Search Results (6 substrates found)
Gene name
Organism
Protein name
Ces1e
Rat
Carboxylesterase RL1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
Q924V9_RAT
- Accession #
- Q924V9
- Protein names
-
- Carboxylesterase RL1
- Gene names
-
- Ces1e
- Ces1
- CESrRL1
- Es22
- Description
-
N/A
- Links
-
Search Kinases of Ces1e (Rat)
N/A

Gsk3b
Rat
Glycogen synthase kinase-3 beta
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
GSK3B_RAT
- Accession #
-
P18266
- Protein names
-
- Glycogen synthase kinase-3 beta
- GSK-3 beta
- EC 2.7.11.26
- Factor A
- FA
- Serine/threonine-protein kinase GSK3B
- EC 2.7.11.1
- Gene names
-
- Gsk3b
- Description
-
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SFPQ upon T-cell activation. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2. Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation. Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation. Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity.
- Links
-
Search Kinases of Gsk3b (Rat)
- Alzheimer's disease
- Axon guidance
- B cell receptor signaling pathway
- Basal cell carcinoma
- Cell cycle
- Chemokine signaling pathway
- Colorectal cancer
- Dopaminergic synapse
- Endometrial cancer
- Epstein-Barr virus infection
- ErbB signaling pathway
- Focal adhesion
- HTLV-I infection
- Hedgehog signaling pathway
- Hepatitis C
- Hippo signaling pathway
- Influenza A
- Insulin signaling pathway
- Measles
- Melanogenesis
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease (NAFLD)
- PI3K-Akt signaling pathway
- Pathways in cancer
- Prolactin signaling pathway
- Prostate cancer
- Signaling pathways regulating pluripotency of stem cells
- T cell receptor signaling pathway
- Thyroid hormone signaling pathway
- Wnt signaling pathway
- ATP binding
- ER overload response
- axonogenesis
- beta-catenin destruction complex
- canonical Wnt signaling pathway involved in positive regulation of apoptotic process
- cell migration
- cellular response to interleukin-3
- cellular response to mechanical stimulus
- centrosome
- circadian rhythm
- cytoplasm
- cytosol
- dendritic shaft
- dendritic spine
- epithelial to mesenchymal transition
- establishment of cell polarity
- establishment or maintenance of cell polarity
- extrinsic apoptotic signaling pathway in absence of ligand
- fat cell differentiation
- glycogen metabolic process
- growth cone
- hippocampus development
- hypermethylation of CpG island
- integrin binding
- intracellular signal transduction
- ionotropic glutamate receptor binding
- kinase activity
- membrane
- membrane raft
- myoblast fusion
- negative regulation of MAP kinase activity
- negative regulation of NFAT protein import into nucleus
- negative regulation of apoptotic process
- negative regulation of cardiac muscle hypertrophy
- negative regulation of dendrite morphogenesis
- negative regulation of protein binding
- negative regulation of protein complex assembly
- neuronal cell body
- nucleus
- organ morphogenesis
- peptidyl-serine phosphorylation
- perinuclear region of cytoplasm
- plasma membrane
- positive regulation of Rac GTPase activity
- positive regulation of apoptotic process
- positive regulation of cell-matrix adhesion
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of peptidyl-threonine phosphorylation
- positive regulation of protein binding
- positive regulation of protein complex assembly
- positive regulation of protein export from nucleus
- positive regulation of stem cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- protein binding
- protein complex
- protein export from nucleus
- protein kinase binding
- protein localization to microtubule
- protein phosphorylation
- protein serine/threonine kinase activity
- re-entry into mitotic cell cycle
- regulation of gene expression by genetic imprinting
- regulation of microtubule-based process
- regulation of neuronal synaptic plasticity
- response to drug
- response to lithium ion
- ribonucleoprotein complex
- superior temporal gyrus development
- tau protein binding
- tau-protein kinase activity

Map2
Rat
Microtubule-associated protein 2
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
MTAP2_RAT
- Accession #
-
P15146
- Protein names
-
- Microtubule-associated protein 2
- MAP-2
- Gene names
-
- Map2
- Mtap2
- Description
-
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
- Links
-
Search Kinases of Map2 (Rat)
N/A

Ptpn20
Rat
Tyrosine-protein phosphatase non-receptor type 20
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
PTN20_RAT
- Accession #
-
A1L1L3
- Protein names
-
- Tyrosine-protein phosphatase non-receptor type 20
- EC 3.1.3.48
- Gene names
-
- Ptpn20
- Description
-
Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates (By similarity).
- Links
-
Search Kinases of Ptpn20 (Rat)
N/A

Slc9a3r2
Rat
Na
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
G3V6D9_RAT
- Accession #
- G3V6D9
- Protein names
-
- Na
- +/H
- + exchange regulatory cofactor NHE-RF2
- Solute carrier family 9
- Sodium/hydrogen exchanger, isoform 3 regulator 2, isoform CRA_b
- Gene names
-
- Slc9a3r2
- rCG_34388
- Description
-
N/A
- Links
-
Search Kinases of Slc9a3r2 (Rat)

Syn1
Rat
Synapsin-1
- Organism
- Rat (Rattus norvegicus)
- Uniprot ID
-
SYN1_RAT
- Accession #
-
P09951
- Protein names
-
- Synapsin-1
- Synapsin I
- Gene names
-
- Syn1
- Description
-
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release.
- Links
-
Search Kinases of Syn1 (Rat)
N/A
