Search Results (32 substrates found)
Gene name
Organism
Protein name
AR
Human
Androgen receptor
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ANDR_HUMAN
- Accession #
-
P10275
- Protein names
-
- Androgen receptor
- Dihydrotestosterone receptor
- Nuclear receptor subfamily 3 group C member 4
- Gene names
-
- AR
- DHTR
- NR3C4
- Description
-
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
- Links
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Search Kinases of AR (Human)
- DNA binding
- RNA polymerase II transcription factor binding
- androgen binding
- androgen receptor activity
- androgen receptor signaling pathway
- beta-catenin binding
- cell death
- cell growth
- cell proliferation
- cell-cell signaling
- chromatin binding
- cytoplasm
- enzyme binding
- gene expression
- intracellular receptor signaling pathway
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- negative regulation of extrinsic apoptotic signaling pathway
- negative regulation of integrin biosynthetic process
- nuclear chromatin
- nucleoplasm
- nucleus
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of cell proliferation
- positive regulation of integrin biosynthetic process
- positive regulation of phosphorylation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase III promoter
- positive regulation of transcription, DNA-templated
- prostate gland development
- protein binding
- protein complex
- protein dimerization activity
- protein oligomerization
- receptor binding
- regulation of establishment of protein localization to plasma membrane
- sequence-specific DNA binding
- sequence-specific DNA binding transcription factor activity
- sex differentiation
- signal transduction
- transcription factor binding
- transcription initiation from RNA polymerase II promoter
- transcription regulatory region DNA binding
- transcription, DNA-templated
- transport
- zinc ion binding

ARPC1B
Human
Actin-related protein 2/3 complex subunit 1B
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ARC1B_HUMAN
- Accession #
-
O15143
- Protein names
-
- Actin-related protein 2/3 complex subunit 1B
- Arp2/3 complex 41 kDa subunit
- p41-ARC
- Gene names
-
- ARPC1B
- ARC41
- Description
-
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
- Links
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Search Kinases of ARPC1B (Human)

AURKA
Human
Aurora kinase A
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
AURKA_HUMAN
- Accession #
-
O14965
- Protein names
-
- Aurora kinase A
- EC 2.7.11.1
- Aurora 2
- Aurora/IPL1-related kinase 1
- ARK-1
- Aurora-related kinase 1
- hARK1
- Breast tumor-amplified kinase
- Serine/threonine-protein kinase 15
- Serine/threonine-protein kinase 6
- Serine/threonine-protein kinase aurora-A
- Gene names
-
- AURKA
- AIK
- AIRK1
- ARK1
- AURA
- AYK1
- BTAK
- IAK1
- STK15
- STK6
- Description
-
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
- Links
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Search Kinases of AURKA (Human)
- ATP binding
- G2/M transition of mitotic cell cycle
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
- cell cycle
- cell projection organization
- centrosome
- cytosol
- microtubule
- microtubule cytoskeleton
- midbody
- mitotic cell cycle
- mitotic nuclear division
- negative regulation of protein binding
- nucleus
- perinuclear region of cytoplasm
- phosphatidylinositol-mediated signaling
- positive regulation of mitosis
- protein autophosphorylation
- protein binding
- protein kinase activity
- protein kinase binding
- protein phosphorylation
- protein serine/threonine kinase activity
- protein serine/threonine/tyrosine kinase activity
- regulation of centrosome cycle
- regulation of protein stability
- spindle
- spindle organization
- spindle pole centrosome
- spindle stabilization

BRCA1
Human
Breast cancer type 1 susceptibility protein
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
BRCA1_HUMAN
- Accession #
-
P38398
- Protein names
-
- Breast cancer type 1 susceptibility protein
- EC 6.3.2.-
- RING finger protein 53
- Gene names
-
- BRCA1
- RNF53
- Description
-
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8.
- Links
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Search Kinases of BRCA1 (Human)
- BRCA1-A complex
- BRCA1-BARD1 complex
- DNA binding
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
- DNA repair
- G2 DNA damage checkpoint
- RNA binding
- androgen receptor binding
- androgen receptor signaling pathway
- apoptotic process
- cellular response to DNA damage stimulus
- cellular response to indole-3-methanol
- chromosome
- chromosome segregation
- cytoplasm
- double-strand break repair
- double-strand break repair via homologous recombination
- enzyme binding
- fatty acid biosynthetic process
- gamma-tubulin ring complex
- intrinsic apoptotic signaling pathway in response to DNA damage
- ligase activity
- negative regulation of centriole replication
- negative regulation of fatty acid biosynthetic process
- negative regulation of histone H3-K9 methylation
- negative regulation of transcription, DNA-templated
- nucleoplasm
- nucleus
- plasma membrane
- positive regulation of DNA repair
- positive regulation of cell cycle arrest
- positive regulation of histone H3-K4 methylation
- positive regulation of histone H3-K9 acetylation
- positive regulation of histone H4-K16 acetylation
- positive regulation of histone H4-K20 methylation
- positive regulation of histone acetylation
- positive regulation of protein ubiquitination
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription, DNA-templated
- postreplication repair
- protein K6-linked ubiquitination
- protein autoubiquitination
- protein binding
- protein complex
- protein ubiquitination
- regulation of apoptotic process
- regulation of cell motility
- regulation of cell proliferation
- regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase III promoter
- response to estrogen
- response to ionizing radiation
- ribonucleoprotein complex
- ruffle
- substrate adhesion-dependent cell spreading
- transcription coactivator activity
- transcription regulatory region DNA binding
- tubulin binding
- ubiquitin ligase complex
- ubiquitin protein ligase binding
- ubiquitin-protein transferase activity
- zinc ion binding

CDC25B
Human
M-phase inducer phosphatase 2
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
MPIP2_HUMAN
- Accession #
-
P30305
- Protein names
-
- M-phase inducer phosphatase 2
- EC 3.1.3.48
- Dual specificity phosphatase Cdc25B
- Gene names
-
- CDC25B
- CDC25HU2
- Description
-
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.
- Links
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Search Kinases of CDC25B (Human)
- G2/M transition of mitotic cell cycle
- centrosome
- cytoplasm
- cytosol
- female meiosis I
- mitotic cell cycle
- mitotic nuclear division
- nucleoplasm
- nucleus
- oocyte maturation
- peptidyl-tyrosine dephosphorylation
- positive regulation of cell proliferation
- positive regulation of cytokinesis
- positive regulation of mitotic cell cycle
- positive regulation of protein kinase activity
- protein binding
- protein kinase binding
- protein phosphorylation
- protein tyrosine phosphatase activity
- spindle pole

CENPA
Human
Histone H3-like centromeric protein A
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CENPA_HUMAN
- Accession #
-
P49450
- Protein names
-
- Histone H3-like centromeric protein A
- Centromere autoantigen A
- Centromere protein A
- CENP-A
- Gene names
-
- CENPA
- Description
-
Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).
- Links
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Search Kinases of CENPA (Human)
N/A
- CENP-A containing nucleosome assembly
- DNA binding
- chromatin binding
- chromosome, centromeric region
- condensed chromosome inner kinetochore
- condensed nuclear chromosome kinetochore
- condensed nuclear chromosome, centromeric region
- cytosol
- establishment of mitotic spindle orientation
- kinetochore assembly
- mitotic cell cycle
- nucleoplasm
- nucleosome
- nucleosome assembly
- nucleus
- protein binding
- protein localization to chromosome, centromeric region
- viral process

CETN2
Human
Centrin-2
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
CETN2_HUMAN
- Accession #
-
P41208
- Protein names
-
- Centrin-2
- Caltractin isoform 1
- Gene names
-
- CETN2
- CALT
- CEN2
- Description
-
Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.
- Links
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Search Kinases of CETN2 (Human)
- ATP binding
- ATP-dependent helicase activity
- G2/M transition of mitotic cell cycle
- XPC complex
- calcium ion binding
- centriole
- centriole replication
- centrosome
- cytosol
- intracellular
- mitotic cell cycle
- mitotic nuclear division
- nucleic acid binding
- nucleotide-excision repair
- photoreceptor connecting cilium
- protein binding
- regulation of cytokinesis
- spermatogenesis

Cpeb1
Mouse
Cytoplasmic polyadenylation element-binding protein 1
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
CPEB1_MOUSE
- Accession #
-
P70166
- Protein names
-
- Cytoplasmic polyadenylation element-binding protein 1
- CPE-BP1
- CPE-binding protein 1
- mCPEB
- mCPEB-1
- Gene names
-
- Cpeb1
- Cpeb
- Description
-
Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the 3'-UTR of mRNAs. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress (By similarity).
- Links
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Search Kinases of Cpeb1 (Mouse)
- RNA binding
- cell junction
- cellular response to amino acid stimulus
- cellular response to hypoxia
- cellular response to insulin stimulus
- cytoplasm
- cytoplasmic mRNA processing body
- mRNA 3'-UTR AU-rich region binding
- mRNA binding
- mRNA processing
- meiotic spindle
- membrane
- metal ion binding
- negative regulation of cytoplasmic translation
- nucleotide binding
- nucleus
- postsynaptic density
- postsynaptic membrane
- protein binding
- regulation of neuronal synaptic plasticity
- regulation of translation
- synaptonemal complex assembly
- translation repressor activity, nucleic acid binding

CRMP1
Human
Dihydropyrimidinase-related protein 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
DPYL1_HUMAN
- Accession #
-
Q14194
- Protein names
-
- Dihydropyrimidinase-related protein 1
- DRP-1
- Collapsin response mediator protein 1
- CRMP-1
- Unc-33-like phosphoprotein 3
- ULIP-3
- Gene names
-
- CRMP1
- DPYSL1
- ULIP3
- Description
-
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis.
- Links
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Search Kinases of CRMP1 (Human)
N/A
- axon guidance
- cytoplasm
- cytosol
- dendrite
- hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
- microtubule organizing center
- nervous system development
- neuronal cell body
- nucleobase-containing compound metabolic process
- protein binding
- pyrimidine nucleobase catabolic process
- spindle

DCTN1
Human
Dynactin subunit 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
DCTN1_HUMAN
- Accession #
-
Q14203
- Protein names
-
- Dynactin subunit 1
- 150 kDa dynein-associated polypeptide
- DAP-150
- DP-150
- p135
- p150-glued
- Gene names
-
- DCTN1
- Description
-
Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.
- Links
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Search Kinases of DCTN1 (Human)
- G2/M transition of mitotic cell cycle
- activation of signaling protein activity involved in unfolded protein response
- antigen processing and presentation of exogenous peptide antigen via MHC class II
- cell death
- cell leading edge
- cellular protein metabolic process
- centrosome
- cytoplasm
- cytosol
- dynactin complex
- dynein complex
- endoplasmic reticulum unfolded protein response
- kinetochore
- microtubule
- microtubule-based transport
- mitotic cell cycle
- mitotic nuclear division
- motor activity
- nervous system development
- protein binding
- spindle pole

DLGAP5
Human
Disks large-associated protein 5
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
DLGP5_HUMAN
- Accession #
-
Q15398
- Protein names
-
- Disks large-associated protein 5
- DAP-5
- Discs large homolog 7
- Disks large-associated protein DLG7
- Hepatoma up-regulated protein
- HURP
- Gene names
-
- DLGAP5
- DLG7
- KIAA0008
- Description
-
Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.
- Links
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Search Kinases of DLGAP5 (Human)
N/A
- cell proliferation
- cell-cell signaling
- cytoplasm
- dephosphorylation
- microtubule organizing center
- mitotic M phase
- mitotic chromosome movement towards spindle pole
- nucleus
- phosphoprotein phosphatase activity
- positive regulation of mitotic metaphase/anaphase transition
- protein binding
- spindle pole centrosome

FADD
Human
FAS-associated death domain protein
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
FADD_HUMAN
- Accession #
-
Q13158
- Protein names
-
- FAS-associated death domain protein
- FAS-associating death domain-containing protein
- Growth-inhibiting gene 3 protein
- Mediator of receptor induced toxicity
- Protein FADD
- Gene names
-
- FADD
- MORT1
- GIG3
- Description
-
Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
- Links
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Search Kinases of FADD (Human)
- CD95 death-inducing signaling complex
- MyD88-independent toll-like receptor signaling pathway
- T cell differentiation in thymus
- T cell homeostasis
- TRIF-dependent toll-like receptor signaling pathway
- activation of cysteine-type endopeptidase activity
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- apoptotic process
- apoptotic signaling pathway
- cell body
- cellular response to mechanical stimulus
- cytosol
- death effector domain binding
- death receptor binding
- death-inducing signaling complex
- defense response to virus
- extrinsic apoptotic signaling pathway
- extrinsic apoptotic signaling pathway in absence of ligand
- extrinsic apoptotic signaling pathway via death domain receptors
- identical protein binding
- innate immune response
- lymph node development
- membrane raft
- motor neuron apoptotic process
- necroptotic signaling pathway
- negative regulation of activation-induced cell death of T cells
- neuron projection
- positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
- positive regulation of I-kappaB kinase/NF-kappaB signaling
- positive regulation of T cell mediated cytotoxicity
- positive regulation of activated T cell proliferation
- positive regulation of adaptive immune response
- positive regulation of apoptotic process
- positive regulation of extrinsic apoptotic signaling pathway
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
- positive regulation of interferon-gamma production
- positive regulation of interleukin-8 production
- positive regulation of macrophage differentiation
- positive regulation of proteolysis
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of tumor necrosis factor production
- positive regulation of type I interferon-mediated signaling pathway
- protease binding
- protein binding
- protein heterooligomerization
- receptor binding
- regulation of extrinsic apoptotic signaling pathway in absence of ligand
- ripoptosome
- spleen development
- thymus development
- toll-like receptor 3 signaling pathway
- toll-like receptor 4 signaling pathway
- toll-like receptor signaling pathway
- tumor necrosis factor receptor superfamily binding
- viral process

FAF1
Human
FAS-associated factor 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
FAF1_HUMAN
- Accession #
-
Q9UNN5
- Protein names
-
- FAS-associated factor 1
- hFAF1
- UBX domain-containing protein 12
- UBX domain-containing protein 3A
- Gene names
-
- FAF1
- UBXD12
- UBXN3A
- CGI-03
- Description
-
Potentiates but cannot initiate FAS-induced apoptosis.
- Links
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Search Kinases of FAF1 (Human)
N/A
- CD95 death-inducing signaling complex
- Cdc48p-Npl4p-Ufd1p AAA ATPase complex
- NF-kappaB binding
- apoptotic process
- cell death
- cytoplasmic sequestering of NF-kappaB
- cytosol
- heat shock protein binding
- nuclear envelope
- nucleus
- perinuclear region of cytoplasm
- positive regulation of apoptotic process
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
- positive regulation of protein complex assembly
- proteasome-mediated ubiquitin-dependent protein catabolic process
- protein binding
- protein kinase binding
- protein kinase regulator activity
- regulation of cell adhesion
- regulation of protein catabolic process
- regulation of protein kinase activity
- ubiquitin binding
- ubiquitin protein ligase binding

GSK3B
Human
Glycogen synthase kinase-3 beta
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
GSK3B_HUMAN
- Accession #
-
P49841
- Protein names
-
- Glycogen synthase kinase-3 beta
- GSK-3 beta
- EC 2.7.11.26
- Serine/threonine-protein kinase GSK3B
- EC 2.7.11.1
- Gene names
-
- GSK3B
- Description
-
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates SFPQ at 'Thr-687' upon T-cell activation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2. Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation. Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation. Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity.
- Links
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Search Kinases of GSK3B (Human)
- Alzheimer's disease
- Axon guidance
- B cell receptor signaling pathway
- Basal cell carcinoma
- Cell cycle
- Chemokine signaling pathway
- Colorectal cancer
- Dopaminergic synapse
- Endometrial cancer
- Epstein-Barr virus infection
- ErbB signaling pathway
- Focal adhesion
- HTLV-I infection
- Hedgehog signaling pathway
- Hepatitis C
- Hippo signaling pathway
- Influenza A
- Insulin signaling pathway
- Measles
- Melanogenesis
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease (NAFLD)
- PI3K-Akt signaling pathway
- Pathways in cancer
- Prolactin signaling pathway
- Prostate cancer
- Signaling pathways regulating pluripotency of stem cells
- T cell receptor signaling pathway
- Thyroid hormone signaling pathway
- Wnt signaling pathway
- ATP binding
- ER overload response
- Fc-epsilon receptor signaling pathway
- NF-kappaB binding
- RNA polymerase II transcription factor binding
- axon guidance
- beta-catenin binding
- beta-catenin destruction complex
- canonical Wnt signaling pathway
- canonical Wnt signaling pathway involved in positive regulation of apoptotic process
- cell migration
- cellular response to interleukin-3
- cellular response to mechanical stimulus
- centrosome
- circadian rhythm
- cytoplasm
- cytosol
- dendritic shaft
- dendritic spine
- epidermal growth factor receptor signaling pathway
- epithelial to mesenchymal transition
- establishment of cell polarity
- extrinsic apoptotic signaling pathway in absence of ligand
- fat cell differentiation
- fibroblast growth factor receptor signaling pathway
- glycogen metabolic process
- growth cone
- hippocampus development
- hypermethylation of CpG island
- innate immune response
- intracellular signal transduction
- kinase activity
- membrane raft
- myoblast fusion
- negative regulation of MAP kinase activity
- negative regulation of NFAT protein import into nucleus
- negative regulation of apoptotic process
- negative regulation of canonical Wnt signaling pathway
- negative regulation of cardiac muscle hypertrophy
- negative regulation of dendrite morphogenesis
- negative regulation of glycogen (starch) synthase activity
- negative regulation of glycogen biosynthetic process
- negative regulation of protein binding
- negative regulation of protein complex assembly
- negative regulation of type B pancreatic cell development
- neuronal cell body
- neurotrophin TRK receptor signaling pathway
- nucleus
- organ morphogenesis
- p53 binding
- peptidyl-serine phosphorylation
- perinuclear region of cytoplasm
- phosphatidylinositol-mediated signaling
- plasma membrane
- positive regulation of Rac GTPase activity
- positive regulation of cell-matrix adhesion
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of peptidyl-threonine phosphorylation
- positive regulation of protein binding
- positive regulation of protein catabolic process
- positive regulation of protein complex assembly
- positive regulation of protein export from nucleus
- positive regulation of stem cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- protein binding
- protein export from nucleus
- protein kinase A catalytic subunit binding
- protein kinase binding
- protein localization to microtubule
- protein phosphorylation
- protein serine/threonine kinase activity
- re-entry into mitotic cell cycle
- regulation of gene expression by genetic imprinting
- regulation of microtubule-based process
- regulation of neuronal synaptic plasticity
- response to drug
- response to lithium ion
- ribonucleoprotein complex
- superior temporal gyrus development
- tau-protein kinase activity
- ubiquitin protein ligase binding

HIST1H3A
Human
Histone H3.1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
H31_HUMAN
- Accession #
-
P68431
- Protein names
-
- Histone H3.1
- Histone H3/a
- Histone H3/b
- Histone H3/c
- Histone H3/d
- Histone H3/f
- Histone H3/h
- Histone H3/i
- Histone H3/j
- Histone H3/k
- Histone H3/l
- Gene names
-
- HIST1H3A
- H3FA
- HIST1H3B
- H3FL
- Description
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Links
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Search Kinases of HIST1H3A (Human)

LATS2
Human
Serine/threonine-protein kinase LATS2
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
LATS2_HUMAN
- Accession #
-
Q9NRM7
- Protein names
-
- Serine/threonine-protein kinase LATS2
- EC 2.7.11.1
- Kinase phosphorylated during mitosis protein
- Large tumor suppressor homolog 2
- Serine/threonine-protein kinase kpm
- Warts-like kinase
- Gene names
-
- LATS2
- KPM
- Description
-
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.
- Links
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Search Kinases of LATS2 (Human)
- ATP binding
- G1/S transition of mitotic cell cycle
- cellular protein localization
- cytosol
- hippo signaling
- hormone-mediated signaling pathway
- intracellular signal transduction
- keratinocyte differentiation
- metal ion binding
- microtubule organizing center
- mitotic nuclear division
- negative regulation of canonical Wnt signaling pathway
- negative regulation of cyclin-dependent protein serine/threonine kinase activity
- nucleus
- protein binding
- protein phosphorylation
- protein serine/threonine kinase activity
- regulation of organ growth
- spindle pole

MAP9
Human
Microtubule-associated protein 9
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
MAP9_HUMAN
- Accession #
-
Q49MG5
- Protein names
-
- Microtubule-associated protein 9
- Aster-associated protein
- Gene names
-
- MAP9
- ASAP
- Description
-
Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules.
- Links
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Search Kinases of MAP9 (Human)
N/A

MAPRE3
Human
Microtubule-associated protein RP/EB family member 3
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
MARE3_HUMAN
- Accession #
-
Q9UPY8
- Protein names
-
- Microtubule-associated protein RP/EB family member 3
- EB1 protein family member 3
- EBF3
- End-binding protein 3
- EB3
- RP3
- Gene names
-
- MAPRE3
- Description
-
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).
- Links
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Search Kinases of MAPRE3 (Human)
N/A

MBD3
Human
Methyl-CpG-binding domain protein 3
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
MBD3_HUMAN
- Accession #
-
O95983
- Protein names
-
- Methyl-CpG-binding domain protein 3
- Methyl-CpG-binding protein MBD3
- Gene names
-
- MBD3
- Description
-
Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (PubMed:12124384). Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases.
- Links
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Search Kinases of MBD3 (Human)
N/A
- ATP-dependent chromatin remodeling
- DNA binding
- NuRD complex
- chromatin binding
- cytoplasm
- heterochromatin
- histone acetylation
- in utero embryonic development
- methyl-CpG binding
- methylation-dependent chromatin silencing
- negative regulation of transcription from RNA polymerase II promoter
- nuclear chromatin
- protein binding
- protein complex
- tissue development
- transcription, DNA-templated

MCM2
Human
DNA replication licensing factor MCM2
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
MCM2_HUMAN
- Accession #
-
P49736
- Protein names
-
- DNA replication licensing factor MCM2
- EC 3.6.4.12
- Minichromosome maintenance protein 2 homolog
- Nuclear protein BM28
- Gene names
-
- MCM2
- BM28
- CCNL1
- CDCL1
- KIAA0030
- Description
-
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.
- Links
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Search Kinases of MCM2 (Human)
- ATP binding
- DNA binding
- DNA helicase activity
- DNA replication
- DNA replication initiation
- DNA replication origin binding
- DNA strand elongation involved in DNA replication
- DNA unwinding involved in DNA replication
- G1/S transition of mitotic cell cycle
- MCM complex
- cell cycle
- cellular response to interleukin-4
- chromatin
- cytoplasm
- metal ion binding
- microtubule cytoskeleton
- mitotic cell cycle
- nuclear origin of replication recognition complex
- nucleoplasm
- nucleosome assembly
- nucleus
- protein binding
