Search Results (99 substrates found)
Gene name
Organism
Protein name
AHNAK
Human
Neuroblast differentiation-associated protein AHNAK
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
AHNK_HUMAN
- Accession #
-
Q09666
- Protein names
-
- Neuroblast differentiation-associated protein AHNAK
- Desmoyokin
- Gene names
-
- AHNAK
- PM227
- Description
-
May be required for neuronal cell differentiation.
- Links
-
Search Kinases of AHNAK (Human)
N/A
- S100 protein binding
- T-tubule
- actin cytoskeleton
- cell-cell contact zone
- costamere
- cytoplasm
- cytosol
- extracellular vesicular exosome
- lysosomal membrane
- nucleus
- plasma membrane
- poly(A) RNA binding
- protein binding
- protein oligomerization
- regulation of RNA splicing
- regulation of voltage-gated calcium channel activity
- sarcolemma
- structural molecule activity conferring elasticity
- vesicle

AR
Human
Androgen receptor
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ANDR_HUMAN
- Accession #
-
P10275
- Protein names
-
- Androgen receptor
- Dihydrotestosterone receptor
- Nuclear receptor subfamily 3 group C member 4
- Gene names
-
- AR
- DHTR
- NR3C4
- Description
-
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
- Links
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Search Kinases of AR (Human)
- DNA binding
- RNA polymerase II transcription factor binding
- androgen binding
- androgen receptor activity
- androgen receptor signaling pathway
- beta-catenin binding
- cell death
- cell growth
- cell proliferation
- cell-cell signaling
- chromatin binding
- cytoplasm
- enzyme binding
- gene expression
- intracellular receptor signaling pathway
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- negative regulation of extrinsic apoptotic signaling pathway
- negative regulation of integrin biosynthetic process
- nuclear chromatin
- nucleoplasm
- nucleus
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of cell proliferation
- positive regulation of integrin biosynthetic process
- positive regulation of phosphorylation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase III promoter
- positive regulation of transcription, DNA-templated
- prostate gland development
- protein binding
- protein complex
- protein dimerization activity
- protein oligomerization
- receptor binding
- regulation of establishment of protein localization to plasma membrane
- sequence-specific DNA binding
- sequence-specific DNA binding transcription factor activity
- sex differentiation
- signal transduction
- transcription factor binding
- transcription initiation from RNA polymerase II promoter
- transcription regulatory region DNA binding
- transcription, DNA-templated
- transport
- zinc ion binding

ARHGAP21
Human
Rho GTPase-activating protein 21
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
RHG21_HUMAN
- Accession #
-
Q5T5U3
- Protein names
-
- Rho GTPase-activating protein 21
- Rho GTPase-activating protein 10
- Rho-type GTPase-activating protein 21
- Gene names
-
- ARHGAP21
- ARHGAP10
- KIAA1424
- Description
-
Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.
- Links
-
Search Kinases of ARHGAP21 (Human)
N/A

ARPC1B
Human
Actin-related protein 2/3 complex subunit 1B
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ARC1B_HUMAN
- Accession #
-
O15143
- Protein names
-
- Actin-related protein 2/3 complex subunit 1B
- Arp2/3 complex 41 kDa subunit
- p41-ARC
- Gene names
-
- ARPC1B
- ARC41
- Description
-
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
- Links
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Search Kinases of ARPC1B (Human)

ATM
Human
Serine-protein kinase ATM
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ATM_HUMAN
- Accession #
-
Q13315
- Protein names
-
- Serine-protein kinase ATM
- EC 2.7.11.1
- Ataxia telangiectasia mutated
- A-T mutated
- Gene names
-
- ATM
- Description
-
Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.
- Links
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Search Kinases of ATM (Human)
- 1-phosphatidylinositol-3-kinase activity
- ATP binding
- DNA binding
- DNA damage induced protein phosphorylation
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- DNA repair
- DNA-dependent protein kinase activity
- brain development
- cell cycle arrest
- cellular response to DNA damage stimulus
- cellular response to gamma radiation
- cytoplasmic membrane-bounded vesicle
- double-strand break repair
- double-strand break repair via homologous recombination
- heart development
- histone mRNA catabolic process
- histone serine kinase activity
- intrinsic apoptotic signaling pathway in response to DNA damage
- lipoprotein catabolic process
- mitotic spindle assembly checkpoint
- negative regulation of B cell proliferation
- neuron apoptotic process
- nucleoplasm
- oocyte development
- peptidyl-serine phosphorylation
- phosphatidylinositol-3-phosphate biosynthetic process
- positive regulation of DNA damage response, signal transduction by p53 class mediator
- positive regulation of apoptotic process
- positive regulation of neuron apoptotic process
- pre-B cell allelic exclusion
- protein N-terminus binding
- protein autophosphorylation
- protein binding
- protein complex binding
- protein dimerization activity
- protein phosphorylation
- protein serine/threonine kinase activity
- reciprocal meiotic recombination
- replicative senescence
- response to hypoxia
- response to ionizing radiation
- signal transduction
- signal transduction involved in mitotic G2 DNA damage checkpoint
- somitogenesis
- spindle
- telomere maintenance

AURKA
Human
Aurora kinase A
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
AURKA_HUMAN
- Accession #
-
O14965
- Protein names
-
- Aurora kinase A
- EC 2.7.11.1
- Aurora 2
- Aurora/IPL1-related kinase 1
- ARK-1
- Aurora-related kinase 1
- hARK1
- Breast tumor-amplified kinase
- Serine/threonine-protein kinase 15
- Serine/threonine-protein kinase 6
- Serine/threonine-protein kinase aurora-A
- Gene names
-
- AURKA
- AIK
- AIRK1
- ARK1
- AURA
- AYK1
- BTAK
- IAK1
- STK15
- STK6
- Description
-
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
- Links
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Search Kinases of AURKA (Human)
- ATP binding
- G2/M transition of mitotic cell cycle
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
- cell cycle
- cell projection organization
- centrosome
- cytosol
- microtubule
- microtubule cytoskeleton
- midbody
- mitotic cell cycle
- mitotic nuclear division
- negative regulation of protein binding
- nucleus
- perinuclear region of cytoplasm
- phosphatidylinositol-mediated signaling
- positive regulation of mitosis
- protein autophosphorylation
- protein binding
- protein kinase activity
- protein kinase binding
- protein phosphorylation
- protein serine/threonine kinase activity
- protein serine/threonine/tyrosine kinase activity
- regulation of centrosome cycle
- regulation of protein stability
- spindle
- spindle organization
- spindle pole centrosome
- spindle stabilization

AURKB
Human
Aurora kinase B
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
AURKB_HUMAN
- Accession #
-
Q96GD4
- Protein names
-
- Aurora kinase B
- EC 2.7.11.1
- Aurora 1
- Aurora- and IPL1-like midbody-associated protein 1
- AIM-1
- Aurora/IPL1-related kinase 2
- ARK-2
- Aurora-related kinase 2
- STK-1
- Serine/threonine-protein kinase 12
- Serine/threonine-protein kinase 5
- Serine/threonine-protein kinase aurora-B
- Gene names
-
- AURKB
- AIK2
- AIM1
- AIRK2
- ARK2
- STK1
- STK12
- STK5
- Description
-
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin, and histone H3. A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between GSG2 and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGOL1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes.
- Links
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Search Kinases of AURKB (Human)
N/A
- ATP binding
- abscission
- aging
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
- attachment of spindle microtubules to kinetochore
- cell proliferation
- cellular response to UV
- chromocenter
- chromosome passenger complex
- cleavage furrow formation
- condensed chromosome, centromeric region
- condensed nuclear chromosome, centromeric region
- cytokinesis checkpoint
- cytosol
- histone H3-S28 phosphorylation
- histone modification
- histone serine kinase activity
- intercellular bridge
- metal ion binding
- midbody
- mitotic cell cycle
- negative regulation of B cell apoptotic process
- negative regulation of cytokinesis
- negative regulation of protein binding
- negative regulation of transcription from RNA polymerase II promoter
- nucleus
- positive regulation of cytokinesis
- protein autophosphorylation
- protein binding
- protein localization to kinetochore
- protein phosphorylation
- protein serine/threonine kinase activity
- protein serine/threonine/tyrosine kinase activity
- regulation of chromosome segregation
- spindle
- spindle checkpoint
- spindle midzone assembly involved in mitosis
- spindle stabilization

BIRC5
Human
Baculoviral IAP repeat-containing protein 5
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
BIRC5_HUMAN
- Accession #
-
O15392
- Protein names
-
- Baculoviral IAP repeat-containing protein 5
- Apoptosis inhibitor 4
- Apoptosis inhibitor survivin
- Gene names
-
- BIRC5
- API4
- IAP4
- Description
-
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.
- Links
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Search Kinases of BIRC5 (Human)
- G2/M transition of mitotic cell cycle
- Ran GTPase binding
- apoptotic process
- cell division
- centriole
- chaperone binding
- chromosome passenger complex
- chromosome segregation
- chromosome, centromeric region
- cobalt ion binding
- cofactor binding
- condensed chromosome kinetochore
- cysteine-type endopeptidase inhibitor activity
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process
- cytokinesis
- cytoplasm
- cytoplasmic microtubule
- cytosol
- enzyme binding
- establishment of chromosome localization
- identical protein binding
- interphase microtubule organizing center
- metal ion binding
- microtubule
- microtubule binding
- midbody
- mitotic cell cycle
- mitotic nuclear division
- negative regulation of apoptotic process
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of transcription, DNA-templated
- nuclear chromosome
- nucleus
- positive regulation of cell proliferation
- positive regulation of exit from mitosis
- positive regulation of mitotic cell cycle
- protein binding
- protein complex localization
- protein heterodimerization activity
- protein homodimerization activity
- protein phosphorylation
- spindle
- spindle checkpoint
- spindle microtubule
- transcription, DNA-templated
- tubulin binding
- zinc ion binding

BRCA1
Human
Breast cancer type 1 susceptibility protein
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
BRCA1_HUMAN
- Accession #
-
P38398
- Protein names
-
- Breast cancer type 1 susceptibility protein
- EC 6.3.2.-
- RING finger protein 53
- Gene names
-
- BRCA1
- RNF53
- Description
-
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8.
- Links
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Search Kinases of BRCA1 (Human)
- BRCA1-A complex
- BRCA1-BARD1 complex
- DNA binding
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
- DNA repair
- G2 DNA damage checkpoint
- RNA binding
- androgen receptor binding
- androgen receptor signaling pathway
- apoptotic process
- cellular response to DNA damage stimulus
- cellular response to indole-3-methanol
- chromosome
- chromosome segregation
- cytoplasm
- double-strand break repair
- double-strand break repair via homologous recombination
- enzyme binding
- fatty acid biosynthetic process
- gamma-tubulin ring complex
- intrinsic apoptotic signaling pathway in response to DNA damage
- ligase activity
- negative regulation of centriole replication
- negative regulation of fatty acid biosynthetic process
- negative regulation of histone H3-K9 methylation
- negative regulation of transcription, DNA-templated
- nucleoplasm
- nucleus
- plasma membrane
- positive regulation of DNA repair
- positive regulation of cell cycle arrest
- positive regulation of histone H3-K4 methylation
- positive regulation of histone H3-K9 acetylation
- positive regulation of histone H4-K16 acetylation
- positive regulation of histone H4-K20 methylation
- positive regulation of histone acetylation
- positive regulation of protein ubiquitination
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription, DNA-templated
- postreplication repair
- protein K6-linked ubiquitination
- protein autoubiquitination
- protein binding
- protein complex
- protein ubiquitination
- regulation of apoptotic process
- regulation of cell motility
- regulation of cell proliferation
- regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase III promoter
- response to estrogen
- response to ionizing radiation
- ribonucleoprotein complex
- ruffle
- substrate adhesion-dependent cell spreading
- transcription coactivator activity
- transcription regulatory region DNA binding
- tubulin binding
- ubiquitin ligase complex
- ubiquitin protein ligase binding
- ubiquitin-protein transferase activity
- zinc ion binding

CASC5
Human
Protein CASC5
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CASC5_HUMAN
- Accession #
-
Q8NG31
- Protein names
-
- Protein CASC5
- ALL1-fused gene from chromosome 15q14 protein
- AF15q14
- Bub-linking kinetochore protein
- Blinkin
- Cancer susceptibility candidate gene 5 protein
- Cancer/testis antigen 29
- CT29
- Kinetochore-null protein 1
- Protein D40/AF15q14
- Gene names
-
- CASC5
- KIAA1570
- KNL1
- Description
-
Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.
- Links
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Search Kinases of CASC5 (Human)
N/A
- CENP-A containing nucleosome assembly
- acrosomal vesicle
- acrosome assembly
- attachment of spindle microtubules to kinetochore
- condensed chromosome kinetochore
- cytoplasm
- cytosol
- extracellular vesicular exosome
- mitotic cell cycle
- mitotic nuclear division
- negative regulation of phosphatase activity
- nucleoplasm
- nucleosome assembly
- nucleus
- protein binding
- protein localization to kinetochore
- spindle assembly checkpoint

CBX5
Human
Chromobox protein homolog 5
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CBX5_HUMAN
- Accession #
-
P45973
- Protein names
-
- Chromobox protein homolog 5
- Antigen p25
- Heterochromatin protein 1 homolog alpha
- HP1 alpha
- Gene names
-
- CBX5
- HP1A
- Description
-
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
- Links
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Search Kinases of CBX5 (Human)
N/A
- blood coagulation
- chromatin binding
- chromocenter
- histone deacetylase complex
- histone methyltransferase complex
- kinetochore
- methylated histone binding
- negative regulation of transcription, DNA-templated
- nuclear envelope
- nuclear heterochromatin
- nuclear pericentric heterochromatin
- nucleolus
- nucleoplasm
- nucleus
- protein binding
- protein binding, bridging
- repressing transcription factor binding
- transcriptional repressor complex
- viral process

CCDC86
Human
Coiled-coil domain-containing protein 86
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CCD86_HUMAN
- Accession #
-
Q9H6F5
- Protein names
-
- Coiled-coil domain-containing protein 86
- Cytokine-induced protein with coiled-coil domain
- Gene names
-
- CCDC86
- CYCLON
- Description
-
N/A
- Links
-
Search Kinases of CCDC86 (Human)
N/A

CDC25B
Human
M-phase inducer phosphatase 2
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
MPIP2_HUMAN
- Accession #
-
P30305
- Protein names
-
- M-phase inducer phosphatase 2
- EC 3.1.3.48
- Dual specificity phosphatase Cdc25B
- Gene names
-
- CDC25B
- CDC25HU2
- Description
-
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.
- Links
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Search Kinases of CDC25B (Human)
- G2/M transition of mitotic cell cycle
- centrosome
- cytoplasm
- cytosol
- female meiosis I
- mitotic cell cycle
- mitotic nuclear division
- nucleoplasm
- nucleus
- oocyte maturation
- peptidyl-tyrosine dephosphorylation
- positive regulation of cell proliferation
- positive regulation of cytokinesis
- positive regulation of mitotic cell cycle
- positive regulation of protein kinase activity
- protein binding
- protein kinase binding
- protein phosphorylation
- protein tyrosine phosphatase activity
- spindle pole

CDCA5
Human
Sororin
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CDCA5_HUMAN
- Accession #
-
Q96FF9
- Protein names
-
- Sororin
- Cell division cycle-associated protein 5
- p35
- Gene names
-
- CDCA5
- Description
-
Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair.
- Links
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Search Kinases of CDCA5 (Human)
- G1/S transition of mitotic cell cycle
- chromatin binding
- chromosome
- chromosome, centromeric region
- cohesin complex
- cytoplasm
- cytosol
- double-strand break repair
- mitotic cell cycle
- mitotic chromosome condensation
- mitotic interphase
- mitotic metaphase plate congression
- mitotic nuclear division
- mitotic sister chromatid cohesion
- nuclear chromatin
- nucleoplasm
- nucleus
- plasma membrane
- protein binding
- regulation of cohesin localization to chromatin

CDCA8
Human
Borealin
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
BOREA_HUMAN
- Accession #
-
Q53HL2
- Protein names
-
- Borealin
- Cell division cycle-associated protein 8
- Dasra-B
- hDasra-B
- Pluripotent embryonic stem cell-related gene 3 protein
- Gene names
-
- CDCA8
- PESCRG3
- Description
-
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
- Links
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Search Kinases of CDCA8 (Human)
N/A

CENPA
Human
Histone H3-like centromeric protein A
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CENPA_HUMAN
- Accession #
-
P49450
- Protein names
-
- Histone H3-like centromeric protein A
- Centromere autoantigen A
- Centromere protein A
- CENP-A
- Gene names
-
- CENPA
- Description
-
Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).
- Links
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Search Kinases of CENPA (Human)
N/A
- CENP-A containing nucleosome assembly
- DNA binding
- chromatin binding
- chromosome, centromeric region
- condensed chromosome inner kinetochore
- condensed nuclear chromosome kinetochore
- condensed nuclear chromosome, centromeric region
- cytosol
- establishment of mitotic spindle orientation
- kinetochore assembly
- mitotic cell cycle
- nucleoplasm
- nucleosome
- nucleosome assembly
- nucleus
- protein binding
- protein localization to chromosome, centromeric region
- viral process

CETN2
Human
Centrin-2
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CETN2_HUMAN
- Accession #
-
P41208
- Protein names
-
- Centrin-2
- Caltractin isoform 1
- Gene names
-
- CETN2
- CALT
- CEN2
- Description
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Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.
- Links
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Search Kinases of CETN2 (Human)
- ATP binding
- ATP-dependent helicase activity
- G2/M transition of mitotic cell cycle
- XPC complex
- calcium ion binding
- centriole
- centriole replication
- centrosome
- cytosol
- intracellular
- mitotic cell cycle
- mitotic nuclear division
- nucleic acid binding
- nucleotide-excision repair
- photoreceptor connecting cilium
- protein binding
- regulation of cytokinesis
- spermatogenesis

CKAP2
Human
Cytoskeleton-associated protein 2
- Organism
- Human (Homo sapiens)
- Uniprot ID
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CKAP2_HUMAN
- Accession #
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Q8WWK9
- Protein names
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- Cytoskeleton-associated protein 2
- CTCL tumor antigen se20-10
- Tumor- and microtubule-associated protein
- Gene names
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- CKAP2
- LB1
- TMAP
- Description
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Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity).
- Links
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Search Kinases of CKAP2 (Human)
N/A

COBLL1
Human
Cordon-bleu protein-like 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
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COBL1_HUMAN
- Accession #
- Q53SF7
- Protein names
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- Cordon-bleu protein-like 1
- Gene names
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- COBLL1
- KIAA0977
- Description
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N/A
- Links
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Search Kinases of COBLL1 (Human)
N/A

Cpeb1
Mouse
Cytoplasmic polyadenylation element-binding protein 1
- Organism
- Mouse (Mus musculus)
- Uniprot ID
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CPEB1_MOUSE
- Accession #
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P70166
- Protein names
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- Cytoplasmic polyadenylation element-binding protein 1
- CPE-BP1
- CPE-binding protein 1
- mCPEB
- mCPEB-1
- Gene names
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- Cpeb1
- Cpeb
- Description
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Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the 3'-UTR of mRNAs. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress (By similarity).
- Links
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Search Kinases of Cpeb1 (Mouse)
- RNA binding
- cell junction
- cellular response to amino acid stimulus
- cellular response to hypoxia
- cellular response to insulin stimulus
- cytoplasm
- cytoplasmic mRNA processing body
- mRNA 3'-UTR AU-rich region binding
- mRNA binding
- mRNA processing
- meiotic spindle
- membrane
- metal ion binding
- negative regulation of cytoplasmic translation
- nucleotide binding
- nucleus
- postsynaptic density
- postsynaptic membrane
- protein binding
- regulation of neuronal synaptic plasticity
- regulation of translation
- synaptonemal complex assembly
- translation repressor activity, nucleic acid binding
