Search Results (98 substrates found)
Gene name
Organism
Protein name
AHNAK
Human
Neuroblast differentiation-associated protein AHNAK
- Organism
- Human (Homo sapiens)
- Uniprot ID
- AHNK_HUMAN
- Accession #
- Q09666
- Protein names
-
- Neuroblast differentiation-associated protein AHNAK
- Desmoyokin
- Gene names
-
- AHNAK
- PM227
- Description
-
May be required for neuronal cell differentiation.
- Links
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Search Kinases of AHNAK (Human)
- RNA binding
- S100 protein binding
- T-tubule
- actin cytoskeleton
- cadherin binding
- cell-cell contact zone
- costamere
- cytoplasm
- cytosol
- extracellular exosome
- focal adhesion
- identical protein binding
- lysosomal membrane
- membrane
- nucleus
- plasma membrane
- regulation of RNA splicing
- regulation of voltage-gated calcium channel activity
- sarcolemma
- structural molecule activity conferring elasticity
- vesicle
AR
Human
Androgen receptor
- Organism
- Human (Homo sapiens)
- Uniprot ID
- ANDR_HUMAN
- Accession #
- P10275
- Protein names
-
- Androgen receptor
- Dihydrotestosterone receptor
- Nuclear receptor subfamily 3 group C member 4
- Gene names
-
- AR
- DHTR
- NR3C4
- Description
-
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; [Isoform 3]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.; [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.
- Links
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Search Kinases of AR (Human)
- ATPase binding
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- Leydig cell differentiation
- POU domain binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- RNA polymerase II general transcription initiation factor binding
- activation of prostate induction by androgen receptor signaling pathway
- androgen binding
- androgen receptor signaling pathway
- animal organ formation
- beta-catenin binding
- cell-cell signaling
- cellular response to estrogen stimulus
- cellular response to steroid hormone stimulus
- cellular response to testosterone stimulus
- chromatin
- chromatin binding
- cytoplasm
- cytosol
- enzyme binding
- epithelial cell differentiation involved in prostate gland development
- epithelial cell morphogenesis
- in utero embryonic development
- intracellular estrogen receptor signaling pathway
- intracellular receptor signaling pathway
- intracellular steroid hormone receptor signaling pathway
- lateral sprouting involved in mammary gland duct morphogenesis
- male genitalia morphogenesis
- male gonad development
- male somatic sex determination
- mammary gland alveolus development
- morphogenesis of an epithelial fold
- multicellular organism growth
- negative regulation of cell population proliferation
- negative regulation of epithelial cell proliferation
- negative regulation of extrinsic apoptotic signaling pathway
- negative regulation of integrin biosynthetic process
- negative regulation of transcription by RNA polymerase II
- nuclear receptor activity
- nuclear speck
- nucleoplasm
- nucleus
- plasma membrane
- positive regulation of MAPK cascade
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of cell differentiation
- positive regulation of cell population proliferation
- positive regulation of epithelial cell proliferation involved in prostate gland development
- positive regulation of gene expression
- positive regulation of insulin-like growth factor receptor signaling pathway
- positive regulation of integrin biosynthetic process
- positive regulation of intracellular estrogen receptor signaling pathway
- positive regulation of phosphorylation
- positive regulation of transcription by RNA polymerase II
- positive regulation of transcription by RNA polymerase III
- positive regulation of transcription, DNA-templated
- prostate gland epithelium morphogenesis
- prostate gland growth
- protein deubiquitination
- protein-containing complex
- regulation of androgen receptor signaling pathway
- regulation of developmental growth
- regulation of protein localization to plasma membrane
- regulation of systemic arterial blood pressure
- regulation of transcription by RNA polymerase II
- seminiferous tubule development
- signal transduction
- signaling receptor binding
- single fertilization
- spermatogenesis
- steroid binding
- tertiary branching involved in mammary gland duct morphogenesis
- transcription cis-regulatory region binding
- transcription factor binding
- transcription initiation from RNA polymerase II promoter
- zinc ion binding
ARHGAP21
Human
Rho GTPase-activating protein 21
- Organism
- Human (Homo sapiens)
- Uniprot ID
- RHG21_HUMAN
- Accession #
- Q5T5U3
- Protein names
-
- Rho GTPase-activating protein 21
- Rho GTPase-activating protein 10
- Rho-type GTPase-activating protein 21
- Gene names
-
- ARHGAP21
- ARHGAP10
- KIAA1424
- Description
-
Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions. {ECO:0000269|PubMed:15793564, ECO:0000269|PubMed:16184169}.
- Links
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Search Kinases of ARHGAP21 (Human)
N/A
- GTPase activator activity
- Golgi apparatus
- Golgi localization
- Golgi membrane
- Golgi organization
- actin cytoskeleton
- cell junction
- cytoplasmic vesicle membrane
- cytosol
- establishment of Golgi localization
- maintenance of Golgi location
- organelle transport along microtubule
- plasma membrane
- positive regulation of GTPase activity
- regulation of small GTPase mediated signal transduction
- signal transduction
ARPC1B
Human
Actin-related protein 2/3 complex subunit 1B
- Organism
- Human (Homo sapiens)
- Uniprot ID
- ARC1B_HUMAN
- Accession #
- O15143
- Protein names
-
- Actin-related protein 2/3 complex subunit 1B
- Arp2/3 complex 41 kDa subunit
- p41-ARC
- Gene names
-
- ARPC1B
- ARC41
- Description
-
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:11741539, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}.
- Links
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Search Kinases of ARPC1B (Human)
- Arp2/3 complex-mediated actin nucleation
- Arp2/3 protein complex
- Fc-gamma receptor signaling pathway involved in phagocytosis
- actin binding
- actin cytoskeleton
- cytosol
- ephrin receptor signaling pathway
- extracellular exosome
- focal adhesion
- nucleus
- protein-containing complex binding
- response to estradiol
- response to estrogen
- structural constituent of cytoskeleton
- tubulobulbar complex
ATM
Human
Serine-protein kinase ATM
- Organism
- Human (Homo sapiens)
- Uniprot ID
- ATM_HUMAN
- Accession #
- Q13315
- Protein names
-
- Serine-protein kinase ATM
- EC 2.7.11.1
- Ataxia telangiectasia mutated
- A-T mutated
- Gene names
-
- ATM
- Description
-
Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:9843217, PubMed:9733515, PubMed:10550055, PubMed:10766245, PubMed:10839545, PubMed:10910365, PubMed:10802669, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:30612738, PubMed:30886146). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response. Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). {ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}.
- Links
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Search Kinases of ATM (Human)
- 1-phosphatidylinositol-3-kinase activity
- ATP binding
- DNA binding
- DNA damage checkpoint signaling
- DNA damage induced protein phosphorylation
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- DNA double-strand break processing
- DNA repair complex
- DNA replication
- DNA-dependent protein kinase activity
- V(D)J recombination
- brain development
- cellular response to DNA damage stimulus
- cellular response to X-ray
- cellular response to gamma radiation
- cellular response to nitrosative stress
- cellular response to retinoic acid
- cytoplasm
- cytoplasmic vesicle
- cytosol
- determination of adult lifespan
- double-strand break repair
- double-strand break repair via homologous recombination
- double-strand break repair via nonhomologous end joining
- establishment of RNA localization to telomere
- establishment of protein-containing complex localization to telomere
- female meiotic nuclear division
- heart development
- histone mRNA catabolic process
- histone phosphorylation
- identical protein binding
- intracellular membrane-bounded organelle
- intrinsic apoptotic signaling pathway in response to DNA damage
- lipoprotein catabolic process
- male meiotic nuclear division
- meiotic telomere clustering
- mitotic spindle assembly checkpoint signaling
- multicellular organism growth
- negative regulation of B cell proliferation
- negative regulation of TORC1 signaling
- negative regulation of telomere capping
- neuron apoptotic process
- nucleolus
- nucleoplasm
- nucleus
- oocyte development
- ovarian follicle development
- peptidyl-serine autophosphorylation
- peptidyl-serine phosphorylation
- peroxisomal matrix
- pexophagy
- positive regulation of DNA catabolic process
- positive regulation of DNA damage response, signal transduction by p53 class mediator
- positive regulation of apoptotic process
- positive regulation of cell adhesion
- positive regulation of cell migration
- positive regulation of gene expression
- positive regulation of histone phosphorylation
- positive regulation of neuron apoptotic process
- positive regulation of telomerase catalytic core complex assembly
- positive regulation of telomere maintenance via telomerase
- positive regulation of telomere maintenance via telomere lengthening
- positive regulation of transcription by RNA polymerase II
- post-embryonic development
- pre-B cell allelic exclusion
- protein N-terminus binding
- protein autophosphorylation
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- protein-containing complex binding
- reciprocal meiotic recombination
- regulation of apoptotic process
- regulation of autophagy
- regulation of cellular response to gamma radiation
- regulation of cellular response to heat
- regulation of microglial cell activation
- regulation of signal transduction by p53 class mediator
- regulation of telomere maintenance via telomerase
- replicative senescence
- response to hypoxia
- response to ionizing radiation
- signal transduction
- somitogenesis
- spindle
- telomere maintenance
- thymus development
AURKA
Human
Aurora kinase A
- Organism
- Human (Homo sapiens)
- Uniprot ID
- AURKA_HUMAN
- Accession #
- O14965
- Protein names
-
- Aurora kinase A
- EC 2.7.11.1
- Aurora 2
- Aurora/IPL1-related kinase 1
- ARK-1
- Aurora-related kinase 1
- hARK1
- Breast tumor-amplified kinase
- Serine/threonine-protein kinase 15
- Serine/threonine-protein kinase 6
- Serine/threonine-protein kinase aurora-A
- Gene names
-
- AURKA
- AIK
- AIRK1
- ARK1
- AURA
- AYK1
- BTAK
- IAK1
- STK15
- STK6
- Description
-
Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:26246606, PubMed:12390251, PubMed:18615013, PubMed:11039908, PubMed:17125279, PubMed:17360485). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:26246606, PubMed:14523000). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:18056443, PubMed:15128871, PubMed:14702041, PubMed:11551964, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18615013). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Necessary for proper cilia disassembly prior to mitosis (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). {ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14523000, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15147269, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:17125279, ECO:0000269|PubMed:17360485, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:18615013, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:26246606, ECO:0000269|PubMed:27335426, ECO:0000269|PubMed:28218735}.
- Links
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Search Kinases of AURKA (Human)
- ATP binding
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- G2/M transition of mitotic cell cycle
- anaphase-promoting complex-dependent catabolic process
- anterior/posterior axis specification
- axon hillock
- cell division
- centriole
- centrosome
- centrosome localization
- chromosome passenger complex
- cilium
- cytosol
- germinal vesicle
- histone serine kinase activity
- liver regeneration
- meiotic spindle
- microtubule
- microtubule cytoskeleton
- midbody
- mitotic cell cycle
- mitotic centrosome separation
- mitotic spindle organization
- mitotic spindle pole
- negative regulation of G2/M transition of mitotic cell cycle
- negative regulation of apoptotic process
- negative regulation of gene expression
- negative regulation of protein binding
- neuron projection extension
- nucleoplasm
- nucleus
- peptidyl-serine phosphorylation
- perinuclear region of cytoplasm
- positive regulation of mitotic nuclear division
- positive regulation of oocyte maturation
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- pronucleus
- protein autophosphorylation
- protein heterodimerization activity
- protein kinase activity
- protein kinase binding
- protein localization to centrosome
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- protein serine/threonine/tyrosine kinase activity
- regulation of G2/M transition of mitotic cell cycle
- regulation of centrosome cycle
- regulation of cytokinesis
- regulation of protein stability
- regulation of signal transduction by p53 class mediator
- response to wounding
- spindle
- spindle assembly involved in female meiosis I
- spindle midzone
- spindle organization
- spindle pole centrosome
- ubiquitin protein ligase binding
- ubiquitin-dependent protein catabolic process
AURKB
Human
Aurora kinase B
- Organism
- Human (Homo sapiens)
- Uniprot ID
- AURKB_HUMAN
- Accession #
- Q96GD4
- Protein names
-
- Aurora kinase B
- EC 2.7.11.1
- Aurora 1
- Aurora- and IPL1-like midbody-associated protein 1
- AIM-1
- Aurora/IPL1-related kinase 2
- ARK-2
- Aurora-related kinase 2
- STK-1
- Serine/threonine-protein kinase 12
- Serine/threonine-protein kinase 5
- Serine/threonine-protein kinase aurora-B
- Gene names
-
- AURKB
- AIK2
- AIM1
- AIRK2
- ARK2
- STK1
- STK12
- STK5
- Description
-
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPTIN1, VIM/vimentin, HASPIN, and histone H3. A positive feedback loop involving HASPIN and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between HASPIN and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGO1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes: acts by mediating phosphorylation of H3S28ph at active promoters in resting B-cells, inhibiting RNF2/RING1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes. {ECO:0000269|PubMed:11516652, ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:11784863, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12458200, ECO:0000269|PubMed:12686604, ECO:0000269|PubMed:12689593, ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:14602875, ECO:0000269|PubMed:14610074, ECO:0000269|PubMed:14722118, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:20959462, ECO:0000269|PubMed:21658950, ECO:0000269|PubMed:22422861, ECO:0000269|PubMed:24814515}.
- Links
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Search Kinases of AURKB (Human)
N/A
- ATP binding
- abscission
- aging
- anaphase-promoting complex-dependent catabolic process
- attachment of spindle microtubules to kinetochore
- cell population proliferation
- cellular response to UV
- chromocenter
- chromosome passenger complex
- cleavage furrow formation
- condensed chromosome, centromeric region
- cytosol
- histone H3-S28 phosphorylation
- histone modification
- histone serine kinase activity
- kinase binding
- kinetochore
- metal ion binding
- midbody
- mitotic cytokinesis checkpoint signaling
- mitotic spindle assembly checkpoint signaling
- mitotic spindle midzone
- mitotic spindle midzone assembly
- mitotic spindle organization
- mitotic spindle pole
- negative regulation of B cell apoptotic process
- negative regulation of cytokinesis
- negative regulation of protein binding
- negative regulation of transcription by RNA polymerase II
- nucleoplasm
- nucleus
- positive regulation of cytokinesis
- positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore
- positive regulation of telomerase activity
- positive regulation of telomere capping
- positive regulation of telomere maintenance via telomerase
- protein autophosphorylation
- protein localization to kinetochore
- protein phosphorylation
- protein serine kinase activity
- protein serine/threonine kinase activity
- protein serine/threonine/tyrosine kinase activity
- regulation of chromosome segregation
- regulation of cytokinesis
- regulation of signal transduction by p53 class mediator
- spindle
- spindle microtubule
- spindle midzone
- spindle organization
- spindle pole centrosome
- ubiquitin-dependent protein catabolic process
BIRC5
Human
Baculoviral IAP repeat-containing protein 5
- Organism
- Human (Homo sapiens)
- Uniprot ID
- BIRC5_HUMAN
- Accession #
- O15392
- Protein names
-
- Baculoviral IAP repeat-containing protein 5
- Apoptosis inhibitor 4
- Apoptosis inhibitor survivin
- Gene names
-
- BIRC5
- API4
- IAP4
- Description
-
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, PubMed:21364656, PubMed:20627126, PubMed:25778398, PubMed:28218735). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed:9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed:20826784). May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7 (PubMed:21536684). Essential for the maintenance of mitochondrial integrity and function (PubMed:25778398). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed:12773388, PubMed:16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed:10626797). {ECO:0000269|PubMed:10626797, ECO:0000269|PubMed:12773388, ECO:0000269|PubMed:16291752, ECO:0000269|PubMed:16322459, ECO:0000269|PubMed:18591255, ECO:0000269|PubMed:20627126, ECO:0000269|PubMed:20826784, ECO:0000269|PubMed:20929775, ECO:0000269|PubMed:21364656, ECO:0000269|PubMed:21536684, ECO:0000269|PubMed:25778398, ECO:0000269|PubMed:28218735, ECO:0000269|PubMed:9859993}.
- Links
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Search Kinases of BIRC5 (Human)
- G2/M transition of mitotic cell cycle
- cell division
- centriole
- chaperone binding
- chromosome passenger complex
- chromosome segregation
- chromosome, centromeric region
- cobalt ion binding
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process
- cytokine-mediated signaling pathway
- cytoplasm
- cytoplasmic microtubule
- cytosol
- enzyme binding
- establishment of chromosome localization
- identical protein binding
- interphase microtubule organizing center
- metal ion binding
- microtubule binding
- midbody
- mitotic cell cycle
- mitotic cytokinesis
- mitotic spindle assembly checkpoint signaling
- mitotic spindle organization
- negative regulation of apoptotic process
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of transcription, DNA-templated
- nuclear chromosome
- nucleoplasm
- nucleus
- positive regulation of cell population proliferation
- positive regulation of exit from mitosis
- positive regulation of mitotic cell cycle
- protein heterodimerization activity
- protein homodimerization activity
- protein phosphorylation
- protein-containing complex
- protein-containing complex localization
- regulation of apoptotic process
- regulation of cell cycle
- sensory perception of sound
- small GTPase binding
- spindle microtubule
- tubulin binding
- zinc ion binding
BRCA1
Human
Breast cancer type 1 susceptibility protein
- Organism
- Human (Homo sapiens)
- Uniprot ID
- BRCA1_HUMAN
- Accession #
- P38398
- Protein names
-
- Breast cancer type 1 susceptibility protein
- EC 2.3.2.27
- RING finger protein 53
- RING-type E3 ubiquitin transferase BRCA1
- Gene names
-
- BRCA1
- RNF53
- Description
-
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:12887909, PubMed:10500182, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:12183412, PubMed:11836499, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719). {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11836499, ECO:0000269|PubMed:12183412, ECO:0000269|PubMed:12887909, ECO:0000269|PubMed:12890688, ECO:0000269|PubMed:14976165, ECO:0000269|PubMed:16326698, ECO:0000269|PubMed:16818604, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:18056443, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19369211, ECO:0000269|PubMed:20160719, ECO:0000269|PubMed:20351172}.
- Links
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Search Kinases of BRCA1 (Human)
- BRCA1-A complex
- BRCA1-BARD1 complex
- DNA binding
- DNA double-strand break processing
- DNA replication
- RNA binding
- RNA polymerase binding
- cellular response to DNA damage stimulus
- cellular response to indole-3-methanol
- cellular response to tumor necrosis factor
- centrosome cycle
- chordate embryonic development
- chromosome
- chromosome segregation
- cytoplasm
- damaged DNA binding
- dosage compensation by inactivation of X chromosome
- double-strand break repair
- double-strand break repair via homologous recombination
- double-strand break repair via nonhomologous end joining
- enzyme binding
- fatty acid biosynthetic process
- intrinsic apoptotic signaling pathway in response to DNA damage
- lateral element
- mitotic G2/M transition checkpoint
- negative regulation of G0 to G1 transition
- negative regulation of centriole replication
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
- negative regulation of fatty acid biosynthetic process
- negative regulation of histone H3-K4 methylation
- negative regulation of histone H3-K9 methylation
- negative regulation of histone acetylation
- negative regulation of intracellular estrogen receptor signaling pathway
- negative regulation of reactive oxygen species metabolic process
- negative regulation of transcription, DNA-templated
- nuclear body
- nucleoplasm
- nucleus
- plasma membrane
- positive regulation of DNA repair
- positive regulation of angiogenesis
- positive regulation of gene expression
- positive regulation of histone H3-K4 methylation
- positive regulation of histone H3-K9 acetylation
- positive regulation of histone H3-K9 methylation
- positive regulation of histone H4-K16 acetylation
- positive regulation of histone H4-K20 methylation
- positive regulation of histone acetylation
- positive regulation of protein ubiquitination
- positive regulation of transcription by RNA polymerase II
- positive regulation of transcription, DNA-templated
- positive regulation of vascular endothelial growth factor production
- postreplication repair
- protein K6-linked ubiquitination
- protein autoubiquitination
- protein deubiquitination
- protein ubiquitination
- protein-containing complex
- regulation of DNA methylation
- regulation of gene expression by genetic imprinting
- regulation of signal transduction by p53 class mediator
- regulation of transcription by RNA polymerase II
- response to estrogen
- response to ionizing radiation
- ribonucleoprotein complex
- transcription cis-regulatory region binding
- transcription coactivator activity
- tubulin binding
- ubiquitin ligase complex
- ubiquitin protein ligase binding
- ubiquitin-protein transferase activity
- zinc ion binding
CAVIN1
Human
Caveolae-associated protein 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
- CAVN1_HUMAN
- Accession #
- Q6NZI2
- Protein names
-
- Caveolae-associated protein 1
- Cavin-1
- Polymerase I and transcript release factor
- Gene names
-
- CAVIN1
- PTRF
- FKSG13
- Description
-
Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity). {ECO:0000250|UniProtKB:O54724, ECO:0000269|PubMed:18056712, ECO:0000269|PubMed:18191225, ECO:0000269|PubMed:19726876}.
- Links
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Search Kinases of CAVIN1 (Human)
N/A
- RNA binding
- caveola
- cytoplasm
- cytosol
- endoplasmic reticulum
- identical protein binding
- intracellular membrane-bounded organelle
- membrane raft
- mitochondrion
- nucleoplasm
- nucleus
- plasma membrane
- positive regulation of cell motility
- protein secretion
- protein-containing complex
- rRNA primary transcript binding
- rRNA transcription
- termination of RNA polymerase I transcription
- transcription initiation from RNA polymerase I promoter
CBX5
Human
Chromobox protein homolog 5
- Organism
- Human (Homo sapiens)
- Uniprot ID
- CBX5_HUMAN
- Accession #
- P45973
- Protein names
-
- Chromobox protein homolog 5
- Antigen p25
- Heterochromatin protein 1 homolog alpha
- HP1 alpha
- Gene names
-
- CBX5
- HP1A
- Description
-
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. {ECO:0000269|PubMed:19783980}.
- Links
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Search Kinases of CBX5 (Human)
N/A
- blood coagulation
- cellular response to DNA damage stimulus
- chromatin binding
- chromocenter
- chromosome, telomeric region
- heterochromatin
- histone deacetylase binding
- histone deacetylase complex
- histone methyltransferase complex
- identical protein binding
- kinetochore
- methylated histone binding
- negative regulation of G0 to G1 transition
- negative regulation of transcription by RNA polymerase II
- negative regulation of transcription, DNA-templated
- nuclear envelope
- nucleolus
- nucleoplasm
- nucleus
- pericentric heterochromatin
- protein-containing complex
- protein-containing complex binding
- protein-macromolecule adaptor activity
- ribonucleoprotein complex
- ribonucleoprotein complex binding
- site of DNA damage
- transcription repressor complex
- viral process
CCDC86
Human
Coiled-coil domain-containing protein 86
- Organism
- Human (Homo sapiens)
- Uniprot ID
- CCD86_HUMAN
- Accession #
- Q9H6F5
- Protein names
-
- Coiled-coil domain-containing protein 86
- Cytokine-induced protein with coiled-coil domain
- Gene names
-
- CCDC86
- CYCLON
- Description
-
N/A
- Links
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Search Kinases of CCDC86 (Human)
N/A
CDC25B
Human
M-phase inducer phosphatase 2
- Organism
- Human (Homo sapiens)
- Uniprot ID
- MPIP2_HUMAN
- Accession #
- P30305
- Protein names
-
- M-phase inducer phosphatase 2
- EC 3.1.3.48
- Dual specificity phosphatase Cdc25B
- Gene names
-
- CDC25B
- CDC25HU2
- Description
-
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity. {ECO:0000269|PubMed:17332740}.
- Links
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Search Kinases of CDC25B (Human)
- G2/M transition of mitotic cell cycle
- cell division
- centrosome
- cytoplasm
- cytosol
- female meiosis I
- mitotic cell cycle
- nucleoplasm
- nucleus
- oocyte maturation
- positive regulation of G2/M transition of mitotic cell cycle
- positive regulation of G2/MI transition of meiotic cell cycle
- positive regulation of cell population proliferation
- positive regulation of cytokinesis
- positive regulation of mitotic cell cycle
- positive regulation of protein kinase activity
- protein kinase binding
- protein phosphorylation
- protein tyrosine phosphatase activity
- spindle pole
CDCA5
Human
Sororin
- Organism
- Human (Homo sapiens)
- Uniprot ID
- CDCA5_HUMAN
- Accession #
- Q96FF9
- Protein names
-
- Sororin
- Cell division cycle-associated protein 5
- p35
- Gene names
-
- CDCA5
- Description
-
Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. {ECO:0000269|PubMed:15837422, ECO:0000269|PubMed:17349791, ECO:0000269|PubMed:21111234}.
- Links
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Search Kinases of CDCA5 (Human)
- cell division
- chromatin
- chromatin binding
- chromosome
- chromosome, centromeric region
- cytoplasm
- cytosol
- double-strand break repair
- mitotic cell cycle
- mitotic chromosome condensation
- mitotic metaphase plate congression
- mitotic sister chromatid cohesion
- nucleoplasm
- nucleus
- positive regulation of exit from mitosis
- protein-containing complex binding
- regulation of cohesin loading
CDCA8
Human
Borealin
- Organism
- Human (Homo sapiens)
- Uniprot ID
- BOREA_HUMAN
- Accession #
- Q53HL2
- Protein names
-
- Borealin
- Cell division cycle-associated protein 8
- Dasra-B
- hDasra-B
- Pluripotent embryonic stem cell-related gene 3 protein
- Gene names
-
- CDCA8
- PESCRG3
- Description
-
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. {ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:15260989, ECO:0000269|PubMed:16571674, ECO:0000269|PubMed:18243099}.
- Links
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Search Kinases of CDCA8 (Human)
N/A
- cell division
- chromocenter
- chromosome organization
- chromosome passenger complex
- chromosome, centromeric region
- cytosol
- intercellular bridge
- midbody
- mitotic metaphase plate congression
- mitotic sister chromatid segregation
- mitotic spindle organization
- nucleolus
- nucleoplasm
- protein-containing complex
- spindle midzone
CENPA
Human
Histone H3-like centromeric protein A
- Organism
- Human (Homo sapiens)
- Uniprot ID
- CENPA_HUMAN
- Accession #
- P49450
- Protein names
-
- Histone H3-like centromeric protein A
- Centromere autoantigen A
- Centromere protein A
- CENP-A
- Gene names
-
- CENPA
- Description
-
Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:7962047, PubMed:9024683, PubMed:11756469, PubMed:14667408, PubMed:15702419, PubMed:15475964, PubMed:15282608, PubMed:17651496, PubMed:19114591, PubMed:27499292, PubMed:20739937). Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:27499292, PubMed:26878239). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15475964, PubMed:15282608, PubMed:26878239, PubMed:20739937, PubMed:21478274). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292). {ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:14667408, ECO:0000269|PubMed:15282608, ECO:0000269|PubMed:15475964, ECO:0000269|PubMed:15702419, ECO:0000269|PubMed:17651496, ECO:0000269|PubMed:18072184, ECO:0000269|PubMed:19114591, ECO:0000269|PubMed:21478274, ECO:0000269|PubMed:23818633, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26878239, ECO:0000269|PubMed:27499292, ECO:0000269|PubMed:7962047, ECO:0000269|PubMed:9024683, ECO:0000305|PubMed:20739937}.
- Links
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Search Kinases of CENPA (Human)
N/A
- CENP-A containing chromatin assembly
- DNA binding
- chromatin binding
- chromosome, centromeric region
- condensed chromosome, centromeric region
- cytosol
- establishment of mitotic spindle orientation
- inner kinetochore
- kinetochore assembly
- mitotic cytokinesis
- mitotic spindle organization
- nucleoplasm
- nucleosome
- nucleus
- pericentric heterochromatin
- protein heterodimerization activity
- protein localization to chromosome, centromeric region
- viral process
CETN2
Human
Centrin-2
- Organism
- Human (Homo sapiens)
- Uniprot ID
- CETN2_HUMAN
- Accession #
- P41208
- Protein names
-
- Centrin-2
- Caltractin isoform 1
- Gene names
-
- CETN2
- CALT
- CEN2
- Description
-
Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.; Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.; The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.; As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. {ECO:0000269|PubMed:22307388, ECO:0000305|PubMed:23591820}.
- Links
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Search Kinases of CETN2 (Human)
- 9+2 motile cilium
- G-protein beta/gamma-subunit complex binding
- G2/M transition of mitotic cell cycle
- XPC complex
- apical part of cell
- calcium ion binding
- cell division
- centriole
- centriole replication
- centrosome
- ciliary basal body
- ciliary basal body-plasma membrane docking
- cytosol
- global genome nucleotide-excision repair
- heterotrimeric G-protein binding
- mRNA transport
- microtubule binding
- mitotic cell cycle
- nuclear pore nuclear basket
- nucleoplasm
- nucleotide-excision repair
- nucleotide-excision repair, DNA damage recognition
- nucleotide-excision repair, DNA duplex unwinding
- nucleotide-excision repair, preincision complex assembly
- photoreceptor connecting cilium
- protein transport
- regulation of G2/M transition of mitotic cell cycle
- regulation of cytokinesis
- spermatogenesis
- transcription export complex 2
CKAP2
Human
Cytoskeleton-associated protein 2
- Organism
- Human (Homo sapiens)
- Uniprot ID
- CKAP2_HUMAN
- Accession #
- Q8WWK9
- Protein names
-
- Cytoskeleton-associated protein 2
- CTCL tumor antigen se20-10
- Tumor- and microtubule-associated protein
- Gene names
-
- CKAP2
- LB1
- TMAP
- Description
-
Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). {ECO:0000250}.
- Links
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Search Kinases of CKAP2 (Human)
N/A
COBLL1
Human
Cordon-bleu protein-like 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
- COBL1_HUMAN
- Accession #
- Q53SF7
- Protein names
-
- Cordon-bleu protein-like 1
- Gene names
-
- COBLL1
- KIAA0977
- Description
-
N/A
- Links
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Search Kinases of COBLL1 (Human)
N/A
Cpeb1
Mouse
Cytoplasmic polyadenylation element-binding protein 1
- Organism
- Mouse (Mus musculus)
- Uniprot ID
- CPEB1_MOUSE
- Accession #
- P70166
- Protein names
-
- Cytoplasmic polyadenylation element-binding protein 1
- CPE-BP1
- CPE-binding protein 1
- mCPEB
- mCPEB-1
- Gene names
-
- Cpeb1
- Cpeb
- Description
-
Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the 3'-UTR of mRNAs. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress (By similarity). Required for cell cycle progression, specifically for prophase entry (By similarity). {ECO:0000250|UniProtKB:Q9BZB8, ECO:0000269|PubMed:11526086, ECO:0000269|PubMed:11980711, ECO:0000269|PubMed:12629046}.
- Links
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Search Kinases of Cpeb1 (Mouse)
- P-body
- RNA binding
- cellular response to amino acid stimulus
- cellular response to hypoxia
- cellular response to insulin stimulus
- centrosome
- cytoplasm
- cytosol
- growth cone
- mRNA 3'-UTR AU-rich region binding
- mRNA 3'-UTR binding
- mRNA binding
- mRNA processing
- mRNA transport
- meiotic spindle
- membrane
- messenger ribonucleoprotein complex
- metal ion binding
- negative regulation of cell population proliferation
- negative regulation of cytoplasmic translation
- negative regulation of translation
- neuron projection
- neuronal cell body
- nucleoplasm
- nucleus
- perinuclear region of cytoplasm
- positive regulation of cell migration
- positive regulation of mRNA polyadenylation
- positive regulation of neuron projection development
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of translation
- postsynaptic density
- regulation of neuronal synaptic plasticity
- regulation of translation
- ribosome binding
- synapse
- synaptonemal complex assembly
- translation factor activity, RNA binding
- translation repressor activity, mRNA regulatory element binding