KANPHOS_Str

Search Results (361 substrates found)

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Gene name
Organism
Protein name
Abce1
Rat
ATP-binding cassette, sub-family E
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
D3ZD23_RAT
Accession #
D3ZD23
Protein names
  • ATP-binding cassette, sub-family E
  • OABP, member 1
  • Protein Abce1
Gene names
  • Abce1
  • rCG_51692
Description
N/A
Links

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KEGG Pathways (0)
N/A
Phosphorylation Site Information
Abi2
Rat
Protein Abi2
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
F1LYA6_RAT
Accession #
F1LYA6
Protein names
  • Protein Abi2
Gene names
  • Abi2
Description
N/A
Links

Search Kinases of Abi2 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
ABL1
Human
Tyrosine-protein kinase ABL1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ABL1_HUMAN
Accession #
P00519
Protein names
  • Tyrosine-protein kinase ABL1
  • EC 2.7.10.2
  • Abelson murine leukemia viral oncogene homolog 1
  • Abelson tyrosine-protein kinase 1
  • Proto-oncogene c-Abl
  • p150
Gene names
  • ABL1
  • ABL
  • JTK7
Description
Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
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Gene Ontology Terms (52)
Phosphorylation Site Information
Ablim1
Rat
Protein Ablim1
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
F1LWK7_RAT
Accession #
F1LWK7
Protein names
  • Protein Ablim1
Gene names
  • Ablim1
Description
N/A
Links

Search Kinases of Ablim1 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Acan
Rat
Aggrecan core protein
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
PGCA_RAT
Accession #
P07897
Protein names
  • Aggrecan core protein
  • Cartilage-specific proteoglycan core protein
  • CSPCP
Gene names
  • Acan
  • Agc
  • Agc1
Description
This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.
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KEGG Pathways (0)
N/A
Phosphorylation Site Information
Acot7
Rat
Cytosolic acyl coenzyme A thioester hydrolase
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
BACH_RAT
Accession #
Q64559
Protein names
  • Cytosolic acyl coenzyme A thioester hydrolase
  • EC 3.1.2.2
  • ACH1
  • ACT
  • Acyl-CoA thioesterase 7
  • Brain acyl-CoA hydrolase
  • BACH
  • CTE-IIa
  • CTE-IIb
  • CTE-II
  • LACH1
  • Long chain acyl-CoA thioester hydrolase
  • MTE-II
Gene names
  • Acot7
  • Bach
Description
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl-CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18.
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Phosphorylation Site Information
Acot9
Rat
Acyl-CoA thioesterase 9
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
Q5U2X8_RAT
Accession #
Q5U2X8
Protein names
  • Acyl-CoA thioesterase 9
  • Protein Acot9
  • Similar to acyl-CoA thioesterase, isoform CRA_b
Gene names
  • Acot9
  • LOC302640
  • rCG_36383
Description
N/A
Links

Search Kinases of Acot9 (Rat)
KEGG Pathways (0)
N/A
Gene Ontology Terms (0)
N/A
Phosphorylation Site Information
Acsbg1
Rat
Long-chain-fatty-acid--CoA ligase ACSBG1
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ACBG1_RAT
Accession #
Q924N5
Protein names
  • Long-chain-fatty-acid--CoA ligase ACSBG1
  • EC 6.2.1.3
  • Acyl-CoA synthetase bubblegum family member 1
  • Gonadotropin-regulated long chain acyl CoA synthetase
  • GR-LACS
Gene names
  • Acsbg1
  • Grlacs
Description
Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids.
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Phosphorylation Site Information
Adap1
Rat
ArfGAP with dual PH domains 1
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
O88768_RAT
Accession #
O88768
Protein names
  • ArfGAP with dual PH domains 1
  • IP4/PIP3 binding protein
  • Protein Adap1
Gene names
  • Adap1
  • Centa1
Description
N/A
Links

Search Kinases of Adap1 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Add2
Rat
Beta-adducin
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
F8WFS9_RAT
Accession #
F8WFS9
Protein names
  • Beta-adducin
Gene names
  • Add2
Description
N/A
Links

Search Kinases of Add2 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Ahcyl2
Rat
Adenosylhomocysteinase
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
D3ZWL6_RAT
Accession #
D3ZWL6
Protein names
  • Adenosylhomocysteinase
  • EC 3.3.1.1
Gene names
  • Ahcyl2
Description
N/A
Links

Search Kinases of Ahcyl2 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Ak5
Rat
Protein Ak5
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
M0R7U1_RAT
Accession #
M0R7U1
Protein names
  • Protein Ak5
  • RCG28422
Gene names
  • Ak5
  • rCG_28422
Description
N/A
Links

Search Kinases of Ak5 (Rat)
Phosphorylation Site Information
Aldoa
Rat
Fructose-bisphosphate aldolase A
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ALDOA_RAT
Accession #
P05065
Protein names
  • Fructose-bisphosphate aldolase A
  • EC 4.1.2.13
  • Muscle-type aldolase
Gene names
  • Aldoa
Description
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).
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Phosphorylation Site Information
Amph
Rat
Amphiphysin
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
AMPH_RAT
Accession #
O08838
Protein names
  • Amphiphysin
Gene names
  • Amph
  • Amph1
Description
May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton (By similarity).
Links

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Phosphorylation Site Information
Apoa1
Rat
Apolipoprotein A-I
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
APOA1_RAT
Accession #
P04639
Protein names
  • Apolipoprotein A-I
  • Apo-AI
  • ApoA-I
  • Apolipoprotein A1 [Cleaved into: Proapolipoprotein A-I
  • ProapoA-I]
Gene names
  • Apoa1
Description
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
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Gene Ontology Terms (56)
Phosphorylation Site Information
Arhgef28
Rat
Rho guanine nucleotide exchange factor 28
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ARG28_RAT
Accession #
P0C6P5
Protein names
  • Rho guanine nucleotide exchange factor 28
  • 190 kDa guanine nucleotide exchange factor
  • p190-RhoGEF
  • p190RhoGEF
  • Rho guanine nucleotide exchange factor
Gene names
  • Arhgef28
  • Rgnef
Description
Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis.
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KEGG Pathways (0)
N/A
Phosphorylation Site Information
Asap1
Rat
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
F1M0L1_RAT
Accession #
F1M0L1
Protein names
  • Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
Gene names
  • Asap1
Description
N/A
Links

Search Kinases of Asap1 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Asap2
Rat
Protein Asap2
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
F1M7E9_RAT
Accession #
F1M7E9
Protein names
  • Protein Asap2
  • Fragment
Gene names
  • Asap2
Description
N/A
Links

Search Kinases of Asap2 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
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