Search Results (1 kinase found)
Gene name
Organism
Protein name
FYN
Human
Tyrosine-protein kinase Fyn
- Organism
- Human (Homo sapiens)
- Uniprot ID
- FYN_HUMAN
- Accession #
- P06241
- Protein names
-
- Tyrosine-protein kinase Fyn
- EC 2.7.10.2
- Proto-oncogene Syn
- Proto-oncogene c-Fyn
- Src-like kinase
- SLK
- p59-Fyn
- Gene names
-
- FYN
- Description
-
Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). {ECO:0000250|UniProtKB:P39688, ECO:0000269|PubMed:11005864, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117, ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091, ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597, ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:7822789}.
- Links
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Search Substrates of FYN (Human)
- Adherens junction
- Axon guidance
- Cholinergic synapse
- Fc epsilon RI signaling pathway
- Focal adhesion
- Natural killer cell mediated cytotoxicity
- Osteoclast differentiation
- Pathogenic Escherichia coli infection
- Phospholipase D signaling pathway
- Platelet activation
- Prion disease
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- Viral myocarditis
- ATP binding
- CD4 receptor binding
- CD8 receptor binding
- Fc-gamma receptor signaling pathway involved in phagocytosis
- MAPK cascade
- Schaffer collateral - CA1 synapse
- T cell costimulation
- T cell receptor binding
- T cell receptor signaling pathway
- actin filament
- activated T cell proliferation
- adaptive immune response
- alpha-tubulin binding
- axon guidance
- blood coagulation
- calcium ion transport
- cell body
- cell differentiation
- cellular response to L-glutamate
- cellular response to amyloid-beta
- cellular response to glycine
- cellular response to peptide hormone stimulus
- cellular response to platelet-derived growth factor stimulus
- cellular response to transforming growth factor beta stimulus
- cytokine-mediated signaling pathway
- cytosol
- dendrite
- dendrite morphogenesis
- dendritic spine maintenance
- detection of mechanical stimulus involved in sensory perception of pain
- disordered domain specific binding
- endosome
- enzyme binding
- ephrin receptor binding
- ephrin receptor signaling pathway
- extrinsic component of cytoplasmic side of plasma membrane
- feeding behavior
- forebrain development
- glial cell projection
- glutamatergic synapse
- growth factor receptor binding
- heart process
- identical protein binding
- innate immune response
- intracellular signal transduction
- learning
- leukocyte migration
- membrane raft
- metal ion binding
- mitochondrion
- modulation of chemical synaptic transmission
- negative regulation of dendritic spine maintenance
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- negative regulation of gene expression
- negative regulation of hydrogen peroxide biosynthetic process
- negative regulation of inflammatory response to antigenic stimulus
- negative regulation of neuron apoptotic process
- negative regulation of oxidative stress-induced cell death
- negative regulation of protein catabolic process
- negative regulation of protein ubiquitination
- neuron migration
- non-membrane spanning protein tyrosine kinase activity
- nucleus
- peptide hormone receptor binding
- peptidyl-tyrosine phosphorylation
- perinuclear endoplasmic reticulum
- perinuclear region of cytoplasm
- phosphatidylinositol 3-kinase binding
- phospholipase activator activity
- phospholipase binding
- plasma membrane
- platelet activation
- positive regulation of I-kappaB kinase/NF-kappaB signaling
- positive regulation of cysteine-type endopeptidase activity
- positive regulation of neuron death
- positive regulation of neuron projection development
- positive regulation of non-membrane spanning protein tyrosine kinase activity
- positive regulation of phosphatidylinositol 3-kinase signaling
- positive regulation of protein kinase B signaling
- positive regulation of protein localization to membrane
- positive regulation of protein localization to nucleus
- positive regulation of protein targeting to membrane
- positive regulation of tyrosine phosphorylation of STAT protein
- postsynaptic density
- postsynaptic density, intracellular component
- protein autophosphorylation
- protein phosphorylation
- protein tyrosine kinase activity
- regulation of calcium ion import across plasma membrane
- regulation of cell shape
- regulation of defense response to virus by virus
- regulation of glutamate receptor signaling pathway
- regulation of peptidyl-tyrosine phosphorylation
- response to amyloid-beta
- response to ethanol
- response to hydrogen peroxide
- response to singlet oxygen
- signaling receptor binding
- stimulatory C-type lectin receptor signaling pathway
- tau protein binding
- tau-protein kinase activity
- transmembrane receptor protein tyrosine kinase activity
- transmembrane receptor protein tyrosine kinase signaling pathway
- transmembrane transporter binding
- type 5 metabotropic glutamate receptor binding
- vascular endothelial growth factor receptor signaling pathway