KANPHOS_Str

Search Results (441 substrates found)

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Gene name
Organism
Protein name
A1i3
Rat
Alpha-1-inhibitor 3
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
A1I3_RAT
Accession #
P14046
Protein names
  • Alpha-1-inhibitor 3
  • Alpha-1-inhibitor 3 variant II
  • Alpha-1-inhibitor III
Gene names
  • A1i3
Description
Protease inhibitor with a wide spectrum of protein targets, which attaches through its thioester function.
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Search Kinases of A1i3 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Abat
Rat
4-aminobutyrate aminotransferase, mitochondrial
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
GABT_RAT
Accession #
P50554
Protein names
  • 4-aminobutyrate aminotransferase, mitochondrial
  • EC 2.6.1.19
  • (S
  • EC 2.6.1.22
  • GABA aminotransferase
  • GABA-AT
  • Gamma-amino-N-butyrate transaminase
  • GABA transaminase
  • GABA-T
  • L-AIBAT
Gene names
  • Abat
  • Gabat
Description
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
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Search Kinases of Abat (Rat)
Phosphorylation Site Information
Abce1
Rat
ATP-binding cassette subfamily E member 1
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
D3ZD23_RAT
Accession #
D3ZD23
Protein names
  • ATP-binding cassette subfamily E member 1
  • ATP-binding cassette, sub-family E (OABP
Gene names
  • Abce1
  • rCG_51692
Description
N/A
Links

Search Kinases of Abce1 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
ABL1
Human
Tyrosine-protein kinase ABL1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ABL1_HUMAN
Accession #
P00519
Protein names
  • Tyrosine-protein kinase ABL1
  • EC 2.7.10.2
  • Abelson murine leukemia viral oncogene homolog 1
  • Abelson tyrosine-protein kinase 1
  • Proto-oncogene c-Abl
  • p150
Gene names
  • ABL1
  • ABL
  • JTK7
Description
Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner. Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}.
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Search Kinases of ABL1 (Human)
Gene Ontology Terms (142)
Phosphorylation Site Information
Acadl
Rat
Long-chain specific acyl-CoA dehydrogenase, mitochondrial
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ACADL_RAT
Accession #
P15650
Protein names
  • Long-chain specific acyl-CoA dehydrogenase, mitochondrial
  • LCAD
  • EC 1.3.8.8
Gene names
  • Acadl
Description
Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:3968063). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:3968063). Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase can act on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains (PubMed:3968063, PubMed:15466478). {ECO:0000269|PubMed:15466478, ECO:0000269|PubMed:3968063, ECO:0000303|PubMed:3968063}.
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Search Kinases of Acadl (Rat)
Phosphorylation Site Information
Aco2
Rat
Aconitate hydratase, mitochondrial
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ACON_RAT
Accession #
Q9ER34
Protein names
  • Aconitate hydratase, mitochondrial
  • Aconitase
  • EC 4.2.1.3
  • Citrate hydro-lyase
Gene names
  • Aco2
Description
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250|UniProtKB:P16276}.
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Search Kinases of Aco2 (Rat)
Phosphorylation Site Information
Acot7
Rat
Cytosolic acyl coenzyme A thioester hydrolase
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
BACH_RAT
Accession #
Q64559
Protein names
  • Cytosolic acyl coenzyme A thioester hydrolase
  • EC 3.1.2.2
  • ACH1
  • ACT
  • Acyl-CoA thioesterase 7
  • Brain acyl-CoA hydrolase
  • BACH
  • CTE-IIa
  • CTE-IIb
  • CTE-II
  • LACH1
  • Long chain acyl-CoA thioester hydrolase
  • MTE-II
Gene names
  • Acot7
  • Bach
Description
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:7906114). Acyl-coenzyme A thioesterase 7/ACOT7 preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (PubMed:7906114). May play an important physiological function in brain (PubMed:7906114). {ECO:0000269|PubMed:7906114, ECO:0000303|PubMed:7906114}.
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Search Kinases of Acot7 (Rat)
Phosphorylation Site Information
Acsbg1
Rat
Long-chain-fatty-acid--CoA ligase ACSBG1
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ACBG1_RAT
Accession #
Q924N5
Protein names
  • Long-chain-fatty-acid--CoA ligase ACSBG1
  • EC 6.2.1.3
  • Acyl-CoA synthetase bubblegum family member 1
  • Gonadotropin-regulated long chain acyl CoA synthetase
  • GR-LACS
Gene names
  • Acsbg1
  • Grlacs
Description
Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. {ECO:0000269|PubMed:11381125}.
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Search Kinases of Acsbg1 (Rat)
Phosphorylation Site Information
Actn4
Rat
Alpha-actinin-4
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ACTN4_RAT
Accession #
Q9QXQ0
Protein names
  • Alpha-actinin-4
  • Non-muscle alpha-actinin 4
Gene names
  • Actn4
Description
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA. {ECO:0000250|UniProtKB:O43707}.
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Search Kinases of Actn4 (Rat)
Phosphorylation Site Information
Adap1
Rat
ArfGAP with dual PH domains 1
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
O88768_RAT
Accession #
O88768
Protein names
  • ArfGAP with dual PH domains 1
  • IP4/PIP3 binding protein
Gene names
  • Adap1
  • Centa1
Description
N/A
Links

Search Kinases of Adap1 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Add1
Rat
Alpha-adducin
Afdn
Rat
Afadin
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
AFAD_RAT
Accession #
O35889
Protein names
  • Afadin
  • Afadin adherens junction formation factor
  • Protein Af-6
Gene names
  • Afdn
  • Af6
  • Mllt4
Description
Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (PubMed:9334353). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:9334353). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (By similarity). {ECO:0000250|UniProtKB:P55196, ECO:0000250|UniProtKB:Q9QZQ1, ECO:0000269|PubMed:9334353}.
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Search Kinases of Afdn (Rat)
Phosphorylation Site Information
Ak1
Rat
Adenylate kinase isoenzyme 1
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
KAD1_RAT
Accession #
P39069
Protein names
  • Adenylate kinase isoenzyme 1
  • AK 1
  • EC 2.7.4.3
  • EC 2.7.4.6
  • ATP-AMP transphosphorylase 1
  • ATP:AMP phosphotransferase
  • Adenylate monophosphate kinase
  • Myokinase
Gene names
  • Ak1
Description
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. {ECO:0000255|HAMAP-Rule:MF_03171}.
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Search Kinases of Ak1 (Rat)
Phosphorylation Site Information
Ak5
Rat
Nucleoside-diphosphate kinase
Aldh6a1
Rat
Aldehyde dehydrogenase family 6, subfamily A1, isoform CRA_b
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
G3V7J0_RAT
Accession #
G3V7J0
Protein names
  • Aldehyde dehydrogenase family 6, subfamily A1, isoform CRA_b
  • Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
Gene names
  • Aldh6a1
  • rCG_20746
Description
N/A
Links

Search Kinases of Aldh6a1 (Rat)
Phosphorylation Site Information
Amph
Rat
Amphiphysin
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
AMPH_RAT
Accession #
O08838
Protein names
  • Amphiphysin
Gene names
  • Amph
  • Amph1
Description
May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton (By similarity). {ECO:0000250}.
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Search Kinases of Amph (Rat)
KEGG Pathways (2)
Phosphorylation Site Information
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