Search Results (9 kinases found)
Gene name
Organism
Protein name
CAMK1
Human
Calcium/calmodulin-dependent protein kinase type 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
- KCC1A_HUMAN
- Accession #
- Q14012
- Protein names
-
- Calcium/calmodulin-dependent protein kinase type 1
- EC 2.7.11.17
- CaM kinase I
- CaM-KI
- CaM kinase I alpha
- CaMKI-alpha
- Gene names
-
- CAMK1
- Description
-
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I. {ECO:0000250, ECO:0000269|PubMed:11114197, ECO:0000269|PubMed:12193581, ECO:0000269|PubMed:14507913, ECO:0000269|PubMed:14754892, ECO:0000269|PubMed:17056143, ECO:0000269|PubMed:17442826, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:20181577}.
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Search Substrates of CAMK1 (Human)
- ATP binding
- calmodulin binding
- calmodulin-dependent protein kinase activity
- cell cycle
- cell differentiation
- chemical synaptic transmission
- cytosol
- glutamatergic synapse
- negative regulation of protein binding
- nervous system development
- nucleocytoplasmic transport
- nucleus
- peptidyl-serine phosphorylation
- positive regulation of dendritic spine development
- positive regulation of muscle cell differentiation
- positive regulation of neuron projection development
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of protein acetylation
- positive regulation of protein export from nucleus
- positive regulation of protein serine/threonine kinase activity
- positive regulation of synapse structural plasticity
- positive regulation of syncytium formation by plasma membrane fusion
- positive regulation of transcription by RNA polymerase II
- postsynaptic density
- protein phosphorylation
- protein serine kinase activity
- regulation of muscle cell differentiation
- regulation of protein binding
- regulation of protein localization
- signal transduction
CAMK2A
Human
Calcium/calmodulin-dependent protein kinase type II subunit alpha
- Organism
- Human (Homo sapiens)
- Uniprot ID
- KCC2A_HUMAN
- Accession #
- Q9UQM7
- Protein names
-
- Calcium/calmodulin-dependent protein kinase type II subunit alpha
- CaM kinase II subunit alpha
- CaMK-II subunit alpha
- EC 2.7.11.17
- Gene names
-
- CAMK2A
- CAMKA
- KIAA0968
- Description
-
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}.
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Search Substrates of CAMK2A (Human)
- Adrenergic signaling in cardiomyocytes
- Aldosterone synthesis and secretion
- Amphetamine addiction
- Axon guidance
- Calcium signaling pathway
- Cholinergic synapse
- Circadian entrainment
- Cushing syndrome
- Diabetic cardiomyopathy
- Dopaminergic synapse
- ErbB signaling pathway
- Gastric acid secretion
- Glioma
- Glucagon signaling pathway
- GnRH signaling pathway
- HIF
- Inflammatory mediator regulation of TRP channels
- Insulin secretion
- Lipid and atherosclerosis
- Long
- Melanogenesis
- Necroptosis
- Neurotrophin signaling pathway
- Olfactory transduction
- Oocyte meiosis
- Oxytocin signaling pathway
- Parkinson disease
- Pathways in cancer
- Pathways of neurodegeneration
- Proteoglycans in cancer
- Tuberculosis
- Wnt signaling pathway
- cAMP signaling pathway
- ATP binding
- G1/S transition of mitotic cell cycle
- MAPK cascade
- Wnt signaling pathway, calcium modulating pathway
- angiotensin-activated signaling pathway
- calcium ion transport
- calcium- and calmodulin-dependent protein kinase complex
- calcium-dependent protein serine/threonine kinase activity
- calmodulin binding
- calmodulin-dependent protein kinase activity
- cytoplasm
- cytosol
- dendritic spine
- dendritic spine development
- endocytic vesicle membrane
- glutamate receptor binding
- identical protein binding
- interferon-gamma-mediated signaling pathway
- kinase activity
- metal ion binding
- mitochondrion
- negative regulation of hydrolase activity
- neuron projection
- nucleoplasm
- nucleus
- peptidyl-serine phosphorylation
- peptidyl-threonine autophosphorylation
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of calcium ion transport
- positive regulation of cardiac muscle cell apoptotic process
- postsynaptic density
- protein autophosphorylation
- protein homodimerization activity
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- regulation of NMDA receptor activity
- regulation of cellular response to heat
- regulation of endocannabinoid signaling pathway
- regulation of mitochondrial membrane permeability involved in apoptotic process
- regulation of neuron migration
- regulation of neuronal synaptic plasticity
- regulation of neurotransmitter secretion
- response to ischemia
CDK5
Human
Cyclin-dependent-like kinase 5
- Organism
- Human (Homo sapiens)
- Uniprot ID
- CDK5_HUMAN
- Accession #
- Q00535
- Protein names
-
- Cyclin-dependent-like kinase 5
- EC 2.7.11.1
- Cell division protein kinase 5
- Serine/threonine-protein kinase PSSALRE
- Tau protein kinase II catalytic subunit
- TPKII catalytic subunit
- Gene names
-
- CDK5
- CDKN5
- Description
-
Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000269|PubMed:12393264, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15992363, ECO:0000269|PubMed:17009320, ECO:0000269|PubMed:17121855, ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:17611284, ECO:0000269|PubMed:17671990, ECO:0000269|PubMed:18042622, ECO:0000269|PubMed:19081376, ECO:0000269|PubMed:19693690, ECO:0000269|PubMed:20061803, ECO:0000269|PubMed:20213743, ECO:0000269|PubMed:20826806, ECO:0000269|PubMed:21209322, ECO:0000269|PubMed:21220307, ECO:0000269|PubMed:21442427, ECO:0000269|PubMed:21465480, ECO:0000269|PubMed:21499257, ECO:0000269|PubMed:24235147, ECO:0000269|PubMed:9822744}.
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Search Substrates of CDK5 (Human)
- ATP binding
- ErbB-2 class receptor binding
- ErbB-3 class receptor binding
- Hsp90 protein binding
- Schaffer collateral - CA1 synapse
- Schwann cell development
- acetylcholine receptor activator activity
- axon
- axon extension
- axonogenesis
- behavioral response to cocaine
- calcium ion import
- cell division
- cell junction
- cell-matrix adhesion
- cellular response to amyloid-beta
- central nervous system neuron development
- cerebellar cortex formation
- chemical synaptic transmission
- corpus callosum development
- cortical actin cytoskeleton organization
- cyclin-dependent protein serine/threonine kinase activity
- cytoplasm
- cytosol
- dendrite
- dendrite morphogenesis
- ephrin receptor binding
- excitatory postsynaptic potential
- filopodium
- glutamatergic synapse
- growth cone
- hippocampus development
- histone phosphorylation
- intracellular protein transport
- kinase activity
- lamellipodium
- layer formation in cerebral cortex
- membrane
- microtubule
- microtubule cytoskeleton organization
- mitochondrion organization
- motor neuron axon guidance
- negative regulation of axon extension
- negative regulation of cell cycle
- negative regulation of neuron death
- negative regulation of protein export from nucleus
- negative regulation of protein ubiquitination
- negative regulation of proteolysis
- negative regulation of synaptic plasticity
- negative regulation of transcription, DNA-templated
- neuromuscular junction
- neuron apoptotic process
- neuron differentiation
- neuron migration
- neuron projection
- neuron projection development
- neuronal cell body
- nucleocytoplasmic transport
- nucleoplasm
- nucleus
- oligodendrocyte differentiation
- p53 binding
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- perikaryon
- phosphorylation
- plasma membrane
- positive regulation of actin cytoskeleton reorganization
- positive regulation of calcium ion-dependent exocytosis
- positive regulation of glial cell apoptotic process
- positive regulation of neuron apoptotic process
- positive regulation of protein binding
- positive regulation of protein kinase activity
- positive regulation of protein targeting to membrane
- positive regulation of voltage-gated calcium channel activity
- postsynaptic density
- presynapse
- protein autophosphorylation
- protein kinase 5 complex
- protein kinase activity
- protein kinase binding
- protein localization to synapse
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- receptor catabolic process
- receptor clustering
- regulation of apoptotic process
- regulation of cell migration
- regulation of dendritic spine morphogenesis
- regulation of macroautophagy
- regulation of protein localization to plasma membrane
- regulation of signal transduction by p53 class mediator
- regulation of synaptic plasticity
- regulation of synaptic transmission, glutamatergic
- regulation of synaptic vesicle recycling
- regulation of transcription involved in G1/S transition of mitotic cell cycle
- response to wounding
- rhythmic process
- sensory perception of pain
- serine phosphorylation of STAT protein
- skeletal muscle tissue development
- synapse assembly
- synapse pruning
- synaptic transmission, dopaminergic
- synaptic transmission, glutamatergic
- synaptic vesicle endocytosis
- synaptic vesicle exocytosis
- synaptic vesicle transport
- tau protein binding
- tau-protein kinase activity
- visual learning
- voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
FYN
Human
Tyrosine-protein kinase Fyn
- Organism
- Human (Homo sapiens)
- Uniprot ID
- FYN_HUMAN
- Accession #
- P06241
- Protein names
-
- Tyrosine-protein kinase Fyn
- EC 2.7.10.2
- Proto-oncogene Syn
- Proto-oncogene c-Fyn
- Src-like kinase
- SLK
- p59-Fyn
- Gene names
-
- FYN
- Description
-
Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). {ECO:0000250|UniProtKB:P39688, ECO:0000269|PubMed:11005864, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117, ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091, ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597, ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:7822789}.
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Search Substrates of FYN (Human)
- Adherens junction
- Axon guidance
- Cholinergic synapse
- Fc epsilon RI signaling pathway
- Focal adhesion
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- Pathogenic Escherichia coli infection
- Phospholipase D signaling pathway
- Platelet activation
- Prion disease
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- Viral myocarditis
- ATP binding
- CD4 receptor binding
- CD8 receptor binding
- Fc-gamma receptor signaling pathway involved in phagocytosis
- MAPK cascade
- Schaffer collateral - CA1 synapse
- T cell costimulation
- T cell receptor binding
- T cell receptor signaling pathway
- actin filament
- activated T cell proliferation
- adaptive immune response
- alpha-tubulin binding
- axon guidance
- blood coagulation
- calcium ion transport
- cell body
- cell differentiation
- cellular response to L-glutamate
- cellular response to amyloid-beta
- cellular response to glycine
- cellular response to peptide hormone stimulus
- cellular response to platelet-derived growth factor stimulus
- cellular response to transforming growth factor beta stimulus
- cytokine-mediated signaling pathway
- cytosol
- dendrite
- dendrite morphogenesis
- dendritic spine maintenance
- detection of mechanical stimulus involved in sensory perception of pain
- disordered domain specific binding
- endosome
- enzyme binding
- ephrin receptor binding
- ephrin receptor signaling pathway
- extrinsic component of cytoplasmic side of plasma membrane
- feeding behavior
- forebrain development
- glial cell projection
- glutamatergic synapse
- growth factor receptor binding
- heart process
- identical protein binding
- innate immune response
- intracellular signal transduction
- learning
- leukocyte migration
- membrane raft
- metal ion binding
- mitochondrion
- modulation of chemical synaptic transmission
- negative regulation of dendritic spine maintenance
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- negative regulation of gene expression
- negative regulation of hydrogen peroxide biosynthetic process
- negative regulation of inflammatory response to antigenic stimulus
- negative regulation of neuron apoptotic process
- negative regulation of oxidative stress-induced cell death
- negative regulation of protein catabolic process
- negative regulation of protein ubiquitination
- neuron migration
- non-membrane spanning protein tyrosine kinase activity
- nucleus
- peptide hormone receptor binding
- peptidyl-tyrosine phosphorylation
- perinuclear endoplasmic reticulum
- perinuclear region of cytoplasm
- phosphatidylinositol 3-kinase binding
- phospholipase activator activity
- phospholipase binding
- plasma membrane
- platelet activation
- positive regulation of I-kappaB kinase/NF-kappaB signaling
- positive regulation of cysteine-type endopeptidase activity
- positive regulation of neuron death
- positive regulation of neuron projection development
- positive regulation of non-membrane spanning protein tyrosine kinase activity
- positive regulation of phosphatidylinositol 3-kinase signaling
- positive regulation of protein kinase B signaling
- positive regulation of protein localization to membrane
- positive regulation of protein localization to nucleus
- positive regulation of protein targeting to membrane
- positive regulation of tyrosine phosphorylation of STAT protein
- postsynaptic density
- postsynaptic density, intracellular component
- protein autophosphorylation
- protein phosphorylation
- protein tyrosine kinase activity
- regulation of calcium ion import across plasma membrane
- regulation of cell shape
- regulation of defense response to virus by virus
- regulation of glutamate receptor signaling pathway
- regulation of peptidyl-tyrosine phosphorylation
- response to amyloid-beta
- response to ethanol
- response to hydrogen peroxide
- response to singlet oxygen
- signaling receptor binding
- stimulatory C-type lectin receptor signaling pathway
- tau protein binding
- tau-protein kinase activity
- transmembrane receptor protein tyrosine kinase activity
- transmembrane receptor protein tyrosine kinase signaling pathway
- transmembrane transporter binding
- type 5 metabotropic glutamate receptor binding
- vascular endothelial growth factor receptor signaling pathway
LYN
Human
Tyrosine-protein kinase Lyn
- Organism
- Human (Homo sapiens)
- Uniprot ID
- LYN_HUMAN
- Accession #
- P07948
- Protein names
-
- Tyrosine-protein kinase Lyn
- EC 2.7.10.2
- Lck/Yes-related novel protein tyrosine kinase
- V-yes-1 Yamaguchi sarcoma viral related oncogene homolog
- p53Lyn
- p56Lyn
- Gene names
-
- LYN
- JTK8
- Description
-
Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity). {ECO:0000250|UniProtKB:P25911, ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:10748115, ECO:0000269|PubMed:10891478, ECO:0000269|PubMed:11435302, ECO:0000269|PubMed:11517336, ECO:0000269|PubMed:11825908, ECO:0000269|PubMed:14726379, ECO:0000269|PubMed:15795233, ECO:0000269|PubMed:16467205, ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:17977829, ECO:0000269|PubMed:18056483, ECO:0000269|PubMed:18070987, ECO:0000269|PubMed:18235045, ECO:0000269|PubMed:18577747, ECO:0000269|PubMed:18802065, ECO:0000269|PubMed:19290919, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:7687428}.
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Search Substrates of LYN (Human)
- ATP binding
- B cell homeostasis
- B cell receptor signaling pathway
- Fc receptor mediated inhibitory signaling pathway
- Fc receptor mediated stimulatory signaling pathway
- Fc-epsilon receptor signaling pathway
- Fc-gamma receptor signaling pathway involved in phagocytosis
- Golgi apparatus
- SH3 domain binding
- T cell costimulation
- adaptive immune response
- adherens junction
- blood coagulation
- cell differentiation
- cellular response to DNA damage stimulus
- cellular response to extracellular stimulus
- cellular response to heat
- cellular response to retinoic acid
- cytoplasm
- cytosol
- dendritic cell differentiation
- enzyme binding
- ephrin receptor binding
- ephrin receptor signaling pathway
- erythrocyte differentiation
- extracellular exosome
- extrinsic component of cytoplasmic side of plasma membrane
- gamma-tubulin binding
- glutamatergic synapse
- glycosphingolipid binding
- growth hormone receptor signaling pathway via JAK-STAT
- histamine secretion by mast cell
- immune response-regulating cell surface receptor signaling pathway
- innate immune response
- integrin alpha2-beta1 complex
- integrin binding
- intracellular membrane-bounded organelle
- intracellular signal transduction
- kinase activity
- leukocyte migration
- lipopolysaccharide-mediated signaling pathway
- membrane raft
- mitochondrial crista
- mitochondrial intermembrane space
- negative regulation of B cell proliferation
- negative regulation of ERK1 and ERK2 cascade
- negative regulation of MAP kinase activity
- negative regulation of cell population proliferation
- negative regulation of immune response
- negative regulation of inflammatory response to antigenic stimulus
- negative regulation of intracellular signal transduction
- negative regulation of mast cell proliferation
- negative regulation of myeloid leukocyte differentiation
- negative regulation of protein phosphorylation
- negative regulation of toll-like receptor 2 signaling pathway
- negative regulation of toll-like receptor 4 signaling pathway
- neuron projection development
- non-membrane spanning protein tyrosine kinase activity
- nucleus
- oligodendrocyte development
- peptidyl-tyrosine phosphorylation
- perinuclear region of cytoplasm
- phosphoprotein binding
- phosphorylation-dependent protein binding
- plasma membrane
- platelet activation
- platelet degranulation
- platelet-derived growth factor receptor binding
- positive regulation of Fc receptor mediated stimulatory signaling pathway
- positive regulation of Ras protein signal transduction
- positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
- positive regulation of cell migration
- positive regulation of cell population proliferation
- positive regulation of cellular component movement
- positive regulation of dendritic cell apoptotic process
- positive regulation of glial cell proliferation
- positive regulation of mast cell proliferation
- positive regulation of neuron projection development
- positive regulation of oligodendrocyte progenitor proliferation
- positive regulation of phosphatidylinositol 3-kinase activity
- positive regulation of phosphatidylinositol 3-kinase signaling
- positive regulation of protein phosphorylation
- positive regulation of stress-activated protein kinase signaling cascade
- positive regulation of tyrosine phosphorylation of STAT protein
- postsynaptic density
- postsynaptic specialization, intracellular component
- protein autophosphorylation
- protein phosphorylation
- protein tyrosine kinase activity
- regulation of B cell apoptotic process
- regulation of B cell receptor signaling pathway
- regulation of ERK1 and ERK2 cascade
- regulation of cell adhesion mediated by integrin
- regulation of cytokine production
- regulation of erythrocyte differentiation
- regulation of mast cell activation
- regulation of mast cell degranulation
- regulation of monocyte chemotaxis
- regulation of platelet aggregation
- regulation of protein phosphorylation
- regulation of release of sequestered calcium ion into cytosol
- response to amino acid
- response to axon injury
- response to carbohydrate
- response to hormone
- response to insulin
- response to organic cyclic compound
- response to sterol depletion
- response to toxic substance
- signal transduction
- signaling receptor binding
- stimulatory C-type lectin receptor signaling pathway
- tolerance induction to self antigen
- toll-like receptor 4 signaling pathway
- transmembrane receptor protein tyrosine kinase activity
- transmembrane receptor protein tyrosine kinase signaling pathway
- transmembrane transporter binding
- ubiquitin protein ligase binding
- viral process
PKA*
Protein kinase A family
- Organism
- ()
- Accession #
- 0000PKA
- Protein names
-
- Protein kinase A family
- Gene names
-
- PKA*
- Description
-
N/A
- Links
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Search Substrates of PKA* ()
N/A
N/A
PRKACA
Human
cAMP-dependent protein kinase catalytic subunit alpha
- Organism
- Human (Homo sapiens)
- Uniprot ID
- KAPCA_HUMAN
- Accession #
- P17612
- Protein names
-
- cAMP-dependent protein kinase catalytic subunit alpha
- PKA C-alpha
- EC 2.7.11.11
- Gene names
-
- PRKACA
- PKACA
- Description
-
Phosphorylates a large number of substrates in the cytoplasm and the nucleus (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984). Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, SOX9 and VASP (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:21423175). RORA is activated by phosphorylation (PubMed:21514275). Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (PubMed:19949837). Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP (PubMed:15642694, PubMed:20356841). Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated (PubMed:17333334). RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+) (PubMed:17693412). PSMC5/RPT6 activation by phosphorylation stimulates proteasome (PubMed:17565987). Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation (PubMed:15905176). NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding (PubMed:15642694). Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By similarity). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA (PubMed:16387847, PubMed:18836454). Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (PubMed:21085490). {ECO:0000250|UniProtKB:P05132, ECO:0000250|UniProtKB:P27791, ECO:0000269|PubMed:15642694, ECO:0000269|PubMed:15905176, ECO:0000269|PubMed:16387847, ECO:0000269|PubMed:17333334, ECO:0000269|PubMed:17565987, ECO:0000269|PubMed:17693412, ECO:0000269|PubMed:18836454, ECO:0000269|PubMed:19949837, ECO:0000269|PubMed:20356841, ECO:0000269|PubMed:21085490, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21514275, ECO:0000269|PubMed:21812984}.; [Isoform 2]: Phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. {ECO:0000250|UniProtKB:P05132}.
- Links
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Search Substrates of PRKACA (Human)
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Aldosterone synthesis and secretion
- Amoebiasis
- Amphetamine addiction
- Apelin signaling pathway
- Autophagy
- Bile secretion
- Calcium signaling pathway
- Chemical carcinogenesis
- Chemokine signaling pathway
- Cholinergic synapse
- Circadian entrainment
- Cocaine addiction
- Cortisol synthesis and secretion
- Cushing syndrome
- Dilated cardiomyopathy
- Dopaminergic synapse
- Endocrine and other factor
- Endocrine resistance
- Estrogen signaling pathway
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glucagon signaling pathway
- Glutamatergic synapse
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hedgehog signaling pathway
- Human T
- Human cytomegalovirus infection
- Human papillomavirus infection
- Inflammatory mediator regulation of TRP channels
- Insulin secretion
- Insulin signaling pathway
- Long
- Longevity regulating pathway
- MAPK signaling pathway
- Melanogenesis
- Morphine addiction
- Olfactory transduction
- Oocyte meiosis
- Ovarian steroidogenesis
- Oxytocin signaling pathway
- Parathyroid hormone synthesis, secretion and action
- Parkinson disease
- Pathways in cancer
- Platelet activation
- Prion disease
- Progesterone
- Proteoglycans in cancer
- Ras signaling pathway
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renin secretion
- Retrograde endocannabinoid signaling
- Salivary secretion
- Serotonergic synapse
- Taste transduction
- Thermogenesis
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- Tight junction
- Vascular smooth muscle contraction
- Vasopressin
- Vibrio cholerae infection
- Viral carcinogenesis
- Wnt signaling pathway
- cAMP signaling pathway
- AMP-activated protein kinase activity
- ATP binding
- G2/M transition of mitotic cell cycle
- acrosomal vesicle
- activation of protein kinase A activity
- adaptive immune response
- blood coagulation
- cAMP-dependent protein kinase activity
- cAMP-dependent protein kinase complex
- calcium channel complex
- calcium-mediated signaling using intracellular calcium source
- cell communication by electrical coupling involved in cardiac conduction
- cellular response to epinephrine stimulus
- cellular response to glucagon stimulus
- cellular response to glucose stimulus
- cellular response to heat
- cellular response to parathyroid hormone stimulus
- centrosome
- chemical synaptic transmission
- ciliary basal body-plasma membrane docking
- ciliary base
- cytokine-mediated signaling pathway
- cytoplasm
- cytosol
- dendritic spine
- extracellular exosome
- high-density lipoprotein particle assembly
- mRNA processing
- magnesium ion binding
- manganese ion binding
- membrane
- mesoderm formation
- mitochondrion
- modulation of chemical synaptic transmission
- negative regulation of inflammatory response to antigenic stimulus
- negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
- neural tube closure
- neuromuscular junction
- nuclear speck
- nucleoplasm
- nucleotide-activated protein kinase complex
- nucleus
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- perinuclear region of cytoplasm
- plasma membrane raft
- positive regulation of protein export from nucleus
- protein autophosphorylation
- protein domain specific binding
- protein kinase A regulatory subunit binding
- protein kinase A signaling
- protein kinase activity
- protein kinase binding
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- protein serine/threonine/tyrosine kinase activity
- regulation of G2/M transition of mitotic cell cycle
- regulation of bicellular tight junction assembly
- regulation of cardiac conduction
- regulation of cardiac muscle contraction
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
- regulation of cytosolic calcium ion concentration
- regulation of heart rate
- regulation of macroautophagy
- regulation of osteoblast differentiation
- regulation of proteasomal protein catabolic process
- regulation of protein binding
- regulation of protein processing
- regulation of ryanodine-sensitive calcium-release channel activity
- renal water homeostasis
- sperm capacitation
- sperm flagellum
- sperm midpiece
- stimulatory C-type lectin receptor signaling pathway
- ubiquitin protein ligase binding
ROCK2
Human
Rho-associated protein kinase 2
- Organism
- Human (Homo sapiens)
- Uniprot ID
- ROCK2_HUMAN
- Accession #
- O75116
- Protein names
-
- Rho-associated protein kinase 2
- EC 2.7.11.1
- Rho kinase 2
- Rho-associated, coiled-coil-containing protein kinase 2
- Rho-associated, coiled-coil-containing protein kinase II
- ROCK-II
- p164 ROCK-2
- Gene names
-
- ROCK2
- KIAA0619
- Description
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Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. {ECO:0000269|PubMed:10579722, ECO:0000269|PubMed:15699075, ECO:0000269|PubMed:16574662, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:21147781}.
- Links
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Search Substrates of ROCK2 (Human)
- Axon guidance
- Chemokine signaling pathway
- Focal adhesion
- Human cytomegalovirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Oxytocin signaling pathway
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Tight junction
- Vascular smooth muscle contraction
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
- cGMP
- ATP binding
- G protein-coupled receptor signaling pathway
- I-kappaB kinase/NF-kappaB signaling
- RNA binding
- Rho protein signal transduction
- Rho-dependent protein serine/threonine kinase activity
- actin cytoskeleton organization
- actomyosin structure organization
- aortic valve morphogenesis
- blood vessel diameter maintenance
- cellular response to acetylcholine
- cellular response to testosterone stimulus
- centrosome
- centrosome duplication
- cortical actin cytoskeleton organization
- cytoplasm
- cytoplasmic ribonucleoprotein granule
- cytoskeleton
- cytosol
- embryonic morphogenesis
- ephrin receptor signaling pathway
- epithelial to mesenchymal transition
- mRNA destabilization
- metal ion binding
- mitotic cytokinesis
- negative regulation of angiogenesis
- negative regulation of bicellular tight junction assembly
- negative regulation of biomineral tissue development
- negative regulation of gene expression
- negative regulation of myosin-light-chain-phosphatase activity
- negative regulation of nitric oxide biosynthetic process
- negative regulation of protein localization to lysosome
- nucleus
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- plasma membrane
- positive regulation of MAPK cascade
- positive regulation of amyloid precursor protein catabolic process
- positive regulation of amyloid-beta formation
- positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
- positive regulation of cardiac muscle hypertrophy
- positive regulation of cell migration
- positive regulation of centrosome duplication
- positive regulation of connective tissue growth factor production
- positive regulation of connective tissue replacement
- positive regulation of endothelial cell migration
- positive regulation of fibroblast growth factor production
- positive regulation of gene expression
- positive regulation of protein localization to early endosome
- positive regulation of protein phosphorylation
- positive regulation of stress fiber assembly
- protein localization to plasma membrane
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- regulation of actin cytoskeleton organization
- regulation of angiotensin-activated signaling pathway
- regulation of cell adhesion
- regulation of cell junction assembly
- regulation of cell motility
- regulation of cellular response to hypoxia
- regulation of circadian rhythm
- regulation of establishment of cell polarity
- regulation of establishment of endothelial barrier
- regulation of focal adhesion assembly
- regulation of keratinocyte differentiation
- regulation of nervous system process
- regulation of protein metabolic process
- regulation of stress fiber assembly
- response to angiotensin
- response to ischemia
- response to transforming growth factor beta
- rhythmic process
- small GTPase binding
- smooth muscle contraction
- structural molecule activity
- tau protein binding
- tau-protein kinase activity
- vascular endothelial growth factor receptor signaling pathway
- viral RNA genome replication
Uknown
- Organism
- ()
- Accession #
- 0000UNKNOWN
- Protein names
-
- Gene names
-
- Uknown
- Description
-
N/A
- Links
-
Search Substrates of Uknown ()
N/A
N/A