Search Results (7 kinases found)
Gene name
Organism
Protein name
CAMK2A
Human
Calcium/calmodulin-dependent protein kinase type II subunit alpha
- Organism
- Human (Homo sapiens)
- Uniprot ID
- KCC2A_HUMAN
- Accession #
- Q9UQM7
- Protein names
-
- Calcium/calmodulin-dependent protein kinase type II subunit alpha
- CaM kinase II subunit alpha
- CaMK-II subunit alpha
- EC 2.7.11.17
- Gene names
-
- CAMK2A
- CAMKA
- KIAA0968
- Description
-
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089}.
- Links
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Search Substrates of CAMK2A (Human)
- Adrenergic signaling in cardiomyocytes
- Aldosterone synthesis and secretion
- Amphetamine addiction
- Axon guidance
- Calcium signaling pathway
- Cholinergic synapse
- Circadian entrainment
- Cushing syndrome
- Diabetic cardiomyopathy
- Dopaminergic synapse
- ErbB signaling pathway
- Gastric acid secretion
- Glioma
- Glucagon signaling pathway
- GnRH signaling pathway
- HIF
- Inflammatory mediator regulation of TRP channels
- Insulin secretion
- Lipid and atherosclerosis
- Long
- Melanogenesis
- Necroptosis
- Neurotrophin signaling pathway
- Olfactory transduction
- Oocyte meiosis
- Oxytocin signaling pathway
- Parkinson disease
- Pathways in cancer
- Pathways of neurodegeneration
- Proteoglycans in cancer
- Tuberculosis
- Wnt signaling pathway
- cAMP signaling pathway
- ATP binding
- G1/S transition of mitotic cell cycle
- MAPK cascade
- Wnt signaling pathway, calcium modulating pathway
- angiotensin-activated signaling pathway
- calcium ion transport
- calcium- and calmodulin-dependent protein kinase complex
- calcium-dependent protein serine/threonine kinase activity
- calmodulin binding
- calmodulin-dependent protein kinase activity
- cytoplasm
- cytosol
- dendritic spine
- dendritic spine development
- endocytic vesicle membrane
- glutamate receptor binding
- identical protein binding
- interferon-gamma-mediated signaling pathway
- kinase activity
- metal ion binding
- mitochondrion
- negative regulation of hydrolase activity
- neuron projection
- nucleoplasm
- nucleus
- peptidyl-serine phosphorylation
- peptidyl-threonine autophosphorylation
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of calcium ion transport
- positive regulation of cardiac muscle cell apoptotic process
- postsynaptic density
- protein autophosphorylation
- protein homodimerization activity
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- regulation of NMDA receptor activity
- regulation of cellular response to heat
- regulation of endocannabinoid signaling pathway
- regulation of mitochondrial membrane permeability involved in apoptotic process
- regulation of neuron migration
- regulation of neuronal synaptic plasticity
- regulation of neurotransmitter secretion
- response to ischemia
CDK5
Human
Cyclin-dependent-like kinase 5
- Organism
- Human (Homo sapiens)
- Uniprot ID
- CDK5_HUMAN
- Accession #
- Q00535
- Protein names
-
- Cyclin-dependent-like kinase 5
- EC 2.7.11.1
- Cell division protein kinase 5
- Serine/threonine-protein kinase PSSALRE
- Tau protein kinase II catalytic subunit
- TPKII catalytic subunit
- Gene names
-
- CDK5
- CDKN5
- Description
-
Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000269|PubMed:12393264, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15992363, ECO:0000269|PubMed:17009320, ECO:0000269|PubMed:17121855, ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:17611284, ECO:0000269|PubMed:17671990, ECO:0000269|PubMed:18042622, ECO:0000269|PubMed:19081376, ECO:0000269|PubMed:19693690, ECO:0000269|PubMed:20061803, ECO:0000269|PubMed:20213743, ECO:0000269|PubMed:20826806, ECO:0000269|PubMed:21209322, ECO:0000269|PubMed:21220307, ECO:0000269|PubMed:21442427, ECO:0000269|PubMed:21465480, ECO:0000269|PubMed:21499257, ECO:0000269|PubMed:24235147, ECO:0000269|PubMed:9822744}.
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Search Substrates of CDK5 (Human)
- ATP binding
- ErbB-2 class receptor binding
- ErbB-3 class receptor binding
- Hsp90 protein binding
- Schaffer collateral - CA1 synapse
- Schwann cell development
- acetylcholine receptor activator activity
- axon
- axon extension
- axonogenesis
- behavioral response to cocaine
- calcium ion import
- cell division
- cell junction
- cell-matrix adhesion
- cellular response to amyloid-beta
- central nervous system neuron development
- cerebellar cortex formation
- chemical synaptic transmission
- corpus callosum development
- cortical actin cytoskeleton organization
- cyclin-dependent protein serine/threonine kinase activity
- cytoplasm
- cytosol
- dendrite
- dendrite morphogenesis
- ephrin receptor binding
- excitatory postsynaptic potential
- filopodium
- glutamatergic synapse
- growth cone
- hippocampus development
- histone phosphorylation
- intracellular protein transport
- kinase activity
- lamellipodium
- layer formation in cerebral cortex
- membrane
- microtubule
- microtubule cytoskeleton organization
- mitochondrion organization
- motor neuron axon guidance
- negative regulation of axon extension
- negative regulation of cell cycle
- negative regulation of neuron death
- negative regulation of protein export from nucleus
- negative regulation of protein ubiquitination
- negative regulation of proteolysis
- negative regulation of synaptic plasticity
- negative regulation of transcription, DNA-templated
- neuromuscular junction
- neuron apoptotic process
- neuron differentiation
- neuron migration
- neuron projection
- neuron projection development
- neuronal cell body
- nucleocytoplasmic transport
- nucleoplasm
- nucleus
- oligodendrocyte differentiation
- p53 binding
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- perikaryon
- phosphorylation
- plasma membrane
- positive regulation of actin cytoskeleton reorganization
- positive regulation of calcium ion-dependent exocytosis
- positive regulation of glial cell apoptotic process
- positive regulation of neuron apoptotic process
- positive regulation of protein binding
- positive regulation of protein kinase activity
- positive regulation of protein targeting to membrane
- positive regulation of voltage-gated calcium channel activity
- postsynaptic density
- presynapse
- protein autophosphorylation
- protein kinase 5 complex
- protein kinase activity
- protein kinase binding
- protein localization to synapse
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- receptor catabolic process
- receptor clustering
- regulation of apoptotic process
- regulation of cell migration
- regulation of dendritic spine morphogenesis
- regulation of macroautophagy
- regulation of protein localization to plasma membrane
- regulation of signal transduction by p53 class mediator
- regulation of synaptic plasticity
- regulation of synaptic transmission, glutamatergic
- regulation of synaptic vesicle recycling
- regulation of transcription involved in G1/S transition of mitotic cell cycle
- response to wounding
- rhythmic process
- sensory perception of pain
- serine phosphorylation of STAT protein
- skeletal muscle tissue development
- synapse assembly
- synapse pruning
- synaptic transmission, dopaminergic
- synaptic transmission, glutamatergic
- synaptic vesicle endocytosis
- synaptic vesicle exocytosis
- synaptic vesicle transport
- tau protein binding
- tau-protein kinase activity
- visual learning
- voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
MAPK*
- Organism
- ()
- Accession #
- 0000MAPK
- Protein names
-
- Gene names
-
- MAPK*
- Description
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N/A
- Links
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Search Substrates of MAPK* ()
N/A
N/A
PKA*
Protein kinase A family
- Organism
- ()
- Accession #
- 0000PKA
- Protein names
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- Protein kinase A family
- Gene names
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- PKA*
- Description
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N/A
- Links
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Search Substrates of PKA* ()
N/A
N/A
PRKCA
Human
Protein kinase C alpha type
- Organism
- Human (Homo sapiens)
- Uniprot ID
- KPCA_HUMAN
- Accession #
- P17252
- Protein names
-
- Protein kinase C alpha type
- PKC-A
- PKC-alpha
- EC 2.7.11.13
- Gene names
-
- PRKCA
- PKCA
- PRKACA
- Description
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Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 (PubMed:28028151). Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Phosphorylates SOCS2 at 'Ser-52' facilitating its ubiquitination and proteosomal degradation (By similarity). {ECO:0000250|UniProtKB:P20444, ECO:0000269|PubMed:10848585, ECO:0000269|PubMed:11909826, ECO:0000269|PubMed:12724315, ECO:0000269|PubMed:12832403, ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:15504744, ECO:0000269|PubMed:15526160, ECO:0000269|PubMed:18056764, ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:21576361, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:28028151, ECO:0000269|PubMed:9738012, ECO:0000269|PubMed:9830023, ECO:0000269|PubMed:9873035, ECO:0000269|PubMed:9927633}.
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Search Substrates of PRKCA (Human)
- AGE
- Adrenergic signaling in cardiomyocytes
- African trypanosomiasis
- Aldosterone
- Aldosterone synthesis and secretion
- Amoebiasis
- Amphetamine addiction
- Axon guidance
- Calcium signaling pathway
- Chemical carcinogenesis
- Choline metabolism in cancer
- Cholinergic synapse
- Circadian entrainment
- Coronavirus disease
- Diabetic cardiomyopathy
- Dopaminergic synapse
- EGFR tyrosine kinase inhibitor resistance
- Endocrine and other factor
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R
- Focal adhesion
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glioma
- Glutamatergic synapse
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- HIF
- Hepatitis B
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Inflammatory mediator regulation of TRP channels
- Influenza A
- Insulin secretion
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Long
- MAPK signaling pathway
- Melanogenesis
- MicroRNAs in cancer
- Morphine addiction
- Natural killer cell mediated cytotoxicity
- Neutrophil extracellular trap formation
- Non
- Oxytocin signaling pathway
- PI3K
- Pancreatic secretion
- Parathyroid hormone synthesis, secretion and action
- Pathways in cancer
- Pathways of neurodegeneration
- Phosphatidylinositol signaling system
- Phospholipase D signaling pathway
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salivary secretion
- Serotonergic synapse
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- VEGF signaling pathway
- Vascular smooth muscle contraction
- Vibrio cholerae infection
- Wnt signaling pathway
- mTOR signaling pathway
- ATP binding
- ERBB2 signaling pathway
- alphav-beta3 integrin-PKCalpha complex
- angiogenesis
- apoptotic signaling pathway
- axon guidance
- calcium-dependent protein kinase C activity
- cell adhesion
- cytoplasm
- cytosol
- desmosome assembly
- endoplasmic reticulum
- enzyme binding
- extracellular exosome
- histone H3-T6 phosphorylation
- histone kinase activity (H3-T6 specific)
- integrin binding
- intracellular signal transduction
- mitochondrial membrane
- mitochondrion
- mitotic nuclear membrane disassembly
- negative regulation of glial cell apoptotic process
- nucleoplasm
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- perinuclear region of cytoplasm
- plasma membrane
- platelet activation
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
- positive regulation of angiogenesis
- positive regulation of blood vessel endothelial cell migration
- positive regulation of bone resorption
- positive regulation of cardiac muscle hypertrophy
- positive regulation of cell adhesion
- positive regulation of cell migration
- positive regulation of dense core granule biogenesis
- positive regulation of endothelial cell migration
- positive regulation of endothelial cell proliferation
- positive regulation of lipopolysaccharide-mediated signaling pathway
- positive regulation of macrophage differentiation
- positive regulation of mitotic cell cycle
- protein kinase C activity
- protein kinase activity
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- regulation of insulin secretion
- regulation of mRNA stability
- regulation of platelet aggregation
- response to interleukin-1
- zinc ion binding
PRKCE
Human
Protein kinase C epsilon type
- Organism
- Human (Homo sapiens)
- Uniprot ID
- KPCE_HUMAN
- Accession #
- Q02156
- Protein names
-
- Protein kinase C epsilon type
- EC 2.7.11.13
- nPKC-epsilon
- Gene names
-
- PRKCE
- PKCE
- Description
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Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (PubMed:19542546). {ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:1374067, ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:17875639, ECO:0000269|PubMed:17875724, ECO:0000269|PubMed:19542546}.
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Search Substrates of PRKCE (Human)
- 14-3-3 protein binding
- ATP binding
- Fc-gamma receptor signaling pathway involved in phagocytosis
- Golgi apparatus
- TRAM-dependent toll-like receptor 4 signaling pathway
- actin monomer binding
- apoptotic process
- calcium-dependent protein kinase C activity
- calcium-independent protein kinase C activity
- cell adhesion
- cell cycle
- cell division
- cell periphery
- cellular response to ethanol
- cellular response to hypoxia
- cellular response to prostaglandin E stimulus
- cytoplasm
- cytosol
- endoplasmic reticulum
- enzyme activator activity
- enzyme binding
- ethanol binding
- intermediate filament cytoskeleton
- intracellular membrane-bounded organelle
- intracellular signal transduction
- lipopolysaccharide-mediated signaling pathway
- locomotory exploration behavior
- macrophage activation involved in immune response
- metal ion binding
- mitochondrion
- negative regulation of protein ubiquitination
- negative regulation of sodium ion transmembrane transporter activity
- nucleus
- peptidyl-serine phosphorylation
- perinuclear region of cytoplasm
- plasma membrane
- platelet activation
- positive regulation of I-kappaB kinase/NF-kappaB signaling
- positive regulation of MAPK cascade
- positive regulation of actin filament polymerization
- positive regulation of cell-substrate adhesion
- positive regulation of cellular glucuronidation
- positive regulation of cytokinesis
- positive regulation of epithelial cell migration
- positive regulation of fibroblast migration
- positive regulation of insulin secretion
- positive regulation of lipid catabolic process
- positive regulation of mucus secretion
- positive regulation of protein localization to plasma membrane
- positive regulation of synaptic transmission, GABAergic
- positive regulation of wound healing
- protein kinase C activity
- protein kinase activity
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- regulation of insulin secretion involved in cellular response to glucose stimulus
- regulation of peptidyl-tyrosine phosphorylation
- regulation of release of sequestered calcium ion into cytosol
- response to morphine
- signal transduction
- signaling receptor activator activity
Uknown
- Organism
- ()
- Accession #
- 0000UNKNOWN
- Protein names
-
- Gene names
-
- Uknown
- Description
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N/A
- Links
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Search Substrates of Uknown ()
N/A
N/A