KANPHOS_Str

Search Results (903 substrates found)

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Gene name
Organism
Protein name
Aanat
Rat
Serotonin N-acetyltransferase
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
SNAT_RAT
Accession #
Q64666
Protein names
  • Serotonin N-acetyltransferase
  • Serotonin acetylase
  • EC 2.3.1.87
  • Aralkylamine N-acetyltransferase
  • AA-NAT
Gene names
  • Aanat
  • Snat
Description
Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. {ECO:0000250|UniProtKB:Q29495}.
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Search Kinases of Aanat (Rat)
Phosphorylation Site Information
ABCB1
Human
ATP-dependent translocase ABCB1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
MDR1_HUMAN
Accession #
P08183
Protein names
  • ATP-dependent translocase ABCB1
  • ATP-binding cassette sub-family B member 1
  • Multidrug resistance protein 1
  • EC 7.6.2.2
  • P-glycoprotein 1
  • Phospholipid transporter ABCB1
  • EC 7.6.2.1
  • CD antigen CD243
Gene names
  • ABCB1
  • MDR1
  • PGY1
Description
Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:9038218). {ECO:0000269|PubMed:2897240, ECO:0000269|PubMed:8898203, ECO:0000269|PubMed:9038218}.
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Search Kinases of ABCB1 (Human)
Phosphorylation Site Information
ABCB7
Human
Iron-sulfur clusters transporter ABCB7, mitochondrial
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ABCB7_HUMAN
Accession #
O75027
Protein names
  • Iron-sulfur clusters transporter ABCB7, mitochondrial
  • ATP-binding cassette sub-family B member 7, mitochondrial
  • ATP-binding cassette transporter 7
  • ABC transporter 7 protein
Gene names
  • ABCB7
  • ABC7
Description
Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]-(GS)4 cluster from the mitochondria to the cytosol in an ATP dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins, in turns participates in iron homeostasis (PubMed:33157103, PubMed:17192393, PubMed:10196363). Moreover through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis (PubMed:30765471). In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1 (By similarity). May also play a role in hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q61102, ECO:0000250|UniProtKB:Q704E8, ECO:0000269|PubMed:10196363, ECO:0000269|PubMed:17192393, ECO:0000269|PubMed:30765471, ECO:0000269|PubMed:33157103}.
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Search Kinases of ABCB7 (Human)
KEGG Pathways (1)
Phosphorylation Site Information
ABCF1
Human
ATP-binding cassette sub-family F member 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ABCF1_HUMAN
Accession #
Q8NE71
Protein names
  • ATP-binding cassette sub-family F member 1
  • ATP-binding cassette 50
  • TNF-alpha-stimulated ABC protein
Gene names
  • ABCF1
  • ABC50
Description
Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis. {ECO:0000269|PubMed:19570978}.
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Search Kinases of ABCF1 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
ACAP1
Human
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ACAP1_HUMAN
Accession #
Q15027
Protein names
  • Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
  • Centaurin-beta-1
  • Cnt-b1
Gene names
  • ACAP1
  • CENTB1
  • KIAA0050
Description
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration. {ECO:0000269|PubMed:11062263, ECO:0000269|PubMed:16256741, ECO:0000269|PubMed:17398097, ECO:0000269|PubMed:17664335, ECO:0000269|PubMed:22645133}.
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Search Kinases of ACAP1 (Human)
KEGG Pathways (1)
Phosphorylation Site Information
ACO1
Human
Cytoplasmic aconitate hydratase
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ACOC_HUMAN
Accession #
P21399
Protein names
  • Cytoplasmic aconitate hydratase
  • Aconitase
  • EC 4.2.1.3
  • Citrate hydro-lyase
  • Ferritin repressor protein
  • Iron regulatory protein 1
  • IRP1
  • Iron-responsive element-binding protein 1
  • IRE-BP 1
Gene names
  • ACO1
  • IREB1
Description
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. {ECO:0000269|PubMed:1946430, ECO:0000269|PubMed:23891004, ECO:0000269|PubMed:8041788}.; Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250}.
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Search Kinases of ACO1 (Human)
Phosphorylation Site Information
Aco1
Rat
Cytoplasmic aconitate hydratase
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ACOC_RAT
Accession #
Q63270
Protein names
  • Cytoplasmic aconitate hydratase
  • Aconitase
  • EC 4.2.1.3
  • Citrate hydro-lyase
  • Iron regulatory protein 1
  • IRP1
  • Iron-responsive element-binding protein 1
  • IRE-BP 1
Gene names
  • Aco1
  • Ireb1
  • Irebp
Description
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. {ECO:0000250|UniProtKB:P21399}.; Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250, ECO:0000250|UniProtKB:P21399}.
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Search Kinases of Aco1 (Rat)
Phosphorylation Site Information
ADAM17
Human
Disintegrin and metalloproteinase domain-containing protein 17
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ADA17_HUMAN
Accession #
P78536
Protein names
  • Disintegrin and metalloproteinase domain-containing protein 17
  • ADAM 17
  • EC 3.4.24.86
  • Snake venom-like protease
  • TNF-alpha convertase
  • TNF-alpha-converting enzyme
  • CD antigen CD156b
Gene names
  • ADAM17
  • CSVP
  • TACE
Description
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:12441351). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (PubMed:26876177, PubMed:28060820). {ECO:0000250|UniProtKB:Q9Z0F8, ECO:0000269|PubMed:12441351, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:24226769, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:28060820, ECO:0000269|PubMed:9034191}.
Links

Search Kinases of ADAM17 (Human)
Gene Ontology Terms (64)
Phosphorylation Site Information
ADAP1
Human
Arf-GAP with dual PH domain-containing protein 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ADAP1_HUMAN
Accession #
O75689
Protein names
  • Arf-GAP with dual PH domain-containing protein 1
  • Centaurin-alpha-1
  • Cnt-a1
  • Putative MAPK-activating protein PM25
Gene names
  • ADAP1
  • CENTA1
Description
GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). {ECO:0000269|PubMed:10448098, ECO:0000303|PubMed:10333475, ECO:0000305}.
Links

Search Kinases of ADAP1 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
ADAP2
Human
Arf-GAP with dual PH domain-containing protein 2
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ADAP2_HUMAN
Accession #
Q9NPF8
Protein names
  • Arf-GAP with dual PH domain-containing protein 2
  • Centaurin-alpha-2
  • Cnt-a2
Gene names
  • ADAP2
  • CENTA2
Description
GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity. {ECO:0000269|PubMed:14690521, ECO:0000305}.
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Search Kinases of ADAP2 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
ADARB1
Human
Double-stranded RNA-specific editase 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
RED1_HUMAN
Accession #
P78563
Protein names
  • Double-stranded RNA-specific editase 1
  • EC 3.5.4.37
  • RNA-editing deaminase 1
  • RNA-editing enzyme 1
  • dsRNA adenosine deaminase
Gene names
  • ADARB1
  • ADAR2
  • DRADA2
  • RED1
Description
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis. {ECO:0000269|PubMed:18178553, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159}.; [Isoform 1]: Has a lower catalytic activity than isoform 2. {ECO:0000269|PubMed:9149227}.; [Isoform 2]: Has a higher catalytic activity than isoform 1. {ECO:0000269|PubMed:9149227}.
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Search Kinases of ADARB1 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Adcy2
Rat
Adenylate cyclase type 2
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ADCY2_RAT
Accession #
P26769
Protein names
  • Adenylate cyclase type 2
  • EC 4.6.1.1
  • ATP pyrophosphate-lyase 2
  • Adenylate cyclase type II
  • Adenylyl cyclase 2
  • AC2
Gene names
  • Adcy2
Description
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:22906005, PubMed:24363043, PubMed:10427002, PubMed:1719547, PubMed:7761832, PubMed:21596131, PubMed:11087399, PubMed:15591060, PubMed:19243146, PubMed:16766715). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production (PubMed:24363043). Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (PubMed:22906005). {ECO:0000269|PubMed:10427002, ECO:0000269|PubMed:11087399, ECO:0000269|PubMed:15591060, ECO:0000269|PubMed:16766715, ECO:0000269|PubMed:1719547, ECO:0000269|PubMed:19243146, ECO:0000269|PubMed:21596131, ECO:0000269|PubMed:22906005, ECO:0000269|PubMed:24363043, ECO:0000269|PubMed:7761832}.
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Search Kinases of Adcy2 (Rat)
Phosphorylation Site Information
Add1
Rat
Alpha-adducin
Add2
Rat
Beta-adducin
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ADDB_RAT
Accession #
Q05764
Protein names
  • Beta-adducin
  • Adducin-63
  • Erythrocyte adducin subunit beta
Gene names
  • Add2
Description
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity). {ECO:0000250}.
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Search Kinases of Add2 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
ADD2
Human
Beta-adducin
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ADDB_HUMAN
Accession #
P35612
Protein names
  • Beta-adducin
  • Erythrocyte adducin subunit beta
Gene names
  • ADD2
  • ADDB
Description
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. {ECO:0000269|PubMed:18347014}.
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Search Kinases of ADD2 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Add3
Rat
Gamma-adducin
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ADDG_RAT
Accession #
Q62847
Protein names
  • Gamma-adducin
  • Adducin-like protein 70
  • Protein kinase C-binding protein 35H
Gene names
  • Add3
Description
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping. Binds to calmodulin. {ECO:0000250|UniProtKB:Q9UEY8}.
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Search Kinases of Add3 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
AFAP1
Human
Actin filament-associated protein 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
AFAP1_HUMAN
Accession #
Q8N556
Protein names
  • Actin filament-associated protein 1
  • 110 kDa actin filament-associated protein
  • AFAP-110
Gene names
  • AFAP1
  • AFAP
Description
Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. {ECO:0000250, ECO:0000269|PubMed:15485829}.
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Search Kinases of AFAP1 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
AGGF1
Human
Angiogenic factor with G patch and FHA domains 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
AGGF1_HUMAN
Accession #
Q8N302
Protein names
  • Angiogenic factor with G patch and FHA domains 1
  • Angiogenic factor VG5Q
  • hVG5Q
  • G patch domain-containing protein 7
  • Vasculogenesis gene on 5q protein
Gene names
  • AGGF1
  • GPATC7
  • GPATCH7
  • VG5Q
Description
Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269|PubMed:14961121}.
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Search Kinases of AGGF1 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Agtr2
Rat
Type-2 angiotensin II receptor
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
AGTR2_RAT
Accession #
P35351
Protein names
  • Type-2 angiotensin II receptor
  • Angiotensin II type-2 receptor
  • AT2
Gene names
  • Agtr2
Description
Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation (By similarity). {ECO:0000250}.
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Search Kinases of Agtr2 (Rat)
Gene Ontology Terms (44)
Phosphorylation Site Information
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