KANPHOS_Str

Search Results (6 substrates found)

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Gene name
Organism
Protein name
Ces1e
Rat
Carboxylesterase RL1
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
Q924V9_RAT
Accession #
Q924V9
Protein names
  • Carboxylesterase RL1
Gene names
  • Ces1e
  • Ces1
  • CESrRL1
  • Es22
Description
N/A
Links

Search Kinases of Ces1e (Rat)
KEGG Pathways (0)
N/A
Gene Ontology Terms (1)
Phosphorylation Site Information
Gsk3b
Rat
Glycogen synthase kinase-3 beta
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
GSK3B_RAT
Accession #
P18266
Protein names
  • Glycogen synthase kinase-3 beta
  • GSK-3 beta
  • EC 2.7.11.26
  • Factor A
  • FA
  • Serine/threonine-protein kinase GSK3B
  • EC 2.7.11.1
Gene names
  • Gsk3b
Description
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SFPQ upon T-cell activation. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2. Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation. Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation. Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity.
Links

Search Kinases of Gsk3b (Rat)
Gene Ontology Terms (71)
Phosphorylation Site Information
Map2
Rat
Microtubule-associated protein 2
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
MTAP2_RAT
Accession #
P15146
Protein names
  • Microtubule-associated protein 2
  • MAP-2
Gene names
  • Map2
  • Mtap2
Description
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
Links

Search Kinases of Map2 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Ptpn20
Rat
Tyrosine-protein phosphatase non-receptor type 20
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
PTN20_RAT
Accession #
A1L1L3
Protein names
  • Tyrosine-protein phosphatase non-receptor type 20
  • EC 3.1.3.48
Gene names
  • Ptpn20
Description
Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates (By similarity).
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Search Kinases of Ptpn20 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Slc9a3r2
Rat
Na
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
G3V6D9_RAT
Accession #
G3V6D9
Protein names
  • Na
  • +/H
  • + exchange regulatory cofactor NHE-RF2
  • Solute carrier family 9
  • Sodium/hydrogen exchanger, isoform 3 regulator 2, isoform CRA_b
Gene names
  • Slc9a3r2
  • rCG_34388
Description
N/A
Links

Search Kinases of Slc9a3r2 (Rat)
Phosphorylation Site Information
Syn1
Rat
Synapsin-1
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
SYN1_RAT
Accession #
P09951
Protein names
  • Synapsin-1
  • Synapsin I
Gene names
  • Syn1
Description
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release.
Links

Search Kinases of Syn1 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information