Search Results (7 kinases found)
Gene name
Organism
Protein name
CDK5
Human
Cyclin-dependent-like kinase 5
- Organism
- Human (Homo sapiens)
- Uniprot ID
- CDK5_HUMAN
- Accession #
- Q00535
- Protein names
-
- Cyclin-dependent-like kinase 5
- EC 2.7.11.1
- Cell division protein kinase 5
- Serine/threonine-protein kinase PSSALRE
- Tau protein kinase II catalytic subunit
- TPKII catalytic subunit
- Gene names
-
- CDK5
- CDKN5
- Description
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Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000269|PubMed:12393264, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15992363, ECO:0000269|PubMed:17009320, ECO:0000269|PubMed:17121855, ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:17611284, ECO:0000269|PubMed:17671990, ECO:0000269|PubMed:18042622, ECO:0000269|PubMed:19081376, ECO:0000269|PubMed:19693690, ECO:0000269|PubMed:20061803, ECO:0000269|PubMed:20213743, ECO:0000269|PubMed:20826806, ECO:0000269|PubMed:21209322, ECO:0000269|PubMed:21220307, ECO:0000269|PubMed:21442427, ECO:0000269|PubMed:21465480, ECO:0000269|PubMed:21499257, ECO:0000269|PubMed:24235147, ECO:0000269|PubMed:9822744}.
- Links
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Search Substrates of CDK5 (Human)
- ATP binding
- ErbB-2 class receptor binding
- ErbB-3 class receptor binding
- Hsp90 protein binding
- Schaffer collateral - CA1 synapse
- Schwann cell development
- acetylcholine receptor activator activity
- axon
- axon extension
- axonogenesis
- behavioral response to cocaine
- calcium ion import
- cell division
- cell junction
- cell-matrix adhesion
- cellular response to amyloid-beta
- central nervous system neuron development
- cerebellar cortex formation
- chemical synaptic transmission
- corpus callosum development
- cortical actin cytoskeleton organization
- cyclin-dependent protein serine/threonine kinase activity
- cytoplasm
- cytosol
- dendrite
- dendrite morphogenesis
- ephrin receptor binding
- excitatory postsynaptic potential
- filopodium
- glutamatergic synapse
- growth cone
- hippocampus development
- histone phosphorylation
- intracellular protein transport
- kinase activity
- lamellipodium
- layer formation in cerebral cortex
- membrane
- microtubule
- microtubule cytoskeleton organization
- mitochondrion organization
- motor neuron axon guidance
- negative regulation of axon extension
- negative regulation of cell cycle
- negative regulation of neuron death
- negative regulation of protein export from nucleus
- negative regulation of protein ubiquitination
- negative regulation of proteolysis
- negative regulation of synaptic plasticity
- negative regulation of transcription, DNA-templated
- neuromuscular junction
- neuron apoptotic process
- neuron differentiation
- neuron migration
- neuron projection
- neuron projection development
- neuronal cell body
- nucleocytoplasmic transport
- nucleoplasm
- nucleus
- oligodendrocyte differentiation
- p53 binding
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- perikaryon
- phosphorylation
- plasma membrane
- positive regulation of actin cytoskeleton reorganization
- positive regulation of calcium ion-dependent exocytosis
- positive regulation of glial cell apoptotic process
- positive regulation of neuron apoptotic process
- positive regulation of protein binding
- positive regulation of protein kinase activity
- positive regulation of protein targeting to membrane
- positive regulation of voltage-gated calcium channel activity
- postsynaptic density
- presynapse
- protein autophosphorylation
- protein kinase 5 complex
- protein kinase activity
- protein kinase binding
- protein localization to synapse
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- receptor catabolic process
- receptor clustering
- regulation of apoptotic process
- regulation of cell migration
- regulation of dendritic spine morphogenesis
- regulation of macroautophagy
- regulation of protein localization to plasma membrane
- regulation of signal transduction by p53 class mediator
- regulation of synaptic plasticity
- regulation of synaptic transmission, glutamatergic
- regulation of synaptic vesicle recycling
- regulation of transcription involved in G1/S transition of mitotic cell cycle
- response to wounding
- rhythmic process
- sensory perception of pain
- serine phosphorylation of STAT protein
- skeletal muscle tissue development
- synapse assembly
- synapse pruning
- synaptic transmission, dopaminergic
- synaptic transmission, glutamatergic
- synaptic vesicle endocytosis
- synaptic vesicle exocytosis
- synaptic vesicle transport
- tau protein binding
- tau-protein kinase activity
- visual learning
- voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
FYN
Human
Tyrosine-protein kinase Fyn
- Organism
- Human (Homo sapiens)
- Uniprot ID
- FYN_HUMAN
- Accession #
- P06241
- Protein names
-
- Tyrosine-protein kinase Fyn
- EC 2.7.10.2
- Proto-oncogene Syn
- Proto-oncogene c-Fyn
- Src-like kinase
- SLK
- p59-Fyn
- Gene names
-
- FYN
- Description
-
Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). {ECO:0000250|UniProtKB:P39688, ECO:0000269|PubMed:11005864, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117, ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091, ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597, ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:7822789}.
- Links
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Search Substrates of FYN (Human)
- Adherens junction
- Axon guidance
- Cholinergic synapse
- Fc epsilon RI signaling pathway
- Focal adhesion
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- Pathogenic Escherichia coli infection
- Phospholipase D signaling pathway
- Platelet activation
- Prion disease
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- Viral myocarditis
- ATP binding
- CD4 receptor binding
- CD8 receptor binding
- Fc-gamma receptor signaling pathway involved in phagocytosis
- MAPK cascade
- Schaffer collateral - CA1 synapse
- T cell costimulation
- T cell receptor binding
- T cell receptor signaling pathway
- actin filament
- activated T cell proliferation
- adaptive immune response
- alpha-tubulin binding
- axon guidance
- blood coagulation
- calcium ion transport
- cell body
- cell differentiation
- cellular response to L-glutamate
- cellular response to amyloid-beta
- cellular response to glycine
- cellular response to peptide hormone stimulus
- cellular response to platelet-derived growth factor stimulus
- cellular response to transforming growth factor beta stimulus
- cytokine-mediated signaling pathway
- cytosol
- dendrite
- dendrite morphogenesis
- dendritic spine maintenance
- detection of mechanical stimulus involved in sensory perception of pain
- disordered domain specific binding
- endosome
- enzyme binding
- ephrin receptor binding
- ephrin receptor signaling pathway
- extrinsic component of cytoplasmic side of plasma membrane
- feeding behavior
- forebrain development
- glial cell projection
- glutamatergic synapse
- growth factor receptor binding
- heart process
- identical protein binding
- innate immune response
- intracellular signal transduction
- learning
- leukocyte migration
- membrane raft
- metal ion binding
- mitochondrion
- modulation of chemical synaptic transmission
- negative regulation of dendritic spine maintenance
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- negative regulation of gene expression
- negative regulation of hydrogen peroxide biosynthetic process
- negative regulation of inflammatory response to antigenic stimulus
- negative regulation of neuron apoptotic process
- negative regulation of oxidative stress-induced cell death
- negative regulation of protein catabolic process
- negative regulation of protein ubiquitination
- neuron migration
- non-membrane spanning protein tyrosine kinase activity
- nucleus
- peptide hormone receptor binding
- peptidyl-tyrosine phosphorylation
- perinuclear endoplasmic reticulum
- perinuclear region of cytoplasm
- phosphatidylinositol 3-kinase binding
- phospholipase activator activity
- phospholipase binding
- plasma membrane
- platelet activation
- positive regulation of I-kappaB kinase/NF-kappaB signaling
- positive regulation of cysteine-type endopeptidase activity
- positive regulation of neuron death
- positive regulation of neuron projection development
- positive regulation of non-membrane spanning protein tyrosine kinase activity
- positive regulation of phosphatidylinositol 3-kinase signaling
- positive regulation of protein kinase B signaling
- positive regulation of protein localization to membrane
- positive regulation of protein localization to nucleus
- positive regulation of protein targeting to membrane
- positive regulation of tyrosine phosphorylation of STAT protein
- postsynaptic density
- postsynaptic density, intracellular component
- protein autophosphorylation
- protein phosphorylation
- protein tyrosine kinase activity
- regulation of calcium ion import across plasma membrane
- regulation of cell shape
- regulation of defense response to virus by virus
- regulation of glutamate receptor signaling pathway
- regulation of peptidyl-tyrosine phosphorylation
- response to amyloid-beta
- response to ethanol
- response to hydrogen peroxide
- response to singlet oxygen
- signaling receptor binding
- stimulatory C-type lectin receptor signaling pathway
- tau protein binding
- tau-protein kinase activity
- transmembrane receptor protein tyrosine kinase activity
- transmembrane receptor protein tyrosine kinase signaling pathway
- transmembrane transporter binding
- type 5 metabotropic glutamate receptor binding
- vascular endothelial growth factor receptor signaling pathway
MAPK*
- Organism
- ()
- Accession #
- 0000MAPK
- Protein names
-
- Gene names
-
- MAPK*
- Description
-
N/A
- Links
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Search Substrates of MAPK* ()
N/A
N/A
MAPK1
Human
Mitogen-activated protein kinase 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
- MK01_HUMAN
- Accession #
- P28482
- Protein names
-
- Mitogen-activated protein kinase 1
- MAP kinase 1
- MAPK 1
- EC 2.7.11.24
- ERT1
- Extracellular signal-regulated kinase 2
- ERK-2
- MAP kinase isoform p42
- p42-MAPK
- Mitogen-activated protein kinase 2
- MAP kinase 2
- MAPK 2
- Gene names
-
- MAPK1
- ERK2
- PRKM1
- PRKM2
- Description
-
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in response to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity). {ECO:0000250|UniProtKB:P63086, ECO:0000269|PubMed:10617468, ECO:0000269|PubMed:10637505, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:12110590, ECO:0000269|PubMed:12356731, ECO:0000269|PubMed:12792650, ECO:0000269|PubMed:12794087, ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:15184391, ECO:0000269|PubMed:15241487, ECO:0000269|PubMed:15616583, ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:15788397, ECO:0000269|PubMed:15952796, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:19879846, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:7588608, ECO:0000269|PubMed:8622688, ECO:0000269|PubMed:9480836, ECO:0000269|PubMed:9596579, ECO:0000269|PubMed:9649500, ECO:0000269|PubMed:9687510, ECO:0000303|PubMed:15526160, ECO:0000303|PubMed:16393692, ECO:0000303|PubMed:19565474, ECO:0000303|PubMed:21779493}.; Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity. {ECO:0000269|PubMed:19879846}.
- Links
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Search Substrates of MAPK1 (Human)
- AGE
- Acute myeloid leukemia
- Adherens junction
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Aldosterone
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy
- Axon guidance
- B cell receptor signaling pathway
- Bladder cancer
- Breast cancer
- C
- Cellular senescence
- Central carbon metabolism in cancer
- Chagas disease
- Chemical carcinogenesis
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Circadian entrainment
- Colorectal cancer
- Coronavirus disease
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- Glutamatergic synapse
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- HIF
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human T
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IL
- Influenza A
- Insulin signaling pathway
- Kaposi sarcoma
- Leishmaniasis
- Lipid and atherosclerosis
- Long
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- MicroRNAs in cancer
- NOD
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non
- Oocyte meiosis
- Osteoclast differentiation
- Oxytocin signaling pathway
- PD
- PI3K
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration
- Pertussis
- Phospholipase D signaling pathway
- Platelet activation
- Platinum drug resistance
- Prion disease
- Progesterone
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Renal cell carcinoma
- Retrograde endocannabinoid signaling
- Salmonella infection
- Serotonergic synapse
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TGF
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thyroid cancer
- Thyroid hormone signaling pathway
- Toll
- Toxoplasmosis
- Tuberculosis
- Type II diabetes mellitus
- VEGF signaling pathway
- Vascular smooth muscle contraction
- Viral carcinogenesis
- Yersinia infection
- cAMP signaling pathway
- cGMP
- mTOR signaling pathway
- ATP binding
- B cell receptor signaling pathway
- Bergmann glial cell differentiation
- ERBB signaling pathway
- ERK1 and ERK2 cascade
- Fc-epsilon receptor signaling pathway
- Fc-gamma receptor signaling pathway involved in phagocytosis
- Golgi apparatus
- MAP kinase activity
- MAP kinase kinase activity
- MAPK cascade
- RNA polymerase II CTD heptapeptide repeat kinase activity
- T cell receptor signaling pathway
- aging
- apoptotic process
- axon
- axon guidance
- azurophil granule lumen
- cardiac neural crest cell development involved in heart development
- caveola
- caveolin-mediated endocytosis
- cell cycle
- cell surface receptor signaling pathway
- cellular response to DNA damage stimulus
- cellular response to amino acid starvation
- cellular response to cadmium ion
- cellular response to dopamine
- cellular response to granulocyte macrophage colony-stimulating factor stimulus
- cellular response to reactive oxygen species
- cellular response to tumor necrosis factor
- chemical synaptic transmission
- chemotaxis
- cytoplasm
- cytosine metabolic process
- cytoskeleton
- cytosol
- decidualization
- dendrite cytoplasm
- diadenosine tetraphosphate biosynthetic process
- double-stranded DNA binding
- early endosome
- endoplasmic reticulum lumen
- extracellular region
- face development
- fibroblast growth factor receptor signaling pathway
- ficolin-1-rich granule lumen
- focal adhesion
- identical protein binding
- intracellular signal transduction
- labyrinthine layer blood vessel development
- late endosome
- learning or memory
- lipopolysaccharide-mediated signaling pathway
- long-term synaptic potentiation
- lung morphogenesis
- mammary gland epithelial cell proliferation
- microtubule organizing center
- mitochondrion
- mitogen-activated protein kinase kinase kinase binding
- mitotic spindle
- negative regulation by symbiont of host apoptotic process
- negative regulation of cell differentiation
- neutrophil degranulation
- nucleoplasm
- nucleus
- obsolete activation of MAPK activity
- obsolete activation of MAPKK activity
- outer ear morphogenesis
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- perikaryon
- phosphatase binding
- phosphotyrosine residue binding
- plasma membrane
- platelet activation
- positive regulation of cardiac muscle cell proliferation
- positive regulation of gene expression
- positive regulation of macrophage chemotaxis
- positive regulation of macrophage proliferation
- positive regulation of peptidyl-threonine phosphorylation
- positive regulation of protein import into nucleus
- positive regulation of telomerase activity
- positive regulation of telomere capping
- positive regulation of telomere maintenance via telomerase
- positive regulation of transcription, DNA-templated
- positive regulation of translation
- postsynaptic density
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- protein-containing complex
- pseudopodium
- regulation of DNA-binding transcription factor activity
- regulation of Golgi inheritance
- regulation of cellular pH
- regulation of cellular response to heat
- regulation of cytoskeleton organization
- regulation of early endosome to late endosome transport
- regulation of ossification
- regulation of phosphatidylinositol 3-kinase signaling
- regulation of protein stability
- regulation of stress-activated MAPK cascade
- response to epidermal growth factor
- response to estrogen
- response to exogenous dsRNA
- response to nicotine
- response to toxic substance
- sensory perception of pain
- signal transduction
- stress-activated MAPK cascade
- thymus development
- thyroid gland development
- trachea formation
- transcription factor binding
- viral process
PKA*
Protein kinase A family
- Organism
- ()
- Accession #
- 0000PKA
- Protein names
-
- Protein kinase A family
- Gene names
-
- PKA*
- Description
-
N/A
- Links
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Search Substrates of PKA* ()
N/A
N/A
PRKACA
Human
cAMP-dependent protein kinase catalytic subunit alpha
- Organism
- Human (Homo sapiens)
- Uniprot ID
- KAPCA_HUMAN
- Accession #
- P17612
- Protein names
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- cAMP-dependent protein kinase catalytic subunit alpha
- PKA C-alpha
- EC 2.7.11.11
- Gene names
-
- PRKACA
- PKACA
- Description
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Phosphorylates a large number of substrates in the cytoplasm and the nucleus (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984). Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, SOX9 and VASP (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:21423175). RORA is activated by phosphorylation (PubMed:21514275). Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts (PubMed:19949837). Involved in chondrogenesis by mediating phosphorylation of SOX9 (By similarity). Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP (PubMed:15642694, PubMed:20356841). Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated (PubMed:17333334). RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+) (PubMed:17693412). PSMC5/RPT6 activation by phosphorylation stimulates proteasome (PubMed:17565987). Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation (PubMed:15905176). NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding (PubMed:15642694). Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation (By similarity). May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT) (By similarity). Phosphorylates APOBEC3G and AICDA (PubMed:16387847, PubMed:18836454). Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (PubMed:21085490). {ECO:0000250|UniProtKB:P05132, ECO:0000250|UniProtKB:P27791, ECO:0000269|PubMed:15642694, ECO:0000269|PubMed:15905176, ECO:0000269|PubMed:16387847, ECO:0000269|PubMed:17333334, ECO:0000269|PubMed:17565987, ECO:0000269|PubMed:17693412, ECO:0000269|PubMed:18836454, ECO:0000269|PubMed:19949837, ECO:0000269|PubMed:20356841, ECO:0000269|PubMed:21085490, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21514275, ECO:0000269|PubMed:21812984}.; [Isoform 2]: Phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. {ECO:0000250|UniProtKB:P05132}.
- Links
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Search Substrates of PRKACA (Human)
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Aldosterone synthesis and secretion
- Amoebiasis
- Amphetamine addiction
- Apelin signaling pathway
- Autophagy
- Bile secretion
- Calcium signaling pathway
- Chemical carcinogenesis
- Chemokine signaling pathway
- Cholinergic synapse
- Circadian entrainment
- Cocaine addiction
- Cortisol synthesis and secretion
- Cushing syndrome
- Dilated cardiomyopathy
- Dopaminergic synapse
- Endocrine and other factor
- Endocrine resistance
- Estrogen signaling pathway
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glucagon signaling pathway
- Glutamatergic synapse
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hedgehog signaling pathway
- Human T
- Human cytomegalovirus infection
- Human papillomavirus infection
- Inflammatory mediator regulation of TRP channels
- Insulin secretion
- Insulin signaling pathway
- Long
- Longevity regulating pathway
- MAPK signaling pathway
- Melanogenesis
- Morphine addiction
- Olfactory transduction
- Oocyte meiosis
- Ovarian steroidogenesis
- Oxytocin signaling pathway
- Parathyroid hormone synthesis, secretion and action
- Parkinson disease
- Pathways in cancer
- Platelet activation
- Prion disease
- Progesterone
- Proteoglycans in cancer
- Ras signaling pathway
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renin secretion
- Retrograde endocannabinoid signaling
- Salivary secretion
- Serotonergic synapse
- Taste transduction
- Thermogenesis
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- Tight junction
- Vascular smooth muscle contraction
- Vasopressin
- Vibrio cholerae infection
- Viral carcinogenesis
- Wnt signaling pathway
- cAMP signaling pathway
- AMP-activated protein kinase activity
- ATP binding
- G2/M transition of mitotic cell cycle
- acrosomal vesicle
- activation of protein kinase A activity
- adaptive immune response
- blood coagulation
- cAMP-dependent protein kinase activity
- cAMP-dependent protein kinase complex
- calcium channel complex
- calcium-mediated signaling using intracellular calcium source
- cell communication by electrical coupling involved in cardiac conduction
- cellular response to epinephrine stimulus
- cellular response to glucagon stimulus
- cellular response to glucose stimulus
- cellular response to heat
- cellular response to parathyroid hormone stimulus
- centrosome
- chemical synaptic transmission
- ciliary basal body-plasma membrane docking
- ciliary base
- cytokine-mediated signaling pathway
- cytoplasm
- cytosol
- dendritic spine
- extracellular exosome
- high-density lipoprotein particle assembly
- mRNA processing
- magnesium ion binding
- manganese ion binding
- membrane
- mesoderm formation
- mitochondrion
- modulation of chemical synaptic transmission
- negative regulation of inflammatory response to antigenic stimulus
- negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
- neural tube closure
- neuromuscular junction
- nuclear speck
- nucleoplasm
- nucleotide-activated protein kinase complex
- nucleus
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- perinuclear region of cytoplasm
- plasma membrane raft
- positive regulation of protein export from nucleus
- protein autophosphorylation
- protein domain specific binding
- protein kinase A regulatory subunit binding
- protein kinase A signaling
- protein kinase activity
- protein kinase binding
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- protein serine/threonine/tyrosine kinase activity
- regulation of G2/M transition of mitotic cell cycle
- regulation of bicellular tight junction assembly
- regulation of cardiac conduction
- regulation of cardiac muscle contraction
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
- regulation of cytosolic calcium ion concentration
- regulation of heart rate
- regulation of macroautophagy
- regulation of osteoblast differentiation
- regulation of proteasomal protein catabolic process
- regulation of protein binding
- regulation of protein processing
- regulation of ryanodine-sensitive calcium-release channel activity
- renal water homeostasis
- sperm capacitation
- sperm flagellum
- sperm midpiece
- stimulatory C-type lectin receptor signaling pathway
- ubiquitin protein ligase binding
STK11
Human
Serine/threonine-protein kinase STK11
- Organism
- Human (Homo sapiens)
- Uniprot ID
- STK11_HUMAN
- Accession #
- Q15831
- Protein names
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- Serine/threonine-protein kinase STK11
- EC 2.7.11.1
- Liver kinase B1
- LKB1
- hLKB1
- Renal carcinoma antigen NY-REN-19
- Gene names
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- STK11
- LKB1
- PJS
- Description
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Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). {ECO:0000269|PubMed:11430832, ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15016379, ECO:0000269|PubMed:15733851, ECO:0000269|PubMed:15987703, ECO:0000269|PubMed:17108107, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}.; [Isoform 2]: Has a role in spermiogenesis. {ECO:0000250}.
- Links
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Search Substrates of STK11 (Human)
- ATP binding
- Golgi localization
- LRR domain binding
- T cell receptor signaling pathway
- activation of protein kinase activity
- anoikis
- autophagy
- axonogenesis
- canonical Wnt signaling pathway
- cellular response to DNA damage stimulus
- cellular response to UV-B
- cytoplasm
- cytosol
- dendrite extension
- establishment of cell polarity
- extracellular exosome
- glucose homeostasis
- intrinsic apoptotic signaling pathway by p53 class mediator
- magnesium ion binding
- membrane
- mitochondrion
- negative regulation of TORC1 signaling
- negative regulation of canonical Wnt signaling pathway
- negative regulation of cell growth
- negative regulation of cell population proliferation
- negative regulation of cold-induced thermogenesis
- negative regulation of epithelial cell proliferation involved in prostate gland development
- nucleoplasm
- nucleus
- p53 binding
- positive regulation of autophagy
- positive regulation of axonogenesis
- positive regulation of protein localization to nucleus
- positive regulation of transforming growth factor beta receptor signaling pathway
- positive regulation of vesicle transport along microtubule
- positive thymic T cell selection
- protein autophosphorylation
- protein dephosphorylation
- protein kinase activator activity
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- regulation of cell growth
- regulation of dendrite morphogenesis
- regulation of protein kinase B signaling
- regulation of signal transduction by p53 class mediator
- response to ionizing radiation
- spermatogenesis
- tissue homeostasis
- vasculature development