Search Results (425 substrates found)
Gene name
Organism
Protein name
A6NN6
Human
Putative UPF0633 protein MGC21881
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
U633A_HUMAN
- Accession #
- A6NN06
- Protein names
-
- Putative UPF0633 protein MGC21881
- Gene names
-
- A6NN6
- Description
-
N/A
- Links
-
Search Kinases of A6NN6 (Human)
N/A
N/A

ABT1
Human
Activator of basal transcription 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ABT1_HUMAN
- Accession #
-
Q9ULW3
- Protein names
-
- Activator of basal transcription 1
- hABT1
- Basal transcriptional activator
- Gene names
-
- ABT1
- Description
-
Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity).
- Links
-
Search Kinases of ABT1 (Human)
N/A

Add1
Mouse
Adducin 1
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
Q8K232_MOUSE
- Accession #
- Q8K232
- Protein names
-
- Adducin 1
- Alpha
- Gene names
-
- Add1
- Description
-
N/A
- Links
-
Search Kinases of Add1 (Mouse)
N/A

Add1
Rat
Alpha-adducin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ADDA_RAT
- Accession #
-
Q63028
- Protein names
-
- Alpha-adducin
- Erythrocyte adducin subunit alpha
- Gene names
-
- Add1
- Description
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
- Links
-
Search Kinases of Add1 (Rat)
N/A
- F-actin capping protein complex
- T cell receptor binding
- actin filament bundle assembly
- barbed-end actin filament capping
- cell morphogenesis
- cell volume homeostasis
- cellular response to retinoic acid
- cytoskeleton organization
- dendrite
- dendritic spine
- erythrocyte differentiation
- hemoglobin metabolic process
- homeostasis of number of cells within a tissue
- in utero embryonic development
- ion transport
- multicellular organism growth
- negative regulation of actin filament polymerization
- nucleus
- perinuclear region of cytoplasm
- plasma membrane
- positive regulation of angiogenesis
- positive regulation of endocytosis
- positive regulation of protein binding
- postsynaptic density
- protein binding
- structural molecule activity
- synapse

ADD1
Human
Alpha-adducin
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ADDA_HUMAN
- Accession #
-
P35611
- Protein names
-
- Alpha-adducin
- Erythrocyte adducin subunit alpha
- Gene names
-
- ADD1
- ADDA
- Description
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
- Links
-
Search Kinases of ADD1 (Human)
N/A
- F-actin capping protein complex
- actin binding
- actin cytoskeleton organization
- actin filament binding
- actin filament bundle assembly
- activation of signaling protein activity involved in unfolded protein response
- apoptotic process
- barbed-end actin filament capping
- cell morphogenesis
- cell volume homeostasis
- cellular component disassembly involved in execution phase of apoptosis
- cellular protein metabolic process
- cellular response to retinoic acid
- cytosol
- dendritic spine
- endoplasmic reticulum unfolded protein response
- erythrocyte differentiation
- hemoglobin metabolic process
- homeostasis of number of cells within a tissue
- in utero embryonic development
- intermediate filament cytoskeleton
- multicellular organism growth
- nucleus
- perinuclear region of cytoplasm
- plasma membrane
- poly(A) RNA binding
- positive regulation of angiogenesis
- positive regulation of endocytosis
- positive regulation of protein binding
- postsynaptic density
- protein heterodimerization activity
- protein homodimerization activity
- spectrin binding
- structural molecule activity
- transcription factor binding

Add2
Rat
Beta-adducin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
F8WFS9_RAT
- Accession #
- F8WFS9
- Protein names
-
- Beta-adducin
- Gene names
-
- Add2
- Description
-
N/A
- Links
-
Search Kinases of Add2 (Rat)
N/A

Add2
Mouse
Beta-adducin
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
ADDB_MOUSE
- Accession #
-
Q9QYB8
- Protein names
-
- Beta-adducin
- Add97
- Erythrocyte adducin subunit beta
- Gene names
-
- Add2
- Description
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity).
- Links
-
Search Kinases of Add2 (Mouse)
N/A

Add3
Rat
Adducin 3
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
G3V9D7_RAT
- Accession #
- G3V9D7
- Protein names
-
- Adducin 3
- Gamma, isoform CRA_a
- Gamma-adducin
- Gene names
-
- Add3
- rCG_57421
- Description
-
N/A
- Links
-
Search Kinases of Add3 (Rat)
N/A

Add3
Mouse
Gamma-adducin
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
ADDG_MOUSE
- Accession #
-
Q9QYB5
- Protein names
-
- Gamma-adducin
- Adducin-like protein 70
- Gene names
-
- Add3
- Addl
- Description
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
- Links
-
Search Kinases of Add3 (Mouse)
N/A

ALKBH1
Human
Alkylated DNA repair protein alkB homolog 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ALKB1_HUMAN
- Accession #
-
Q13686
- Protein names
-
- Alkylated DNA repair protein alkB homolog 1
- EC 1.14.11.33
- Alpha-ketoglutarate-dependent dioxygenase ABH1
- DNA lyase ABH1
- EC 4.2.99.18
- DNA oxidative demethylase ALKBH1
- Gene names
-
- ALKBH1
- ABH
- ABH1
- ALKBH
- Description
-
Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron.
- Links
-
Search Kinases of ALKBH1 (Human)
N/A
- DNA catabolic process, endonucleolytic
- DNA dealkylation involved in DNA repair
- DNA demethylation
- DNA repair
- DNA-(apurinic or apyrimidinic site) lyase activity
- RNA repair
- chemoattractant activity
- developmental growth
- ferrous iron binding
- in utero embryonic development
- methylcytosine dioxygenase activity
- mitochondrion
- negative regulation of neuron apoptotic process
- neuron migration
- neuron projection development
- nuclear euchromatin
- oxidative demethylation
- placenta development

ALKBH3
Human
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ALKB3_HUMAN
- Accession #
-
Q96Q83
- Protein names
-
- Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
- EC 1.14.11.-
- Alkylated DNA repair protein alkB homolog 3
- DEPC-1
- Prostate cancer antigen 1
- Gene names
-
- ALKBH3
- ABH3
- DEPC1
- Description
-
Dioxygenase that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron.
- Links
-
Search Kinases of ALKBH3 (Human)
N/A

Als2
Rat
Alsin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
ALS2_RAT
- Accession #
-
P0C5Y8
- Protein names
-
- Alsin
- Amyotrophic lateral sclerosis 2 protein homolog
- Gene names
-
- Als2
- Description
-
May act as a GTPase regulator (By similarity). Controls survival and growth of spinal motoneurons.
- Links
-
Search Kinases of Als2 (Rat)
- Rab GTPase binding
- Rab guanyl-nucleotide exchange factor activity
- Rac guanyl-nucleotide exchange factor activity
- Rac protein signal transduction
- axon
- axonogenesis
- cell death
- cytoplasm
- cytosol
- dendrite
- early endosome
- growth cone
- in utero embryonic development
- intracellular membrane-bounded organelle
- membrane
- neuron projection
- neuron projection morphogenesis
- neuronal cell body
- positive regulation of Rac GTPase activity
- positive regulation of protein kinase activity
- positive regulation of protein serine/threonine kinase activity
- protein complex
- protein homodimerization activity
- protein serine/threonine kinase activator activity
- regulation of Rab GTPase activity
- regulation of Rac GTPase activity
- regulation of endosome size
- vesicle

Amph
Rat
Amphiphysin
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
AMPH_RAT
- Accession #
-
O08838
- Protein names
-
- Amphiphysin
- Gene names
-
- Amph
- Amph1
- Description
-
May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton (By similarity).
- Links
-
Search Kinases of Amph (Rat)

Ankrd50
Mouse
Protein Ankrd50
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
F7BE84_MOUSE
- Accession #
- F7BE84
- Protein names
-
- Protein Ankrd50
- Fragment
- Gene names
-
- Ankrd50
- Description
-
N/A
- Links
-
Search Kinases of Ankrd50 (Mouse)
N/A
N/A

APEX2
Human
DNA-
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
APEX2_HUMAN
- Accession #
-
Q9UBZ4
- Protein names
-
- DNA-
- apurinic or apyrimidinic site lyase 2
- EC 3.1.-.-
- EC 4.2.99.18
- AP endonuclease XTH2
- APEX nuclease 2
- APEX nuclease-like 2
- Apurinic-apyrimidinic endonuclease 2
- AP endonuclease 2
- Gene names
-
- APEX2
- APE2
- APEXL2
- XTH2
- Description
-
Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.
- Links
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Search Kinases of APEX2 (Human)

APOC4
Human
Apolipoprotein C-IV
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
APOC4_HUMAN
- Accession #
-
P55056
- Protein names
-
- Apolipoprotein C-IV
- Apo-CIV
- ApoC-IV
- Apolipoprotein C4
- Gene names
-
- APOC4
- Description
-
May participate in lipoprotein metabolism.
- Links
-
Search Kinases of APOC4 (Human)
N/A

App
Rat
Amyloid beta A4 protein
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
A4_RAT
- Accession #
-
P08592
- Protein names
-
- Amyloid beta A4 protein
- ABPP
- APP
- Alzheimer disease amyloid A4 protein homolog
- Amyloidogenic glycoprotein
- AG [Cleaved into: N-APP
- Soluble APP-alpha
- S-APP-alpha
- Soluble APP-beta
- S-APP-beta
- C99
- Beta-amyloid protein 42
- Beta-APP42
- Beta-amyloid protein 40
- Beta-APP40
- C83
- P3
- 42
- Gene names
-
- App
- Description
-
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). May be involved in copper homeostasis/oxidative stress through copper ion reduction. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV (By similarity). The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1 (By similarity).Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Binds transient metals such as copper, zinc and iron. Rat and mouse beta-amyloid peptides bind only weakly transient metals and have little reducing activity due to substitutions of transient metal chelating residues. Beta-APP42 may activate mononuclear phagocytes in the brain and elicits inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Also bind GPC1 in lipid rafts (By similarity).Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain.The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis (By similarity).N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6) (By similarity).
- Links
-
Search Kinases of App (Rat)
- DNA binding
- Golgi apparatus
- Notch signaling pathway
- adult locomotory behavior
- apical part of cell
- axon
- axon cargo transport
- axon midline choice point recognition
- axonogenesis
- cell adhesion
- cell surface
- cellular copper ion homeostasis
- cholesterol metabolic process
- ciliary rootlet
- coated pit
- collateral sprouting in absence of injury
- cytoplasm
- cytoplasmic vesicle
- dendrite development
- dendritic shaft
- dendritic spine
- endocytosis
- extracellular matrix organization
- forebrain development
- growth factor receptor binding
- heparin binding
- integral component of membrane
- ionotropic glutamate receptor signaling pathway
- locomotory behavior
- mRNA polyadenylation
- mating behavior
- mitotic G2 phase
- negative regulation of neuron differentiation
- neuromuscular junction
- neuromuscular process controlling balance
- neuron apoptotic process
- neuron projection
- neuron projection development
- neuron remodeling
- peptidase activator activity
- perinuclear region of cytoplasm
- plasma membrane
- positive regulation of G2/M transition of mitotic cell cycle
- positive regulation of mitotic cell cycle
- positive regulation of peptidase activity
- positive regulation of transcription from RNA polymerase II promoter
- protein binding
- protein phosphorylation
- regulation of epidermal growth factor-activated receptor activity
- regulation of multicellular organism growth
- regulation of protein binding
- regulation of synapse structure and activity
- regulation of translation
- response to oxidative stress
- serine-type endopeptidase inhibitor activity
- smooth endoplasmic reticulum calcium ion homeostasis
- spindle midzone
- suckling behavior
- synaptic growth at neuromuscular junction
- transition metal ion binding
- visual learning

Arf5
Mouse
ADP-ribosylation factor 5
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
ARF5_MOUSE
- Accession #
-
P84084
- Protein names
-
- ADP-ribosylation factor 5
- Gene names
-
- Arf5
- Description
-
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
- Links
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Search Kinases of Arf5 (Mouse)

Arhgap21
Rat
Protein Arhgap21
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
F1LXQ7_RAT
- Accession #
- F1LXQ7
- Protein names
-
- Protein Arhgap21
- Fragment
- Gene names
-
- Arhgap21
- Description
-
N/A
- Links
-
Search Kinases of Arhgap21 (Rat)
N/A

ARHGAP24
Human
Rho GTPase-activating protein 24
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
RHG24_HUMAN
- Accession #
-
Q8N264
- Protein names
-
- Rho GTPase-activating protein 24
- Filamin-A-associated RhoGAP
- FilGAP
- RAC1- and CDC42-specific GTPase-activating protein of 72 kDa
- RC-GAP72
- Rho-type GTPase-activating protein 24
- RhoGAP of 73 kDa
- Sarcoma antigen NY-SAR-88
- p73RhoGAP
- Gene names
-
- ARHGAP24
- FILGAP
- Description
-
Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.
- Links
-
Search Kinases of ARHGAP24 (Human)
N/A
- Rac GTPase activator activity
- activation of Rac GTPase activity
- angiogenesis
- cell differentiation
- cell projection
- cytoskeleton
- cytosol
- focal adhesion
- negative regulation of Rac protein signal transduction
- negative regulation of ruffle assembly
- protein binding
- regulation of small GTPase mediated signal transduction
- small GTPase mediated signal transduction
- wound healing, spreading of epidermal cells
