Search Results (15 substrates found)
Gene name
Organism
Protein name
ARL6IP4
Human
ADP-ribosylation factor-like protein 6-interacting protein 4
- Organism
- Human (Homo sapiens)
- Uniprot ID
- AR6P4_HUMAN
- Accession #
- Q66PJ3
- Protein names
-
- ADP-ribosylation factor-like protein 6-interacting protein 4
- ARL-6-interacting protein 4
- Aip-4
- HSP-975
- HSVI-binding protein
- SR-15
- SRp25
- SR-25
- Splicing factor SRrp37
- Gene names
-
- ARL6IP4
- Description
-
Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site. In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA. {ECO:0000269|PubMed:19582790}.
- Links
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Search Kinases of ARL6IP4 (Human)
N/A
C1orf174
Human
UPF0688 protein C1orf174
- Organism
- Human (Homo sapiens)
- Uniprot ID
- CA174_HUMAN
- Accession #
- Q8IYL3
- Protein names
-
- UPF0688 protein C1orf174
- Gene names
-
- C1orf174
- Description
-
N/A
- Links
-
Search Kinases of C1orf174 (Human)
N/A
CWC15
Human
Spliceosome-associated protein CWC15 homolog
- Organism
- Human (Homo sapiens)
- Uniprot ID
- CWC15_HUMAN
- Accession #
- Q9P013
- Protein names
-
- Spliceosome-associated protein CWC15 homolog
- Gene names
-
- CWC15
- C11orf5
- AD-002
- HSPC148
- Description
-
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. {ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}.
- Links
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Search Kinases of CWC15 (Human)
DNAJC16
Human
DnaJ homolog subfamily C member 16
- Organism
- Human (Homo sapiens)
- Uniprot ID
- DJC16_HUMAN
- Accession #
- Q9Y2G8
- Protein names
-
- DnaJ homolog subfamily C member 16
- Gene names
-
- DNAJC16
- KIAA0962
- Description
-
N/A
- Links
-
Search Kinases of DNAJC16 (Human)
N/A
EFHD2
Human
EF-hand domain-containing protein D2
- Organism
- Human (Homo sapiens)
- Uniprot ID
- EFHD2_HUMAN
- Accession #
- Q96C19
- Protein names
-
- EF-hand domain-containing protein D2
- Swiprosin-1
- Gene names
-
- EFHD2
- SWS1
- Description
-
May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance. {ECO:0000250}.
- Links
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Search Kinases of EFHD2 (Human)
N/A
FAH
Human
Fumarylacetoacetase
- Organism
- Human (Homo sapiens)
- Uniprot ID
- FAAA_HUMAN
- Accession #
- P16930
- Protein names
-
- Fumarylacetoacetase
- FAA
- EC 3.7.1.2
- Beta-diketonase
- Fumarylacetoacetate hydrolase
- Gene names
-
- FAH
- Description
-
N/A
- Links
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Search Kinases of FAH (Human)
GTF2F1
Human
General transcription factor IIF subunit 1
- Organism
- Human (Homo sapiens)
- Uniprot ID
- T2FA_HUMAN
- Accession #
- P35269
- Protein names
-
- General transcription factor IIF subunit 1
- General transcription factor IIF 74 kDa subunit
- Transcription initiation factor IIF subunit alpha
- TFIIF-alpha
- Transcription initiation factor RAP74
- Gene names
-
- GTF2F1
- RAP74
- Description
-
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269|PubMed:10428810}.
- Links
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Search Kinases of GTF2F1 (Human)
- 7-methylguanosine mRNA capping
- DNA binding
- RNA binding
- RNA metabolic process
- RNA polymerase II general transcription initiation factor activity
- TFIIF-class transcription factor complex binding
- cell junction
- fibroblast growth factor receptor signaling pathway
- intracellular membrane-bounded organelle
- mRNA splicing, via spliceosome
- negative regulation of protein binding
- nucleoplasm
- nucleus
- phosphatase activator activity
- positive regulation of transcription by RNA polymerase II
- positive regulation of transcription elongation from RNA polymerase II promoter
- positive regulation of viral transcription
- promoter-specific chromatin binding
- protein domain specific binding
- protein phosphatase binding
- protein-containing complex
- response to virus
- snRNA transcription by RNA polymerase II
- transcription by RNA polymerase II
- transcription elongation from RNA polymerase II promoter
- transcription factor TFIID complex
- transcription factor TFIIF complex
- transcription factor binding
- transcription initiation from RNA polymerase II promoter
JHY
Human
Jhy protein homolog
- Organism
- Human (Homo sapiens)
- Uniprot ID
- JHY_HUMAN
- Accession #
- Q6NUN7
- Protein names
-
- Jhy protein homolog
- Gene names
-
- JHY
- C11orf63
- Description
-
Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces. {ECO:0000250|UniProtKB:E9Q793}.
- Links
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Search Kinases of JHY (Human)
N/A
LMOD1
Human
Leiomodin-1
- Organism
- Human (Homo sapiens)
- Uniprot ID
- LMOD1_HUMAN
- Accession #
- P29536
- Protein names
-
- Leiomodin-1
- 64 kDa autoantigen 1D
- 64 kDa autoantigen 1D3
- 64 kDa autoantigen D1
- Leiomodin, muscle form
- Smooth muscle leiomodin
- SM-Lmod
- Thyroid-associated ophthalmopathy autoantigen
- Gene names
-
- LMOD1
- Description
-
Mediates nucleation of actin filaments. {ECO:0000269|PubMed:26370058}.
- Links
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Search Kinases of LMOD1 (Human)
N/A
METTL1
Human
tRNA
- Organism
- Human (Homo sapiens)
- Uniprot ID
- TRMB_HUMAN
- Accession #
- Q9UBP6
- Protein names
-
- tRNA
- guanine-N(7
- EC 2.1.1.33
- Methyltransferase-like protein 1
- mRNA (guanine-N(7
- EC 2.1.1.-
- miRNA (guanine-N(7
- Gene names
-
- METTL1
- C12orf1
- Description
-
Methyltransferase that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031084, PubMed:31031083). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (PubMed:12403464, PubMed:31031084). Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs (PubMed:31031084). Internal N(7)-methylguanine methylation of mRNAs regulates translation (PubMed:31031084). Also methylates a specific subset of miRNAs, such as let-7 (PubMed:31031083). N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA) (PubMed:31031083). Acts as a regulator of embryonic stem cell self-renewal and differentiation (By similarity). {ECO:0000255|HAMAP-Rule:MF_03055, ECO:0000269|PubMed:12403464, ECO:0000269|PubMed:31031083, ECO:0000269|PubMed:31031084}.
- Links
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Search Kinases of METTL1 (Human)
N/A
PIGS
Human
GPI transamidase component PIG-S
- Organism
- Human (Homo sapiens)
- Uniprot ID
- PIGS_HUMAN
- Accession #
- Q96S52
- Protein names
-
- GPI transamidase component PIG-S
- Phosphatidylinositol-glycan biosynthesis class S protein
- Gene names
-
- PIGS
- UNQ1873/PRO4316
- Description
-
Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates. {ECO:0000269|PubMed:11483512, ECO:0000269|PubMed:30269814}.
- Links
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Search Kinases of PIGS (Human)
PSME3IP1
Human
PSME3-interacting protein
- Organism
- Human (Homo sapiens)
- Uniprot ID
- PIP30_HUMAN
- Accession #
- Q9GZU8
- Protein names
-
- PSME3-interacting protein
- NEFA-interacting nuclear protein NIP30
- PA28G-interacting protein
- Gene names
-
- PSME3IP1
- C16orf94
- FAM192A
- NIP30
- PIP30
- CDA018
- CDA10
- Description
-
Promotes the association of the proteasome activator complex subunit PSME3 with the 20S proteasome and regulates its activity. Inhibits PSME3-mediated degradation of some proteasome substrates, probably by affecting their diffusion rate into the catalytic chamber of the proteasome. Also inhibits the interaction of PSME3 with COIL, inhibits accumulation of PSME3 in Cajal bodies and positively regulates the number of Cajal bodies in the nucleus. {ECO:0000269|PubMed:29934401}.
- Links
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Search Kinases of PSME3IP1 (Human)
N/A
RNF13
Human
E3 ubiquitin-protein ligase RNF13
- Organism
- Human (Homo sapiens)
- Uniprot ID
- RNF13_HUMAN
- Accession #
- O43567
- Protein names
-
- E3 ubiquitin-protein ligase RNF13
- EC 2.3.2.27
- RING finger protein 13
- RING-type E3 ubiquitin transferase RNF13
- Gene names
-
- RNF13
- RZF
- Description
-
E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA (PubMed:23378536, PubMed:30595371). {ECO:0000269|PubMed:18794910, ECO:0000269|PubMed:23378536, ECO:0000269|PubMed:30595371}.
- Links
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Search Kinases of RNF13 (Human)
N/A
- Golgi membrane
- JUN kinase binding
- cytosol
- endoplasmic reticulum
- endoplasmic reticulum membrane
- integral component of membrane
- intracellular membrane-bounded organelle
- late endosome membrane
- lysosomal membrane
- metal ion binding
- nuclear inner membrane
- nucleoplasm
- positive regulation of stress-activated protein kinase signaling cascade
- protein autoubiquitination
- ubiquitin protein ligase activity
- ubiquitin-dependent protein catabolic process
- ubiquitin-protein transferase activity
RPAP3
Human
RNA polymerase II-associated protein 3
- Organism
- Human (Homo sapiens)
- Uniprot ID
- RPAP3_HUMAN
- Accession #
- Q9H6T3
- Protein names
-
- RNA polymerase II-associated protein 3
- Gene names
-
- RPAP3
- Description
-
Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. {ECO:0000269|PubMed:17643375}.
- Links
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Search Kinases of RPAP3 (Human)
N/A
RTN2
Human
Reticulon
- Organism
- Human (Homo sapiens)
- Uniprot ID
- Q6GMT0_HUMAN
- Accession #
- Q6GMT0
- Protein names
-
- Reticulon
- Gene names
-
- RTN2
- Description
-
N/A
- Links
-
Search Kinases of RTN2 (Human)
N/A