KANPHOS_Str

Search Results (240 substrates found)

Displaying 1 - 20 of 240 Items
items per page
Order by
/12 page
 
Gene name
Organism
Protein name
ABL1
Human
Tyrosine-protein kinase ABL1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ABL1_HUMAN
Accession #
P00519
Protein names
  • Tyrosine-protein kinase ABL1
  • EC 2.7.10.2
  • Abelson murine leukemia viral oncogene homolog 1
  • Abelson tyrosine-protein kinase 1
  • Proto-oncogene c-Abl
  • p150
Gene names
  • ABL1
  • ABL
  • JTK7
Description
Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
Links

Search Kinases of ABL1 (Human)
Gene Ontology Terms (52)
Phosphorylation Site Information
Acan
Rat
Aggrecan core protein
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
PGCA_RAT
Accession #
P07897
Protein names
  • Aggrecan core protein
  • Cartilage-specific proteoglycan core protein
  • CSPCP
Gene names
  • Acan
  • Agc
  • Agc1
Description
This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.
Links

Search Kinases of Acan (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Acsbg1
Rat
Long-chain-fatty-acid--CoA ligase ACSBG1
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ACBG1_RAT
Accession #
Q924N5
Protein names
  • Long-chain-fatty-acid--CoA ligase ACSBG1
  • EC 6.2.1.3
  • Acyl-CoA synthetase bubblegum family member 1
  • Gonadotropin-regulated long chain acyl CoA synthetase
  • GR-LACS
Gene names
  • Acsbg1
  • Grlacs
Description
Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids.
Links

Search Kinases of Acsbg1 (Rat)
Phosphorylation Site Information
Adap1
Rat
ArfGAP with dual PH domains 1
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
O88768_RAT
Accession #
O88768
Protein names
  • ArfGAP with dual PH domains 1
  • IP4/PIP3 binding protein
  • Protein Adap1
Gene names
  • Adap1
  • Centa1
Description
N/A
Links

Search Kinases of Adap1 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Add2
Rat
Beta-adducin
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
F8WFS9_RAT
Accession #
F8WFS9
Protein names
  • Beta-adducin
Gene names
  • Add2
Description
N/A
Links

Search Kinases of Add2 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Ak5
Rat
Protein Ak5
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
M0R7U1_RAT
Accession #
M0R7U1
Protein names
  • Protein Ak5
  • RCG28422
Gene names
  • Ak5
  • rCG_28422
Description
N/A
Links

Search Kinases of Ak5 (Rat)
Phosphorylation Site Information
Aldoa
Rat
Fructose-bisphosphate aldolase A
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ALDOA_RAT
Accession #
P05065
Protein names
  • Fructose-bisphosphate aldolase A
  • EC 4.1.2.13
  • Muscle-type aldolase
Gene names
  • Aldoa
Description
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).
Links

Search Kinases of Aldoa (Rat)
Phosphorylation Site Information
Amph
Rat
Amphiphysin
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
AMPH_RAT
Accession #
O08838
Protein names
  • Amphiphysin
Gene names
  • Amph
  • Amph1
Description
May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton (By similarity).
Links

Search Kinases of Amph (Rat)
Phosphorylation Site Information
Arhgef28
Rat
Rho guanine nucleotide exchange factor 28
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ARG28_RAT
Accession #
P0C6P5
Protein names
  • Rho guanine nucleotide exchange factor 28
  • 190 kDa guanine nucleotide exchange factor
  • p190-RhoGEF
  • p190RhoGEF
  • Rho guanine nucleotide exchange factor
Gene names
  • Arhgef28
  • Rgnef
Description
Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis.
Links

Search Kinases of Arhgef28 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
ATAT1
Human
Alpha-tubulin N-acetyltransferase 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
B7Z4Q7_HUMAN
Accession #
B7Z4Q7
Protein names
  • Alpha-tubulin N-acetyltransferase 1
  • Alpha-TAT
  • Alpha-TAT1
  • TAT
  • EC 2.3.1.108
  • Acetyltransferase mec-17 homolog
Gene names
  • ATAT1
  • MEC17
Description
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Required for normal sperm flagellar function. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly (By similarity).
Links

Search Kinases of ATAT1 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Atp2a3
Rat
Calcium-transporting ATPase
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
D3ZHJ6_RAT
Accession #
D3ZHJ6
Protein names
  • Calcium-transporting ATPase
  • EC 3.6.3.8
Gene names
  • Atp2a3
Description
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity).
Links

Search Kinases of Atp2a3 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Atp5a1
Rat
ATP synthase subunit alpha
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
F1LP05_RAT
Accession #
F1LP05
Protein names
  • ATP synthase subunit alpha
Gene names
  • Atp5a1
Description
Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity).
Links

Search Kinases of Atp5a1 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Atp6v1a
Rat
Protein Atp6v1a
Atp6v1b2
Rat
V-type proton ATPase subunit B, brain isoform
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
VATB2_RAT
Accession #
P62815
Protein names
  • V-type proton ATPase subunit B, brain isoform
  • V-ATPase subunit B 2
  • Endomembrane proton pump 58 kDa subunit
  • Vacuolar proton pump subunit B 2
Gene names
  • Atp6v1b2
  • Atp6b2
  • Vat2
Description
Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Links

Search Kinases of Atp6v1b2 (Rat)
Phosphorylation Site Information
Atp6v1f
Rat
V-type proton ATPase subunit F
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
VATF_RAT
Accession #
P50408
Protein names
  • V-type proton ATPase subunit F
  • V-ATPase subunit F
  • V-ATPase 14 kDa subunit
  • Vacuolar proton pump subunit F
Gene names
  • Atp6v1f
  • Atp6s14
  • Vatf
Description
Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Links

Search Kinases of Atp6v1f (Rat)
Phosphorylation Site Information
Atp6v1h
Rat
Protein Atp6v1h
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
E9PTI1_RAT
Accession #
E9PTI1
Protein names
  • Protein Atp6v1h
Gene names
  • Atp6v1h
Description
N/A
Links

Search Kinases of Atp6v1h (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Bcan
Rat
Brevican, isoform CRA_a
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
G3V8G4_RAT
Accession #
G3V8G4
Protein names
  • Brevican, isoform CRA_a
  • Protein LOC100910284
Gene names
  • Bcan
  • LOC100910284
  • rCG_62833
Description
N/A
Links

Search Kinases of Bcan (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
/12 page