KANPHOS_Str

Search Results (425 substrates found)

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Gene name
Organism
Protein name
A6NN6
Human
Putative UPF0633 protein MGC21881
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
U633A_HUMAN
Accession #
A6NN06
Protein names
  • Putative UPF0633 protein MGC21881
Gene names
  • A6NN6
Description
N/A
Links

Search Kinases of A6NN6 (Human)
KEGG Pathways (0)
N/A
Gene Ontology Terms (0)
N/A
Phosphorylation Site Information
ABT1
Human
Activator of basal transcription 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ABT1_HUMAN
Accession #
Q9ULW3
Protein names
  • Activator of basal transcription 1
  • hABT1
  • Basal transcriptional activator
Gene names
  • ABT1
Description
Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity).
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KEGG Pathways (0)
N/A
Phosphorylation Site Information
Add1
Mouse
Adducin 1
ADD1
Human
Alpha-adducin
Add2
Rat
Beta-adducin
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
F8WFS9_RAT
Accession #
F8WFS9
Protein names
  • Beta-adducin
Gene names
  • Add2
Description
N/A
Links

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KEGG Pathways (0)
N/A
Phosphorylation Site Information
Add2
Mouse
Beta-adducin
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
ADDB_MOUSE
Accession #
Q9QYB8
Protein names
  • Beta-adducin
  • Add97
  • Erythrocyte adducin subunit beta
Gene names
  • Add2
Description
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity).
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KEGG Pathways (0)
N/A
Phosphorylation Site Information
Add3
Rat
Adducin 3
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
G3V9D7_RAT
Accession #
G3V9D7
Protein names
  • Adducin 3
  • Gamma, isoform CRA_a
  • Gamma-adducin
Gene names
  • Add3
  • rCG_57421
Description
N/A
Links

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KEGG Pathways (0)
N/A
Phosphorylation Site Information
Add3
Mouse
Gamma-adducin
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
ADDG_MOUSE
Accession #
Q9QYB5
Protein names
  • Gamma-adducin
  • Adducin-like protein 70
Gene names
  • Add3
  • Addl
Description
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
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KEGG Pathways (0)
N/A
Phosphorylation Site Information
ALKBH1
Human
Alkylated DNA repair protein alkB homolog 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ALKB1_HUMAN
Accession #
Q13686
Protein names
  • Alkylated DNA repair protein alkB homolog 1
  • EC 1.14.11.33
  • Alpha-ketoglutarate-dependent dioxygenase ABH1
  • DNA lyase ABH1
  • EC 4.2.99.18
  • DNA oxidative demethylase ALKBH1
Gene names
  • ALKBH1
  • ABH
  • ABH1
  • ALKBH
Description
Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron.
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KEGG Pathways (0)
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Phosphorylation Site Information
ALKBH3
Human
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ALKB3_HUMAN
Accession #
Q96Q83
Protein names
  • Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
  • EC 1.14.11.-
  • Alkylated DNA repair protein alkB homolog 3
  • DEPC-1
  • Prostate cancer antigen 1
Gene names
  • ALKBH3
  • ABH3
  • DEPC1
Description
Dioxygenase that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron.
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Phosphorylation Site Information
Amph
Rat
Amphiphysin
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
AMPH_RAT
Accession #
O08838
Protein names
  • Amphiphysin
Gene names
  • Amph
  • Amph1
Description
May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton (By similarity).
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Phosphorylation Site Information
Ankrd50
Mouse
Protein Ankrd50
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
F7BE84_MOUSE
Accession #
F7BE84
Protein names
  • Protein Ankrd50
  • Fragment
Gene names
  • Ankrd50
Description
N/A
Links

Search Kinases of Ankrd50 (Mouse)
KEGG Pathways (0)
N/A
Gene Ontology Terms (0)
N/A
Phosphorylation Site Information
APEX2
Human
DNA-
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
APEX2_HUMAN
Accession #
Q9UBZ4
Protein names
  • DNA-
  • apurinic or apyrimidinic site lyase 2
  • EC 3.1.-.-
  • EC 4.2.99.18
  • AP endonuclease XTH2
  • APEX nuclease 2
  • APEX nuclease-like 2
  • Apurinic-apyrimidinic endonuclease 2
  • AP endonuclease 2
Gene names
  • APEX2
  • APE2
  • APEXL2
  • XTH2
Description
Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.
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KEGG Pathways (1)
Phosphorylation Site Information
APOC4
Human
Apolipoprotein C-IV
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
APOC4_HUMAN
Accession #
P55056
Protein names
  • Apolipoprotein C-IV
  • Apo-CIV
  • ApoC-IV
  • Apolipoprotein C4
Gene names
  • APOC4
Description
May participate in lipoprotein metabolism.
Links

Search Kinases of APOC4 (Human)
KEGG Pathways (0)
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Phosphorylation Site Information
App
Rat
Amyloid beta A4 protein
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
A4_RAT
Accession #
P08592
Protein names
  • Amyloid beta A4 protein
  • ABPP
  • APP
  • Alzheimer disease amyloid A4 protein homolog
  • Amyloidogenic glycoprotein
  • AG [Cleaved into: N-APP
  • Soluble APP-alpha
  • S-APP-alpha
  • Soluble APP-beta
  • S-APP-beta
  • C99
  • Beta-amyloid protein 42
  • Beta-APP42
  • Beta-amyloid protein 40
  • Beta-APP40
  • C83
  • P3
  • 42
Gene names
  • App
Description
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). May be involved in copper homeostasis/oxidative stress through copper ion reduction. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV (By similarity). The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1 (By similarity).Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Binds transient metals such as copper, zinc and iron. Rat and mouse beta-amyloid peptides bind only weakly transient metals and have little reducing activity due to substitutions of transient metal chelating residues. Beta-APP42 may activate mononuclear phagocytes in the brain and elicits inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Also bind GPC1 in lipid rafts (By similarity).Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain.The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis (By similarity).N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6) (By similarity).
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Gene Ontology Terms (61)
Phosphorylation Site Information
Arf5
Mouse
ADP-ribosylation factor 5
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
ARF5_MOUSE
Accession #
P84084
Protein names
  • ADP-ribosylation factor 5
Gene names
  • Arf5
Description
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
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KEGG Pathways (1)
Phosphorylation Site Information
Arhgap21
Rat
Protein Arhgap21
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
F1LXQ7_RAT
Accession #
F1LXQ7
Protein names
  • Protein Arhgap21
  • Fragment
Gene names
  • Arhgap21
Description
N/A
Links

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KEGG Pathways (0)
N/A
Phosphorylation Site Information
ARHGAP24
Human
Rho GTPase-activating protein 24
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
RHG24_HUMAN
Accession #
Q8N264
Protein names
  • Rho GTPase-activating protein 24
  • Filamin-A-associated RhoGAP
  • FilGAP
  • RAC1- and CDC42-specific GTPase-activating protein of 72 kDa
  • RC-GAP72
  • Rho-type GTPase-activating protein 24
  • RhoGAP of 73 kDa
  • Sarcoma antigen NY-SAR-88
  • p73RhoGAP
Gene names
  • ARHGAP24
  • FILGAP
Description
Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.
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