Search Results (455 substrates found)
Gene name
Organism
Protein name
Aak1
Mouse
AP2-associated protein kinase 1
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
AAK1_MOUSE
- Accession #
-
Q3UHJ0
- Protein names
-
- AP2-associated protein kinase 1
- EC 2.7.11.1
- Adaptor-associated kinase 1
- Gene names
-
- Aak1
- Kiaa1048
- Description
-
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Preferentially, may phosphorylate substrates on threonine residues. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity. {ECO:0000250|UniProtKB:Q2M2I8}.
- Links
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Search Kinases of Aak1 (Mouse)
N/A
- AP-2 adaptor complex binding
- ATP binding
- Notch binding
- cell leading edge
- clathrin complex
- clathrin-coated pit
- clathrin-coated vesicle
- cytoplasm
- endocytosis
- extrinsic component of plasma membrane
- positive regulation of Notch signaling pathway
- presynapse
- protein autophosphorylation
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- protein stabilization
- regulation of clathrin-dependent endocytosis
- regulation of protein localization
- terminal bouton

ABI1
Human
Abl interactor 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ABI1_HUMAN
- Accession #
-
Q8IZP0
- Protein names
-
- Abl interactor 1
- Abelson interactor 1
- Abi-1
- Abl-binding protein 4
- AblBP4
- Eps8 SH3 domain-binding protein
- Eps8-binding protein
- Nap1-binding protein
- Nap1BP
- Spectrin SH3 domain-binding protein 1
- e3B1
- Gene names
-
- ABI1
- SSH3BP1
- Description
-
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}.
- Links
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Search Kinases of ABI1 (Human)
- Fc-gamma receptor signaling pathway involved in phagocytosis
- SCAR complex
- SH3 domain binding
- actin polymerization or depolymerization
- cadherin binding
- cytoskeletal protein binding
- cytoskeleton
- cytosol
- endoplasmic reticulum
- extracellular exosome
- filopodium tip
- growth cone
- lamellipodium
- negative regulation of cell population proliferation
- nucleus
- peptidyl-tyrosine phosphorylation
- postsynaptic density
- protein tyrosine kinase activator activity
- signaling adaptor activity
- transmembrane receptor protein tyrosine kinase signaling pathway
- vascular endothelial growth factor receptor signaling pathway
- viral process

Abi2
Mouse
Abi2 protein
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
Q6AXD2_MOUSE
- Accession #
- Q6AXD2
- Protein names
-
- Abi2 protein
- Abl interactor 2
- Gene names
-
- Abi2
- Description
-
N/A
- Links
-
Search Kinases of Abi2 (Mouse)
N/A

Abl2
Mouse
Tyrosine-protein kinase
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
F8VQH0_MOUSE
- Accession #
- F8VQH0
- Protein names
-
- Tyrosine-protein kinase
- EC 2.7.10.2
- Gene names
-
- Abl2
- Description
-
N/A
- Links
-
Search Kinases of Abl2 (Mouse)
N/A
- ATP binding
- cellular response to retinoic acid
- magnesium ion binding
- manganese ion binding
- non-membrane spanning protein tyrosine kinase activity
- phosphotyrosine residue binding
- positive regulation of cytosolic calcium ion concentration
- positive regulation of neuron projection development
- positive regulation of oxidoreductase activity
- positive regulation of phospholipase C activity
- transmembrane receptor protein tyrosine kinase activity

Ablim1
Mouse
Actin-binding LIM protein 1
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
E9Q9Q7_MOUSE
- Accession #
- E9Q9Q7
- Protein names
-
- Actin-binding LIM protein 1
- Gene names
-
- Ablim1
- Description
-
N/A
- Links
-
Search Kinases of Ablim1 (Mouse)
N/A

Adam17
Mouse
Disintegrin and metalloproteinase domain-containing protein 17
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
ADA17_MOUSE
- Accession #
-
Q9Z0F8
- Protein names
-
- Disintegrin and metalloproteinase domain-containing protein 17
- ADAM 17
- EC 3.4.24.86
- TNF-alpha convertase
- TNF-alpha-converting enzyme
- CD antigen CD156b
- Gene names
-
- Adam17
- Tace
- Description
-
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Plays a role in the proteolytic processing of ACE2 (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:10799547, PubMed:11108241). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called notch extracellular truncation (NEXT) (PubMed:10882063). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (PubMed:12907434). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (PubMed:17245433). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (By similarity). {ECO:0000250|UniProtKB:P78536, ECO:0000269|PubMed:10799547, ECO:0000269|PubMed:10882063, ECO:0000269|PubMed:11108241, ECO:0000269|PubMed:12907434, ECO:0000269|PubMed:17245433}.
- Links
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Search Kinases of Adam17 (Mouse)
- B cell differentiation
- Notch binding
- Notch receptor processing
- Notch signaling pathway
- PDZ domain binding
- SH3 domain binding
- T cell differentiation in thymus
- actin cytoskeleton
- amyloid precursor protein catabolic process
- apical part of cell
- apical plasma membrane
- cell adhesion
- cell adhesion mediated by integrin
- cell motility
- cell surface
- cellular response to high density lipoprotein particle stimulus
- cytoplasm
- cytoplasmic vesicle
- cytosol
- defense response to Gram-positive bacterium
- endopeptidase activity
- epidermal growth factor receptor signaling pathway
- extracellular region
- germinal center formation
- integral component of plasma membrane
- integrin binding
- interleukin-6 receptor binding
- membrane
- membrane protein ectodomain proteolysis
- membrane raft
- metal ion binding
- metalloendopeptidase activity
- metalloendopeptidase activity involved in amyloid precursor protein catabolic process
- metallopeptidase activity
- negative regulation of apoptotic process
- negative regulation of cold-induced thermogenesis
- negative regulation of neuron projection development
- negative regulation of transforming growth factor beta receptor signaling pathway
- plasma membrane
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of G1/S transition of mitotic cell cycle
- positive regulation of T cell chemotaxis
- positive regulation of apoptotic process
- positive regulation of blood vessel endothelial cell migration
- positive regulation of cell growth
- positive regulation of cell migration
- positive regulation of cell population proliferation
- positive regulation of cellular component movement
- positive regulation of chemokine production
- positive regulation of cyclin-dependent protein serine/threonine kinase activity
- positive regulation of epidermal growth factor-activated receptor activity
- positive regulation of neuron projection development
- positive regulation of protein phosphorylation
- positive regulation of transforming growth factor beta receptor signaling pathway
- positive regulation of tumor necrosis factor-mediated signaling pathway
- positive regulation of vascular endothelial cell proliferation
- production of molecular mediator involved in inflammatory response
- protein processing
- proteolysis
- receptor transactivation
- regulation of axon regeneration
- regulation of mast cell apoptotic process
- regulation of neuron migration
- response to hypoxia
- response to lipopolysaccharide
- spleen development

ADAM17
Human
Disintegrin and metalloproteinase domain-containing protein 17
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
ADA17_HUMAN
- Accession #
-
P78536
- Protein names
-
- Disintegrin and metalloproteinase domain-containing protein 17
- ADAM 17
- EC 3.4.24.86
- Snake venom-like protease
- TNF-alpha convertase
- TNF-alpha-converting enzyme
- CD antigen CD156b
- Gene names
-
- ADAM17
- CSVP
- TACE
- Description
-
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:12441351). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (PubMed:26876177, PubMed:28060820). {ECO:0000250|UniProtKB:Q9Z0F8, ECO:0000269|PubMed:12441351, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:24226769, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:28060820, ECO:0000269|PubMed:9034191}.
- Links
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Search Kinases of ADAM17 (Human)
- B cell differentiation
- Golgi membrane
- Notch binding
- Notch receptor processing
- Notch signaling pathway
- PDZ domain binding
- SH3 domain binding
- T cell differentiation in thymus
- actin cytoskeleton
- amyloid precursor protein catabolic process
- apical plasma membrane
- cell adhesion
- cell adhesion mediated by integrin
- cell motility
- cell surface
- cellular response to high density lipoprotein particle stimulus
- cytoplasm
- cytosol
- defense response to Gram-positive bacterium
- endopeptidase activity
- endoplasmic reticulum lumen
- epidermal growth factor receptor signaling pathway
- germinal center formation
- integral component of plasma membrane
- integrin binding
- interleukin-6 receptor binding
- membrane
- membrane protein ectodomain proteolysis
- membrane protein intracellular domain proteolysis
- membrane raft
- metal ion binding
- metalloendopeptidase activity
- metalloendopeptidase activity involved in amyloid precursor protein catabolic process
- metallopeptidase activity
- negative regulation of cold-induced thermogenesis
- negative regulation of inflammatory response to antigenic stimulus
- negative regulation of transforming growth factor beta receptor signaling pathway
- neutrophil mediated immunity
- peptidase activity
- plasma membrane
- positive regulation of G1/S transition of mitotic cell cycle
- positive regulation of T cell chemotaxis
- positive regulation of blood vessel endothelial cell migration
- positive regulation of cell growth
- positive regulation of cell migration
- positive regulation of cell population proliferation
- positive regulation of cellular component movement
- positive regulation of chemokine production
- positive regulation of cyclin-dependent protein serine/threonine kinase activity
- positive regulation of epidermal growth factor-activated receptor activity
- positive regulation of leukocyte chemotaxis
- positive regulation of protein phosphorylation
- positive regulation of transforming growth factor beta receptor signaling pathway
- positive regulation of tumor necrosis factor-mediated signaling pathway
- positive regulation of vascular endothelial cell proliferation
- protein processing
- proteolysis
- receptor transactivation
- regulation of mast cell apoptotic process
- response to hypoxia
- response to lipopolysaccharide
- spleen development
- tumor necrosis factor-mediated signaling pathway
- wound healing, spreading of epidermal cells

Aebp1
Mouse
Adipocyte enhancer-binding protein 1
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
AEBP1_MOUSE
- Accession #
-
Q640N1
- Protein names
-
- Adipocyte enhancer-binding protein 1
- AE-binding protein 1
- Aortic carboxypeptidase-like protein
- Gene names
-
- Aebp1
- Aclp
- Description
-
[Isoform 1]: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix. {ECO:0000250|UniProtKB:Q8IUX7}.; [Isoform 2]: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. {ECO:0000269|PubMed:10406805, ECO:0000269|PubMed:11152475, ECO:0000269|PubMed:11438679, ECO:0000269|PubMed:14729459, ECO:0000269|PubMed:16307171, ECO:0000269|PubMed:16461908, ECO:0000269|PubMed:16538615, ECO:0000269|PubMed:17202411, ECO:0000269|PubMed:7477299}.
- Links
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Search Kinases of Aebp1 (Mouse)
N/A
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- calmodulin binding
- carboxypeptidase activity
- collagen binding
- cytoplasm
- extracellular space
- negative regulation of transcription by RNA polymerase II
- nucleus
- regulation of collagen fibril organization
- regulation of transcription, DNA-templated
- zinc ion binding

Afdn
Mouse
Afadin
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
E9Q9C3_MOUSE
- Accession #
- E9Q9C3
- Protein names
-
- Afadin
- Gene names
-
- Afdn
- Description
-
N/A
- Links
-
Search Kinases of Afdn (Mouse)
N/A

Agap2
Mouse
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
AGAP2_MOUSE
- Accession #
-
Q3UHD9
- Protein names
-
- Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
- AGAP-2
- Centaurin-gamma-1
- Cnt-g1
- Phosphatidylinositol 3-kinase enhancer
- PIKE
- Gene names
-
- Agap2
- Centg1
- Kiaa0167
- Description
-
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. Aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase (By similarity). {ECO:0000250}.
- Links
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Search Kinases of Agap2 (Mouse)
- ATP binding
- Flemming body
- GTP binding
- GTPase activator activity
- GTPase activity
- actin cytoskeleton organization
- cytoplasm
- cytosol
- endosomal transport
- endosome
- mammary gland alveolus development
- metal ion binding
- negative regulation of apoptotic process
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- negative regulation of neuron apoptotic process
- negative regulation of protein catabolic process
- nucleoplasm
- nucleus
- phosphatidylinositol 3-kinase regulator activity
- positive regulation of mammary gland epithelial cell proliferation
- positive regulation of phosphatidylinositol 3-kinase signaling
- positive regulation of protein kinase activity
- positive regulation of receptor signaling pathway via JAK-STAT
- positive regulation of transcription by RNA polymerase II
- protein kinase activator activity
- protein kinase binding

Agfg1
Mouse
Arf-GAP domain and FG repeat-containing protein 1
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
AGFG1_MOUSE
- Accession #
-
Q8K2K6
- Protein names
-
- Arf-GAP domain and FG repeat-containing protein 1
- HIV-1 Rev-binding protein homolog
- Nucleoporin-like protein RIP
- Gene names
-
- Agfg1
- Hrb
- Rip
- Description
-
Required for vesicle docking or fusion during acrosome biogenesis. May play a role in RNA trafficking or localization. {ECO:0000269|PubMed:11711676}.
- Links
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Search Kinases of Agfg1 (Mouse)
N/A
- DNA binding
- GTPase activator activity
- acrosome assembly
- cell projection
- cytoplasmic vesicle
- intermediate filament organization
- intracellular membrane-bounded organelle
- metal ion binding
- multicellular organism development
- neuronal cell body
- nucleus
- positive regulation of GTPase activity
- spermatid nucleus differentiation

Ahctf1
Mouse
Protein ELYS
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
ELYS_MOUSE
- Accession #
-
Q8CJF7
- Protein names
-
- Protein ELYS
- Embryonic large molecule derived from yolk sac
- Protein MEL-28
- Putative AT-hook-containing transcription factor 1
- Gene names
-
- Ahctf1
- Elys
- Description
-
Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis (By similarity). Has also been proposed to function as a transcription factor which may play a specific role in hematopoietic tissues (PubMed:11952839). {ECO:0000250, ECO:0000269|PubMed:11952839}.
- Links
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Search Kinases of Ahctf1 (Mouse)

Ahnak2
Mouse
AHNAK nucleoprotein 2
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
Q3URZ6_MOUSE
- Accession #
- Q3URZ6
- Protein names
-
- AHNAK nucleoprotein 2
- Gene names
-
- Ahnak2
- AI450948
- Description
-
N/A
- Links
-
Search Kinases of Ahnak2 (Mouse)
N/A

Akap12
Mouse
A-kinase anchor protein 12
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
AKA12_MOUSE
- Accession #
-
Q9WTQ5
- Protein names
-
- A-kinase anchor protein 12
- AKAP-12
- Germ cell lineage protein gercelin
- Src-suppressed C kinase substrate
- SSeCKS
- Gene names
-
- Akap12
- Gag12
- Ssecks
- Description
-
Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). {ECO:0000250}.
- Links
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Search Kinases of Akap12 (Mouse)
N/A
- Schaffer collateral - CA1 synapse
- adenylate cyclase binding
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
- calmodulin binding
- cellular response to interleukin-1
- cellular response to tumor necrosis factor
- cytoplasm
- cytoskeleton
- cytosol
- hepatic stellate cell activation
- modulation of chemical synaptic transmission
- negative regulation of vascular permeability
- neuronal cell body
- plasma membrane
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of hepatic stellate cell migration
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of oligodendrocyte apoptotic process
- positive regulation of protein kinase A signaling
- positive regulation of tumor necrosis factor production
- protein kinase A binding
- regulation of protein kinase A signaling
- regulation of protein kinase C signaling
- response to electrical stimulus
- response to lipopolysaccharide
- signal transduction
- signaling receptor complex adaptor activity

Akap6
Mouse
Uncharacterized protein
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
Q3UHI8_MOUSE
- Accession #
-
Q3UHI8
- Protein names
-
- Uncharacterized protein
- Gene names
-
- Akap6
- Description
-
N/A
- Links
-
Search Kinases of Akap6 (Mouse)
N/A
- T-tubule
- adenylate cyclase binding
- calcium channel complex
- caveola
- cellular response to cAMP
- cellular response to cytokine stimulus
- cellular response to epinephrine stimulus
- cytoplasm
- enzyme binding
- intercalated disc
- junctional sarcoplasmic reticulum membrane
- molecular adaptor activity
- negative regulation of adenylate cyclase activity
- nuclear envelope
- nuclear membrane
- nucleus
- perinuclear region of cytoplasm
- positive regulation of cAMP-dependent protein kinase activity
- positive regulation of calcineurin-NFAT signaling cascade
- positive regulation of cell growth
- positive regulation of cell growth involved in cardiac muscle cell development
- positive regulation of delayed rectifier potassium channel activity
- positive regulation of potassium ion transmembrane transport
- positive regulation of protein phosphorylation
- positive regulation of release of sequestered calcium ion into cytosol
- positive regulation of ryanodine-sensitive calcium-release channel activity
- positive regulation of translation
- protein kinase A binding
- protein kinase A regulatory subunit binding
- protein phosphatase 2A binding
- protein-containing complex
- protein-membrane adaptor activity
- regulation of cardiac muscle cell contraction
- regulation of membrane repolarization
- regulation of protein kinase A signaling
- regulation of relaxation of cardiac muscle
- sarcolemma
- sarcoplasmic reticulum
- transmembrane transporter binding

Akt1
Mouse
RAC-alpha serine/threonine-protein kinase
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
AKT1_MOUSE
- Accession #
-
P31750
- Protein names
-
- RAC-alpha serine/threonine-protein kinase
- EC 2.7.11.1
- AKT1 kinase
- Protein kinase B
- PKB
- Protein kinase B alpha
- PKB alpha
- Proto-oncogene c-Akt
- RAC-PK-alpha
- Thymoma viral proto-oncogene
- Gene names
-
- Akt1
- Akt
- Rac
- Description
-
AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported (PubMed:11882383, PubMed:21620960, PubMed:21432781). AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface (PubMed:9415393). Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling (PubMed:11579209). Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport (PubMed:11994271). AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity (PubMed:22057101). Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven (PubMed:22057101). AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1 (By similarity). AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis (By similarity). Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis (PubMed:10454575). Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity (By similarity). The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth (By similarity). AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (PubMed:19778506). Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I) (PubMed:11282895, PubMed:18288188). AKT mediates the antiapoptotic effects of IGF-I (PubMed:11282895). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (By similarity). May be involved in the regulation of the placental development (PubMed:12783884). Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation. Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation. Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity. Phosphorylation of BAD stimulates its pro-apoptotic activity. Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53. Phosphorylates palladin (PALLD), modulating cytoskeletal organization and cell motility. Phosphorylates prohibitin (PHB), playing an important role in cell metabolism and proliferation. Phosphorylates CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation (By similarity). Phosphorylates PCK1 at 'Ser-90', reducing the binding affinity of PCK1 to oxaloacetate and changing PCK1 into an atypical protein kinase activity using GTP as donor (By similarity). Also acts as an activator of TMEM175 potassium channel activity in response to growth factors: forms the lysoK(GF) complex together with TMEM175 and acts by promoting TMEM175 channel activation, independently of its protein kinase activity (PubMed:32228865). {ECO:0000250|UniProtKB:P31749, ECO:0000250|UniProtKB:P47196, ECO:0000269|PubMed:10454575, ECO:0000269|PubMed:11282895, ECO:0000269|PubMed:11579209, ECO:0000269|PubMed:11994271, ECO:0000269|PubMed:12783884, ECO:0000269|PubMed:18288188, ECO:0000269|PubMed:19778506, ECO:0000269|PubMed:22057101, ECO:0000269|PubMed:32228865, ECO:0000269|PubMed:9415393, ECO:0000303|PubMed:11882383, ECO:0000303|PubMed:21432781, ECO:0000303|PubMed:21620960}.
- Links
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Search Kinases of Akt1 (Mouse)
- AGE
- AMPK signaling pathway
- Acute myeloid leukemia
- Adipocytokine signaling pathway
- Adrenergic signaling in cardiomyocytes
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy
- B cell receptor signaling pathway
- Breast cancer
- C
- Carbohydrate digestion and absorption
- Cellular senescence
- Central carbon metabolism in cancer
- Chagas disease
- Chemical carcinogenesis
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- Diabetic cardiomyopathy
- Dopaminergic synapse
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- Epstein
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- Gastric cancer
- Glioma
- Glucagon signaling pathway
- GnRH secretion
- Growth hormone synthesis, secretion and action
- HIF
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Herpes simplex virus 1 infection
- Human T
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Influenza A
- Insulin resistance
- Insulin signaling pathway
- JAK
- Kaposi sarcoma
- Lipid and atherosclerosis
- Longevity regulating pathway
- MAPK signaling pathway
- Measles
- Melanoma
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non
- Osteoclast differentiation
- PD
- PI3K
- Pancreatic cancer
- Pathways in cancer
- Phospholipase D signaling pathway
- Platelet activation
- Platinum drug resistance
- Progesterone
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renal cell carcinoma
- Salmonella infection
- Signaling pathways regulating pluripotency of stem cells
- Small cell lung cancer
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Thyroid hormone signaling pathway
- Toll
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
- cAMP signaling pathway
- cGMP
- mTOR signaling pathway
- 14-3-3 protein binding
- ATP binding
- GTPase activating protein binding
- I-kappaB kinase/NF-kappaB signaling
- NIK/NF-kappaB signaling
- activation-induced cell death of T cells
- aging
- apoptotic mitochondrial changes
- calmodulin binding
- carbohydrate transport
- cell migration involved in sprouting angiogenesis
- cell projection organization
- cell-cell junction
- cellular response to DNA damage stimulus
- cellular response to cadmium ion
- cellular response to decreased oxygen levels
- cellular response to epidermal growth factor stimulus
- cellular response to granulocyte macrophage colony-stimulating factor stimulus
- cellular response to growth factor stimulus
- cellular response to hypoxia
- cellular response to insulin stimulus
- cellular response to mechanical stimulus
- cellular response to nerve growth factor stimulus
- cellular response to organic cyclic compound
- cellular response to oxidised low-density lipoprotein particle stimulus
- cellular response to peptide
- cellular response to prostaglandin E stimulus
- cellular response to reactive oxygen species
- cellular response to tumor necrosis factor
- cellular response to vascular endothelial growth factor stimulus
- ciliary basal body
- cytoplasm
- cytoskeleton organization
- cytosol
- enzyme binding
- epidermal growth factor receptor signaling pathway
- establishment of protein localization to mitochondrion
- execution phase of apoptosis
- gene expression
- germ cell development
- glucose homeostasis
- glucose metabolic process
- glycogen biosynthetic process
- glycogen cell differentiation involved in embryonic placenta development
- glycogen metabolic process
- hyaluronan metabolic process
- identical protein binding
- inflammatory response
- insulin receptor signaling pathway
- insulin-like growth factor receptor signaling pathway
- interleukin-18-mediated signaling pathway
- intracellular signal transduction
- kinase activity
- labyrinthine layer blood vessel development
- lipopolysaccharide-mediated signaling pathway
- maintenance of protein location in mitochondrion
- maternal placenta development
- microtubule cytoskeleton
- mitochondrion
- negative regulation of JNK cascade
- negative regulation of apoptotic process
- negative regulation of autophagy
- negative regulation of calcium import into the mitochondrion
- negative regulation of cell size
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of endopeptidase activity
- negative regulation of fatty acid beta-oxidation
- negative regulation of gene expression
- negative regulation of intrinsic apoptotic signaling pathway
- negative regulation of leukocyte cell-cell adhesion
- negative regulation of long-chain fatty acid import across plasma membrane
- negative regulation of lymphocyte migration
- negative regulation of protein binding
- negative regulation of protein kinase activity
- negative regulation of protein ubiquitination
- negative regulation of proteolysis
- negative regulation of release of cytochrome c from mitochondria
- negative regulation of superoxide anion generation
- nitric-oxide synthase regulator activity
- nucleoplasm
- nucleus
- osteoblast differentiation
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- peripheral nervous system myelin maintenance
- phosphatidylinositol 3-kinase signaling
- phosphatidylinositol-3,4,5-trisphosphate binding
- phosphatidylinositol-3,4-bisphosphate binding
- phosphorylation
- plasma membrane
- positive regulation of DNA-binding transcription factor activity
- positive regulation of G1/S transition of mitotic cell cycle
- positive regulation of I-kappaB phosphorylation
- positive regulation of apoptotic process
- positive regulation of blood vessel endothelial cell migration
- positive regulation of cell growth
- positive regulation of cell population proliferation
- positive regulation of cellular protein metabolic process
- positive regulation of cyclin-dependent protein serine/threonine kinase activity
- positive regulation of endodeoxyribonuclease activity
- positive regulation of endothelial cell migration
- positive regulation of endothelial cell proliferation
- positive regulation of fat cell differentiation
- positive regulation of fibroblast migration
- positive regulation of gene expression
- positive regulation of glucose import
- positive regulation of glucose metabolic process
- positive regulation of glycogen biosynthetic process
- positive regulation of lipid biosynthetic process
- positive regulation of mitochondrial membrane potential
- positive regulation of nitric oxide biosynthetic process
- positive regulation of nitric-oxide synthase activity
- positive regulation of organ growth
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of protein localization to cell surface
- positive regulation of protein localization to nucleus
- positive regulation of protein localization to plasma membrane
- positive regulation of protein phosphorylation
- positive regulation of smooth muscle cell proliferation
- positive regulation of sodium ion transport
- positive regulation of transcription by RNA polymerase II
- positive regulation of transcription, DNA-templated
- positive regulation of vasoconstriction
- potassium channel activator activity
- protein catabolic process
- protein homodimerization activity
- protein import into nucleus
- protein kinase B signaling
- protein kinase C binding
- protein kinase activity
- protein kinase binding
- protein phosphatase 2A binding
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- protein serine/threonine/tyrosine kinase activity
- protein ubiquitination
- protein-containing complex
- regulation of aerobic respiration
- regulation of apoptotic process
- regulation of cell migration
- regulation of glycogen biosynthetic process
- regulation of myelination
- regulation of neuron projection development
- regulation of protein localization
- regulation of translation
- response to UV-A
- response to fluid shear stress
- response to food
- response to growth hormone
- response to hormone
- response to insulin-like growth factor stimulus
- response to ischemia
- response to organic substance
- response to oxidative stress
- signal transduction
- sphingosine-1-phosphate receptor signaling pathway
- spinal cord development
- spindle
- striated muscle cell differentiation
- translation
- vesicle

AKT3
Human
RAC-gamma serine/threonine-protein kinase
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
AKT3_HUMAN
- Accession #
-
Q9Y243
- Protein names
-
- RAC-gamma serine/threonine-protein kinase
- EC 2.7.11.1
- Protein kinase Akt-3
- Protein kinase B gamma
- PKB gamma
- RAC-PK-gamma
- STK-2
- Gene names
-
- AKT3
- PKBG
- Description
-
AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. {ECO:0000269|PubMed:18524868, ECO:0000269|PubMed:21191416}.
- Links
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Search Kinases of AKT3 (Human)
- AGE
- AMPK signaling pathway
- Acute myeloid leukemia
- Adipocytokine signaling pathway
- Adrenergic signaling in cardiomyocytes
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy
- B cell receptor signaling pathway
- Breast cancer
- C
- Carbohydrate digestion and absorption
- Cellular senescence
- Central carbon metabolism in cancer
- Chagas disease
- Chemical carcinogenesis
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- Diabetic cardiomyopathy
- Dopaminergic synapse
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- Epstein
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- Gastric cancer
- Glioma
- Glucagon signaling pathway
- GnRH secretion
- Growth hormone synthesis, secretion and action
- HIF
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Herpes simplex virus 1 infection
- Human T
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Influenza A
- Insulin resistance
- Insulin signaling pathway
- JAK
- Kaposi sarcoma
- Lipid and atherosclerosis
- Longevity regulating pathway
- MAPK signaling pathway
- Measles
- Melanoma
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non
- Osteoclast differentiation
- PD
- PI3K
- Pancreatic cancer
- Pathways in cancer
- Phospholipase D signaling pathway
- Platelet activation
- Platinum drug resistance
- Progesterone
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renal cell carcinoma
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Small cell lung cancer
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Thyroid hormone signaling pathway
- Toll
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
- cAMP signaling pathway
- cGMP
- mTOR signaling pathway
- ATP binding
- brain morphogenesis
- cytoplasm
- homeostasis of number of cells within a tissue
- intracellular signal transduction
- membrane
- mitochondrial genome maintenance
- negative regulation of cellular senescence
- nucleus
- peptidyl-serine phosphorylation
- positive regulation of TOR signaling
- positive regulation of angiogenesis
- positive regulation of artery morphogenesis
- positive regulation of blood vessel endothelial cell migration
- positive regulation of cell migration involved in sprouting angiogenesis
- positive regulation of cell size
- positive regulation of endothelial cell proliferation
- positive regulation of vascular endothelial cell proliferation
- protein kinase activity
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- signal transduction

ALOX5
Human
Polyunsaturated fatty acid 5-lipoxygenase
- Organism
- Human (Homo sapiens)
- Uniprot ID
-
LOX5_HUMAN
- Accession #
-
P09917
- Protein names
-
- Polyunsaturated fatty acid 5-lipoxygenase
- EC 1.13.11.-
- Arachidonate 5-lipoxygenase
- 5-LO
- 5-lipoxygenase
- EC 1.13.11.34
- Gene names
-
- ALOX5
- LOG5
- Description
-
Catalyzes the oxygenation of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to 5-hydroperoxyeicosatetraenoate (5-HPETE) followed by the dehydration to 5,6- epoxyeicosatetraenoate (Leukotriene A4/LTA4), the first two steps in the biosynthesis of leukotrienes, which are potent mediators of inflammation (PubMed:8631361, PubMed:21233389, PubMed:22516296, PubMed:24282679, PubMed:19022417, PubMed:23246375, PubMed:8615788, PubMed:24893149, PubMed:31664810). Also catalyzes the oxygenation of arachidonate into 8-hydroperoxyicosatetraenoate (8-HPETE) and 12-hydroperoxyicosatetraenoate (12-HPETE) (PubMed:23246375). Displays lipoxin synthase activity being able to convert (15S)-HETE into a conjugate tetraene (PubMed:31664810). Although arachidonate is the preferred substrate, this enzyme can also metabolize oxidized fatty acids derived from arachidonate such as (15S)-HETE, eicosapentaenoate (EPA) such as (18R)- and (18S)-HEPE or docosahexaenoate (DHA) which lead to the formation of specialized pro-resolving mediators (SPM) lipoxin and resolvins E and D respectively, therefore it participates in anti-inflammatory responses (PubMed:21206090, PubMed:31664810, PubMed:8615788, PubMed:17114001, PubMed:32404334). Oxidation of DHA directly inhibits endothelial cell proliferation and sprouting angiogenesis via peroxisome proliferator-activated receptor gamma (PPARgamma) (By similarity). It does not catalyze the oxygenation of linoleic acid and does not convert (5S)-HETE to lipoxin isomers (PubMed:31664810). In addition to inflammatory processes, it participates in dendritic cell migration, wound healing through an antioxidant mechanism based on heme oxygenase-1 (HO-1) regulation expression, monocyte adhesion to the endothelium via ITGAM expression on monocytes (By similarity). Moreover, it helps establish an adaptive humoral immunity by regulating primary resting B cells and follicular helper T cells and participates in the CD40-induced production of reactive oxygen species (ROS) after CD40 ligation in B cells through interaction with PIK3R1 that bridges ALOX5 with CD40 (PubMed:21200133). Also may play a role in glucose homeostasis, regulation of insulin secretion and palmitic acid-induced insulin resistance via AMPK (By similarity). Can regulate bone mineralization and fat cell differentiation increases in induced pluripotent stem cells (By similarity). {ECO:0000250|UniProtKB:P48999, ECO:0000269|PubMed:17114001, ECO:0000269|PubMed:19022417, ECO:0000269|PubMed:21200133, ECO:0000269|PubMed:21206090, ECO:0000269|PubMed:21233389, ECO:0000269|PubMed:22516296, ECO:0000269|PubMed:23246375, ECO:0000269|PubMed:24282679, ECO:0000269|PubMed:24893149, ECO:0000269|PubMed:31664810, ECO:0000269|PubMed:32404334, ECO:0000269|PubMed:8615788, ECO:0000269|PubMed:8631361}.
- Links
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Search Kinases of ALOX5 (Human)
- arachidonate 12(S)-lipoxygenase activity
- arachidonate 5-lipoxygenase activity
- arachidonate 8(S)-lipoxygenase activity
- arachidonic acid metabolic process
- cytokine-mediated signaling pathway
- cytosol
- dendritic cell migration
- extracellular region
- extracellular space
- ficolin-1-rich granule lumen
- glucose homeostasis
- hepoxilin biosynthetic process
- humoral immune response
- hydrolase activity
- interleukin-18-mediated signaling pathway
- iron ion binding
- leukocyte chemotaxis involved in inflammatory response
- leukocyte migration involved in inflammatory response
- leukotriene A4 biosynthetic process
- leukotriene biosynthetic process
- leukotriene metabolic process
- leukotriene production involved in inflammatory response
- linoleic acid metabolic process
- lipid oxidation
- lipoxin biosynthetic process
- lipoxygenase pathway
- long-chain fatty acid biosynthetic process
- negative regulation of angiogenesis
- negative regulation of endothelial cell proliferation
- negative regulation of inflammatory response
- negative regulation of response to endoplasmic reticulum stress
- negative regulation of sprouting angiogenesis
- negative regulation of vascular wound healing
- negative regulation of wound healing
- neutrophil degranulation
- nuclear envelope
- nuclear envelope lumen
- nuclear matrix
- nuclear membrane
- nucleoplasm
- oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
- perinuclear region of cytoplasm
- positive regulation of bone mineralization
- positive regulation of leukocyte adhesion to arterial endothelial cell
- regulation of cellular response to oxidative stress
- regulation of cytokine production involved in inflammatory response
- regulation of fat cell differentiation
- regulation of inflammatory response
- regulation of inflammatory response to wounding
- regulation of insulin secretion
- regulation of reactive oxygen species biosynthetic process
- secretory granule lumen

Ampd2
Mouse
AMP deaminase
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
A2AE27_MOUSE
- Accession #
- A2AE27
- Protein names
-
- AMP deaminase
- EC 3.5.4.6
- Gene names
-
- Ampd2
- Description
-
N/A
- Links
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Search Kinases of Ampd2 (Mouse)
N/A

Ankrd34a
Mouse
Ankyrin repeat domain 34A
- Organism
- Mouse (Mus musculus)
- Uniprot ID
-
B2RW11_MOUSE
- Accession #
- B2RW11
- Protein names
-
- Ankyrin repeat domain 34A
- Gene names
-
- Ankrd34a
- Description
-
N/A
- Links
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Search Kinases of Ankrd34a (Mouse)
N/A
N/A
