KANPHOS_Str

Search Results (14 substrates found)

Displaying 1 - 14 of 14 Items
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Gene name
Organism
Protein name
Camk4
Rat
Calcium/calmodulin-dependent protein kinase type IV
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
KCC4_RAT
Accession #
P13234
Protein names
  • Calcium/calmodulin-dependent protein kinase type IV
  • CaMK IV
  • EC 2.7.11.17
  • CaM kinase-GR
  • Calspermin
Gene names
  • Camk4
Description
[Isoform 1]: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18 (By similarity). {ECO:0000250}.; [Isoform 2]: Heat-stable, acidic, calmodulin-binding protein. {ECO:0000269|PubMed:1646483, ECO:0000269|PubMed:8065343, ECO:0000269|PubMed:8621702}.
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Search Kinases of Camk4 (Rat)
Phosphorylation Site Information
Creb1
Rat
Cyclic AMP-responsive element-binding protein 1
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
CREB1_RAT
Accession #
P15337
Protein names
  • Cyclic AMP-responsive element-binding protein 1
  • CREB-1
  • cAMP-responsive element-binding protein 1
Gene names
  • Creb1
  • Creb-1
Description
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). {ECO:0000250}.
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Search Kinases of Creb1 (Rat)
Gene Ontology Terms (81)
Phosphorylation Site Information
CREB1
Human
Cyclic AMP-responsive element-binding protein 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CREB1_HUMAN
Accession #
P16220
Protein names
  • Cyclic AMP-responsive element-binding protein 1
  • CREB-1
  • cAMP-responsive element-binding protein 1
Gene names
  • CREB1
Description
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
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Search Kinases of CREB1 (Human)
Gene Ontology Terms (71)
Phosphorylation Site Information
Crebbp
Mouse
Histone lysine acetyltransferase CREBBP
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
CBP_MOUSE
Accession #
P45481
Protein names
  • Histone lysine acetyltransferase CREBBP
  • EC 2.3.1.48
  • Protein-lysine acetyltransferase CREBBP
  • EC 2.3.1.-
Gene names
  • Crebbp
  • Cbp
Description
Acetylates histones, giving a specific tag for transcriptional activation (By similarity). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10207073, PubMed:11701890, PubMed:16287980, PubMed:15220471). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes (By similarity). Acts as a coactivator of ALX1 (By similarity). Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (By similarity). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24737000). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (By similarity). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (By similarity). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (By similarity). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q92793, ECO:0000269|PubMed:10207073, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:16287980, ECO:0000269|PubMed:24737000}.
Links

Search Kinases of Crebbp (Mouse)
KEGG Pathways (0)
N/A
Gene Ontology Terms (56)
Phosphorylation Site Information
Crebbp
Rat
Histone lysine acetyltransferase CREBBP
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
CBP_RAT
Accession #
Q6JHU9
Protein names
  • Histone lysine acetyltransferase CREBBP
  • EC 2.3.1.48
  • Protein-lysine acetyltransferase CREBBP
  • EC 2.3.1.-
Gene names
  • Crebbp
  • Cbp
Description
Acetylates histones, giving a specific tag for transcriptional activation (By similarity). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (By similarity). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (By similarity). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (By similarity). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (By similarity). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (By similarity). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (By similarity). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (By similarity). {ECO:0000250|UniProtKB:P45481, ECO:0000250|UniProtKB:Q92793}.
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Search Kinases of Crebbp (Rat)
KEGG Pathways (0)
N/A
Gene Ontology Terms (55)
Phosphorylation Site Information
HDAC5
Human
Histone deacetylase 5
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
HDAC5_HUMAN
Accession #
Q9UQL6
Protein names
  • Histone deacetylase 5
  • HD5
  • EC 3.5.1.98
  • Antigen NY-CO-9
Gene names
  • HDAC5
  • KIAA0600
Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). {ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:28167758}.
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Search Kinases of HDAC5 (Human)
Phosphorylation Site Information
HNRNPL
Human
Heterogeneous nuclear ribonucleoprotein L
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
HNRPL_HUMAN
Accession #
P14866
Protein names
  • Heterogeneous nuclear ribonucleoprotein L
  • hnRNP L
Gene names
  • HNRNPL
  • HNRPL
  • P/OKcl.14
Description
Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). {ECO:0000269|PubMed:11809897, ECO:0000269|PubMed:22570490, ECO:0000269|PubMed:25623890, ECO:0000269|PubMed:26051023, ECO:0000269|PubMed:2687284}.
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Search Kinases of HNRNPL (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Il6st
Mouse
Interleukin-6 receptor subunit beta
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
IL6RB_MOUSE
Accession #
Q00560
Protein names
  • Interleukin-6 receptor subunit beta
  • IL-6 receptor subunit beta
  • IL-6R subunit beta
  • IL-6R-beta
  • IL-6RB
  • Interleukin-6 signal transducer
  • Membrane glycoprotein 130
  • gp130
  • Oncostatin-M receptor subunit alpha
  • CD antigen CD130
Gene names
  • Il6st
Description
Signal-transducing molecule (PubMed:1602143). The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activate the intracellular JAK-MAPK and JAK-STAT3 signaling pathways (PubMed:1602143, PubMed:10661409). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:10661409). In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (PubMed:9202125). Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (PubMed:25731159). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (PubMed:10661409, PubMed:26255596, PubMed:25057188, PubMed:8552649). Has a role in embryonic development (PubMed:10661409). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (PubMed:10377352). Required for expression of TRPA1 in nociceptive neurons (PubMed:25057188). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (PubMed:25228504). Required for normal trabecular bone mass and cortical bone composition (PubMed:24339143, PubMed:9348227, PubMed:26255596). {ECO:0000250|UniProtKB:P40189, ECO:0000269|PubMed:10377352, ECO:0000269|PubMed:10661409, ECO:0000269|PubMed:1602143, ECO:0000269|PubMed:24339143, ECO:0000269|PubMed:25057188, ECO:0000269|PubMed:25228504, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:26255596, ECO:0000269|PubMed:8552649, ECO:0000269|PubMed:9202125, ECO:0000269|PubMed:9348227}.
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Search Kinases of Il6st (Mouse)
Gene Ontology Terms (43)
Phosphorylation Site Information
Myh9
Rat
Myosin-9
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
MYH9_RAT
Accession #
Q62812
Protein names
  • Myosin-9
  • Cellular myosin heavy chain, type A
  • Myosin heavy chain 9
  • Myosin heavy chain, non-muscle IIa
  • Non-muscle myosin heavy chain A
  • NMMHC-A
  • Non-muscle myosin heavy chain IIa
  • NMMHC II-a
  • NMMHC-IIA
Gene names
  • Myh9
Description
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping (By similarity). Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (By similarity). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (By similarity). {ECO:0000250|UniProtKB:P35579, ECO:0000250|UniProtKB:Q8VDD5}.
Links

Search Kinases of Myh9 (Rat)
KEGG Pathways (0)
N/A
Gene Ontology Terms (89)
Phosphorylation Site Information
NUMB
Human
Protein numb homolog
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
NUMB_HUMAN
Accession #
P49757
Protein names
  • Protein numb homolog
  • h-Numb
  • Protein S171
Gene names
  • NUMB
  • C14orf41
Description
Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity). {ECO:0000250|UniProtKB:Q9QZS3, ECO:0000269|PubMed:18657069}.
Links

Search Kinases of NUMB (Human)
KEGG Pathways (1)
Phosphorylation Site Information
PHB2
Human
Prohibitin-2
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
PHB2_HUMAN
Accession #
Q99623
Protein names
  • Prohibitin-2
  • B-cell receptor-associated protein BAP37
  • D-prohibitin
  • Repressor of estrogen receptor activity
Gene names
  • PHB2
  • BAP
  • REA
Description
Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. {ECO:0000269|PubMed:10359819, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:24003225, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117}.; In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration (PubMed:20959514, PubMed:11302691). Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:20959514, PubMed:11302691). Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:28017329). Involved in mitochondrial-mediated antiviral innate immunity, activates DDX58/RIG-I-mediated signal transduction and production of IFNB1 and proinflammatory cytokine IL6 (PubMed:31522117). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:28017329, ECO:0000269|PubMed:31522117, ECO:0000305|PubMed:25904163}.; In the nucleus, serves as transcriptional co-regulator (Probable). Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000305|PubMed:25904163}.; In the plasma membrane, is involved in IGFBP6-induced cell migration (PubMed:24003225). Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). {ECO:0000250|UniProtKB:O35129, ECO:0000269|PubMed:24003225}.; (Microbial infection) Involved in human enterovirus 71/EV-71 infection by enhancing the autophagy mechanism during the infection. {ECO:0000269|PubMed:32276428}.
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Search Kinases of PHB2 (Human)
KEGG Pathways (0)
N/A
Gene Ontology Terms (57)
Phosphorylation Site Information
RELA
Human
Transcription factor p65
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
TF65_HUMAN
Accession #
Q04206
Protein names
  • Transcription factor p65
  • Nuclear factor NF-kappa-B p65 subunit
  • Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
Gene names
  • RELA
  • NFKB3
Description
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Beside its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:10928981, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:33440148}.
Links

Search Kinases of RELA (Human)
KEGG Pathways (74)
Gene Ontology Terms (111)
Phosphorylation Site Information
Snf1lk2
Rat
Non-specific serine/threonine protein kinase
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
Q3LRT3_RAT
Accession #
Q3LRT3
Protein names
  • Non-specific serine/threonine protein kinase
  • EC 2.7.11.1
Gene names
  • Snf1lk2
Description
N/A
Links

Search Kinases of Snf1lk2 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
STMN1
Human
Stathmin
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
STMN1_HUMAN
Accession #
P16949
Protein names
  • Stathmin
  • Leukemia-associated phosphoprotein p18
  • Metablastin
  • Oncoprotein 18
  • Op18
  • Phosphoprotein p19
  • pp19
  • Prosolin
  • Protein Pr22
  • pp17
Gene names
  • STMN1
  • C1orf215
  • LAP18
  • OP18
Description
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). {ECO:0000250}.
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Search Kinases of STMN1 (Human)
Phosphorylation Site Information