KANPHOS_Str

Search Results (32 substrates found)

Displaying 1 - 20 of 32 Items
items per page
Order by
/2 page
 
Gene name
Organism
Protein name
AR
Human
Androgen receptor
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ANDR_HUMAN
Accession #
P10275
Protein names
  • Androgen receptor
  • Dihydrotestosterone receptor
  • Nuclear receptor subfamily 3 group C member 4
Gene names
  • AR
  • DHTR
  • NR3C4
Description
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Links

Search Kinases of AR (Human)
Phosphorylation Site Information
ARPC1B
Human
Actin-related protein 2/3 complex subunit 1B
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ARC1B_HUMAN
Accession #
O15143
Protein names
  • Actin-related protein 2/3 complex subunit 1B
  • Arp2/3 complex 41 kDa subunit
  • p41-ARC
Gene names
  • ARPC1B
  • ARC41
Description
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Links

Search Kinases of ARPC1B (Human)
Phosphorylation Site Information
AURKA
Human
Aurora kinase A
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
AURKA_HUMAN
Accession #
O14965
Protein names
  • Aurora kinase A
  • EC 2.7.11.1
  • Aurora 2
  • Aurora/IPL1-related kinase 1
  • ARK-1
  • Aurora-related kinase 1
  • hARK1
  • Breast tumor-amplified kinase
  • Serine/threonine-protein kinase 15
  • Serine/threonine-protein kinase 6
  • Serine/threonine-protein kinase aurora-A
Gene names
  • AURKA
  • AIK
  • AIRK1
  • ARK1
  • AURA
  • AYK1
  • BTAK
  • IAK1
  • STK15
  • STK6
Description
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
Links

Search Kinases of AURKA (Human)
KEGG Pathways (1)
Phosphorylation Site Information
BRCA1
Human
Breast cancer type 1 susceptibility protein
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
BRCA1_HUMAN
Accession #
P38398
Protein names
  • Breast cancer type 1 susceptibility protein
  • EC 6.3.2.-
  • RING finger protein 53
Gene names
  • BRCA1
  • RNF53
Description
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8.
Links

Search Kinases of BRCA1 (Human)
Gene Ontology Terms (62)
Phosphorylation Site Information
CDC25B
Human
M-phase inducer phosphatase 2
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
MPIP2_HUMAN
Accession #
P30305
Protein names
  • M-phase inducer phosphatase 2
  • EC 3.1.3.48
  • Dual specificity phosphatase Cdc25B
Gene names
  • CDC25B
  • CDC25HU2
Description
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.
Links

Search Kinases of CDC25B (Human)
Phosphorylation Site Information
CENPA
Human
Histone H3-like centromeric protein A
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CENPA_HUMAN
Accession #
P49450
Protein names
  • Histone H3-like centromeric protein A
  • Centromere autoantigen A
  • Centromere protein A
  • CENP-A
Gene names
  • CENPA
Description
Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).
Links

Search Kinases of CENPA (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
CETN2
Human
Centrin-2
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CETN2_HUMAN
Accession #
P41208
Protein names
  • Centrin-2
  • Caltractin isoform 1
Gene names
  • CETN2
  • CALT
  • CEN2
Description
Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.
Links

Search Kinases of CETN2 (Human)
Phosphorylation Site Information
Cpeb1
Mouse
Cytoplasmic polyadenylation element-binding protein 1
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
CPEB1_MOUSE
Accession #
P70166
Protein names
  • Cytoplasmic polyadenylation element-binding protein 1
  • CPE-BP1
  • CPE-binding protein 1
  • mCPEB
  • mCPEB-1
Gene names
  • Cpeb1
  • Cpeb
Description
Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the 3'-UTR of mRNAs. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress (By similarity).
Links

Search Kinases of Cpeb1 (Mouse)
Phosphorylation Site Information
CRMP1
Human
Dihydropyrimidinase-related protein 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
DPYL1_HUMAN
Accession #
Q14194
Protein names
  • Dihydropyrimidinase-related protein 1
  • DRP-1
  • Collapsin response mediator protein 1
  • CRMP-1
  • Unc-33-like phosphoprotein 3
  • ULIP-3
Gene names
  • CRMP1
  • DPYSL1
  • ULIP3
Description
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis.
Links

Search Kinases of CRMP1 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
DCTN1
Human
Dynactin subunit 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
DCTN1_HUMAN
Accession #
Q14203
Protein names
  • Dynactin subunit 1
  • 150 kDa dynein-associated polypeptide
  • DAP-150
  • DP-150
  • p135
  • p150-glued
Gene names
  • DCTN1
Description
Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.
Links

Search Kinases of DCTN1 (Human)
Phosphorylation Site Information
DLGAP5
Human
Disks large-associated protein 5
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
DLGP5_HUMAN
Accession #
Q15398
Protein names
  • Disks large-associated protein 5
  • DAP-5
  • Discs large homolog 7
  • Disks large-associated protein DLG7
  • Hepatoma up-regulated protein
  • HURP
Gene names
  • DLGAP5
  • DLG7
  • KIAA0008
Description
Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.
Links

Search Kinases of DLGAP5 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
FADD
Human
FAS-associated death domain protein
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
FADD_HUMAN
Accession #
Q13158
Protein names
  • FAS-associated death domain protein
  • FAS-associating death domain-containing protein
  • Growth-inhibiting gene 3 protein
  • Mediator of receptor induced toxicity
  • Protein FADD
Gene names
  • FADD
  • MORT1
  • GIG3
Description
Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
Links

Search Kinases of FADD (Human)
Gene Ontology Terms (55)
Phosphorylation Site Information
GSK3B
Human
Glycogen synthase kinase-3 beta
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
GSK3B_HUMAN
Accession #
P49841
Protein names
  • Glycogen synthase kinase-3 beta
  • GSK-3 beta
  • EC 2.7.11.26
  • Serine/threonine-protein kinase GSK3B
  • EC 2.7.11.1
Gene names
  • GSK3B
Description
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates SFPQ at 'Thr-687' upon T-cell activation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2. Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation. Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation. Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity.
Links

Search Kinases of GSK3B (Human)
Gene Ontology Terms (82)
Phosphorylation Site Information
HIST1H3A
Human
Histone H3.1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
H31_HUMAN
Accession #
P68431
Protein names
  • Histone H3.1
  • Histone H3/a
  • Histone H3/b
  • Histone H3/c
  • Histone H3/d
  • Histone H3/f
  • Histone H3/h
  • Histone H3/i
  • Histone H3/j
  • Histone H3/k
  • Histone H3/l
Gene names
  • HIST1H3A
  • H3FA
  • HIST1H3B
  • H3FL
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Links

Search Kinases of HIST1H3A (Human)
Phosphorylation Site Information
LATS2
Human
Serine/threonine-protein kinase LATS2
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
LATS2_HUMAN
Accession #
Q9NRM7
Protein names
  • Serine/threonine-protein kinase LATS2
  • EC 2.7.11.1
  • Kinase phosphorylated during mitosis protein
  • Large tumor suppressor homolog 2
  • Serine/threonine-protein kinase kpm
  • Warts-like kinase
Gene names
  • LATS2
  • KPM
Description
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.
Links

Search Kinases of LATS2 (Human)
KEGG Pathways (1)
Phosphorylation Site Information
MAP9
Human
Microtubule-associated protein 9
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
MAP9_HUMAN
Accession #
Q49MG5
Protein names
  • Microtubule-associated protein 9
  • Aster-associated protein
Gene names
  • MAP9
  • ASAP
Description
Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules.
Links

Search Kinases of MAP9 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
MAPRE3
Human
Microtubule-associated protein RP/EB family member 3
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
MARE3_HUMAN
Accession #
Q9UPY8
Protein names
  • Microtubule-associated protein RP/EB family member 3
  • EB1 protein family member 3
  • EBF3
  • End-binding protein 3
  • EB3
  • RP3
Gene names
  • MAPRE3
Description
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).
Links

Search Kinases of MAPRE3 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
MBD3
Human
Methyl-CpG-binding domain protein 3
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
MBD3_HUMAN
Accession #
O95983
Protein names
  • Methyl-CpG-binding domain protein 3
  • Methyl-CpG-binding protein MBD3
Gene names
  • MBD3
Description
Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (PubMed:12124384). Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases.
Links

Search Kinases of MBD3 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
MCM2
Human
DNA replication licensing factor MCM2
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
MCM2_HUMAN
Accession #
P49736
Protein names
  • DNA replication licensing factor MCM2
  • EC 3.6.4.12
  • Minichromosome maintenance protein 2 homolog
  • Nuclear protein BM28
Gene names
  • MCM2
  • BM28
  • CCNL1
  • CDCL1
  • KIAA0030
Description
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.
Links

Search Kinases of MCM2 (Human)
Phosphorylation Site Information
/2 page