KANPHOS_Str

Search Results (128 substrates found)

Displaying 1 - 20 of 128 Items
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Gene name
Organism
Protein name
ADD2
Human
Beta-adducin
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ADDB_HUMAN
Accession #
P35612
Protein names
  • Beta-adducin
  • Erythrocyte adducin subunit beta
Gene names
  • ADD2
  • ADDB
Description
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. {ECO:0000269|PubMed:18347014}.
Links

Search Kinases of ADD2 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Add2
Rat
Beta-adducin
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ADDB_RAT
Accession #
Q05764
Protein names
  • Beta-adducin
  • Adducin-63
  • Erythrocyte adducin subunit beta
Gene names
  • Add2
Description
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity). {ECO:0000250}.
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Search Kinases of Add2 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
APC
Human
Adenomatous polyposis coli protein
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
APC_HUMAN
Accession #
P25054
Protein names
  • Adenomatous polyposis coli protein
  • Protein APC
  • Deleted in polyposis 2.5
Gene names
  • APC
  • DP2.5
Description
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}.
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Search Kinases of APC (Human)
Gene Ontology Terms (56)
Phosphorylation Site Information
App
Rat
Amyloid-beta A4 protein
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
A4_RAT
Accession #
P08592
Protein names
  • Amyloid-beta A4 protein
  • ABPP
  • APP
  • Alzheimer disease amyloid A4 protein homolog
  • Amyloid precursor protein
  • Amyloid-beta precursor protein
  • Amyloidogenic glycoprotein
  • AG
  • S-APP-alpha
  • S-APP-beta
  • Beta-secretase C-terminal fragment
  • Beta-CTF
  • Abeta42
  • Beta-APP42
  • Abeta40
  • Beta-APP40
  • Alpha-secretase C-terminal fragment
  • Alpha-CTF
  • 42
  • 40
  • Gamma-CTF(59
  • Gamma-CTF(57
  • Gamma-CTF(50
Gene names
  • App
Description
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapes in axons (By similarity). May be involved in copper homeostasis/oxidative stress through copper ion reduction. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV (By similarity). The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1 (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P05067}.; Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Binds transient metals such as copper, zinc and iron. Rat and mouse amyloid-beta peptides bind only weakly transient metals and have little reducing activity due to substitutions of transient metal chelating residues. Amyloid-beta protein 42 may activate mononuclear phagocytes in the brain and elicits inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Also binds GPC1 in lipid rafts (By similarity). {ECO:0000250}.; Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain.; The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis. {ECO:0000250}.; N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). {ECO:0000250}.
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Search Kinases of App (Rat)
Gene Ontology Terms (148)
Phosphorylation Site Information
ARNTL
Human
Aryl hydrocarbon receptor nuclear translocator-like protein 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
BMAL1_HUMAN
Accession #
O00327
Protein names
  • Aryl hydrocarbon receptor nuclear translocator-like protein 1
  • Basic-helix-loop-helix-PAS protein MOP3
  • Brain and muscle ARNT-like 1
  • Class E basic helix-loop-helix protein 5
  • bHLHe5
  • Member of PAS protein 3
  • PAS domain-containing protein 3
  • bHLH-PAS protein JAP3
Gene names
  • ARNTL
  • BHLHE5
  • BMAL1
  • MOP3
  • PASD3
Description
Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. ARNTL/BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART and KLF11. The CLOCK-ARNTL/BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The NPAS2-ARNTL/BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The preferred binding motif for the CLOCK-ARNTL/BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking Ala residue in addition to the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while ARNTL binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-ARNTL/BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1 (PubMed:28985504). Plays a role in protecting against lethal sepsis by limiting the expression of immune checkpoint protein CD274 in macrophages in a PKM2-dependent manner (By similarity). Regulates the diurnal rhythms of skeletal muscle metabolism via transcriptional activation of genes promoting triglyceride synthesis (DGAT2) and metabolic efficiency (COQ10B) (By similarity). {ECO:0000250|UniProtKB:Q9WTL8, ECO:0000269|PubMed:11441146, ECO:0000269|PubMed:12738229, ECO:0000269|PubMed:18587630, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:23955654, ECO:0000269|PubMed:24005054, ECO:0000269|PubMed:28985504}.
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Search Kinases of ARNTL (Human)
Gene Ontology Terms (44)
Phosphorylation Site Information
ATXN3
Human
Ataxin-3
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
ATX3_HUMAN
Accession #
P54252
Protein names
  • Ataxin-3
  • EC 3.4.19.12
  • Machado-Joseph disease protein 1
  • Spinocerebellar ataxia type 3 protein
Gene names
  • ATXN3
  • ATX3
  • MJD
  • MJD1
  • SCA3
Description
Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:16118278). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). {ECO:0000250|UniProtKB:Q9CVD2, ECO:0000269|PubMed:12297501, ECO:0000269|PubMed:16118278, ECO:0000269|PubMed:17696782, ECO:0000269|PubMed:23625928, ECO:0000269|PubMed:28445460}.
Links

Search Kinases of ATXN3 (Human)
Phosphorylation Site Information
Atxn3
Mouse
Ataxin-3
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
ATX3_MOUSE
Accession #
Q9CVD2
Protein names
  • Ataxin-3
  • EC 3.4.19.12
  • Machado-Joseph disease protein 1 homolog
Gene names
  • Atxn3
  • Mjd
Description
Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (By similarity). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (PubMed:21855799). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (By similarity). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). {ECO:0000250|UniProtKB:P54252, ECO:0000269|PubMed:21855799, ECO:0000269|PubMed:28445460}.
Links

Search Kinases of Atxn3 (Mouse)
Phosphorylation Site Information
Axin1
Mouse
Axin-1
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
AXIN1_MOUSE
Accession #
O35625
Protein names
  • Axin-1
  • Axis inhibition protein 1
  • Protein Fused
Gene names
  • Axin1
  • Axin
  • Fu
Description
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (By similarity). Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. {ECO:0000250, ECO:0000269|PubMed:12223491, ECO:0000269|PubMed:15526030, ECO:0000269|PubMed:17681137}.
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Search Kinases of Axin1 (Mouse)
Gene Ontology Terms (70)
Phosphorylation Site Information
BAX
Human
Apoptosis regulator BAX
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
BAX_HUMAN
Accession #
Q07812
Protein names
  • Apoptosis regulator BAX
  • Bcl-2-like protein 4
  • Bcl2-L-4
Gene names
  • BAX
  • BCL2L4
Description
Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. {ECO:0000269|PubMed:10772918, ECO:0000269|PubMed:16113678, ECO:0000269|PubMed:18948948, ECO:0000269|PubMed:21199865, ECO:0000269|PubMed:21458670, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:8358790, ECO:0000269|PubMed:8521816}.
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Search Kinases of BAX (Human)
Gene Ontology Terms (109)
Phosphorylation Site Information
BCAM
Human
Basal cell adhesion molecule
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
BCAM_HUMAN
Accession #
P50895
Protein names
  • Basal cell adhesion molecule
  • Auberger B antigen
  • B-CAM cell surface glycoprotein
  • F8/G253 antigen
  • Lutheran antigen
  • Lutheran blood group glycoprotein
  • CD antigen CD239
Gene names
  • BCAM
  • LU
  • MSK19
Description
Laminin alpha-5 receptor. May mediate intracellular signaling. {ECO:0000269|PubMed:9616226}.
Links

Search Kinases of BCAM (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
BCL2L1
Human
Bcl-2-like protein 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
B2CL1_HUMAN
Accession #
Q07817
Protein names
  • Bcl-2-like protein 1
  • Bcl2-L-1
  • Apoptosis regulator Bcl-X
Gene names
  • BCL2L1
  • BCL2L
  • BCLX
Description
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.; Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). {ECO:0000269|PubMed:17418785}.; Isoform Bcl-X(S) promotes apoptosis.
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Search Kinases of BCL2L1 (Human)
Gene Ontology Terms (42)
Phosphorylation Site Information
BCLAF1
Human
Bcl-2-associated transcription factor 1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
BCLF1_HUMAN
Accession #
Q9NYF8
Protein names
  • Bcl-2-associated transcription factor 1
  • Btf
  • BCLAF1 and THRAP3 family member 1
Gene names
  • BCLAF1
  • BTF
  • KIAA0164
Description
Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269|PubMed:18794151}.
Links

Search Kinases of BCLAF1 (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
BORA
Human
Protein aurora borealis
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
BORA_HUMAN
Accession #
Q6PGQ7
Protein names
  • Protein aurora borealis
  • HsBora
Gene names
  • BORA
  • C13orf34
Description
Required for the activation of AURKA at the onset of mitosis. {ECO:0000269|PubMed:16890155}.
Links

Search Kinases of BORA (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
CABYR
Human
Calcium-binding tyrosine phosphorylation-regulated protein
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CABYR_HUMAN
Accession #
O75952
Protein names
  • Calcium-binding tyrosine phosphorylation-regulated protein
  • Calcium-binding protein 86
  • Cancer/testis antigen 88
  • CT88
  • Fibrousheathin II
  • Fibrousheathin-2
  • FSP-2
  • Testis-specific calcium-binding protein CBP86
Gene names
  • CABYR
  • CBP86
  • FSP2
Description
May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium.
Links

Search Kinases of CABYR (Human)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
CCND1
Human
G1/S-specific cyclin-D1
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CCND1_HUMAN
Accession #
P24385
Protein names
  • G1/S-specific cyclin-D1
  • B-cell lymphoma 1 protein
  • BCL-1
  • BCL-1 oncogene
  • PRAD1 oncogene
Gene names
  • CCND1
  • BCL1
  • PRAD1
Description
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. {ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:16569215, ECO:0000269|PubMed:18417529, ECO:0000269|PubMed:9106657}.
Links

Search Kinases of CCND1 (Human)
Gene Ontology Terms (54)
Phosphorylation Site Information
Ccnd1
Mouse
G1/S-specific cyclin-D1
Substrate Information
Organism
Mouse (Mus musculus)
Uniprot ID
CCND1_MOUSE
Accession #
P25322
Protein names
  • G1/S-specific cyclin-D1
Gene names
  • Ccnd1
  • Cyl-1
Description
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (By similarity). {ECO:0000250}.
Links

Search Kinases of Ccnd1 (Mouse)
Gene Ontology Terms (57)
Phosphorylation Site Information
CCND2
Human
G1/S-specific cyclin-D2
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CCND2_HUMAN
Accession #
P30279
Protein names
  • G1/S-specific cyclin-D2
Gene names
  • CCND2
Description
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). {ECO:0000250}.
Links

Search Kinases of CCND2 (Human)
Phosphorylation Site Information
CCND3
Human
G1/S-specific cyclin-D3
Substrate Information
Organism
Human (Homo sapiens)
Uniprot ID
CCND3_HUMAN
Accession #
P30281
Protein names
  • G1/S-specific cyclin-D3
Gene names
  • CCND3
Description
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. {ECO:0000269|PubMed:15358120}.
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Search Kinases of CCND3 (Human)
Phosphorylation Site Information
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