KANPHOS_Str

Search Results (2 kinases found)

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Gene name
Organism
Protein name
CAMK2A
Human
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Kinase Information
Organism
Human (Homo sapiens)
Uniprot ID
KCC2A_HUMAN
Accession #
Q9UQM7
Protein names
  • Calcium/calmodulin-dependent protein kinase type II subunit alpha
  • CaM kinase II subunit alpha
  • CaMK-II subunit alpha
  • EC 2.7.11.17
Gene names
  • CAMK2A
  • CAMKA
  • KIAA0968
Description
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}.
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Search Substrates of CAMK2A (Human)
Phosphorylation Site Information
CAMK4
Human
Calcium/calmodulin-dependent protein kinase type IV
Kinase Information
Organism
Human (Homo sapiens)
Uniprot ID
KCC4_HUMAN
Accession #
Q16566
Protein names
  • Calcium/calmodulin-dependent protein kinase type IV
  • CaMK IV
  • EC 2.7.11.17
  • CaM kinase-GR
Gene names
  • CAMK4
  • CAMK
  • CAMK-GR
  • CAMKIV
Description
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. {ECO:0000269|PubMed:10617605, ECO:0000269|PubMed:17909078, ECO:0000269|PubMed:18829949, ECO:0000269|PubMed:7961813, ECO:0000269|PubMed:8065343, ECO:0000269|PubMed:8855261, ECO:0000269|PubMed:8980227, ECO:0000269|PubMed:9154845}.
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Search Substrates of CAMK4 (Human)
Phosphorylation Site Information