Search Results (598 substrates found)
Gene name
Organism
Protein name
A1i3
Rat
Alpha-1-inhibitor 3
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
A1I3_RAT
- Accession #
-
P14046
- Protein names
-
- Alpha-1-inhibitor 3
- Alpha-1-inhibitor 3 variant II
- Alpha-1-inhibitor III
- Gene names
-
- A1i3
- Description
-
Protease inhibitor with a wide spectrum of protein targets, which attaches through its thioester function.
- Links
-
Search Kinases of A1i3 (Rat)
N/A

Abat
Rat
4-aminobutyrate aminotransferase, mitochondrial
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
GABT_RAT
- Accession #
-
P50554
- Protein names
-
- 4-aminobutyrate aminotransferase, mitochondrial
- EC 2.6.1.19
- (S
- EC 2.6.1.22
- GABA aminotransferase
- GABA-AT
- Gamma-amino-N-butyrate transaminase
- GABA transaminase
- GABA-T
- L-AIBAT
- Gene names
-
- Abat
- Gabat
- Description
-
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
- Links
-
Search Kinases of Abat (Rat)
- (S)-3-amino-2-methylpropionate transaminase activity
- 4-aminobutyrate transaminase activity
- 4-aminobutyrate transaminase complex
- 4-aminobutyrate:2-oxoglutarate transaminase activity
- aging
- behavioral response to cocaine
- cerebellum development
- copulation
- exploration behavior
- gamma-aminobutyric acid biosynthetic process
- gamma-aminobutyric acid catabolic process
- gamma-aminobutyric acid metabolic process
- identical protein binding
- iron-sulfur cluster binding
- locomotory behavior
- metal ion binding
- mitochondrial matrix
- mitochondrion
- negative regulation of blood pressure
- negative regulation of dopamine secretion
- negative regulation of gamma-aminobutyric acid secretion
- negative regulation of platelet aggregation
- neuron projection
- neurotransmitter catabolic process
- positive regulation of aspartate secretion
- positive regulation of dopamine metabolic process
- positive regulation of heat generation
- positive regulation of inhibitory postsynaptic potential
- positive regulation of insulin secretion
- positive regulation of prolactin secretion
- positive regulation of uterine smooth muscle contraction
- pyridoxal phosphate binding
- response to cocaine
- response to ethanol
- response to hypoxia
- response to iron ion
- response to nicotine
- succinate-semialdehyde dehydrogenase binding

Abce1
Rat
ATP-binding cassette subfamily E member 1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
D3ZD23_RAT
- Accession #
- D3ZD23
- Protein names
-
- ATP-binding cassette subfamily E member 1
- ATP-binding cassette, sub-family E (OABP
- Gene names
-
- Abce1
- rCG_51692
- Description
-
N/A
- Links
-
Search Kinases of Abce1 (Rat)
N/A
- ATP binding
- ATPase-coupled transmembrane transporter activity
- cytoplasm
- cytosol
- endoribonuclease inhibitor activity
- iron ion binding
- mitochondrion
- negative regulation of endoribonuclease activity
- ribosomal small subunit binding
- ribosomal subunit export from nucleus
- translational initiation
- translational termination

Abcf3
Rat
ATP-binding cassette sub-family F member 3
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ABCF3_RAT
- Accession #
- Q66H39
- Protein names
-
- ATP-binding cassette sub-family F member 3
- Gene names
-
- Abcf3
- Description
-
Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B. {ECO:0000250}.
- Links
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Search Kinases of Abcf3 (Rat)
N/A

Abi1
Rat
Abl interactor 1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ABI1_RAT
- Accession #
-
Q9QZM5
- Protein names
-
- Abl interactor 1
- Abelson interactor 1
- Abi-1
- Eps8 SH3 domain-binding protein
- Eps8-binding protein
- e3B1
- Gene names
-
- Abi1
- Description
-
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:17304222}.
- Links
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Search Kinases of Abi1 (Rat)
N/A
- SCAR complex
- SH3 domain binding
- actin polymerization or depolymerization
- cell leading edge
- cytoskeleton
- dendrite morphogenesis
- filopodium tip
- glutamatergic synapse
- growth cone
- lamellipodium
- lamellipodium morphogenesis
- megakaryocyte development
- neuron projection
- nucleus
- peptidyl-tyrosine phosphorylation
- postsynapse to nucleus signaling pathway
- postsynaptic density
- protein tyrosine kinase activator activity
- signaling adaptor activity
- somitogenesis
- transcription factor binding

Abi2
Rat
Abl-interactor 2
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
F1LYA6_RAT
- Accession #
- F1LYA6
- Protein names
-
- Abl-interactor 2
- Gene names
-
- Abi2
- Description
-
N/A
- Links
-
Search Kinases of Abi2 (Rat)
N/A
- Rac protein signal transduction
- SCAR complex
- SH3 domain binding
- actin polymerization or depolymerization
- adherens junction
- camera-type eye development
- cell migration
- cytosol
- dendrite
- dendrite development
- dendritic spine
- filopodium tip
- glutamatergic synapse
- lamellipodium
- learning or memory
- lens fiber cell morphogenesis
- nucleoplasm
- peptidyl-tyrosine phosphorylation
- positive regulation of Arp2/3 complex-mediated actin nucleation
- positive regulation of lamellipodium assembly
- postsynaptic actin cytoskeleton
- postsynaptic actin cytoskeleton organization
- proline-rich region binding
- regulation of dendritic spine morphogenesis
- signaling adaptor activity
- ubiquitin protein ligase binding

Ablim2
Rat
Actin-binding LIM protein 2
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ABLM2_RAT
- Accession #
-
Q6KC51
- Protein names
-
- Actin-binding LIM protein 2
- abLIM-2
- Actin-binding LIM protein family member 2
- Gene names
-
- Ablim2
- Description
-
May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity (By similarity). {ECO:0000250}.
- Links
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Search Kinases of Ablim2 (Rat)

Abraxas2
Rat
Abraxas 2, BRISC complex subunit
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
D4A415_RAT
- Accession #
-
D4A415
- Protein names
-
- Abraxas 2, BRISC complex subunit
- Gene names
-
- Abraxas2
- Fam175b
- Description
-
N/A
- Links
-
Search Kinases of Abraxas2 (Rat)
N/A
- BRISC complex
- attachment of spindle microtubules to kinetochore
- cellular response to freezing
- chromosome segregation
- cytoplasm
- microtubule binding
- microtubule minus-end
- midbody
- mitotic cell cycle
- mitotic spindle assembly
- negative regulation of apoptotic process
- nucleus
- polyubiquitin modification-dependent protein binding
- protein K63-linked deubiquitination
- response to ischemia
- spindle pole centrosome

Acaca
Rat
Acetyl-CoA carboxylase 1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ACACA_RAT
- Accession #
-
P11497
- Protein names
-
- Acetyl-CoA carboxylase 1
- ACC1
- EC 6.4.1.2
- ACC-alpha
- Gene names
-
- Acaca
- Acac
- Description
-
Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. {ECO:0000250|UniProtKB:Q13085}.
- Links
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Search Kinases of Acaca (Rat)
- ATP binding
- acetyl-CoA carboxylase activity
- acetyl-CoA metabolic process
- biotin binding
- cellular response to prostaglandin E stimulus
- cytosol
- fatty acid biosynthetic process
- identical protein binding
- lipid homeostasis
- lipid metabolic process
- malonyl-CoA biosynthetic process
- metal ion binding
- protein homotetramerization
- protein metabolic process
- response to organic cyclic compound
- tissue homeostasis

Acadl
Rat
Long-chain specific acyl-CoA dehydrogenase, mitochondrial
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ACADL_RAT
- Accession #
-
P15650
- Protein names
-
- Long-chain specific acyl-CoA dehydrogenase, mitochondrial
- LCAD
- EC 1.3.8.8
- Gene names
-
- Acadl
- Description
-
Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:3968063). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:3968063). Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase can act on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains (PubMed:3968063, PubMed:15466478). {ECO:0000269|PubMed:15466478, ECO:0000269|PubMed:3968063, ECO:0000303|PubMed:3968063}.
- Links
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Search Kinases of Acadl (Rat)
- acyl-CoA dehydrogenase activity
- carnitine catabolic process
- carnitine metabolic process, CoA-linked
- cellular lipid catabolic process
- fatty acid beta-oxidation using acyl-CoA dehydrogenase
- fatty acid catabolic process
- fatty-acyl-CoA binding
- flavin adenine dinucleotide binding
- identical protein binding
- long-chain fatty acid catabolic process
- long-chain-acyl-CoA dehydrogenase activity
- mitochondrial matrix
- mitochondrial membrane
- mitochondrion
- negative regulation of fatty acid biosynthetic process
- negative regulation of fatty acid oxidation
- palmitoyl-CoA oxidase activity
- positive regulation of cold-induced thermogenesis
- regulation of cholesterol metabolic process
- response to cold
- temperature homeostasis

Aco2
Rat
Aconitate hydratase, mitochondrial
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ACON_RAT
- Accession #
-
Q9ER34
- Protein names
-
- Aconitate hydratase, mitochondrial
- Aconitase
- EC 4.2.1.3
- Citrate hydro-lyase
- Gene names
-
- Aco2
- Description
-
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250|UniProtKB:P16276}.
- Links
-
Search Kinases of Aco2 (Rat)

Acot7
Rat
Cytosolic acyl coenzyme A thioester hydrolase
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
BACH_RAT
- Accession #
-
Q64559
- Protein names
-
- Cytosolic acyl coenzyme A thioester hydrolase
- EC 3.1.2.2
- ACH1
- ACT
- Acyl-CoA thioesterase 7
- Brain acyl-CoA hydrolase
- BACH
- CTE-IIa
- CTE-IIb
- CTE-II
- LACH1
- Long chain acyl-CoA thioester hydrolase
- MTE-II
- Gene names
-
- Acot7
- Bach
- Description
-
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:7906114). Acyl-coenzyme A thioesterase 7/ACOT7 preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (PubMed:7906114). May play an important physiological function in brain (PubMed:7906114). {ECO:0000269|PubMed:7906114, ECO:0000303|PubMed:7906114}.
- Links
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Search Kinases of Acot7 (Rat)
- acyl-CoA hydrolase activity
- acyl-CoA metabolic process
- carboxylic ester hydrolase activity
- cell body
- coenzyme A biosynthetic process
- cytoplasm
- cytosol
- fatty acid catabolic process
- fatty acid metabolic process
- fatty-acyl-CoA binding
- identical protein binding
- long-chain fatty acyl-CoA binding
- long-chain fatty-acyl-CoA catabolic process
- medium-chain fatty acid biosynthetic process
- medium-chain fatty-acyl-CoA catabolic process
- myristoyl-CoA hydrolase activity
- neuron projection
- nucleoplasm
- palmitic acid biosynthetic process
- palmitoyl-CoA hydrolase activity
- protein homodimerization activity

Acot9
Rat
Acyl-CoA thioesterase 9
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
Q5U2X8_RAT
- Accession #
- Q5U2X8
- Protein names
-
- Acyl-CoA thioesterase 9
- Similar to acyl-CoA thioesterase, isoform CRA_b
- Gene names
-
- Acot9
- LOC302640
- rCG_36383
- Description
-
N/A
- Links
-
Search Kinases of Acot9 (Rat)
N/A

Acsbg1
Rat
Long-chain-fatty-acid--CoA ligase ACSBG1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ACBG1_RAT
- Accession #
-
Q924N5
- Protein names
-
- Long-chain-fatty-acid--CoA ligase ACSBG1
- EC 6.2.1.3
- Acyl-CoA synthetase bubblegum family member 1
- Gonadotropin-regulated long chain acyl CoA synthetase
- GR-LACS
- Gene names
-
- Acsbg1
- Grlacs
- Description
-
Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. {ECO:0000269|PubMed:11381125}.
- Links
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Search Kinases of Acsbg1 (Rat)
- ATP binding
- CoA-ligase activity
- cytoplasm
- cytoplasmic vesicle
- endoplasmic reticulum
- long-chain fatty acid biosynthetic process
- long-chain fatty acid metabolic process
- long-chain fatty acid-CoA ligase activity
- ovarian follicle atresia
- plasma membrane
- response to glucocorticoid
- very long-chain fatty acid metabolic process
- very long-chain fatty acid-CoA ligase activity

Acss2
Rat
Propionate--CoA ligase
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
G3V9U0_RAT
- Accession #
- G3V9U0
- Protein names
-
- Propionate--CoA ligase
- EC 6.2.1.17
- Gene names
-
- Acss2
- Acss2_predicted
- rCG_37495
- Description
-
N/A
- Links
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Search Kinases of Acss2 (Rat)

Actn1
Rat
Alpha-actinin-1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ACTN1_RAT
- Accession #
-
Q9Z1P2
- Protein names
-
- Alpha-actinin-1
- Alpha-actinin cytoskeletal isoform
- F-actin cross-linking protein
- Non-muscle alpha-actinin-1
- Gene names
-
- Actn1
- Description
-
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). {ECO:0000250}.
- Links
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Search Kinases of Actn1 (Rat)
- Z disc
- actin filament binding
- actin filament bundle assembly
- actin filament network formation
- actin filament organization
- brush border
- calcium ion binding
- cell junction
- cell projection
- cell-cell junction
- cytoplasm
- cytoskeletal regulatory protein binding
- cytoskeleton
- cytosol
- dendritic spine
- double-stranded RNA binding
- fascia adherens
- focal adhesion
- focal adhesion assembly
- glutamatergic synapse
- integrin binding
- negative regulation of cellular component movement
- nuclear receptor coactivator activity
- nucleus
- plasma membrane
- platelet formation
- platelet morphogenesis
- protein domain specific binding
- protein homodimerization activity
- ruffle
- sarcomere
- stress fiber
- structural constituent of postsynapse
- transmembrane transporter binding
- vinculin binding

Acyp1
Rat
Acylphosphatase
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
D4A6X4_RAT
- Accession #
- D4A6X4
- Protein names
-
- Acylphosphatase
- EC 3.6.1.7
- Gene names
-
- Acyp1
- Acyp1_predicted
- rCG_20688
- Description
-
N/A
- Links
-
Search Kinases of Acyp1 (Rat)

Acyp2
Rat
Acylphosphatase-2
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ACYP2_RAT
- Accession #
- P35745
- Protein names
-
- Acylphosphatase-2
- EC 3.6.1.7
- Acylphosphatase, muscle type isozyme
- Acylphosphate phosphohydrolase 2
- Gene names
-
- Acyp2
- Acyp
- Description
-
Its physiological role is not yet clear.
- Links
-
Search Kinases of Acyp2 (Rat)
N/A

Adap1
Rat
ArfGAP with dual PH domains 1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
O88768_RAT
- Accession #
- O88768
- Protein names
-
- ArfGAP with dual PH domains 1
- IP4/PIP3 binding protein
- Gene names
-
- Adap1
- Centa1
- Description
-
N/A
- Links
-
Search Kinases of Adap1 (Rat)
N/A

Add1
Rat
Alpha-adducin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ADDA_RAT
- Accession #
-
Q63028
- Protein names
-
- Alpha-adducin
- Erythrocyte adducin subunit alpha
- Gene names
-
- Add1
- Description
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
- Links
-
Search Kinases of Add1 (Rat)
N/A
- F-actin capping protein complex
- T cell receptor binding
- actin filament binding
- actin filament bundle assembly
- adherens junction
- barbed-end actin filament capping
- calmodulin binding
- cell morphogenesis
- cell volume homeostasis
- cellular response to calcium ion
- cellular response to retinoic acid
- cytoplasm
- cytoskeleton
- cytoskeleton organization
- dendrite
- dendritic spine
- erythrocyte differentiation
- hemoglobin metabolic process
- homeostasis of number of cells within a tissue
- in utero embryonic development
- ion transport
- membrane
- multicellular organism growth
- negative regulation of actin filament polymerization
- nucleus
- perinuclear region of cytoplasm
- plasma membrane
- positive regulation of adherens junction organization
- positive regulation of angiogenesis
- positive regulation of endocytosis
- positive regulation of establishment of endothelial barrier
- positive regulation of protein binding
- postsynaptic density
- protein heterodimerization activity
- protein homodimerization activity
- spectrin binding
- structural constituent of cytoskeleton
- synapse
- transcription factor binding
