KANPHOS_Str

Search Results (99 substrates found)

Displaying 1 - 20 of 99 Items
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Gene name
Organism
Protein name
AHNAK
Human
Neuroblast differentiation-associated protein AHNAK
AR
Human
Androgen receptor
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ANDR_HUMAN
Accession #
P10275
Protein names
  • Androgen receptor
  • Dihydrotestosterone receptor
  • Nuclear receptor subfamily 3 group C member 4
Gene names
  • AR
  • DHTR
  • NR3C4
Description
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
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Search Kinases of AR (Human)
Phosphorylation Site Information
ARHGAP21
Human
Rho GTPase-activating protein 21
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
RHG21_HUMAN
Accession #
Q5T5U3
Protein names
  • Rho GTPase-activating protein 21
  • Rho GTPase-activating protein 10
  • Rho-type GTPase-activating protein 21
Gene names
  • ARHGAP21
  • ARHGAP10
  • KIAA1424
Description
Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.
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Search Kinases of ARHGAP21 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
ARPC1B
Human
Actin-related protein 2/3 complex subunit 1B
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ARC1B_HUMAN
Accession #
O15143
Protein names
  • Actin-related protein 2/3 complex subunit 1B
  • Arp2/3 complex 41 kDa subunit
  • p41-ARC
Gene names
  • ARPC1B
  • ARC41
Description
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
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Search Kinases of ARPC1B (Human)
Phosphorylation Site Information
ATM
Human
Serine-protein kinase ATM
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ATM_HUMAN
Accession #
Q13315
Protein names
  • Serine-protein kinase ATM
  • EC 2.7.11.1
  • Ataxia telangiectasia mutated
  • A-T mutated
Gene names
  • ATM
Description
Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.
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Search Kinases of ATM (Human)
Gene Ontology Terms (46)
Phosphorylation Site Information
AURKA
Human
Aurora kinase A
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
AURKA_HUMAN
Accession #
O14965
Protein names
  • Aurora kinase A
  • EC 2.7.11.1
  • Aurora 2
  • Aurora/IPL1-related kinase 1
  • ARK-1
  • Aurora-related kinase 1
  • hARK1
  • Breast tumor-amplified kinase
  • Serine/threonine-protein kinase 15
  • Serine/threonine-protein kinase 6
  • Serine/threonine-protein kinase aurora-A
Gene names
  • AURKA
  • AIK
  • AIRK1
  • ARK1
  • AURA
  • AYK1
  • BTAK
  • IAK1
  • STK15
  • STK6
Description
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
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Search Kinases of AURKA (Human)
KEGG Pathways (1)
Phosphorylation Site Information
AURKB
Human
Aurora kinase B
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
AURKB_HUMAN
Accession #
Q96GD4
Protein names
  • Aurora kinase B
  • EC 2.7.11.1
  • Aurora 1
  • Aurora- and IPL1-like midbody-associated protein 1
  • AIM-1
  • Aurora/IPL1-related kinase 2
  • ARK-2
  • Aurora-related kinase 2
  • STK-1
  • Serine/threonine-protein kinase 12
  • Serine/threonine-protein kinase 5
  • Serine/threonine-protein kinase aurora-B
Gene names
  • AURKB
  • AIK2
  • AIM1
  • AIRK2
  • ARK2
  • STK1
  • STK12
  • STK5
Description
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin, and histone H3. A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between GSG2 and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGOL1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes.
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Search Kinases of AURKB (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
BIRC5
Human
Baculoviral IAP repeat-containing protein 5
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
BIRC5_HUMAN
Accession #
O15392
Protein names
  • Baculoviral IAP repeat-containing protein 5
  • Apoptosis inhibitor 4
  • Apoptosis inhibitor survivin
Gene names
  • BIRC5
  • API4
  • IAP4
Description
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.
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Search Kinases of BIRC5 (Human)
Phosphorylation Site Information
BRCA1
Human
Breast cancer type 1 susceptibility protein
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
BRCA1_HUMAN
Accession #
P38398
Protein names
  • Breast cancer type 1 susceptibility protein
  • EC 6.3.2.-
  • RING finger protein 53
Gene names
  • BRCA1
  • RNF53
Description
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8.
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Search Kinases of BRCA1 (Human)
Gene Ontology Terms (62)
Phosphorylation Site Information
CASC5
Human
Protein CASC5
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CASC5_HUMAN
Accession #
Q8NG31
Protein names
  • Protein CASC5
  • ALL1-fused gene from chromosome 15q14 protein
  • AF15q14
  • Bub-linking kinetochore protein
  • Blinkin
  • Cancer susceptibility candidate gene 5 protein
  • Cancer/testis antigen 29
  • CT29
  • Kinetochore-null protein 1
  • Protein D40/AF15q14
Gene names
  • CASC5
  • KIAA1570
  • KNL1
Description
Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.
Links

Search Kinases of CASC5 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
CBX5
Human
Chromobox protein homolog 5
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CBX5_HUMAN
Accession #
P45973
Protein names
  • Chromobox protein homolog 5
  • Antigen p25
  • Heterochromatin protein 1 homolog alpha
  • HP1 alpha
Gene names
  • CBX5
  • HP1A
Description
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
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Search Kinases of CBX5 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
CCDC86
Human
Coiled-coil domain-containing protein 86
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CCD86_HUMAN
Accession #
Q9H6F5
Protein names
  • Coiled-coil domain-containing protein 86
  • Cytokine-induced protein with coiled-coil domain
Gene names
  • CCDC86
  • CYCLON
Description
N/A
Links

Search Kinases of CCDC86 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
CDC25B
Human
M-phase inducer phosphatase 2
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
MPIP2_HUMAN
Accession #
P30305
Protein names
  • M-phase inducer phosphatase 2
  • EC 3.1.3.48
  • Dual specificity phosphatase Cdc25B
Gene names
  • CDC25B
  • CDC25HU2
Description
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.
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Search Kinases of CDC25B (Human)
Phosphorylation Site Information
CDCA5
Human
Sororin
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CDCA5_HUMAN
Accession #
Q96FF9
Protein names
  • Sororin
  • Cell division cycle-associated protein 5
  • p35
Gene names
  • CDCA5
Description
Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair.
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Search Kinases of CDCA5 (Human)
KEGG Pathways (1)
Phosphorylation Site Information
CDCA8
Human
Borealin
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
BOREA_HUMAN
Accession #
Q53HL2
Protein names
  • Borealin
  • Cell division cycle-associated protein 8
  • Dasra-B
  • hDasra-B
  • Pluripotent embryonic stem cell-related gene 3 protein
Gene names
  • CDCA8
  • PESCRG3
Description
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
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Search Kinases of CDCA8 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
CENPA
Human
Histone H3-like centromeric protein A
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CENPA_HUMAN
Accession #
P49450
Protein names
  • Histone H3-like centromeric protein A
  • Centromere autoantigen A
  • Centromere protein A
  • CENP-A
Gene names
  • CENPA
Description
Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).
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Search Kinases of CENPA (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
CETN2
Human
Centrin-2
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CETN2_HUMAN
Accession #
P41208
Protein names
  • Centrin-2
  • Caltractin isoform 1
Gene names
  • CETN2
  • CALT
  • CEN2
Description
Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.
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Search Kinases of CETN2 (Human)
Phosphorylation Site Information
CKAP2
Human
Cytoskeleton-associated protein 2
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CKAP2_HUMAN
Accession #
Q8WWK9
Protein names
  • Cytoskeleton-associated protein 2
  • CTCL tumor antigen se20-10
  • Tumor- and microtubule-associated protein
Gene names
  • CKAP2
  • LB1
  • TMAP
Description
Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity).
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Search Kinases of CKAP2 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
COBLL1
Human
Cordon-bleu protein-like 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
COBL1_HUMAN
Accession #
Q53SF7
Protein names
  • Cordon-bleu protein-like 1
Gene names
  • COBLL1
  • KIAA0977
Description
N/A
Links

Search Kinases of COBLL1 (Human)
KEGG Pathways (0)
N/A
Gene Ontology Terms (1)
Phosphorylation Site Information
Cpeb1
Mouse
Cytoplasmic polyadenylation element-binding protein 1
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
CPEB1_MOUSE
Accession #
P70166
Protein names
  • Cytoplasmic polyadenylation element-binding protein 1
  • CPE-BP1
  • CPE-binding protein 1
  • mCPEB
  • mCPEB-1
Gene names
  • Cpeb1
  • Cpeb
Description
Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the 3'-UTR of mRNAs. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress (By similarity).
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Search Kinases of Cpeb1 (Mouse)
Phosphorylation Site Information
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