Search Results (1 kinase found)
Gene name
Organism
Protein name
MAPK1
Human
Mitogen-activated protein kinase 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
- MK01_HUMAN
- Accession #
- P28482
- Protein names
-
- Mitogen-activated protein kinase 1
- MAP kinase 1
- MAPK 1
- EC 2.7.11.24
- ERT1
- Extracellular signal-regulated kinase 2
- ERK-2
- MAP kinase isoform p42
- p42-MAPK
- Mitogen-activated protein kinase 2
- MAP kinase 2
- MAPK 2
- Gene names
-
- MAPK1
- ERK2
- PRKM1
- PRKM2
- Description
-
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in response to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity). {ECO:0000250|UniProtKB:P63086, ECO:0000269|PubMed:10617468, ECO:0000269|PubMed:10637505, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:12110590, ECO:0000269|PubMed:12356731, ECO:0000269|PubMed:12792650, ECO:0000269|PubMed:12794087, ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:15184391, ECO:0000269|PubMed:15241487, ECO:0000269|PubMed:15616583, ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:15788397, ECO:0000269|PubMed:15952796, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:19879846, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:7588608, ECO:0000269|PubMed:8622688, ECO:0000269|PubMed:9480836, ECO:0000269|PubMed:9596579, ECO:0000269|PubMed:9649500, ECO:0000269|PubMed:9687510, ECO:0000303|PubMed:15526160, ECO:0000303|PubMed:16393692, ECO:0000303|PubMed:19565474, ECO:0000303|PubMed:21779493}.; Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity. {ECO:0000269|PubMed:19879846}.
- Links
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Search Substrates of MAPK1 (Human)
- AGE
- Acute myeloid leukemia
- Adherens junction
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Aldosterone
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy
- Axon guidance
- B cell receptor signaling pathway
- Bladder cancer
- Breast cancer
- C
- Cellular senescence
- Central carbon metabolism in cancer
- Chagas disease
- Chemical carcinogenesis
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Circadian entrainment
- Colorectal cancer
- Coronavirus disease
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- Glutamatergic synapse
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- HIF
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human T
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IL
- Influenza A
- Insulin signaling pathway
- Kaposi sarcoma
- Leishmaniasis
- Lipid and atherosclerosis
- Long
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- MicroRNAs in cancer
- NOD
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non
- Oocyte meiosis
- Osteoclast differentiation
- Oxytocin signaling pathway
- PD
- PI3K
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration
- Pertussis
- Phospholipase D signaling pathway
- Platelet activation
- Platinum drug resistance
- Prion disease
- Progesterone
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Renal cell carcinoma
- Retrograde endocannabinoid signaling
- Salmonella infection
- Serotonergic synapse
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TGF
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thyroid cancer
- Thyroid hormone signaling pathway
- Toll
- Toxoplasmosis
- Tuberculosis
- Type II diabetes mellitus
- VEGF signaling pathway
- Vascular smooth muscle contraction
- Viral carcinogenesis
- Yersinia infection
- cAMP signaling pathway
- cGMP
- mTOR signaling pathway
- ATP binding
- B cell receptor signaling pathway
- Bergmann glial cell differentiation
- ERBB signaling pathway
- ERK1 and ERK2 cascade
- Fc-epsilon receptor signaling pathway
- Fc-gamma receptor signaling pathway involved in phagocytosis
- Golgi apparatus
- MAP kinase activity
- MAP kinase kinase activity
- MAPK cascade
- RNA polymerase II CTD heptapeptide repeat kinase activity
- T cell receptor signaling pathway
- aging
- apoptotic process
- axon
- axon guidance
- azurophil granule lumen
- cardiac neural crest cell development involved in heart development
- caveola
- caveolin-mediated endocytosis
- cell cycle
- cell surface receptor signaling pathway
- cellular response to DNA damage stimulus
- cellular response to amino acid starvation
- cellular response to cadmium ion
- cellular response to dopamine
- cellular response to granulocyte macrophage colony-stimulating factor stimulus
- cellular response to reactive oxygen species
- cellular response to tumor necrosis factor
- chemical synaptic transmission
- chemotaxis
- cytoplasm
- cytosine metabolic process
- cytoskeleton
- cytosol
- decidualization
- dendrite cytoplasm
- diadenosine tetraphosphate biosynthetic process
- double-stranded DNA binding
- early endosome
- endoplasmic reticulum lumen
- extracellular region
- face development
- fibroblast growth factor receptor signaling pathway
- ficolin-1-rich granule lumen
- focal adhesion
- identical protein binding
- intracellular signal transduction
- labyrinthine layer blood vessel development
- late endosome
- learning or memory
- lipopolysaccharide-mediated signaling pathway
- long-term synaptic potentiation
- lung morphogenesis
- mammary gland epithelial cell proliferation
- microtubule organizing center
- mitochondrion
- mitogen-activated protein kinase kinase kinase binding
- mitotic spindle
- negative regulation by symbiont of host apoptotic process
- negative regulation of cell differentiation
- neutrophil degranulation
- nucleoplasm
- nucleus
- obsolete activation of MAPK activity
- obsolete activation of MAPKK activity
- outer ear morphogenesis
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- perikaryon
- phosphatase binding
- phosphotyrosine residue binding
- plasma membrane
- platelet activation
- positive regulation of cardiac muscle cell proliferation
- positive regulation of gene expression
- positive regulation of macrophage chemotaxis
- positive regulation of macrophage proliferation
- positive regulation of peptidyl-threonine phosphorylation
- positive regulation of protein import into nucleus
- positive regulation of telomerase activity
- positive regulation of telomere capping
- positive regulation of telomere maintenance via telomerase
- positive regulation of transcription, DNA-templated
- positive regulation of translation
- postsynaptic density
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- protein-containing complex
- pseudopodium
- regulation of DNA-binding transcription factor activity
- regulation of Golgi inheritance
- regulation of cellular pH
- regulation of cellular response to heat
- regulation of cytoskeleton organization
- regulation of early endosome to late endosome transport
- regulation of ossification
- regulation of phosphatidylinositol 3-kinase signaling
- regulation of protein stability
- regulation of stress-activated MAPK cascade
- response to epidermal growth factor
- response to estrogen
- response to exogenous dsRNA
- response to nicotine
- response to toxic substance
- sensory perception of pain
- signal transduction
- stress-activated MAPK cascade
- thymus development
- thyroid gland development
- trachea formation
- transcription factor binding
- viral process