Search Results (361 substrates found)
Gene name
Organism
Protein name
Abce1
Rat
ATP-binding cassette, sub-family E
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
D3ZD23_RAT
- Accession #
- D3ZD23
- Protein names
-
- ATP-binding cassette, sub-family E
- OABP, member 1
- Protein Abce1
- Gene names
-
- Abce1
- rCG_51692
- Description
-
N/A
- Links
-
Search Kinases of Abce1 (Rat)
N/A

Abi2
Rat
Protein Abi2
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
F1LYA6_RAT
- Accession #
- F1LYA6
- Protein names
-
- Protein Abi2
- Gene names
-
- Abi2
- Description
-
N/A
- Links
-
Search Kinases of Abi2 (Rat)
N/A

ABL1
Human
Tyrosine-protein kinase ABL1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ABL1_HUMAN
- Accession #
-
P00519
- Protein names
-
- Tyrosine-protein kinase ABL1
- EC 2.7.10.2
- Abelson murine leukemia viral oncogene homolog 1
- Abelson tyrosine-protein kinase 1
- Proto-oncogene c-Abl
- p150
- Gene names
-
- ABL1
- ABL
- JTK7
- Description
-
Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
- Links
-
Search Kinases of ABL1 (Human)
- ATP binding
- DNA binding
- DNA damage induced protein phosphorylation
- Fc-gamma receptor signaling pathway involved in phagocytosis
- SH3 domain binding
- actin cytoskeleton
- actin cytoskeleton organization
- actin monomer binding
- autophagy
- axon guidance
- blood coagulation
- cell adhesion
- cell leading edge
- cellular protein modification process
- cellular response to DNA damage stimulus
- cytoplasm
- cytosol
- innate immune response
- intrinsic apoptotic signaling pathway in response to DNA damage
- magnesium ion binding
- manganese ion binding
- mismatch repair
- mitochondrion
- mitogen-activated protein kinase binding
- muscle cell differentiation
- negative regulation of protein serine/threonine kinase activity
- nicotinate-nucleotide adenylyltransferase activity
- non-membrane spanning protein tyrosine kinase activity
- nuclear membrane
- nucleolus
- nucleus
- peptidyl-tyrosine phosphorylation
- perinuclear region of cytoplasm
- platelet-derived growth factor receptor signaling pathway
- positive regulation of apoptotic process
- positive regulation of muscle cell differentiation
- positive regulation of oxidoreductase activity
- positive regulation of peptidyl-tyrosine phosphorylation
- proline-rich region binding
- protein C-terminus binding
- protein binding
- protein tyrosine kinase activity
- regulation of actin cytoskeleton reorganization
- regulation of autophagy
- regulation of cell adhesion
- regulation of cell cycle
- regulation of cell motility
- regulation of endocytosis
- regulation of response to DNA damage stimulus
- regulation of transcription, DNA-templated
- signal transduction in response to DNA damage
- syntaxin binding

Ablim1
Rat
Protein Ablim1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
F1LWK7_RAT
- Accession #
- F1LWK7
- Protein names
-
- Protein Ablim1
- Gene names
-
- Ablim1
- Description
-
N/A
- Links
-
Search Kinases of Ablim1 (Rat)
N/A

Acadl
Rat
Long-chain specific acyl-CoA dehydrogenase, mitochondrial
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ACADL_RAT
- Accession #
-
P15650
- Protein names
-
- Long-chain specific acyl-CoA dehydrogenase, mitochondrial
- LCAD
- EC 1.3.8.8
- Gene names
-
- Acadl
- Description
-
N/A
- Links
-
Search Kinases of Acadl (Rat)
- carnitine catabolic process
- carnitine metabolic process, CoA-linked
- fatty acid beta-oxidation using acyl-CoA dehydrogenase
- fatty-acyl-CoA binding
- flavin adenine dinucleotide binding
- long-chain fatty acid catabolic process
- long-chain-acyl-CoA dehydrogenase activity
- mitochondrial matrix
- mitochondrial membrane
- mitochondrion
- negative regulation of fatty acid biosynthetic process
- negative regulation of fatty acid oxidation
- palmitoyl-CoA oxidase activity
- protein homotetramerization
- regulation of cholesterol metabolic process
- temperature homeostasis

Acan
Rat
Aggrecan core protein
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
PGCA_RAT
- Accession #
- P07897
- Protein names
-
- Aggrecan core protein
- Cartilage-specific proteoglycan core protein
- CSPCP
- Gene names
-
- Acan
- Agc
- Agc1
- Description
-
This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.
- Links
-
Search Kinases of Acan (Rat)
N/A
- calcium ion binding
- carbohydrate binding
- cell adhesion
- cellular response to growth factor stimulus
- central nervous system development
- chondroblast differentiation
- extracellular matrix structural constituent
- hyaluronic acid binding
- multicellular organismal aging
- negative regulation of cell migration
- ossification
- perineuronal net
- proteinaceous extracellular matrix
- response to acidic pH
- response to drug
- response to glucose
- response to gravity
- response to mechanical stimulus
- response to organic cyclic compound
- response to radiation
- spinal cord development

Acot7
Rat
Cytosolic acyl coenzyme A thioester hydrolase
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
BACH_RAT
- Accession #
-
Q64559
- Protein names
-
- Cytosolic acyl coenzyme A thioester hydrolase
- EC 3.1.2.2
- ACH1
- ACT
- Acyl-CoA thioesterase 7
- Brain acyl-CoA hydrolase
- BACH
- CTE-IIa
- CTE-IIb
- CTE-II
- LACH1
- Long chain acyl-CoA thioester hydrolase
- MTE-II
- Gene names
-
- Acot7
- Bach
- Description
-
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl-CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18.
- Links
-
Search Kinases of Acot7 (Rat)

Acot9
Rat
Acyl-CoA thioesterase 9
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
Q5U2X8_RAT
- Accession #
- Q5U2X8
- Protein names
-
- Acyl-CoA thioesterase 9
- Protein Acot9
- Similar to acyl-CoA thioesterase, isoform CRA_b
- Gene names
-
- Acot9
- LOC302640
- rCG_36383
- Description
-
N/A
- Links
-
Search Kinases of Acot9 (Rat)
N/A
N/A

Acsbg1
Rat
Long-chain-fatty-acid--CoA ligase ACSBG1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ACBG1_RAT
- Accession #
-
Q924N5
- Protein names
-
- Long-chain-fatty-acid--CoA ligase ACSBG1
- EC 6.2.1.3
- Acyl-CoA synthetase bubblegum family member 1
- Gonadotropin-regulated long chain acyl CoA synthetase
- GR-LACS
- Gene names
-
- Acsbg1
- Grlacs
- Description
-
Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids.
- Links
-
Search Kinases of Acsbg1 (Rat)
- ATP binding
- cytoplasm
- cytoplasmic membrane-bounded vesicle
- endoplasmic reticulum
- long-chain fatty acid metabolic process
- long-chain fatty acid-CoA ligase activity
- ovarian follicle atresia
- response to glucocorticoid
- very long-chain fatty acid metabolic process
- very long-chain fatty acid-CoA ligase activity

Adap1
Rat
ArfGAP with dual PH domains 1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
O88768_RAT
- Accession #
- O88768
- Protein names
-
- ArfGAP with dual PH domains 1
- IP4/PIP3 binding protein
- Protein Adap1
- Gene names
-
- Adap1
- Centa1
- Description
-
N/A
- Links
-
Search Kinases of Adap1 (Rat)
N/A

Add2
Rat
Beta-adducin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
F8WFS9_RAT
- Accession #
- F8WFS9
- Protein names
-
- Beta-adducin
- Gene names
-
- Add2
- Description
-
N/A
- Links
-
Search Kinases of Add2 (Rat)
N/A

Ahcyl2
Rat
Adenosylhomocysteinase
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
D3ZWL6_RAT
- Accession #
-
D3ZWL6
- Protein names
-
- Adenosylhomocysteinase
- EC 3.3.1.1
- Gene names
-
- Ahcyl2
- Description
-
N/A
- Links
-
Search Kinases of Ahcyl2 (Rat)
N/A

Ak5
Rat
Protein Ak5
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
M0R7U1_RAT
- Accession #
- M0R7U1
- Protein names
-
- Protein Ak5
- RCG28422
- Gene names
-
- Ak5
- rCG_28422
- Description
-
N/A
- Links
-
Search Kinases of Ak5 (Rat)

Aldoa
Rat
Fructose-bisphosphate aldolase A
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ALDOA_RAT
- Accession #
-
P05065
- Protein names
-
- Fructose-bisphosphate aldolase A
- EC 4.1.2.13
- Muscle-type aldolase
- Gene names
-
- Aldoa
- Description
-
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).
- Links
-
Search Kinases of Aldoa (Rat)

Aldoc
Rat
Fructose-bisphosphate aldolase C
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ALDOC_RAT
- Accession #
-
P09117
- Protein names
-
- Fructose-bisphosphate aldolase C
- EC 4.1.2.13
- Brain-type aldolase
- Gene names
-
- Aldoc
- Description
-
N/A
- Links
-
Search Kinases of Aldoc (Rat)
- aging
- apoptotic process
- axon
- cytoplasm
- fructose 1,6-bisphosphate metabolic process
- fructose-bisphosphate aldolase activity
- glycolytic process
- mitochondrion
- organ regeneration
- protein binding
- protein heterotetramerization
- protein homotetramerization
- response to hypoxia
- response to organic cyclic compound
- response to organonitrogen compound

Amph
Rat
Amphiphysin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
AMPH_RAT
- Accession #
-
O08838
- Protein names
-
- Amphiphysin
- Gene names
-
- Amph
- Amph1
- Description
-
May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton (By similarity).
- Links
-
Search Kinases of Amph (Rat)

Apoa1
Rat
Apolipoprotein A-I
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
APOA1_RAT
- Accession #
- P04639
- Protein names
-
- Apolipoprotein A-I
- Apo-AI
- ApoA-I
- Apolipoprotein A1 [Cleaved into: Proapolipoprotein A-I
- ProapoA-I]
- Gene names
-
- Apoa1
- Description
-
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
- Links
-
Search Kinases of Apoa1 (Rat)
- G-protein coupled receptor signaling pathway
- adrenal gland development
- beta-amyloid binding
- blood vessel endothelial cell migration
- cell surface
- cholesterol binding
- cholesterol biosynthetic process
- cholesterol efflux
- cholesterol homeostasis
- cholesterol import
- cholesterol transport
- cholesterol transporter activity
- discoidal high-density lipoprotein particle
- endocytic vesicle
- endothelial cell proliferation
- extracellular space
- glucocorticoid metabolic process
- high-density lipoprotein particle assembly
- high-density lipoprotein particle binding
- lipase inhibitor activity
- lipid storage
- lipoprotein biosynthetic process
- negative regulation of cell adhesion molecule production
- negative regulation of cytokine secretion involved in immune response
- negative regulation of heterotypic cell-cell adhesion
- negative regulation of inflammatory response
- negative regulation of interleukin-1 beta secretion
- negative regulation of lipase activity
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of very-low-density lipoprotein particle remodeling
- nucleus
- organ regeneration
- peptidyl-methionine modification
- peripheral nervous system axon regeneration
- phosphatidylcholine biosynthetic process
- phosphatidylcholine-sterol O-acyltransferase activator activity
- phospholipid binding
- phospholipid efflux
- phospholipid homeostasis
- phospholipid transport
- phospholipid transporter activity
- positive regulation of cholesterol esterification
- positive regulation of hydrolase activity
- positive regulation of transferase activity
- protein oxidation
- protein stabilization
- regulation of Cdc42 protein signal transduction
- regulation of intestinal cholesterol absorption
- regulation of protein phosphorylation
- response to drug
- response to estrogen
- response to nutrient
- reverse cholesterol transport
- spherical high-density lipoprotein particle
- triglyceride homeostasis
- very-low-density lipoprotein particle

Arhgef28
Rat
Rho guanine nucleotide exchange factor 28
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ARG28_RAT
- Accession #
-
P0C6P5
- Protein names
-
- Rho guanine nucleotide exchange factor 28
- 190 kDa guanine nucleotide exchange factor
- p190-RhoGEF
- p190RhoGEF
- Rho guanine nucleotide exchange factor
- Gene names
-
- Arhgef28
- Rgnef
- Description
-
Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis.
- Links
-
Search Kinases of Arhgef28 (Rat)
N/A

Asap1
Rat
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
F1M0L1_RAT
- Accession #
- F1M0L1
- Protein names
-
- Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
- Gene names
-
- Asap1
- Description
-
N/A
- Links
-
Search Kinases of Asap1 (Rat)
N/A

Asap2
Rat
Protein Asap2
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
F1M7E9_RAT
- Accession #
- F1M7E9
- Protein names
-
- Protein Asap2
- Fragment
- Gene names
-
- Asap2
- Description
-
N/A
- Links
-
Search Kinases of Asap2 (Rat)
N/A
