KANPHOS_Str

Search Results (118 substrates found)

Displaying 1 - 20 of 118 Items
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Gene name
Organism
Protein name
Add1
Rat
Alpha-adducin
Add3
Rat
Gamma-adducin
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ADDG_RAT
Accession #
Q62847
Protein names
  • Gamma-adducin
  • Adducin-like protein 70
  • Protein kinase C-binding protein 35H
Gene names
  • Add3
Description
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping. Binds to calmodulin. {ECO:0000250|UniProtKB:Q9UEY8}.
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Search Kinases of Add3 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Amph
Rat
Amphiphysin
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
AMPH_RAT
Accession #
O08838
Protein names
  • Amphiphysin
Gene names
  • Amph
  • Amph1
Description
May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton (By similarity). {ECO:0000250}.
Links

Search Kinases of Amph (Rat)
KEGG Pathways (2)
Phosphorylation Site Information
Ankrd34a
Rat
Ankyrin repeat domain-containing protein 34A
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
AN34A_RAT
Accession #
Q5BJT1
Protein names
  • Ankyrin repeat domain-containing protein 34A
Gene names
  • Ankrd34a
Description
N/A
Links

Search Kinases of Ankrd34a (Rat)
KEGG Pathways (0)
N/A
Gene Ontology Terms (0)
N/A
Phosphorylation Site Information
Apc
Rat
Adenomatosis polyposis coli, isoform CRA_a
Araf
Rat
Serine/threonine-protein kinase A-Raf
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ARAF_RAT
Accession #
P14056
Protein names
  • Serine/threonine-protein kinase A-Raf
  • EC 2.7.11.1
  • Proto-oncogene A-Raf
  • Proto-oncogene A-Raf-1
Gene names
  • Araf
  • A-raf
  • Araf1
Description
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity). {ECO:0000250}.
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Search Kinases of Araf (Rat)
Phosphorylation Site Information
Arhgef7
Rat
Rho guanine nucleotide exchange factor 7
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ARHG7_RAT
Accession #
O55043
Protein names
  • Rho guanine nucleotide exchange factor 7
  • Beta-Pix
  • PAK-interacting exchange factor beta
Gene names
  • Arhgef7
  • Pak3bp
  • Pixb
Description
Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity). {ECO:0000250}.
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Search Kinases of Arhgef7 (Rat)
Phosphorylation Site Information
Arl8b
Rat
ADP-ribosylation factor-like protein 8B
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
ARL8B_RAT
Accession #
Q66HA6
Protein names
  • ADP-ribosylation factor-like protein 8B
  • EC 3.6.5.2
Gene names
  • Arl8b
Description
Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins playing a key role in the regulation of lysosomal positioning which is important for nutrient sensing, natural killer cell-mediated cytotoxicity and antigen presentation. Along with its effectors, orchestrates lysosomal transport and fusion. Localizes specifically to lysosomal membranes and mediates anterograde lysosomal motility by recruiting PLEKHM2, which in turn recruits the motor protein kinesin-1 on lysosomes. Required for lysosomal and cytolytic granule exocytosis. Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (By similarity). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). Also acts as a regulator of endosome to lysosome trafficking pathways of special significance for host defense. Regulates cargo trafficking to lysosomes by binding to PLEKHM1 and recruiting the HOPS subunit VPS41, resulting in functional assembly of the HOPS complex on lysosomal membranes. Plays an important role in cargo delivery to lysosomes for antigen presentation and microbial killing. Directs the intersection of CD1d with lipid antigens in lysosomes, and plays a role in intersecting phagosomes with lysosomes to generate phagolysosomes that kill microbes (By similarity). Involved in the process of MHC II presentation. Regulates the delivery of antigens to lysosomes and the formation of MHC II-peptide complexes through the recruitment of the HOPS complex to lysosomes allowing the fusion of late endosomes to lysosomes (By similarity). May play a role in chromosome segregation (By similarity). {ECO:0000250|UniProtKB:Q9CQW2, ECO:0000250|UniProtKB:Q9NVJ2}.
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Search Kinases of Arl8b (Rat)
KEGG Pathways (1)
Phosphorylation Site Information
Atp6v1d
Rat
V-type proton ATPase subunit D
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
Q6P503_RAT
Accession #
Q6P503
Protein names
  • V-type proton ATPase subunit D
  • V-type proton ATPase subunit d
  • Vacuolar proton pump subunit D
Gene names
  • Atp6v1d
  • rCG_61537
Description
N/A
Links

Search Kinases of Atp6v1d (Rat)
Phosphorylation Site Information
Atp6v1e1
Rat
ATPase, H+ transporting, V1 subunit E isoform 1, isoform CRA_a
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
G3V7L8_RAT
Accession #
G3V7L8
Protein names
  • ATPase, H+ transporting, V1 subunit E isoform 1, isoform CRA_a
  • V-type proton ATPase subunit E 1
Gene names
  • Atp6v1e1
  • rCG_30091
Description
N/A
Links

Search Kinases of Atp6v1e1 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Atxn2l
Rat
Ataxin 2-like
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
B3DMA1_RAT
Accession #
B3DMA1
Protein names
  • Ataxin 2-like
  • Atxn2l protein
Gene names
  • Atxn2l
Description
N/A
Links

Search Kinases of Atxn2l (Rat)
Phosphorylation Site Information
Bin1
Rat
Myc box-dependent-interacting protein 1
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
BIN1_RAT
Accession #
O08839
Protein names
  • Myc box-dependent-interacting protein 1
  • Amphiphysin II
  • Amphiphysin-like protein
  • Bridging integrator 1
Gene names
  • Bin1
  • Amph2
  • Amphl
Description
Is a key player in the control of plasma membrane curvature, and membrane shaping and remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (By similarity). Is a negative regulator of endocytosis (PubMed:9736607, PubMed:27760323). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (By similarity). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (PubMed:27760323). May be involved in the regulation of MYC activity and the control cell proliferation (By similarity). {ECO:0000250|UniProtKB:O00499, ECO:0000250|UniProtKB:O08539, ECO:0000269|PubMed:27760323, ECO:0000269|PubMed:9736607}.
Links

Search Kinases of Bin1 (Rat)
KEGG Pathways (2)
Phosphorylation Site Information
Camkk1
Rat
Calcium/calmodulin-dependent protein kinase kinase 1
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
F1LQD2_RAT
Accession #
F1LQD2
Protein names
  • Calcium/calmodulin-dependent protein kinase kinase 1
  • Calcium/calmodulin-dependent protein kinase kinase 1, alpha
Gene names
  • Camkk1
  • rCG_35534
Description
N/A
Links

Search Kinases of Camkk1 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Camkk1
Rat
Calcium/calmodulin-dependent protein kinase kinase 1
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
KKCC1_RAT
Accession #
P97756
Protein names
  • Calcium/calmodulin-dependent protein kinase kinase 1
  • CaM-KK 1
  • CaM-kinase kinase 1
  • CaMKK 1
  • EC 2.7.11.17
  • CaM-kinase IV kinase
  • Calcium/calmodulin-dependent protein kinase kinase alpha
  • CaM-KK alpha
  • CaM-kinase kinase alpha
  • CaMKK alpha
Gene names
  • Camkk1
Description
Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:7642608, ECO:0000269|PubMed:8631893, ECO:0000269|PubMed:9859994}.
Links

Search Kinases of Camkk1 (Rat)
KEGG Pathways (1)
Phosphorylation Site Information
Camkk2
Rat
Calcium/calmodulin-dependent protein kinase kinase 2
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
KKCC2_RAT
Accession #
O88831
Protein names
  • Calcium/calmodulin-dependent protein kinase kinase 2
  • CaM-KK 2
  • CaM-kinase kinase 2
  • CaMKK 2
  • EC 2.7.11.17
  • Calcium/calmodulin-dependent protein kinase kinase beta
  • CaM-KK beta
  • CaM-kinase kinase beta
  • CaMKK beta
Gene names
  • Camkk2
Description
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1 and CAMK4. Phosphorylates CAMK1D (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals. May play a role in neurite growth. Isoform 2 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:21807092, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:8631893, ECO:0000269|PubMed:9822657}.
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Search Kinases of Camkk2 (Rat)
Phosphorylation Site Information
Cct3
Rat
T-complex protein 1 subunit gamma
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
TCPG_RAT
Accession #
Q6P502
Protein names
  • T-complex protein 1 subunit gamma
  • TCP-1-gamma
  • CCT-gamma
Gene names
  • Cct3
Description
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. {ECO:0000250|UniProtKB:P49368}.
Links

Search Kinases of Cct3 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
Cct4
Rat
T-complex protein 1 subunit delta
Substrate Information
Organism
Rat (Rattus norvegicus)
Uniprot ID
TCPD_RAT
Accession #
Q7TPB1
Protein names
  • T-complex protein 1 subunit delta
  • TCP-1-delta
  • CCT-delta
Gene names
  • Cct4
Description
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. {ECO:0000250|UniProtKB:P50991}.
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Search Kinases of Cct4 (Rat)
KEGG Pathways (0)
N/A
Phosphorylation Site Information
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