
- negative regulation of actin filament polymerization
- nucleus
- perinuclear region of cytoplasm
- plasma membrane
- positive regulation of adherens junction organization
- positive regulation of angiogenesis
- positive regulation of endocytosis
- positive regulation of establishment of endothelial barrier
- positive regulation of protein binding
- postsynaptic density
- protein heterodimerization activity
- protein homodimerization activity
- spectrin binding
- structural constituent of cytoskeleton
- synapse
- transcription factor binding

Add2
Rat
Beta-adducin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
F8WFS9_RAT
- Accession #
- F8WFS9
- Protein names
-
- Beta-adducin
- Gene names
-
- Add2
- Description
-
N/A
- Links
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Search Kinases of Add2 (Rat)
N/A
- F-actin capping protein complex
- actin filament binding
- actin filament bundle assembly
- barbed-end actin filament capping
- cytoplasmic vesicle
- hemopoiesis
- leukocyte tethering or rolling
- plasma membrane raft
- positive regulation of protein binding
- postsynaptic density
- protein heterodimerization activity
- protein homodimerization activity
- protein kinase binding
- protein-containing complex assembly
- spectrin binding
- structural constituent of cytoskeleton
- synapse assembly

Afdn
Rat
Afadin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
AFAD_RAT
- Accession #
-
O35889
- Protein names
-
- Afadin
- Afadin adherens junction formation factor
- Protein Af-6
- Gene names
-
- Afdn
- Af6
- Mllt4
- Description
-
Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (PubMed:9334353). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:9334353). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (By similarity). {ECO:0000250|UniProtKB:P55196, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:9334353}.
- Links
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Search Kinases of Afdn (Rat)
- LIM domain binding
- adherens junction
- adherens junction maintenance
- apical junction complex
- apical part of cell
- axon
- bicellular tight junction assembly
- brain morphogenesis
- cell adhesion molecule binding
- cell junction
- cell-cell adhesion mediated by cadherin
- cell-cell contact zone
- cell-cell junction
- cerebral cortex development
- cytoplasm
- cytosol
- dendrite arborization
- establishment of endothelial intestinal barrier
- establishment of protein localization to plasma membrane
- homeostasis of number of cells
- neuroepithelial cell differentiation
- pore complex
- pore complex assembly
- positive regulation of GTPase activity
- positive regulation of cell-cell adhesion
- positive regulation of cell-cell adhesion mediated by cadherin
- positive regulation of dendrite extension
- positive regulation of dendrite morphogenesis
- positive regulation of dendritic spine morphogenesis
- positive regulation of gene expression
- positive regulation of mini excitatory postsynaptic potential
- protein localization to cell junction
- radial glial cell differentiation
- regulation of oligodendrocyte progenitor proliferation
- regulation of protein localization
- signal transduction
- small GTPase binding
- somatodendritic compartment
- telencephalon development
- tight junction

Ak1
Rat
Adenylate kinase isoenzyme 1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
KAD1_RAT
- Accession #
-
P39069
- Protein names
-
- Adenylate kinase isoenzyme 1
- AK 1
- EC 2.7.4.3
- EC 2.7.4.6
- ATP-AMP transphosphorylase 1
- ATP:AMP phosphotransferase
- Adenylate monophosphate kinase
- Myokinase
- Gene names
-
- Ak1
- Description
-
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. {ECO:0000255|HAMAP-Rule:MF_03171}.
- Links
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Search Kinases of Ak1 (Rat)
- ADP biosynthetic process
- AMP metabolic process
- ATP binding
- ATP metabolic process
- adenine metabolic process
- adenylate kinase activity
- cerebellum development
- cytoplasm
- cytosol
- inosine biosynthetic process
- muscle organ development
- neuron differentiation
- neuron projection
- nucleoside diphosphate kinase activity
- nucleoside diphosphate phosphorylation
- nucleoside triphosphate biosynthetic process
- olfactory bulb development
- outer dense fiber
- perinuclear region of cytoplasm
- plasma membrane
- positive regulation of glucose transmembrane transport
- positive regulation of neuron maturation
- response to activity
- response to estradiol
- response to testosterone
- sarcomere
- sperm flagellum

Ak5
Rat
Nucleoside-diphosphate kinase
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
M0R7U1_RAT
- Accession #
- M0R7U1
- Protein names
-
- Nucleoside-diphosphate kinase
- EC 2.7.4.6
- Gene names
-
- Ak5
- rCG_28422
- Description
-
N/A
- Links
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Search Kinases of Ak5 (Rat)

Aldh6a1
Rat
Aldehyde dehydrogenase family 6, subfamily A1, isoform CRA_b
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
G3V7J0_RAT
- Accession #
- G3V7J0
- Protein names
-
- Aldehyde dehydrogenase family 6, subfamily A1, isoform CRA_b
- Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
- Gene names
-
- Aldh6a1
- rCG_20746
- Description
-
N/A
- Links
-
Search Kinases of Aldh6a1 (Rat)

Aldoa
Rat
Fructose-bisphosphate aldolase A
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ALDOA_RAT
- Accession #
-
P05065
- Protein names
-
- Fructose-bisphosphate aldolase A
- EC 4.1.2.13
- Muscle-type aldolase
- Gene names
-
- Aldoa
- Description
-
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). {ECO:0000250}.
- Links
-
Search Kinases of Aldoa (Rat)
- M band
- Z disc
- cytoplasm
- cytosol
- fructose 1,6-bisphosphate metabolic process
- fructose-bisphosphate aldolase activity
- glycolytic process
- heterochromatin
- membrane
- methylglyoxal biosynthetic process
- mitochondrion
- plasma membrane
- positive regulation of cell migration
- protease binding
- protein homotetramerization
- protein-containing complex
- response to estrogen
- response to heat
- response to hypoxia
- response to lipopolysaccharide
- response to nicotine
- sperm fibrous sheath

Aldoc
Rat
Fructose-bisphosphate aldolase C
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ALDOC_RAT
- Accession #
-
P09117
- Protein names
-
- Fructose-bisphosphate aldolase C
- EC 4.1.2.13
- Brain-type aldolase
- Gene names
-
- Aldoc
- Description
-
N/A
- Links
-
Search Kinases of Aldoc (Rat)
- aging
- animal organ regeneration
- apoptotic process
- axon
- cytoplasm
- cytoskeletal protein binding
- cytosol
- epithelial cell differentiation
- fructose 1,6-bisphosphate metabolic process
- fructose-bisphosphate aldolase activity
- glycolytic process
- identical protein binding
- postsynaptic cytosol
- protein-containing complex binding
- response to hypoxia
- response to organic cyclic compound
- response to organonitrogen compound

Amph
Rat
Amphiphysin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
AMPH_RAT
- Accession #
-
O08838
- Protein names
-
- Amphiphysin
- Gene names
-
- Amph
- Amph1
- Description
-
May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton (By similarity). {ECO:0000250}.
- Links
-
Search Kinases of Amph (Rat)
- axon terminus
- cytoskeleton
- extrinsic component of synaptic vesicle membrane
- glutamatergic synapse
- leading edge membrane
- learning
- phospholipid binding
- photoreceptor ribbon synapse
- plasma membrane
- positive regulation of GTPase activity
- positive regulation of endocytosis
- presynapse
- presynaptic endocytic zone
- protein C-terminus binding
- protein-containing complex binding
- synaptic vesicle
- synaptic vesicle endocytosis
- terminal bouton
