Search Results (240 substrates found)
Gene name
Organism
Protein name
ABL1
Human
Tyrosine-protein kinase ABL1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ABL1_HUMAN
- Accession #
-
P00519
- Protein names
-
- Tyrosine-protein kinase ABL1
- EC 2.7.10.2
- Abelson murine leukemia viral oncogene homolog 1
- Abelson tyrosine-protein kinase 1
- Proto-oncogene c-Abl
- p150
- Gene names
-
- ABL1
- ABL
- JTK7
- Description
-
Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
- Links
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Search Kinases of ABL1 (Human)
- ATP binding
- DNA binding
- DNA damage induced protein phosphorylation
- Fc-gamma receptor signaling pathway involved in phagocytosis
- SH3 domain binding
- actin cytoskeleton
- actin cytoskeleton organization
- actin monomer binding
- autophagy
- axon guidance
- blood coagulation
- cell adhesion
- cell leading edge
- cellular protein modification process
- cellular response to DNA damage stimulus
- cytoplasm
- cytosol
- innate immune response
- intrinsic apoptotic signaling pathway in response to DNA damage
- magnesium ion binding
- manganese ion binding
- mismatch repair
- mitochondrion
- mitogen-activated protein kinase binding
- muscle cell differentiation
- negative regulation of protein serine/threonine kinase activity
- nicotinate-nucleotide adenylyltransferase activity
- non-membrane spanning protein tyrosine kinase activity
- nuclear membrane
- nucleolus
- nucleus
- peptidyl-tyrosine phosphorylation
- perinuclear region of cytoplasm
- platelet-derived growth factor receptor signaling pathway
- positive regulation of apoptotic process
- positive regulation of muscle cell differentiation
- positive regulation of oxidoreductase activity
- positive regulation of peptidyl-tyrosine phosphorylation
- proline-rich region binding
- protein C-terminus binding
- protein binding
- protein tyrosine kinase activity
- regulation of actin cytoskeleton reorganization
- regulation of autophagy
- regulation of cell adhesion
- regulation of cell cycle
- regulation of cell motility
- regulation of endocytosis
- regulation of response to DNA damage stimulus
- regulation of transcription, DNA-templated
- signal transduction in response to DNA damage
- syntaxin binding

Acan
Rat
Aggrecan core protein
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
PGCA_RAT
- Accession #
- P07897
- Protein names
-
- Aggrecan core protein
- Cartilage-specific proteoglycan core protein
- CSPCP
- Gene names
-
- Acan
- Agc
- Agc1
- Description
-
This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.
- Links
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Search Kinases of Acan (Rat)
N/A
- calcium ion binding
- carbohydrate binding
- cell adhesion
- cellular response to growth factor stimulus
- central nervous system development
- chondroblast differentiation
- extracellular matrix structural constituent
- hyaluronic acid binding
- multicellular organismal aging
- negative regulation of cell migration
- ossification
- perineuronal net
- proteinaceous extracellular matrix
- response to acidic pH
- response to drug
- response to glucose
- response to gravity
- response to mechanical stimulus
- response to organic cyclic compound
- response to radiation
- spinal cord development

Acsbg1
Rat
Long-chain-fatty-acid--CoA ligase ACSBG1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ACBG1_RAT
- Accession #
-
Q924N5
- Protein names
-
- Long-chain-fatty-acid--CoA ligase ACSBG1
- EC 6.2.1.3
- Acyl-CoA synthetase bubblegum family member 1
- Gonadotropin-regulated long chain acyl CoA synthetase
- GR-LACS
- Gene names
-
- Acsbg1
- Grlacs
- Description
-
Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids.
- Links
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Search Kinases of Acsbg1 (Rat)
- ATP binding
- cytoplasm
- cytoplasmic membrane-bounded vesicle
- endoplasmic reticulum
- long-chain fatty acid metabolic process
- long-chain fatty acid-CoA ligase activity
- ovarian follicle atresia
- response to glucocorticoid
- very long-chain fatty acid metabolic process
- very long-chain fatty acid-CoA ligase activity

Adap1
Rat
ArfGAP with dual PH domains 1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
O88768_RAT
- Accession #
- O88768
- Protein names
-
- ArfGAP with dual PH domains 1
- IP4/PIP3 binding protein
- Protein Adap1
- Gene names
-
- Adap1
- Centa1
- Description
-
N/A
- Links
-
Search Kinases of Adap1 (Rat)
N/A

Add2
Rat
Beta-adducin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
F8WFS9_RAT
- Accession #
- F8WFS9
- Protein names
-
- Beta-adducin
- Gene names
-
- Add2
- Description
-
N/A
- Links
-
Search Kinases of Add2 (Rat)
N/A

Ak5
Rat
Protein Ak5
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
M0R7U1_RAT
- Accession #
- M0R7U1
- Protein names
-
- Protein Ak5
- RCG28422
- Gene names
-
- Ak5
- rCG_28422
- Description
-
N/A
- Links
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Search Kinases of Ak5 (Rat)

Aldoa
Rat
Fructose-bisphosphate aldolase A
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ALDOA_RAT
- Accession #
-
P05065
- Protein names
-
- Fructose-bisphosphate aldolase A
- EC 4.1.2.13
- Muscle-type aldolase
- Gene names
-
- Aldoa
- Description
-
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).
- Links
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Search Kinases of Aldoa (Rat)

Aldoc
Rat
Fructose-bisphosphate aldolase C
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ALDOC_RAT
- Accession #
-
P09117
- Protein names
-
- Fructose-bisphosphate aldolase C
- EC 4.1.2.13
- Brain-type aldolase
- Gene names
-
- Aldoc
- Description
-
N/A
- Links
-
Search Kinases of Aldoc (Rat)
- aging
- apoptotic process
- axon
- cytoplasm
- fructose 1,6-bisphosphate metabolic process
- fructose-bisphosphate aldolase activity
- glycolytic process
- mitochondrion
- organ regeneration
- protein binding
- protein heterotetramerization
- protein homotetramerization
- response to hypoxia
- response to organic cyclic compound
- response to organonitrogen compound

Amph
Rat
Amphiphysin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
AMPH_RAT
- Accession #
-
O08838
- Protein names
-
- Amphiphysin
- Gene names
-
- Amph
- Amph1
- Description
-
May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton (By similarity).
- Links
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Search Kinases of Amph (Rat)

Arhgef28
Rat
Rho guanine nucleotide exchange factor 28
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ARG28_RAT
- Accession #
-
P0C6P5
- Protein names
-
- Rho guanine nucleotide exchange factor 28
- 190 kDa guanine nucleotide exchange factor
- p190-RhoGEF
- p190RhoGEF
- Rho guanine nucleotide exchange factor
- Gene names
-
- Arhgef28
- Rgnef
- Description
-
Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis.
- Links
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Search Kinases of Arhgef28 (Rat)
N/A

ATAT1
Human
Alpha-tubulin N-acetyltransferase 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
B7Z4Q7_HUMAN
- Accession #
- B7Z4Q7
- Protein names
-
- Alpha-tubulin N-acetyltransferase 1
- Alpha-TAT
- Alpha-TAT1
- TAT
- EC 2.3.1.108
- Acetyltransferase mec-17 homolog
- Gene names
-
- ATAT1
- MEC17
- Description
-
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Required for normal sperm flagellar function. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly (By similarity).
- Links
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Search Kinases of ATAT1 (Human)
N/A

Atp2a3
Rat
Calcium-transporting ATPase
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
D3ZHJ6_RAT
- Accession #
- D3ZHJ6
- Protein names
-
- Calcium-transporting ATPase
- EC 3.6.3.8
- Gene names
-
- Atp2a3
- Description
-
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity).
- Links
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Search Kinases of Atp2a3 (Rat)
N/A

Atp5a1
Rat
ATP synthase subunit alpha
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
F1LP05_RAT
- Accession #
- F1LP05
- Protein names
-
- ATP synthase subunit alpha
- Gene names
-
- Atp5a1
- Description
-
Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity).
- Links
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Search Kinases of Atp5a1 (Rat)
N/A
- ATP binding
- ATP hydrolysis coupled proton transport
- ATP synthesis coupled proton transport
- embryo development
- lipid metabolic process
- mitochondrial inner membrane
- proton-transporting ATP synthase activity, rotational mechanism
- proton-transporting ATP synthase complex, catalytic core F(1)
- proton-transporting ATPase activity, rotational mechanism

Atp5b
Rat
ATP synthase subunit beta
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
G3V6D3_RAT
- Accession #
- G3V6D3
- Protein names
-
- ATP synthase subunit beta
- EC 3.6.3.14
- Gene names
-
- Atp5b
- rCG_42467
- Description
-
Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity).
- Links
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Search Kinases of Atp5b (Rat)
N/A
- ATP binding
- ATP hydrolysis coupled proton transport
- ATP synthesis coupled proton transport
- angiogenesis
- cell surface
- lipid metabolic process
- mitochondrial nucleoid
- mitochondrial proton-transporting ATP synthase complex
- negative regulation of cell adhesion involved in substrate-bound cell migration
- plasma membrane
- proton-transporting ATP synthase activity, rotational mechanism
- proton-transporting ATP synthase complex, catalytic core F(1)
- proton-transporting ATPase activity, rotational mechanism
- regulation of intracellular pH

Atp6v1a
Rat
Protein Atp6v1a
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
D4A133_RAT
- Accession #
- D4A133
- Protein names
-
- Protein Atp6v1a
- RCG52629
- Gene names
-
- Atp6v1a
- rCG_52629
- Description
-
N/A
- Links
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Search Kinases of Atp6v1a (Rat)

Atp6v1b2
Rat
V-type proton ATPase subunit B, brain isoform
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
VATB2_RAT
- Accession #
-
P62815
- Protein names
-
- V-type proton ATPase subunit B, brain isoform
- V-ATPase subunit B 2
- Endomembrane proton pump 58 kDa subunit
- Vacuolar proton pump subunit B 2
- Gene names
-
- Atp6v1b2
- Atp6b2
- Vat2
- Description
-
Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
- Links
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Search Kinases of Atp6v1b2 (Rat)
- ATP binding
- ATP hydrolysis coupled proton transport
- ATP metabolic process
- Golgi apparatus
- cytosol
- hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
- integral component of membrane
- lysosomal membrane
- melanosome
- microvillus
- plasma membrane
- proton-transporting V-type ATPase, V1 domain
- regulation of cellular pH
- vacuolar acidification

Atp6v1f
Rat
V-type proton ATPase subunit F
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
VATF_RAT
- Accession #
- P50408
- Protein names
-
- V-type proton ATPase subunit F
- V-ATPase subunit F
- V-ATPase 14 kDa subunit
- Vacuolar proton pump subunit F
- Gene names
-
- Atp6v1f
- Atp6s14
- Vatf
- Description
-
Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
- Links
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Search Kinases of Atp6v1f (Rat)

Atp6v1h
Rat
Protein Atp6v1h
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
E9PTI1_RAT
- Accession #
- E9PTI1
- Protein names
-
- Protein Atp6v1h
- Gene names
-
- Atp6v1h
- Description
-
N/A
- Links
-
Search Kinases of Atp6v1h (Rat)
N/A

Bcan
Rat
Brevican, isoform CRA_a
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
G3V8G4_RAT
- Accession #
- G3V8G4
- Protein names
-
- Brevican, isoform CRA_a
- Protein LOC100910284
- Gene names
-
- Bcan
- LOC100910284
- rCG_62833
- Description
-
N/A
- Links
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Search Kinases of Bcan (Rat)
N/A

BCR
Human
Breakpoint cluster region protein
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
BCR_HUMAN
- Accession #
-
P11274
- Protein names
-
- Breakpoint cluster region protein
- EC 2.7.11.1
- Renal carcinoma antigen NY-REN-26
- Gene names
-
- BCR
- BCR1
- D22S11
- Description
-
GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.
- Links
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Search Kinases of BCR (Human)
- ATP binding
- GTPase activator activity
- Rac GTPase activator activity
- Rho guanyl-nucleotide exchange factor activity
- actin cytoskeleton organization
- brain development
- cytosol
- extracellular vesicular exosome
- inner ear morphogenesis
- kinase activity
- negative regulation of cell migration
- negative regulation of inflammatory response
- negative regulation of neutrophil degranulation
- neuromuscular process controlling balance
- peptidyl-tyrosine phosphorylation
- plasma membrane
- platelet-derived growth factor receptor signaling pathway
- positive regulation of phagocytosis
- protein autophosphorylation
- protein binding
- protein complex
- protein phosphorylation
- protein serine/threonine kinase activity
- protein tyrosine kinase activity
- regulation of cell cycle
- regulation of small GTPase mediated signal transduction
- response to lipopolysaccharide
- signal transduction
- small GTPase mediated signal transduction
